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公开(公告)号:US20110197724A1
公开(公告)日:2011-08-18
申请号:US11816975
申请日:2006-06-02
申请人: David J. Harris , Neil R. Seacroft
发明人: David J. Harris , Neil R. Seacroft
CPC分类号: B26D5/20 , B26D7/01 , B26D7/1863 , C03B33/06 , H01J9/52 , Y02W30/828 , Y10T83/04 , Y10T83/051 , Y10T83/207 , Y10T83/536 , Y10T83/541 , Y10T83/865
摘要: An apparatus 12 for cutting a cathode ray tube 10 comprises a support means 14 for supporting the screen 16 of the cathode ray tube 10, first and second sensors 18,20 (shown in FIGS. 3 and 4) for determining the external dimensions of the screen 16, first and second spaced diamond cutting means 22,24, and displacement means 26 for moving the support means 14 relative to the diamond cutting means 22,24.
摘要翻译: 用于切割阴极射线管10的装置12包括用于支撑阴极射线管10的屏幕16的支撑装置14,用于确定阴极射线管10的外部尺寸的第一和第二传感器18,20(图3和图4所示) 屏幕16,第一和第二间隔金刚石切割装置22,24以及用于使支撑装置14相对于金刚石切割装置22,24移动的移位装置26。
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公开(公告)号:US20110142952A1
公开(公告)日:2011-06-16
申请号:US13000114
申请日:2009-06-17
申请人: David J. Harris , Stephen Randall Holmes-Farley , Steven C. Polomoscanlk , Adnan Salameh , Bruce Shutts , Richard Silva
发明人: David J. Harris , Stephen Randall Holmes-Farley , Steven C. Polomoscanlk , Adnan Salameh , Bruce Shutts , Richard Silva
IPC分类号: A61K9/16 , A61K31/785 , A61K31/132 , C08G73/02 , C07C217/42 , B32B5/16
CPC分类号: A61K9/1641 , Y10T428/2982
摘要: This invention relates to crosslinked amine-containing polymers for binding compounds or ions, and more specifically relates to pharmaceutically acceptable compositions for binding compounds or ions that include crosslinked amine-containing polymers. The pharmaceutically acceptable composition includes, for example, crosslinked polyamine particles, or pharmaceutically acceptable salts thereof, having a particle size distribution wherein greater than 10 vol. % of the particles have a particle size greater than 500 μm.
摘要翻译: 本发明涉及用于结合化合物或离子的交联的含胺聚合物,更具体地涉及用于结合包含交联的含胺聚合物的化合物或离子的药学上可接受的组合物。 药学上可接受的组合物包括例如交联的多胺颗粒或其药学上可接受的盐,其具有大于10体积% 颗粒的%具有大于500μm的粒度。
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公开(公告)号:US20090155368A1
公开(公告)日:2009-06-18
申请号:US12314554
申请日:2008-12-12
申请人: Stephen Randall Holmes-Farley , David J. Harris , Steven C. Polomoscanik , Adnan Salameh , Bruce Shutts , Richard Silva , Pradeep K. Dhal , Lynne Sole
发明人: Stephen Randall Holmes-Farley , David J. Harris , Steven C. Polomoscanik , Adnan Salameh , Bruce Shutts , Richard Silva , Pradeep K. Dhal , Lynne Sole
IPC分类号: A61K9/14 , A61K31/785 , A61P1/00
CPC分类号: A61K31/785 , A61K9/146 , A61K9/16 , A61K9/1688 , A61K9/20 , A61K9/2031 , A61K9/2077 , A61K9/2095 , A61K9/282 , A61K9/284 , A61K9/2853 , B01J41/14 , Y10T428/2982
摘要: The present invention relates to crosslinked polyamine particles and/or pharmaceutical compositions comprising, at least in part, crosslinked polyamine particles and aggregates of such particles (including cured aggregates of crosslinked polyamine particles). The compositions may be in the form of tablets comprising, for example, particles larger than 500 μm, and used for treating patients, for example, patients with hyperphosphatemia.
摘要翻译: 本发明涉及交联的多胺颗粒和/或药物组合物,其至少部分地包含交联的多胺颗粒和这种颗粒的聚集体(包括交联的聚胺颗粒的固化聚集体)。 组合物可以是包含例如大于500μm的颗粒的片剂的形式,并且用于治疗患者,例如高磷酸盐血症的患者。
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公开(公告)号:US20080146533A1
公开(公告)日:2008-06-19
申请号:US11881738
申请日:2007-07-27
IPC分类号: A61K31/397 , A61K31/5375 , A61K31/498 , A61P9/10 , A61P31/04 , A61P13/12 , A61K31/445 , A61K31/40
CPC分类号: A61K31/397 , A61K31/40 , A61K31/445 , A61K31/498 , A61K31/5375 , C07D295/13 , C07D317/54 , C07D319/18 , C07D321/10 , Y02A50/473
摘要: The present invention provides amino ceramide-like compounds which inhibit glucosyl ceramide (GlyCer) formation by inhibiting the enzyme GlyCer synthase, thereby lowering the level of glycosphingolipids. The compounds of the present invention have improved GlcCer synthase inhibition activity and are therefore useful in therapeutic methods for treating various conditions and diseases associated with altered glycosphingolipid levels.
摘要翻译: 本发明提供通过抑制GlyCer合酶抑制葡萄糖基神经酰胺(GlyCer)形成的氨基神经酰胺样化合物,从而降低糖鞘脂的含量。 本发明的化合物具有改善的GlcCer合酶抑制活性,因此可用于治疗与改变的鞘糖脂水平相关的各种病症和疾病的治疗方法。
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公开(公告)号:US5040233A
公开(公告)日:1991-08-13
申请号:US462206
申请日:1990-01-09
申请人: Rex W. Davy , David J. Harris
发明人: Rex W. Davy , David J. Harris
摘要: A method of modifying a digital representation of an image in which digital data defines the content of pixels of the image. The method comprisesa) determining whether a predetermined degree of compression can be achieved if data defining a block of pixels is compressed by applying a predetermined compression algorithm; and, if not,b) discarding a portion of the data in the block, andrepeating steps a and b on the most recently modified block until the predetermined degree of compression is achieved, and generating a compressed version of the image.
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公开(公告)号:US4701641A
公开(公告)日:1987-10-20
申请号:US665871
申请日:1984-10-29
申请人: David J. Harris , Charles L. Vinn
发明人: David J. Harris , Charles L. Vinn
IPC分类号: H03M1/00 , H03K19/20 , G05B1/00 , G06F7/38 , H03K19/086
CPC分类号: H03M1/745
摘要: A digital-to-analog conversion circuitry is provided wherein a switching network is adapted to couple, or decouple, a selected one, or ones, of a plurality of identical current sources to, or from, an output bus selectively in accordance with the digital word being converted to produce an output current through an output bus having a level related to such digital word. The switching network includes: a logic network for selectively combining the plurality of bits of the digital word to produce a plurality of control signals, at least one thereof being related to a plurality of the bits of the digital word; and, a plurality of switching transistors, each one thereof having: a control (or base) electrode coupled to a corresponding one of the plurality of control signals; a first (or emitter) electrode coupled to a corresponding one of the plurality of identical current sources; and a second (or collector) electrode coupled to the output bus, such current source being coupled to, or decoupled from, such output bus selectively in accordance with the control signal fed to the control electrode of the transistor coupled to such current source, the logic network produces the plurality of control signals with substantially equal switching level variations. With such arrangement, the level of current produced by each current source and its contribution to the total output current are independent of the digital word being coverted and the level of current contributing to the total current flow through the output bus is also independent of the digital word being converted. Further, the switching time of the switching transistors is also independent of the digital word being converted.
摘要翻译: 提供了一种数模转换电路,其中交换网络适于将多个相同电流源中的一个或多个选择的一个或多个耦合或去耦合到输出总线或从输出总线选择性地根据数字 字被转换以通过具有与这种数字字相关的电平的输出总线产生输出电流。 交换网络包括:逻辑网络,用于选择性地组合数字字的多个位以产生多个控制信号,其至少一个与数字字的多个位相关; 以及多个开关晶体管,其中的每一个具有:耦合到所述多个控制信号中的相应一个控制信号的控制(或基极)电极; 耦合到所述多个相同电流源中的相应一个的第一(或发射极)电极; 以及耦合到输出总线的第二(或集电极)电极,这样的电流源根据馈送到耦合到这种电流源的晶体管的控制电极的控制信号选择性地耦合到这种输出总线或从该输出总线去耦, 逻辑网络产生具有基本相等的开关电平变化的多个控制信号。 通过这样的布置,每个电流源产生的电流水平及其对总输出电流的贡献与被覆盖的数字字无关,并且对通过输出总线的总电流有贡献的电流水平也与数字 正在转换字。 此外,开关晶体管的切换时间也与被转换的数字字无关。
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公开(公告)号:US4037990A
公开(公告)日:1977-07-26
申请号:US691390
申请日:1976-06-01
申请人: David J. Harris
发明人: David J. Harris
CPC分类号: F01D5/3053
摘要: A turbomachinery rotor comprising a rotatable hub and a composite blade attached to the periphery thereof. The blade comprises a plurality of bonded filament laminates extending between, and wrapped around, a pair of hollow, semicylindrical inserts at the blade root. The laminates are bonded to the inserts so as to form a cylindrical blade root profile for insertion into a complementary cylindrical groove in the periphery of the hub. A slotted pin is positioned within the inserts to prevent the root from collapsing under loadings and to retain the blade in the hub.
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48.
公开(公告)号:US20120322787A1
公开(公告)日:2012-12-20
申请号:US13595349
申请日:2012-08-27
申请人: Craig Siegel , Cecilia M. Bastos , David J. Harris , Angeles Dios , Edward Lee , Richard Silva , Lisa M. Cuff , Mikaela Levine , Cassandra A. Celatka , Frederic Vinick , Thomas H. Jozefiak , Yibin Xiang , John Kane , Junkai Liao
发明人: Craig Siegel , Cecilia M. Bastos , David J. Harris , Angeles Dios , Edward Lee , Richard Silva , Lisa M. Cuff , Mikaela Levine , Cassandra A. Celatka , Frederic Vinick , Thomas H. Jozefiak , Yibin Xiang , John Kane , Junkai Liao
IPC分类号: A61K31/4025 , A61P3/10 , A61P13/12 , C07D409/14 , A61K31/4439 , A61K31/397 , A61K31/422 , C07D417/14 , A61K31/428 , A61K31/4245 , A61K31/444 , A61K31/5377 , C07D405/10 , C07D413/14
CPC分类号: C07D417/14 , C07D295/125 , C07D319/18 , C07D405/06 , C07D405/12 , C07D405/14 , C07D407/12 , C07D409/12 , C07D409/14 , C07D411/12 , C07D413/12 , C07D413/14
摘要: A compound is represented by Structural Formula (I): or a pharmaceutically acceptable salt thereof. A pharmaceutical composition comprises a compound represented by Structural Formula (I) or a pharmaceutically acceptable salt thereof. A method of treating a subject in need thereof comprises administering to the subject a therapeutically effective amount of a compound represented by Structural Formula (I) or a pharmaceutically acceptable salt thereof. The subject has type 2 diabetes; renal hypertrophy or hyperplasia associated with diabetic nephropathy; Tay-Sachs; Gaucher's; or Fabry's disease. Methods of decreasing plasma TNF-α, lowering blood glucose levels, decreasing glycated hemoglobin levels, inhibiting glucosylceramide synthase, and lowering glycosphingolipid concentrations in a subject in need thereof respectively comprise administering to the subject a therapeutically effective amount of a compound represented by Structural Formula (I) or a pharmaceutically acceptable salt thereof.
摘要翻译: 化合物由结构式(I)表示:或其药学上可接受的盐。 药物组合物包含由结构式(I)表示的化合物或其药学上可接受的盐。 治疗有需要的受试者的方法包括向受试者施用治疗有效量的由结构式(I)表示的化合物或其药学上可接受的盐。 受试者患有2型糖尿病; 肾脏肥大或与糖尿病肾病相关的增生; 泰撒 戈谢的 或法布里氏病。 分别在有需要的受试者中降低血浆TNF-α,降低血糖水平,降低糖化血红蛋白水平,抑制葡萄糖神经酰胺合成酶和降低糖鞘醇浓度的方法包括向受试者施用治疗有效量的由结构式( I)或其药学上可接受的盐。
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49.
公开(公告)号:US20110184021A1
公开(公告)日:2011-07-28
申请号:US13122135
申请日:2009-10-02
申请人: Craig Siegel , Cecilia M. Bastos , David J. Harris , Angeles Dios , Edward Lee , Richard Silva , Lisa M. Cuff , Mikaela Levine , Cassandra A. Celatka , Thomas H. Jozafiak , Frederic Vinick , Yibin Xiang , John Kane , Junkai Liao
发明人: Craig Siegel , Cecilia M. Bastos , David J. Harris , Angeles Dios , Edward Lee , Richard Silva , Lisa M. Cuff , Mikaela Levine , Cassandra A. Celatka , Thomas H. Jozafiak , Frederic Vinick , Yibin Xiang , John Kane , Junkai Liao
IPC分类号: A61K31/453 , A61K31/40 , A61K31/4025 , A61K31/4439 , A61K31/422 , A61K31/428 , A61P13/12
CPC分类号: A61K31/4025 , C07C271/12 , C07D207/12 , C07D317/60 , C07D319/18 , C07D319/20 , C07D333/16 , C07D407/06 , C07D407/12 , C07D409/04 , C07D413/04 , C07D417/12
摘要: A compound for use in treating polycystic kidney disease is represented by Structural Formula (I): or a pharmaceutically acceptable salt thereof. A pharmaceutical composition comprises a compound represented by Structural Formula (I) or a pharmaceutically acceptable salt thereof. A method of treating polycystic kidney disease in a subject in need thereof comprises administering to the subject a therapeutically effective amount of a compound represented by Structural Formula (I) or a pharmaceutically acceptable salt thereof. Methods of treating in polycystic kidney disease in a subject in need thereof respectively comprise administering to the subject a therapeutically effective amount of a compound represented by Structural Formula (I) or a pharmaceutically acceptable salt thereof.
摘要翻译: 用于治疗多囊肾病的化合物由结构式(I)表示:或其药学上可接受的盐。 药物组合物包含由结构式(I)表示的化合物或其药学上可接受的盐。 在有需要的受试者中治疗多囊肾病的方法包括向受试者施用治疗有效量的由结构式(I)表示的化合物或其药学上可接受的盐。 分别在有需要的受试者中治疗多囊肾病的方法包括向受试者施用治疗有效量的由结构式(I)表示的化合物或其药学上可接受的盐。
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公开(公告)号:US20100069500A1
公开(公告)日:2010-03-18
申请号:US12311362
申请日:2007-09-26
申请人: Pradeep K. Dhal , David J. Harris , Stephen Randall Holmes-Farley , Chad C. Huval , Vitaly Nivorozhkin , Bruce Shutts
发明人: Pradeep K. Dhal , David J. Harris , Stephen Randall Holmes-Farley , Chad C. Huval , Vitaly Nivorozhkin , Bruce Shutts
CPC分类号: C08G69/40 , A61K8/72 , A61K31/785 , C07C235/08 , C07C237/10 , C08G83/003 , C08L101/00
摘要: Amide compounds, amide polymers, compositions including amide compounds and amide polymers may be used to bind target ions, such as phosphorous-containing compounds in the gastrointestinal tract of animals. In some cases, amide compounds and amide polymers may include a core derived from an amide polyol and an organic polyacid or ester.
摘要翻译: 酰胺化合物,酰胺聚合物,包括酰胺化合物和酰胺聚合物的组合物可用于结合目标离子,例如动物胃肠道中的含磷化合物。 在一些情况下,酰胺化合物和酰胺聚合物可以包括衍生自酰胺多元醇和有机多酸或酯的核。
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