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11 条记录 (耗时 0.015 秒)

    M-protein peptides of influenza virus as antiviral agents
    1.
    发明授权
    M-protein peptides of influenza virus as antiviral agents 失效
    流感病毒的M蛋白肽作为抗病毒剂

    公开(公告)号：US5616327A

    公开(公告)日：1997-04-01

    申请号：US335303

    申请日：1994-11-07

    申请人： Amrit K. Judd ,  Doris J. Bucher

    发明人： Amrit K. Judd ,  Doris J. Bucher

    IPC分类号： A61K38/00 ,  A61K38/55 ,  A61P31/12 ,  A61P31/16 ,  C07K7/08 ,  C07K14/11 ,  A61K39/385 ,  A61K9/127 ,  A61K38/10 ,  C07K17/02

    CPC分类号： C07K14/005 ,  A61K38/00 ,  C12N2760/16122 ,  C12N2760/16222

    摘要： Peptides substantially corresponding to the 148-162 region of type A influenza M protein and additionally containing at least one amino acid in the 163-166 region are disclosed to have high activity as influenza transcription inhibitors and thus as antiviral agents against influenza virus and other RNA viruses. The modification of these peptides by incorporation into liposomes or by addition of long-chain alkylamino acids is also shown as in the use of all such materials in antiviral drug formulations.

    摘要翻译： 公开了基本上对应于A型流感M蛋白的148-162区域并且另外在163-166区域中含有至少一个氨基酸的肽作为流感转录抑制剂具有高活性，因此作为抗流感病毒和其它RNA的抗病毒剂 病毒 通过掺入脂质体或通过加入长链烷基氨基酸对这些肽的修饰也显示为在抗病毒药物制剂中使用所有这些材料。

    Polypeptide pertussis toxin vaccine
    2.
    发明授权
    Polypeptide pertussis toxin vaccine 失效
    多肽百日咳毒素疫苗

    公开(公告)号：US5000952A

    公开(公告)日：1991-03-19

    申请号：US227372

    申请日：1988-08-02

    申请人： Lawrence Steinman ,  Jorge R. Oksenberg ,  Gary K. Schoolnik ,  Amrit K. Judd

    发明人： Lawrence Steinman ,  Jorge R. Oksenberg ,  Gary K. Schoolnik ,  Amrit K. Judd

    IPC分类号： G01N33/53 ,  A61K38/00 ,  A61K39/00 ,  A61K39/10 ,  A61P37/04 ,  C07K7/06 ,  C07K7/08 ,  C07K14/195 ,  C07K14/235 ,  C07K14/41 ,  C07K16/12 ,  G01N33/50 ,  G01N33/569

    CPC分类号： C07K16/1225 ,  C07K14/235 ,  G01N33/505 ,  A61K39/00

    摘要： A novel method of defining oligopeptides is provided for determining useful immunodominant sequences for use as vaccines for pathogens. The method involves identifying sequences by particular selection procedures and using such sequences with antigen-presenting cells and T-cells to demonstrate activation of the common histocompatibility antigens DQ and DR in humans and their analogs in other animals. The oligopeptides may then be used individually or in combination to produce safe and effective vaccines, where genes may be prepared encoding the oligopeptides and used for expression of the oligopeptides or combinations of the oligopeptides or the gene transformed into the appropriate host, e.g., B. pertussis, for use as a vaccine to the intact organism.

    摘要翻译： 提供了一种定义寡肽的新方法，用于确定用作病原体疫苗的有用的免疫显性序列。 该方法包括通过特定选择程序鉴定序列，并使用具有抗原呈递细胞和T细胞的这些序列来证明人及其他动物中人类及其类似物中常见的组织相容性抗原DQ和DR的活化。 然后可以单独或组合使用寡肽以产生安全和有效的疫苗，其中可以制备编码寡肽的基因并用于表达寡肽或寡肽或转化到合适宿主例如B中的基因的组合。 百日咳，用作完整生物体的疫苗。

    NOCICEPTIN-BASED ANALGESICS
    5.
    发明申请
    NOCICEPTIN-BASED ANALGESICS 有权
    基于NOCICEPTIN的分析

    公开(公告)号：US20080221304A1

    公开(公告)日：2008-09-11

    申请号：US11740120

    申请日：2007-04-25

    申请人： Amrit K. Judd

    发明人： Amrit K. Judd

    IPC分类号： C07K7/06

    CPC分类号： C07K14/665 ,  A61K38/00

    摘要： The invention relates to a family of hexapeptide compounds exhibiting activity with regard to the ORL-1 receptor. The compounds share a general formula of Arg-Tyr-Tyr-Arg-Trp-Arg, and may be constructed having modifications or substitutions at any position, and may include modifications of the amino- and carboxy-termini of the hexapeptide. These compounds include agents exhibiting agonist activity and antagonist activity when exposed to the human ORL-1 receptor. As such, the hexapeptides may be useful as analgesics, anxiolytics, diuretics, and anti-cancer agents.

    摘要翻译： 本发明涉及一种对于ORL-1受体具有活性的六肽化合物家族。 所述化合物具有Arg-Tyr-Tyr-Arg-Trp-Arg的通式，并且可以构建为在任何位置具有修饰或取代，并且可以包括六肽的氨基和羧基末端的修饰。 这些化合物包括当暴露于人类ORL-1受体时显示激动剂活性和拮抗剂活性的试剂。 因此，六肽可用作止痛剂，抗焦虑剂，利尿剂和抗癌剂。

    Nociceptin-based analgesics
    6.
    发明授权
    Nociceptin-based analgesics 有权
    基于伤害肽的镇痛药

    公开(公告)号：US07863416B2

    公开(公告)日：2011-01-04

    申请号：US11740120

    申请日：2007-04-25

    申请人： Amrit K. Judd

    发明人： Amrit K. Judd

    IPC分类号： C07K7/06

    CPC分类号： C07K14/665 ,  A61K38/00

    摘要： The invention relates to a family of hexapeptide compounds exhibiting activity with regard to the ORL-1 receptor. The compounds share a general formula of Arg-Tyr-Tyr-Arg-Trp-Arg, and may be constructed having modifications or substitutions at any position, and may include modifications of the amino- and carboxy-termini of the hexapeptide. These compounds include agents exhibiting agonist activity and antagonist activity when exposed to the human ORL-1 receptor. As such, the hexapeptides may be useful as analgesics, anxiolytics, diuretics, and anti-cancer agents.

    摘要翻译： 本发明涉及一种对于ORL-1受体具有活性的六肽化合物家族。 所述化合物具有Arg-Tyr-Tyr-Arg-Trp-Arg的通式，并且可以构建为在任何位置具有修饰或取代，并且可以包括六肽的氨基和羧基末端的修饰。 这些化合物包括当暴露于人类ORL-1受体时显示激动剂活性和拮抗剂活性的试剂。 因此，六肽可用作止痛剂，抗焦虑剂，利尿剂和抗癌剂。

    Nociceptin-based analgesics
    7.
    发明授权
    Nociceptin-based analgesics 有权

    公开(公告)号：US07049287B2

    公开(公告)日：2006-05-23

    申请号：US10268020

    申请日：2002-10-09

    申请人： Amrit K. Judd

    发明人： Amrit K. Judd

    IPC分类号： A61K38/16

    CPC分类号： C07K14/665 ,  A61K38/00

    摘要： The invention relates to a family of hexapeptide compounds exhibiting activity with regard to the ORL-1 receptor. The compounds share a general formula of Arg-Tyr-Tyr-Arg-Trp-Arg, and may be constructed having modifications or substitutions at any position, and may include modifications of the amino- and carboxy-termini of the hexapeptide. These compounds include agents exhibiting agonist activity and antagonist activity when exposed to the human ORL-1 receptor. As such, the hexapeptides may be useful as analgesics, anxiolytics, diuretics, and anti-cancer agents.

    Multiple polymer synthesizer
    9.
    发明授权
    Multiple polymer synthesizer 失效
    多重聚合物合成仪

    公开(公告)号：US5053454A

    公开(公告)日：1991-10-01

    申请号：US312069

    申请日：1989-02-15

    申请人： Amrit K. Judd

    发明人： Amrit K. Judd

    IPC分类号： B01J19/00 ,  C07K1/04 ,  C40B40/10 ,  C40B50/14 ,  C40B60/14

    CPC分类号： C07K1/045 ,  B01J19/0046 ,  B01J2219/00286 ,  B01J2219/00306 ,  B01J2219/00308 ,  B01J2219/00342 ,  B01J2219/00364 ,  B01J2219/00416 ,  B01J2219/00423 ,  B01J2219/00454 ,  B01J2219/00497 ,  B01J2219/00585 ,  B01J2219/0059 ,  B01J2219/00596 ,  B01J2219/00725 ,  C40B40/10 ,  C40B50/14 ,  C40B60/14

    摘要： An apparatus for simultaneously performing a multiplicity of synthesis reactions is disclosed. The synthesizer includes at least one reaction vessel having an access port and a synthesis compartment adjacent the access port. A closable exit channel with an exit port is adjacent the synthesis compartment. The apparatus also includes a base having a plurality of inlets, each of the inlets configured to receive the exit channel of the reaction vessel. A fluid outlet is present that is in communication with the plurality of inlets. A vacuum pump and vacuum line are connected to the fluid outlet for sucking excess reagents and by-products from the reaction vessel. The apparatus further includes a shaker for shaking the reaction vessel while synthesis is proceeding.

    摘要翻译： 公开了同时进行多次合成反应的装置。 合成器包括至少一个反应容器，其具有邻近进入口的进入口和合成室。 具有出口的可关闭的出口通道与合成室相邻。 该设备还包括具有多个入口的基座，每个入口被配置为接收反应容器的出口通道。 存在与多个入口连通的流体出口。 真空泵和真空管线连接到流体出口，用于从反应容器吸取多余的试剂和副产物。 该装置还包括用于在合成进行期间摇动反应容器的摇动器。