公开(公告)号：US20070092485A1

公开(公告)日：2007-04-26

申请号：US11551807

申请日：2006-10-23

Applicant: JULIA NOVAK ,  Scott Presnell ,  Cindy Sprecher ,  Donald Foster ,  Richard Holly ,  Jane Gross ,  Janet Johnston ,  Andrew Nelson ,  Stacey Dillon ,  Angela Hammond

Inventor： JULIA NOVAK ,  Scott Presnell ,  Cindy Sprecher ,  Donald Foster ,  Richard Holly ,  Jane Gross ,  Janet Johnston ,  Andrew Nelson ,  Stacey Dillon ,  Angela Hammond

IPC: A61K38/19 ,  C07K14/52 ,  C07H21/04 ,  C12P21/02

CPC classification number: A61K38/17

Abstract: Antibodies that bind to polypeptides and peptides comprising the sequence of zalpha11 Ligand as shown in SEQ ID NO: 2 are described. The antibodies may bind the full length sequence of 162 amino acid residues or a fragment thereof, including a mature polypeptide of 131 amino acid residues and smaller polypeptide and peptide sequences. The antibodies may include antibodies that are polyclonal, monoclonal, murine, humanized or neutralizing. Methods for producing the antibodies are also described.

公开(公告)号：US20070059825A1

公开(公告)日：2007-03-15

申请号：US11551127

申请日：2006-10-19

Applicant: Julia Novak ,  Scott Presnell ,  Cindy Sprecher ,  Donald Foster ,  Richard Holly ,  Jane Gross ,  Janet Johnston ,  Andrew Nelson ,  Stacey Dillon ,  Angela Hammond

Inventor： Julia Novak ,  Scott Presnell ,  Cindy Sprecher ,  Donald Foster ,  Richard Holly ,  Jane Gross ,  Janet Johnston ,  Andrew Nelson ,  Stacey Dillon ,  Angela Hammond

IPC: C12N5/08

CPC classification number: C07K14/001 ,  A01K67/0275 ,  A01K2217/05 ,  A01K2227/105 ,  A01K2267/03 ,  A61K38/00 ,  A61K38/18 ,  C07K14/52 ,  C07K14/535 ,  C07K14/54 ,  C07K14/5406 ,  C07K14/715 ,  C07K16/24 ,  C07K16/2866 ,  C07K2317/73 ,  C07K2319/00 ,  C07K2319/21 ,  C07K2319/24 ,  C07K2319/30 ,  C07K2319/55 ,  C12N15/62 ,  C12N15/8509 ,  C12N2799/026 ,  G01N2333/52 ,  A61K2300/00

Abstract: Antibodies that bind to polypeptides and peptides comprising the sequence of zalpha11 Ligand as shown in SEQ ID NO: 2 are described. The antibodies may bind the full length sequence of 162 amino acid residues or a fragment thereof, including a mature polypeptide of 131 amino acid residues and smaller polypeptide and peptide sequences. The antibodies may include antibodies that are polyclonal, monoclonal, murine, humanized or neutralizing. Methods for producing the antibodies are also described.

公开(公告)号：US20070048264A1

公开(公告)日：2007-03-01

申请号：US11539479

申请日：2006-10-06

Applicant: Wayne Kindsvogel ,  Steven Hughes ,  Richard Holly ,  Christopher Clegg ,  Donald Foster ,  Rebecca Johnson ,  Mark Heipel ,  Pallavur Sivakumar

Inventor： Wayne Kindsvogel ,  Steven Hughes ,  Richard Holly ,  Christopher Clegg ,  Donald Foster ,  Rebecca Johnson ,  Mark Heipel ,  Pallavur Sivakumar

IPC: A61K38/20 ,  A61K39/395

CPC classification number: C07K16/32 ,  A61K38/20 ,  A61K39/395 ,  A61K39/39558 ,  C07K16/2818 ,  C07K16/2896 ,  C07K2317/732 ,  A61K2300/00

Abstract: Methods for treating cancer by co-administering a therapeutic monoclonal antibody with IL-21 are described. Exemplary monoclonal antibodies that can be used are rituximab, trastuzumab and anti-CTLA-4 antibodies. The enhanced antitumor of the combination therapy is particularly useful for patient populations that are recalcitrant to monoclonal therapy, relapse after treatment with monoclonal antibodies or where the enhanced IL-21 antitumor effect reduces toxicities associated with treatment using the monoclonal antibodies.

公开(公告)号：US20070045356A1

公开(公告)日：2007-03-01

申请号：US11211348

申请日：2005-08-25

Applicant: Donald Foster ,  Philip Nelson

Inventor： Donald Foster ,  Philip Nelson

IPC: B65D35/38

CPC classification number: B65D47/2068

Abstract: A closure is removably attachable to a container and comprises a dispensing orifice and a valve element that is biased closed over the orifice. By inverting the container so that a liquid contents of the container exerts pressure on the valve element, or by squeezing the container causing the liquid contents to exert pressure on the valve element, the valve element opens the dispensing orifice allowing the liquid contents to be dispensed from the container. On removing the pressure from the valve element, the valve element resiliently closes the dispensing orifice.

Abstract translation: 封闭件可移除地附接到容器并且包括分配孔和被偏置在孔上方的阀元件。 通过翻转容器使得容器的液体内容物对阀元件施加压力，或者通过挤压容器使液体内容物对阀元件施加压力，阀元件打开分配孔，允许液体内容物被分配 从容器。 在从阀元件移除压力时，阀元件弹性地关闭分配孔。

公开(公告)号：US20060269551A1

公开(公告)日：2006-11-30

申请号：US11458666

申请日：2006-07-19

Applicant: Penny Thompson ,  Donald Foster ,  Wenfeng Xu ,  Karen Madden ,  James Kelly ,  Cindy Sprecher ,  Hal Blumberg ,  Maribeth Eagan ,  Stephen Jaspers ,  Yasmin Chandrasekher ,  Julia Novak

Inventor： Penny Thompson ,  Donald Foster ,  Wenfeng Xu ,  Karen Madden ,  James Kelly ,  Cindy Sprecher ,  Hal Blumberg ,  Maribeth Eagan ,  Stephen Jaspers ,  Yasmin Chandrasekher ,  Julia Novak

IPC: A61K39/395 ,  A61K38/13 ,  A61K31/59 ,  A61K31/573 ,  A61K31/366 ,  A61K31/525 ,  A61K31/20 ,  A61K31/07 ,  A61K31/203

CPC classification number: C07K16/244 ,  A61K31/07 ,  A61K31/20 ,  A61K31/203 ,  A61K31/366 ,  A61K31/519 ,  A61K31/525 ,  A61K31/573 ,  A61K31/59 ,  A61K38/13 ,  A61K39/395 ,  A61K39/3955 ,  A61K45/06 ,  C07K14/7155 ,  C07K16/2887 ,  C07K2319/00 ,  C07K2319/30 ,  Y10S514/886 ,  A61K2300/00

Abstract: A method for treating IL-20 induced inflammation. An antagonist to IL-20 is administered to treat inflammation and associated diseases. The antagonist can be an antibody that binds to IL-20 or its receptor or a soluble receptor that binds to IL-20. Examples of such diseases are adult respiratory disease, psoriasis, eczema, contact dermatitis, atopic dermatitis, septic shock, multiple organ failure, inflammatory lung injury, bacterial pneumonia, inflammatory bowel disease, rheumatoid arthritis, asthma, ulcerative colitis and Crohn's disease.

公开(公告)号：US20060086763A1

公开(公告)日：2006-04-27

申请号：US11176050

申请日：2005-07-07

Applicant: Donald Foster

Inventor： Donald Foster

IPC: B67D5/40

CPC classification number: B05B11/3011 ,  B05B11/0044 ,  B05B11/3074 ,  B05B11/3077

Abstract: A venting system of a manually operated trigger sprayer vents the interior of a liquid container connected to the trigger sprayer. The trigger sprayer is provided with a vent chamber that surrounds the pump chamber, and a vent piston that surrounds the pump piston. The vent piston is received in the vent chamber for reciprocating movements between a vent closed and vent opened position in the vent chamber, and the vent chamber having two different interior diameter sections with a larger interior diameter section reducing drag on the vent piston when the vent piston is moved to the vent opened position.

Abstract translation: 手动触发喷雾器的排气系统通向连接到扳机喷雾器的液体容器的内部。 触发式喷雾器设置有围绕泵室的排气室和围绕泵活塞的排气活塞。 通气活塞被容纳在通风室中，用于在通气室中的通风口闭合和通气打开位置之间的往复运动，并且排气室具有两个不同的内径部分，其具有较大的内径部分，当排气口 活塞移动到通风口打开位置。

公开(公告)号：US20060086762A1

公开(公告)日：2006-04-27

申请号：US10961954

申请日：2004-10-11

Applicant: Donald Foster ,  Philip Nelson

Inventor： Donald Foster ,  Philip Nelson

IPC: B67D5/40

CPC classification number: B05B11/3087 ,  B05B7/0025 ,  B05B11/3011

Abstract: A manually operated liquid foaming dispenser is attached to the top of a container of liquid and is manually reciprocated to dispense the liquid from the container as a foam. The dispenser includes a liquid pump chamber and an air pump chamber that respectively pump liquid and air under pressure to a discharge passage of the pump where the liquid and air are mixed, generating the foam dispensed from the dispenser. The air pump chamber has a tube valve controlling the discharge of air from the air pump to the discharge passage, and the air pump chamber is charged with air by opening the air pump chamber to the exterior environment of the dispenser.

Abstract translation: 手动操作的液体发泡分配器附着在液体容器的顶部，并且被人工往复运动以便将泡沫从容器中分配出来。 分配器包括液体泵室和空气泵室，其分别将液体和空气在压力下泵送到泵的排出通道，在该排出通道中混合有液体和空气，产生从分配器分配的泡沫。 空气泵室具有管阀，其控制从空气泵排出到排出通道的空气，并且通过将空气泵室打开到分配器的外部环境来为空气泵室充满空气。

公开(公告)号：US20050004021A1

公开(公告)日：2005-01-06

申请号：US10800057

申请日：2004-03-12

Applicant: Cindy Sprecher ,  Walt Kisiel ,  Donald Foster

Inventor： Cindy Sprecher ,  Walt Kisiel ,  Donald Foster

IPC: C12N15/02 ,  A61K38/00 ,  A61K38/55 ,  A61P7/02 ,  C07K14/745 ,  C07K14/81 ,  C12N1/19 ,  C12N1/21 ,  C12N5/10 ,  C12N15/09 ,  C12N15/15 ,  C12P21/02 ,  C12P21/08 ,  C12Q1/68 ,  C12R1/19 ,  C12R1/865 ,  C12R1/91 ,  A61K48/00 ,  A61K38/54 ,  C07H21/04 ,  C12N9/99

CPC classification number: C07K14/8114 ,  A61K38/00

Abstract: The present invention provides isolated DNA molecules comprising a DNA segment encoding novel human Kunitz-type inhibitors. Also provided are DNA constructs comprising a first DNA segment encoding a novel human Kunitz-type inhibitor wherein said first DNA segment is operably linked to additional DNA segments required for the expression for the first DNA segment, as well as host cells containing such DNA constructs and methods for producing proteins from the host cells.

Abstract translation: 本发明提供了分离的DNA分子，其包含编码新型人Kunitz型抑制剂的DNA区段。 还提供了包含编码新型人Kunitz型抑制剂的第一DNA区段的DNA构建体，其中所述第一DNA区段可操作地连接到第一DNA区段的表达所需的另外的DNA区段，以及含有这种DNA构建体的宿主细胞， 从宿主细胞产生蛋白质的方法。