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    APPARATUS FOR FORMULATING AND ASEPTICALLY FILLING LIQUID PRODUCTS
    41.
    发明申请
    APPARATUS FOR FORMULATING AND ASEPTICALLY FILLING LIQUID PRODUCTS 有权
    用于配制和辅助填充液体产品的装置

    公开(公告)号：US20090094940A1

    公开(公告)日：2009-04-16

    申请号：US12245678

    申请日：2008-10-03

    Applicant: Daniel Py

    Inventor： Daniel Py

    IPC: B65B3/12 ,  B65B55/02 ,  B65B55/14

    CPC classification number: A23L3/04 ,  A23L2/46 ,  A23L3/22 ,  B65B3/04 ,  B65B55/025 ,  B65B55/10 ,  B65B55/12

    Abstract: An apparatus and method are provided for formulating and aseptically filling liquid products. A first liquid source includes at least one first liquid component; a second liquid source includes at least one second liquid component; and a container includes a body defining an empty, sterile storage chamber therein that is sealed with respect to ambient atmosphere. The container is introduced into a sterile filling chamber. A first filling member coupled in fluid communication with the first liquid source is placed in fluid communication with the storage chamber of the container located in the sterile filling chamber, and the first liquid component is aseptically introduced through the first filling member and into the storage chamber. A second filling member coupled in fluid communication with the second liquid source is placed in fluid communication with the storage chamber of the container located in the sterile filling chamber, and the second liquid component is aseptically introduced through the second filling member and into the storage chamber and, in turn, the first and second liquid components are combined into a liquid product formulation within the sterile chamber of the container. The first and second filling members are withdrawn from fluid communication with the storage chamber of the container located within the sterile filling chamber, and the filled storage chamber is sealed with respect to ambient atmosphere to hermetically seal the liquid product formulation within the storage chamber of the container.

    Abstract translation: 提供了用于配制和无菌灌装液体产品的装置和方法。 第一液体源包括至少一个第一液体组分; 第二液体源包括至少一个第二液体组分; 并且容器包括在其中限定相对于环境大气密封的空的无菌储存室的主体。 将容器引入无菌填充室。 与第一液体源流体连通的第一填充构件被放置成与位于无菌填充室中的容器的储存室流体连通，第一液体组分被无菌地通过第一填充构件引入储存室 。 与第二液体源流体连通的第二填充构件被放置成与位于无菌填充室中的容器的储存室流体连通，并且第二液体组分被无菌地通过第二填充构件引入并进入储存室 而又将第一和第二液体组分组合成容器无菌室内的液体产品制剂。 第一和第二填充构件与位于无菌填充室内的容器的储存室流体连通地取出，并且填充的储存室相对于环境大气密封，以将液体产品配制物气密地密封在储存室内 容器。

    Apparatus for sealing and engaging sterile chambers
    44.
    发明申请
    Apparatus for sealing and engaging sterile chambers 审中-公开
    用于密封和接合无菌室的装置

    公开(公告)号：US20080083788A1

    公开(公告)日：2008-04-10

    申请号：US11900227

    申请日：2007-09-10

    Applicant: Daniel Py ,  Brian Tulley ,  Jeff Willey

    Inventor： Daniel Py ,  Brian Tulley ,  Jeff Willey

    IPC: B67D5/00 ,  B65D35/56 ,  B65D37/00 ,  B67D5/06

    CPC classification number: B67D1/10 ,  B05B11/0054 ,  B05B11/303 ,  B05B11/3032 ,  B65D75/5866 ,  B65D75/5883 ,  B65D77/067 ,  B67D1/0082 ,  B67D1/02 ,  B67D2001/0827

    Abstract: An apparatus comprises a hermetically sealed, sterile storage chamber, a dispensing valve including a hermetically sealed, sterile inlet; a pump coupled between the dispensing valve and storage chamber; and a sealing surface located between the dispensing valve and storage chamber. The sealing surface and/or the dispensing valve is movable relative to the other between (i) a sealing position hermetically sealing the dispensing valve relative to the storage chamber to thereby prevent fluid flow therebetween, and (ii) a non-sealing position allowing fluid flow therebetween.

    Abstract translation: 一种装置包括密封的无菌储存室，分配阀，包括气密密封的无菌入口; 耦合在分配阀和存储室之间的泵; 以及位于分配阀和储存室之间的密封表面。 密封表面和/或分配阀可以在（i）密封位置之间相对于另一个移动，密封位置相对于储存室气密地密封分配阀，从而防止流体在其间流动，以及（ii）非密封位置，允许流体 流动。

    Dispenser and apparatus and method for filling a dispenser
    45.
    发明授权
    Dispenser and apparatus and method for filling a dispenser 有权
    分配器以及用于填充分配器的装置和方法

    公开(公告)号：US07328729B2

    公开(公告)日：2008-02-12

    申请号：US11349873

    申请日：2006-02-08

    Applicant: Daniel Py ,  Julian V. Chan

    Inventor： Daniel Py ,  Julian V. Chan

    IPC: B65B1/04

    CPC classification number: B65D83/62 ,  A61J1/00 ,  A61J1/1443 ,  B65B3/30 ,  B65B31/044 ,  B65D83/425

    Abstract: A dispenser for holding multiple doses of fluids or other substances, and for dispensing the substances, has a variable volume storage chamber. A filling valve is coupled in fluid communication with the storage chamber and defines (1) a normally closed, fluid-tight position hermetically sealing the storage chamber from the ambient atmosphere, and (2) an open position allowing the passage of fluid through the valve both to evacuate the storage chamber and to introduce fluid through the valve to fill the storage chamber. A dispensing valve is coupled in fluid communication with the storage chamber and defines (1) a normally closed, fluid-tight position preventing the passage of fluid out of the dispenser, and (2) an open position for dispensing fluid therethrough. The sealed, empty dispenser is sterilized, such as by applying gamma radiation thereto. Then, the sterilized, sealed, empty dispenser is filled with fluid by engaging the filling valve with a filling member and introducing fluid from the filling member through the filling valve and into the storage chamber. The fluid in the storage chamber is dispensed through the dispensing valve.

    Abstract translation: 用于保持多个剂量的流体或其他物质并用于分配物质的分配器具有可变容积的储存室。 填充阀与储存室流体连通地联接并且限定（1）将储存室与环境大气密封的常闭密封的流体密封位置，和（2）允许流体通过阀门的打开位置 两者都抽真空储存室并引入流体通过阀门填充储存室。 分配阀与存储室流体连通地联接并且限定（1）常闭的流体密封位置，防止流体从分配器通过，以及（2）用于分配流体的打开位置。 密封的空分配器被灭菌，例如通过对其施加γ射线。 然后，通过将填充阀与填充构件接合并将填充构件的流体通过填充阀引入到储存室中，灭菌的密封的空分配器充满流体。 存储室中的流体通过分配阀分配。

    Sealed containers and methods of making and filling same
    46.
    发明申请
    Sealed containers and methods of making and filling same 有权
    密封容器及其制造和填充方法

    公开(公告)号：US20070000573A1

    公开(公告)日：2007-01-04

    申请号：US11515162

    申请日：2006-09-01

    Applicant: Daniel Py ,  Norbert Assion

    Inventor： Daniel Py ,  Norbert Assion

    IPC: B65B1/04

    CPC classification number: B65B3/003 ,  A61J1/1406 ,  A61J1/1412 ,  A61J1/1425 ,  A61J1/1431 ,  A61J1/1468 ,  A61J1/18 ,  A61J1/201 ,  A61J1/2013 ,  A61J1/2055 ,  A61J1/2075 ,  A61J1/2096 ,  A61M2207/00 ,  A61M2209/045 ,  B65B3/027 ,  B65B7/161 ,  B65B51/10 ,  B65B55/08 ,  B65B2039/009 ,  B65D51/002

    Abstract: Disclosed is a uniquely configured medicament vial assembly which includes a storage vial, a stopper member and a securing ring. The vial assembly is configured to improve healthcare worker safety by providing a shielded gripping location to aid in the reduction of accidental needle sticks. The storage vial has a body portion which defines an interior chamber for storing a predetermined medicament and a neck portion through which medicament is received into and withdrawn from the interior chamber. The stopper member is inserted into the mouth of the vial and establishes a first seal. The securing ring is engaged with the mouth of the vial and adapted and configured for retaining the stopper member within the vial mouth and effectuating a second seal. The securing ring is formed from a thermoplastic and/or elastic material. Preferably, the securing ring is formed by molding the thermoplastic and/or elastic material over a portion of the storage vial and stopper member when engaged within the vial mouth.

    Abstract translation: 公开了一种独特构造的药物小瓶组件，其包括存储小瓶，止动构件和固定环。 小瓶组件被配置成通过提供屏蔽夹持位置来帮助减少意外的针棒来改善医护人员的安全性。 存储小瓶具有主体部分，其限定用于存储预定药物的内部腔室和颈部部分，药物通过所述颈部部分容纳到内部腔室中并从内部腔室中排出。 止动件插入小瓶的口中并建立第一密封。 固定环与小瓶的口接合并适于和构造成将止动件保持在小瓶口内并实现第二密封。 固定环由热塑性和/或弹性材料形成。 优选地，固定环通过在接合在小瓶口中时将热塑性和/或弹性材料模制在存储小瓶和止动构件的一部分上而形成。

    Apparatus and method for needle filling and laser resealing
    47.
    发明申请
    Apparatus and method for needle filling and laser resealing 有权
    针刺和激光重新密封的装置和方法

    公开(公告)号：US20060283522A1

    公开(公告)日：2006-12-21

    申请号：US11510961

    申请日：2006-08-28

    Applicant: Daniel Py

    Inventor： Daniel Py

    IPC: B67C3/00

    CPC classification number: B65B7/161 ,  B65B3/003 ,  B65B7/00 ,  B65B37/06 ,  B65B43/54 ,  B65B51/22 ,  B65B55/04 ,  B65B55/08 ,  B65B57/00 ,  B65B65/02

    Abstract: An apparatus is provided for needle filling and thermally resealing containers having stoppers that are needle penetrable for filling the containers with a substance, and are thermally resealable for thermally sealing a needle hole in the stopper upon withdrawal of a needle therefrom. A container support of the apparatus supports at least one container having a resealable stopper in a substantially fixed position during needle filling and thermally resealing a needle hole in the stopper upon withdrawal of a needle therefrom. A manifold is drivingly mounted over the container support and comprises (1) a needle cartridge including a needle for penetrating the resealable stopper and introducing a substance through the needle and into the container, a needle mount for mounting the needle cartridge on the manifold, and a needle cover releasably coupled to the needle mount for covering the needle during transportation, installation and/or removal of the needle cartridge from the manifold, and that is removable from the needle cartridge upon mounting the needle cartridge to the manifold. The manifold further includes a thermal source for heating a needle penetrated region of the stopper and, in turn, sealing a needle hole in the stopper.

    Abstract translation: 提供了一种用于针头填充和热重新密封容器的装置，其具有用于针对物品填充容器的可穿刺的塞子，并且在从其中取出针时，可热再密封用于热封塞塞中的针孔。 装置的容器支撑件支撑至少一个具有可重新封闭的塞子的容器，该容器在针填充期间处于基本上固定的位置，并且在从针头中​​取出针时，在塞子中对针孔进行热再密封。 歧管被驱动地安装在容器支架上方，并且包括（1）针筒，其包括用于穿透可再密封塞子并将物质通过针引入容器的针，用于将针筒安装在歧管上的针座，以及 可拆卸地联接到针座的针罩，用于在从歧管运输，安装和/或移除针筒期间覆盖针头，并且当将针筒安装到歧管上时可从针筒上移除。 歧管还包括用于加热塞子的针穿入区域的热源，并且进而密封塞子中的针孔。

    Sterile de-molding apparatus and method
    48.
    发明申请
    Sterile de-molding apparatus and method 有权
    无菌脱模装置及方法

    公开(公告)号：US20060225809A1

    公开(公告)日：2006-10-12

    申请号：US11374522

    申请日：2006-03-13

    Applicant: Daniel Py

    Inventor： Daniel Py

    IPC: B65B1/04

    CPC classification number: B65B3/022

    Abstract: Apparatus is provided for molding and filling a container having a container body defining an opening in communication with an interior chamber for receiving a substance therein, and a stopper receivable within the opening for sealing the opening and substance received in the container. A barrier enclosure defines an aseptic chamber. A mold includes within the aseptic chamber plural mold cavities shaped to form the stopper and container body, and substantially sterile surfaces extending about and contiguous to the peripheries of the mold cavities. An assembly device including end-of-arm tooling having an engaging portion engageable with each of the container body and stopper is movable relative to the mold to engage and de-mold the substantially sterile stoppers and container bodies from the mold cavities. A source of sterile air is in fluid communication with the aseptic chamber and directs a flow of sterile air into the aseptic chamber and over the sterile surfaces of the mold for maintaining the sterility of the mold surfaces and stopper and container bodies during de-molding thereof. First flexible barriers are coupled to the mold between the sterile surfaces and the molding machine to substantially prevent the passage of contaminants from the molding machine therethrough. A second flexible barrier is coupled to the tool between the engaging portion and a base portion of the tool to substantially prevent the passage of contaminants from the base portion of the tool therethrough. A needle filling and thermal resealing station is configured to receive the sealed, empty sterile containers, needle fill the interior chambers of the containers, and thermally reseal resulting needle holes in the stoppers.

    Abstract translation: 提供了用于模制和填充具有容器主体的容器的容器，该容器主体限定与用于容纳物质的内部室相连通的开口，以及可接收在开口内的止动件，用于密封容纳在容器中的开口和物质。 隔离罩限定了无菌室。 模具包括在无菌室内的多个模具腔，其形状形成止动器和容器主体，以及基本上无菌的表面，其围绕并邻近模腔周边延伸。 一种包括端臂工具的装配装置具有可与容器主体和止动件中的每一个接合的接合部分，可相对于模具移动，从而将基本上无菌的止动器和容器主体与模具腔接合并脱模。 无菌空气源与无菌室流体连通，并将无菌空气流引导到无菌室和模具的无菌表面上，以保持模具表面和塞子和容器主体在其脱模期间的无菌性 。 第一柔性屏障耦合到无菌表面和成型机之间的模具，以基本上防止来自成型机的污染物通过其中。 第二柔性屏障在接合部分和工具的基部之间联接到工具，以基本上防止污染物从工具的基部通过其中。 针填充和热再密封台被构造成接收密封的空的无菌容器，针填充容器的内部腔室，并且对止动器中的针孔加热再密封。

    Method of using one-way valve and related apparatus
    50.
    发明申请
    Method of using one-way valve and related apparatus 有权
    使用单向阀及相关设备的方法

    公开(公告)号：US20060169722A1

    公开(公告)日：2006-08-03

    申请号：US11295251

    申请日：2005-12-05

    Applicant: Daniel Py ,  Julian Chan ,  Benoit Adamo

    Inventor： Daniel Py ,  Julian Chan ,  Benoit Adamo

    IPC: B65D37/00

    CPC classification number: B67D1/0004 ,  B65B39/004 ,  B67D1/0007 ,  B67D1/0009 ,  B67D1/0082 ,  B67D1/10 ,  B67D1/108 ,  B67D1/1279 ,  B67D3/04 ,  B67D2001/0827 ,  F04B43/1238 ,  F04B53/1037 ,  Y10T137/7761

    Abstract: An apparatus has a valve body defining a first passageway, a valve seat, and a flow aperture extending through the valve body and coupled in fluid communication with the first passageway. A valve cover of the apparatus is formed of an elastic material and includes a cover base mounted on the valve body and fixedly secured against movement relative thereto, and a valve portion overlying the valve seat. The valve portion defines a predetermined radial thickness and forms an interference fit with the valve seat. The valve portion and the valve seat define a normally closed, axially-extending valve opening therebetween. The valve portion is movable between a normally closed position with the valve portion engaging the valve seat, and an open position with at least a segment of the valve portion spaced away from the valve seat to connect the valve opening in fluid communication with the flow aperture to thereby allow the passage of fluid from the flow aperture through the valve opening. A hermetically sealed variable-volume storage chamber stores therein multiple portions of the fluid and is connectible in fluid communication with the one-way valve assembly. A pump is coupled between the variable-volume storage chamber and the one-way valve assembly, and is configured to pump discrete portions of fluid from the variable-volume storage chamber, through the flow aperture, and through the valve opening to dispense the portions of fluid through the valve assembly.

    Abstract translation: 一种装置具有限定第一通道，阀座和延伸穿过阀体并与第一通道流体连通地联接的流动孔的阀体。 该装置的阀盖由弹性材料形成，并且包括安装在阀体上的盖基座，并且固定地抵靠其相对移动，以及覆盖在阀座上的阀部分。 阀部分限定预定的径向厚度并与阀座形成过盈配合。 阀部分和阀座限定了其间的常闭的，轴向延伸的阀开口。 阀部分可以在与阀座接合的阀部分的常闭位置和打开位置之间移动，打开位置具有与阀座间隔开的阀部分的至少一段，以连接与开口流体连通的阀开口 从而允许流体从流动孔通过阀开口。 气密密封的可变容积储存室在其中存储有多个流体部分，并可与单向阀组件流体连通。 泵连接在可变容积存储室和单向阀组件之间，并且构造成从可变容积储存室通过流动孔泵送离散的流体部分，并且通过阀开口分配部分 的流体通过阀组件。

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