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    Integrated circuit Zener diode
    1.
    发明授权
    Integrated circuit Zener diode 失效
    集成电路齐纳二极管

    公开(公告)号：US4646114A

    公开(公告)日：1987-02-24

    申请号：US687894

    申请日：1984-12-31

    申请人： Charles L. Vinn ,  David J. Harris

    发明人： Charles L. Vinn ,  David J. Harris

    IPC分类号： H01L29/861 ,  H01L29/866 ,  H01L29/90

    CPC分类号： H01L29/866

    摘要： A subsurface Zener diode is provided wherein a semiconductor has formed thereon spaced apart anode and cathode regions of opposite type conductivity, such regions having opposing surface portions, and disposed beneath a surface of such semiconductor a buried region of conductivity type the same as one of such regions, such buried region extending laterally through the spaced apart regions, one of the spaced apart regions having an opposing surface portion thereof formed with a portion which protrudes towards the opposing surface portion of the other one of the spaced apart regions. With such arrangement, an electric field produced between the spaced apart regions becomes concentrated at the protrusion with the result that Zener breakdown occurs repeatedly at the same point in the semiconductor thereby reducing long term drift. Also, a Kelvin buried Zener diode is provided by forming a second laterally spaced anode region with the cathode region disposed between the pair of anode regions. One of the pair of anodes provides the force anode and the other the sense anode. The buried region extends laterally through the pair of anodes and the cathode region. The cathode region is provided with the portion which protrudes towards the force anode of the pair of anode regions and such cathode is elongated along an axis which passes between the pair of force and sense anode regions. The elongated cathode thus improves isolation between the force and sense anodes.

    摘要翻译： 提供了一个次表面的齐纳二极管，其中半导体已经在其上形成了具有相反导电性的间隔开的阳极和阴极区域，这些区域具有相对的表面部分，并且在这种半导体的表面下方设置与其中之一相同的导电类型的掩埋区域 区域，这样的掩埋区域横向延伸穿过间隔开的区域，其中一个间隔开的区域具有相对的表面部分，其形成有朝向另一个间隔开的区域的相对表面部分突出的部分。 通过这样的布置，在间隔开的区域之间产生的电场在突起处变得集中，结果是在半导体的同一点处重新产生齐纳击穿从而减少长期漂移。 此外，通过形成第二横向间隔开的阳极区域，其中阴极区域设置在一对阳极区域之间，提供开尔文掩埋齐纳二极管。 一对阳极中的一个提供了力阳极和另一个阳极。 埋入区域横向延伸穿过一对阳极和阴极区域。 阴极区域设置有朝向一对阳极区域的力阳极突出的部分，并且该阴极沿着在一对力和感测阳极区域之间通过的轴线延伸。 因此，细长的阴极改善了力和感应阳极之间的隔离。

    Digital-to-analog converter
    2.
    发明授权
    Digital-to-analog converter 失效
    数模转换器

    公开(公告)号：US4492954A

    公开(公告)日：1985-01-08

    申请号：US608928

    申请日：1984-05-11

    申请人： David J. Harris ,  Charles L. Vinn

    发明人： David J. Harris ,  Charles L. Vinn

    IPC分类号： H03M1/00 ,  H03K13/05

    CPC分类号： H03M1/747

    摘要： A digital-to-analog conversion circuitry is provided wherein a switching network is adapted to couple, or decouple, a selected one, or ones, of a plurality of identical current sources to, or from, an output bus selectively in accordance with the digital word being converted to produce an output current through an output bus having a level related to such digital word. The switching network includes: a logic network for selectively combining the plurality of bits of the digital word to produce a plurality of control signals, at least one thereof being related to a plurality of the bits of the digital word; and, a plurality of switching transistors, each one thereof having: a control (or base) electrode coupled to a corresponding one of the plurality of control signals; a first (or emitter) electrode coupled to a corresponding one of the plurality of identical current sources; and a second (or collector) electrode coupled to the output bus, such current source being coupled to, or decoupled from, such output bus selectively in accordance with the control signal fed to the control electrode of the transistor coupled to such current source, the logic network produces the plurality of control signals with substantially equal switching level variations.

    摘要翻译： 提供了一种数模转换电路，其中交换网络适于将多个相同电流源中的一个或多个选择的一个或多个耦合或去耦合到输出总线或从输出总线选择性地根据数字 字被转换以通过具有与这种数字字相关的电平的输出总线产生输出电流。 交换网络包括：逻辑网络，用于选择性地组合数字字的多个位以产生多个控制信号，其至少一个与数字字的多个位相关; 以及多个开关晶体管，其中的每一个具有：耦合到所述多个控制信号中的相应一个控制信号的控制（或基极）电极; 耦合到所述多个相同电流源中的相应一个的第一（或发射极）电极; 以及耦合到输出总线的第二（或集电极）电极，这样的电流源根据馈送到耦合到这种电流源的晶体管的控制电极的控制信号选择性地耦合到这种输出总线或从该输出总线去耦， 逻辑网络产生具有基本相等的开关电平变化的多个控制信号。

    Logic network for D/A conversion
    3.
    发明授权
    Logic network for D/A conversion 失效
    用于D / A转换的逻辑网络

    公开(公告)号：US4701641A

    公开(公告)日：1987-10-20

    申请号：US665871

    申请日：1984-10-29

    申请人： David J. Harris ,  Charles L. Vinn

    发明人： David J. Harris ,  Charles L. Vinn

    IPC分类号： H03M1/00 ,  H03K19/20 ,  G05B1/00 ,  G06F7/38 ,  H03K19/086

    CPC分类号： H03M1/745

    摘要： A digital-to-analog conversion circuitry is provided wherein a switching network is adapted to couple, or decouple, a selected one, or ones, of a plurality of identical current sources to, or from, an output bus selectively in accordance with the digital word being converted to produce an output current through an output bus having a level related to such digital word. The switching network includes: a logic network for selectively combining the plurality of bits of the digital word to produce a plurality of control signals, at least one thereof being related to a plurality of the bits of the digital word; and, a plurality of switching transistors, each one thereof having: a control (or base) electrode coupled to a corresponding one of the plurality of control signals; a first (or emitter) electrode coupled to a corresponding one of the plurality of identical current sources; and a second (or collector) electrode coupled to the output bus, such current source being coupled to, or decoupled from, such output bus selectively in accordance with the control signal fed to the control electrode of the transistor coupled to such current source, the logic network produces the plurality of control signals with substantially equal switching level variations. With such arrangement, the level of current produced by each current source and its contribution to the total output current are independent of the digital word being coverted and the level of current contributing to the total current flow through the output bus is also independent of the digital word being converted. Further, the switching time of the switching transistors is also independent of the digital word being converted.

    摘要翻译： 提供了一种数模转换电路，其中交换网络适于将多个相同电流源中的一个或多个选择的一个或多个耦合或去耦合到输出总线或从输出总线选择性地根据数字 字被转换以通过具有与这种数字字相关的电平的输出总线产生输出电流。 交换网络包括：逻辑网络，用于选择性地组合数字字的多个位以产生多个控制信号，其至少一个与数字字的多个位相关; 以及多个开关晶体管，其中的每一个具有：耦合到所述多个控制信号中的相应一个控制信号的控制（或基极）电极; 耦合到所述多个相同电流源中的相应一个的第一（或发射极）电极; 以及耦合到输出总线的第二（或集电极）电极，这样的电流源根据馈送到耦合到这种电流源的晶体管的控制电极的控制信号选择性地耦合到这种输出总线或从该输出总线去耦， 逻辑网络产生具有基本相等的开关电平变化的多个控制信号。 通过这样的布置，每个电流源产生的电流水平及其对总输出电流的贡献与被覆盖的数字字无关，并且对通过输出总线的总电流有贡献的电流水平也与数字 正在转换字。 此外，开关晶体管的切换时间也与被转换的数字字无关。

    Cationic amphiphiles containing spermine or spermidine cationic group for intracellular delivery of therapeutic molecules
    7.
    发明授权
    Cationic amphiphiles containing spermine or spermidine cationic group for intracellular delivery of therapeutic molecules 失效
    含有精胺或亚精胺阳离子基团的阳离子两亲物用于细胞内递送治疗分子

    公开(公告)号：US5783565A

    公开(公告)日：1998-07-21

    申请号：US595375

    申请日：1996-02-01

    申请人： Edward R. Lee ,  David J. Harris ,  Craig S. Siegel ,  Seng H. Cheng ,  Simon J. Eastman ,  John Marshall ,  Ronald K. Scheule

    发明人： Edward R. Lee ,  David J. Harris ,  Craig S. Siegel ,  Seng H. Cheng ,  Simon J. Eastman ,  John Marshall ,  Ronald K. Scheule

    IPC分类号： A61K9/127 ,  A61K47/48 ,  A61K48/00 ,  C07J41/00 ,  C07J43/00 ,  C12N15/88 ,  B01F17/16 ,  C12N15/00

    CPC分类号： B82Y5/00 ,  A61K47/48023 ,  A61K47/48038 ,  A61K47/48046 ,  A61K47/48123 ,  A61K48/00 ,  A61K9/1272 ,  C07J41/0005 ,  C07J41/0055 ,  C07J41/0061 ,  C07J43/003 ,  C12N15/88 ,  Y10S516/07

    摘要： Novel cationic amphiphiles are provided that facilitate transport of biologically active (therapeutic) molecules into cells. The amphiphiles contain lipophilic groups derived from steroids, from mono or dialkylamines, or from alkyl or acyl groups; and cationic groups, protonatable at physiological pH, derived from amines, alkylamines or polyalkylamines. There are provided also therapeutic compositions prepared typically by contacting a dispersion of one or more cationic amphiphiles with the therapeutic molecules. Therapeutic molecules that can be delivered into cells according to the practice of the invention include DNA, RNA, and polypeptides. Representative uses of the therapeutic compositions of the invention include providing gene therapy, and delivery of antisense polynucleotides or biologically active polypeptides to cells. With respect to therapeutic compositions for gene therapy, the DNA is provided typically in the form of a plasmid for complexing with the cationic amphiphile. Novel and highly effective plasmid constructs are also disclosed, including those that are particularly effective at providing gene therapy for clinical conditions complicated by inflammation. Additionally, targeting of organs for gene therapy by intravenous administration of therapeutic compositions is described.

    摘要翻译： 提供了新的阳离子两亲物，其促进生物活性（治疗性）分子进入细胞。 两亲物含有衍生自类固醇的单亲或二烷基胺或烷基或酰基的亲脂基团; 和在生理pH下可质子化的阳离子基团，衍生自胺，烷基胺或多烷基胺。 还提供了通常通过使一种或多种阳离子两亲物的分散体与治疗分子接触而制备的治疗组合物。 根据本发明的实践可以递送到细胞中的治疗分子包括DNA，RNA和多肽。 本发明治疗组合物的代表性用途包括提供基因治疗以及向细胞递送反义多核苷酸或生物活性多肽。 关于基因治疗的治疗组合物，通常以与阳离子两亲物络合的质粒的形式提供DNA。 还公开了新型和高效的质粒构建体，包括在为炎症复杂的临床病症提供基因治疗方面特别有效的质粒构建体。 另外，描述了通过静脉内施用治疗组合物靶向用于基因治疗的器官。

    Composite blade for turbofan engine fan
    8.
    发明授权
    Composite blade for turbofan engine fan 失效
    涡轮风扇发动机风扇复合叶片

    公开(公告)号：US4343593A

    公开(公告)日：1982-08-10

    申请号：US115516

    申请日：1980-01-25

    申请人： David J. Harris

    发明人： David J. Harris

    IPC分类号： F01D5/28 ,  F01D5/30

    CPC分类号： F01D5/282 ,  F01D5/30 ,  Y02T50/672

    摘要： A turbofan engine fan blade made of composite material, and a method of making the fan, are taught. The fan blade essentially comprises an airfoil section having a root end and made of a plurality of bonded plies of composite material which are splayed and which are in a staggered condition at the root end; a two-piece platform section made of titanium or of aluminum, with one piece of the platform on each side of the airfoil section; and a steel outsert section which holds and secures the platform section to the airfoil section, with the outsert section having a triangular shaped cavity located at the root end of the airfoil section, between the splayed and staggered plies of the airfoil section. Among other advantages, the cavity eliminates the "insert plies" (or wedge) used in the prior art and the inherent disadvantages associated with such use.

    摘要翻译： 教导了由复合材料制成的涡轮风扇发动机风扇叶片和制造风扇的方法。 风扇叶片基本上包括具有根端并由多个复合材料的粘合层制成的翼型部分，该复合材料层被张开并且在根端处于交错状态; 由钛或铝制成的两件式平台部分，在翼型部分的每一侧具有一个平台; 以及钢板外插部分，其将平台部分保持并固定到翼型部分，外插部分具有位于翼型部分根部的三角形空腔之间，在翼型部分的张开和交错的层之间。 除了其它优点之外，腔体消除了现有技术中使用的“插入层”（或楔形）以及与这种使用相关的固有缺点。