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58 条记录 (耗时 0.039 秒)

    Novel Immunomodulating Peptide
    42.
    发明申请
    Novel Immunomodulating Peptide 有权
    新型免疫调节肽

    公开(公告)号：US20070280954A1

    公开(公告)日：2007-12-06

    申请号：US10556756

    申请日：2004-05-14

    申请人： Lawrence Steinman ,  Hideki Garren ,  Paulo Fontoura

    发明人： Lawrence Steinman ,  Hideki Garren ,  Paulo Fontoura

    IPC分类号： A61K39/00 ,  A61P37/02 ,  G01N33/53

    CPC分类号： A61K45/06 ,  A61K38/1709 ,  G01N33/564 ,  A61K2300/00

    摘要： Epitopic fragments of Nogo, including Nogo 45-66, elicit a specific and strong T cell response, and a B cell response. T cells reactive to Nogo antigens are capable of ameliorating ongoing disease, which may be induced with other antigens. The present invention provides compositions and methods for the identification and use of Nogo epitopic fragments in the treatment of immune related disease.

    摘要翻译： Nogo的异位片段，包括Nogo 45-66，引发特异性和强T细胞应答和B细胞反应。 与Nogo抗原反应的T细胞能够改善正在进行的疾病，其可以用其他抗原诱导。 本发明提供用于鉴定和使用Nogo表位片段治疗免疫相关疾病的组合物和方法。

    T-cell receptor varible transcripts as disease related markers
    44.
    发明授权
    T-cell receptor varible transcripts as disease related markers 失效
    T细胞受体可变转录物作为疾病相关标志物

    公开(公告)号：US5667967A

    公开(公告)日：1997-09-16

    申请号：US66325

    申请日：1993-05-21

    申请人： Lawrence Steinman ,  Jorge Oksenberg ,  Claude Bernard

    发明人： Lawrence Steinman ,  Jorge Oksenberg ,  Claude Bernard

    IPC分类号： C12Q1/68 ,  C12P19/34

    CPC分类号： C12Q1/6883 ,  G01N2800/285

    摘要： Methods are provided for determining relations between autoimmune degenerative diseases and specific variable regions of T-cell receptors as associated with the host HLA or T-cells associated with umbatting neoprofilerative diseases. By identifying the particular T-cell receptors which cause or are the disease in mammals, various prophylactic and therapeutic techniques may be employed for inhibiting the attack of the T-cell receptors on the native protein or tissue enhance the defense. In addition, individuals may be diagnosed as to their propensity for a particular autoimmune disease or the occurrence of such a disease.

    摘要翻译： 提供了用于确定自身免疫性退行性疾病与T细胞受体的特异性可变区之间的关系的方法，所述T细胞受体与与神经调节性新生儿疾病相关的宿主HLA或T细胞相关。 通过鉴定在哺乳动物中引起或者是疾病的特定T细胞受体，可以采用各种预防和治疗技术来抑制天然蛋白质或组织上的T细胞受体的攻击增强了防御性。 此外，个体可能被诊断为其对特定自身免疫疾病的倾向或这种疾病的发生。

    Polypeptide pertussis toxin vaccine
    45.
    发明授权
    Polypeptide pertussis toxin vaccine 失效
    多肽百日咳毒素疫苗

    公开(公告)号：US5000952A

    公开(公告)日：1991-03-19

    申请号：US227372

    申请日：1988-08-02

    申请人： Lawrence Steinman ,  Jorge R. Oksenberg ,  Gary K. Schoolnik ,  Amrit K. Judd

    发明人： Lawrence Steinman ,  Jorge R. Oksenberg ,  Gary K. Schoolnik ,  Amrit K. Judd

    IPC分类号： G01N33/53 ,  A61K38/00 ,  A61K39/00 ,  A61K39/10 ,  A61P37/04 ,  C07K7/06 ,  C07K7/08 ,  C07K14/195 ,  C07K14/235 ,  C07K14/41 ,  C07K16/12 ,  G01N33/50 ,  G01N33/569

    CPC分类号： C07K16/1225 ,  C07K14/235 ,  G01N33/505 ,  A61K39/00

    摘要： A novel method of defining oligopeptides is provided for determining useful immunodominant sequences for use as vaccines for pathogens. The method involves identifying sequences by particular selection procedures and using such sequences with antigen-presenting cells and T-cells to demonstrate activation of the common histocompatibility antigens DQ and DR in humans and their analogs in other animals. The oligopeptides may then be used individually or in combination to produce safe and effective vaccines, where genes may be prepared encoding the oligopeptides and used for expression of the oligopeptides or combinations of the oligopeptides or the gene transformed into the appropriate host, e.g., B. pertussis, for use as a vaccine to the intact organism.

    摘要翻译： 提供了一种定义寡肽的新方法，用于确定用作病原体疫苗的有用的免疫显性序列。 该方法包括通过特定选择程序鉴定序列，并使用具有抗原呈递细胞和T细胞的这些序列来证明人及其他动物中人类及其类似物中常见的组织相容性抗原DQ和DR的活化。 然后可以单独或组合使用寡肽以产生安全和有效的疫苗，其中可以制备编码寡肽的基因并用于表达寡肽或寡肽或转化到合适宿主例如B中的基因的组合。 百日咳，用作完整生物体的疫苗。

    Markers for determination of patient responsiveness
    46.
    发明授权
    Markers for determination of patient responsiveness 有权
    确定患者反应性的标记

    公开(公告)号：US08828668B2

    公开(公告)日：2014-09-09

    申请号：US13026173

    申请日：2011-02-11

    申请人： Robert C. Axtell ,  Lawrence Steinman ,  May H. Han ,  Brigit A. de Jong ,  Chander Raman ,  Michael Walker ,  Jing Shi

    发明人： Robert C. Axtell ,  Lawrence Steinman ,  May H. Han ,  Brigit A. de Jong ,  Chander Raman ,  Michael Walker ,  Jing Shi

    IPC分类号： G01N33/53 ,  A61K39/395 ,  A61K38/00

    CPC分类号： A61K31/225 ,  A61K31/18 ,  G01N33/6863 ,  G01N33/6896 ,  G01N2333/54 ,  G01N2800/285 ,  Y02A90/26

    摘要： Compositions and methods are provided for prognostic classification of inflammatory diseases, e.g. inflammatory demyelinating disease, patients into subtypes, which subtypes are informative of the patient's need for therapy and responsiveness to a therapy of interest. The patterns of cytokines provides for a signature pattern that can identify patients likely to benefit from therapeutic intervention as well as discriminate patients that have a high probability of responsiveness to a therapy from those that have a low probability of responsiveness. Assessment of this signature pattern thus allows improved methods of care. In one embodiment of the invention, the autoimmune disease is multiple sclerosis or neuromyelitis optica.

    摘要翻译： 提供组合物和方法用于炎性疾病的预后分类，例如 炎症性脱髓鞘疾病，患者进入亚型，哪些亚型对患者的治疗需求和对感兴趣的治疗的反应有信息。 细胞因子的模式提供了一种能够识别可能受益于治疗干预的患者的特征模式，并且将具有高反应概率的那些对治疗具有高反应能力的患者区分开来。 因此，这种签名模式的评估允许改进护理方法。 在本发明的一个实施方案中，自身免疫性疾病是多发性硬化症或神经性脊髓炎。

    Trp/his exchange and kynurenine induced Trp transport
    47.
    发明授权
    Trp/his exchange and kynurenine induced Trp transport 失效
    Trp /他的交换和kynurenine诱导Trp运输

    公开(公告)号：US07935494B2

    公开(公告)日：2011-05-03

    申请号：US12040524

    申请日：2008-02-29

    申请人： Thijs Kaper ,  Michael Platten ,  Lawrence Steinman ,  Wolf Frommer

    发明人： Thijs Kaper ,  Michael Platten ,  Lawrence Steinman ,  Wolf Frommer

    IPC分类号： G01N33/53

    CPC分类号： G01N33/6872 ,  G01N33/5008 ,  G01N2333/70596 ,  G01N2800/24

    摘要： The present invention provides methods for detecting changes in tryptophan concentrations in a cell and methods for identifying agents that modulate cellular tryptophan concentrations. In particular, the present invention provides methods for detecting cellular exchange between tryptophan and kynurenine, and methods for identifying agents that modulate this exchange. The present invention also provides methods for treating a disease associated with immunosuppression in a subject in need thereof. In particular, the present invention is directed toward a method of treating a disease associated with immunosuppression comprising contacting the disease with an agent that modulates cellular Trp/kynurenine exchange. Furthermore, the present invention provides methods for identifying an agent that modulates an immunosuppression.

    摘要翻译： 本发明提供了用于检测细胞中色氨酸浓度变化的方法以及鉴定调节细胞色氨酸浓度的试剂的方法。 特别地，本发明提供了检测色氨酸和犬尿氨酸之间的细胞交换的方法，以及用于鉴定调节该交换的试剂的方法。 本发明还提供了在有需要的受试者中治疗与免疫抑制相关的疾病的方法。 特别地，本发明涉及一种治疗与免疫抑制相关的疾病的方法，其包括将疾病与调节细胞Trp /犬尿苷交换的药物接触。 此外，本发明提供了鉴定调节免疫抑制的药剂的方法。

    THERAPEUTIC AND DIAGNOSTIC USES OF ANTIBODY SPECIFICITY PROFILES
    48.
    发明申请
    THERAPEUTIC AND DIAGNOSTIC USES OF ANTIBODY SPECIFICITY PROFILES 审中-公开
    抗生素特异性分析的治疗和诊断用途

    公开(公告)号：US20100330110A1

    公开(公告)日：2010-12-30

    申请号：US12871765

    申请日：2010-08-30

    申请人： William H. Robinson ,  David L. Hirschberg ,  Lawrence Steinman ,  Pedro Jose Ruiz ,  Paul J. Utz ,  Hideki Garren

    发明人： William H. Robinson ,  David L. Hirschberg ,  Lawrence Steinman ,  Pedro Jose Ruiz ,  Paul J. Utz ,  Hideki Garren

    IPC分类号： A61K39/00 ,  C40B30/04 ,  C40B40/10 ,  A61P3/10

    CPC分类号： A61K39/0008 ,  G01N33/564 ,  G01N33/6854 ,  G01N2800/102 ,  G01N2800/24 ,  G01N2800/52

    摘要： This invention provides a method for determining the antibody specificity profile in an individual. This specificity profile reveals the individual's immune response to multiple antigens and/or epitopes of autoantigens, allergens, graft antigens, etc. The antibody specificity profile is determined through the binding of patient samples comprising antibodies to the arrays. The array can comprises antigens and epitopes. The invention also provides the means and methods for determining antigen or epitope specificity profiles that can be used in the development of either generic and individualized diagnosis and treatment for immune related diseases, including autoimmune disease, allergy and graft rejection.

    摘要翻译： 本发明提供了确定个体中抗体特异性谱的方法。 该特异性特征揭示了个体对多种抗原和/或自身抗原，变应原，移植抗原等表位的免疫应答。通过将包含抗体的患者样品与阵列的结合来确定抗体特异性谱。 阵列可以包括抗原和表位。 本发明还提供了用于确定抗原或表位特异性谱的方法和方法，所述抗原或表位特异性特征可用于开发针对免疫相关疾病的通用和个体化诊断和治疗，包括自身免疫疾病，变态反应和移植排斥反应。

    Methods and immune modulatory nucleic acid compositions for preventing and treating disease
    49.
    发明授权
    Methods and immune modulatory nucleic acid compositions for preventing and treating disease 有权
    用于预防和治疗疾病的方法和免疫调节核酸组合物

    公开(公告)号：US07811813B2

    公开(公告)日：2010-10-12

    申请号：US10524643

    申请日：2003-11-21

    申请人： Hideki Garren ,  Peggy P. Ho ,  Lawrence Steinman

    发明人： Hideki Garren ,  Peggy P. Ho ,  Lawrence Steinman

    IPC分类号： C12N15/00

    CPC分类号： A61K31/715 ,  A61K31/70 ,  A61K48/00

    摘要： This invention relates to methods and compositions for treating or preventing disease comprising the administration of immune modulatory nucleic acids having one or more immune modulatory sequences (IMSs). The invention further relates to the means and methods for the identification of the IMSs for preventing or treating disease, more particularly the treatment and prevention of autoimmune or inflammatory diseases. The invention also relates to the treatment or prevention of disease comprising the administration of the immune modulatory nucleic acids alone or in combination with a polynucleotide encoding self-protein(s), -polypeptide(s) or -peptide(s). The present invention also relates to methods and compositions for treating diseases in a subject associated with one or more self-protein(s), -polypeptide(s) or -peptide(s) that are present in the subject and involved in a non-physiological state.

    摘要翻译： 本发明涉及用于治疗或预防疾病的方法和组合物，其包括施用具有一种或多种免疫调节序列（IMS）的免疫调节核酸。 本发明还涉及用于鉴定用于预防或治疗疾病的IMS的方法和方法，更具体地涉及治疗和预防自身免疫性或炎性疾病。 本发明还涉及治疗或预防疾病，其包括单独施用免疫调节性核酸或与编码自身蛋白，多肽或多肽的多核苷酸组合施用。 本发明还涉及用于治疗与受试者中存在的一种或多种自身蛋白，多肽或肽的受试者相关的疾病的方法和组合物， 生理状态。