公开(公告)号：US20200093591A1

公开(公告)日：2020-03-26

申请号：US16694203

申请日：2019-11-25

Applicant: Edwards Lifesciences Corporation

Inventor： Tamir S. Levi ,  Son V. Nguyen ,  Netanel Benichou ,  David Maimon ,  Ziv Yohanan ,  Nikolay Gurovich ,  Bella Felsen ,  Larisa Dadonkina ,  Ron Sharoni ,  Elena Sherman

IPC: A61F2/24

Abstract: Embodiments of a radially collapsible and expandable prosthetic heart valve are disclosed. A valve frame can have a tapered profile when mounted on a delivery shaft, with an inflow end portion having a smaller diameter than an outflow end portion. The valve can comprise generally V-shaped leaflets, reducing material within the inflow end of the frame. An outer skirt can be secured to the outside of the inflow end portion of the frame, the outer skirt having longitudinal slack when the valve is expanded and lying flat against the frame when the valve is collapsed. A diagonally woven inner skirt can elongate axially with the frame. Side tabs of adjacent leaflets can extend through and be secured to window frame portions of the frame to form commissures. The window frame portions can be depressed radially inward relative to surrounding frame portions when the valve is crimped onto a delivery shaft.

公开(公告)号：US20200069420A1

公开(公告)日：2020-03-05

申请号：US16601414

申请日：2019-10-14

Applicant: Edwards Lifesciences Corporation

Inventor： Tamir S. Levi ,  Son V. Nguyen ,  Netanel Benichou ,  David Maimon ,  Ziv Yohanan ,  Nikolay Gurovich ,  Bella Felsen ,  Larisa Dadonkina ,  Ron Sharoni ,  Elena Sherman

IPC: A61F2/24

Abstract: Embodiments of a radially collapsible and expandable prosthetic heart valve are disclosed. A valve frame can have a tapered profile when mounted on a delivery shaft, with an inflow end portion having a smaller diameter than an outflow end portion. The valve can comprise generally V-shaped leaflets, reducing material within the inflow end of the frame. An outer skirt can be secured to the outside of the inflow end portion of the frame, the outer skirt having longitudinal slack when the valve is expanded and lying flat against the frame when the valve is collapsed. A diagonally woven inner skirt can elongate axially with the frame. Side tabs of adjacent leaflets can extend through and be secured to window frame portions of the frame to form commissures. The window frame portions can be depressed radially inward relative to surrounding frame portions when the valve is crimped onto a delivery shaft.

公开(公告)号：US20200030090A1

公开(公告)日：2020-01-30

申请号：US16516089

申请日：2019-07-18

Applicant: Edwards Lifesciences Corporation

Inventor： Tamir S. Levi ,  Son V. Nguyen ,  Netanel Benichou ,  David Maimon ,  Ziv Yohanan ,  Nikolay Gurovich ,  Bella Felsen ,  Larisa Dadonkina ,  Ron Sharoni ,  Elena Sherman

IPC: A61F2/24

Abstract: Embodiments of a radially collapsible and expandable prosthetic heart valve are disclosed. A valve frame can have a tapered profile when mounted on a delivery shaft, with an inflow end portion having a smaller diameter than an outflow end portion. The valve can comprise generally V-shaped leaflets, reducing material within the inflow end of the frame. An outer skirt can be secured to the outside of the inflow end portion of the frame, the outer skirt having longitudinal slack when the valve is expanded and lying flat against the frame when the valve is collapsed. A diagonally woven inner skirt can elongate axially with the frame. Side tabs of adjacent leaflets can extend through and be secured to window frame portions of the frame to form commissures. The window frame portions can be depressed radially inward relative to surrounding frame portions when the valve is crimped onto a delivery shaft.

公开(公告)号：US20190159895A1

公开(公告)日：2019-05-30

申请号：US16262188

申请日：2019-01-30

Applicant: Edwards Lifesciences Corporation

Inventor： Tamir S. Levi ,  Ron Sharoni ,  Elena Sherman ,  Oren H. Wintner ,  Kevin D. Rupp ,  Son V. Nguyen ,  Ajay Chadha ,  Jeff Lindstrom

IPC: A61F2/24

Abstract: Embodiments of a radially collapsible and expandable prosthetic heart valve are disclosed. The prosthetic valve can comprise an annular frame, leaflets, an inner skirt, and an outer skirt. The outer skirt can be secured to the outside of the inflow end portion of the frame, the outer skirt having longitudinal slack that buckles outward radially when the valve is in the expanded configuration and which lies flat when the valve is in the collapsed configuration. In some embodiments, the outer skirt is stiffer in the axial direction of the valve than in the circumferential direction of the valve. In additional embodiments, the outer skirt comprises a self-expandable fabric comprising fibers made of a shape memory material having a shape memory set to enhance the radially outward buckling of the outer skirt. Methods of crimping such valves to a collapsed or partially collapsed configuration are also disclosed.

公开(公告)号：US20190159894A1

公开(公告)日：2019-05-30

申请号：US16202469

申请日：2018-11-28

Applicant: Edwards Lifesciences Corporation

Inventor： Tamir S. Levi ,  Son V. Nguyen ,  Netanel Benichou ,  David Maimon ,  Ziv Yohanan ,  Nikolay Gurovich ,  Bella Felsen ,  Larisa Dadonkina ,  Ron Sharoni ,  Elena Sherman

IPC: A61F2/24

Abstract: Embodiments of a radially collapsible and expandable prosthetic heart valve are disclosed. A valve frame can have a tapered profile when mounted on a delivery shaft, with an inflow end portion having a smaller diameter than an outflow end portion. The valve can comprise generally V-shaped leaflets, reducing material within the inflow end of the frame. An outer skirt can be secured to the outside of the inflow end portion of the frame, the outer skirt having longitudinal slack when the valve is expanded and lying flat against the frame when the valve is collapsed. A diagonally woven inner skirt can elongate axially with the frame. Side tabs of adjacent leaflets can extend through and be secured to window frame portions of the frame to form commissures. The window frame portions can be depressed radially inward relative to surrounding frame portions when the valve is crimped onto a delivery shaft.

公开(公告)号：US20160374802A1

公开(公告)日：2016-12-29

申请号：US15194375

申请日：2016-06-27

Applicant: Edwards Lifesciences Corporation

Inventor： Tamir S. Levi ,  Son V. Nguyen ,  Netanel Benichou ,  David Maimon ,  Ziv Yohanan ,  Nikolay Gurovich ,  Bella Felsen ,  Larisa Dadonkina ,  Ron Sharoni ,  Elena Sherman

IPC: A61F2/24

Abstract: Embodiments of a radially collapsible and expandable prosthetic heart valve are disclosed. A valve frame can have a tapered profile when mounted on a delivery shaft, with an inflow end portion having a smaller diameter than an outflow end portion. The valve can comprise generally V-shaped leaflets, reducing material within the inflow end of the frame. An outer skirt can be secured to the outside of the inflow end portion of the frame, the outer skirt having longitudinal slack when the valve is expanded and lying flat against the frame when the valve is collapsed. A diagonally woven inner skirt can elongate axially with the frame. Side tabs of adjacent leaflets can extend through and be secured to window frame portions of the frame to form commissures. The window frame portions can be depressed radially inward relative to surrounding frame portions when the valve is crimped onto a delivery shaft.

Abstract translation: 公开了径向可折叠和可扩张的假体心脏瓣膜的实施例。 当安装在输送轴上时，阀架可以具有锥形轮廓，流入端部的直径小于流出端部分的直径。 阀可以包括大致V形的小叶，在框架的流入端内还原材料。 外裙可以固定到框架的流入端部分的外部，当阀门膨胀时，外裙部具有纵向松弛，并且当阀门折叠时，外裙部平放在框架上。 对角编织的内裙可以与框架轴向伸长。 相邻小叶的侧翼可以延伸穿过并固定到框架的窗框部分以形成连合。 当阀被压接到输送轴上时，窗框部分可以相对于周围的框架部分径向向内按压。

公开(公告)号：US20160184096A1

公开(公告)日：2016-06-30

申请号：US15063319

申请日：2016-03-07

Applicant: Edwards Lifesciences Corporation

Inventor： David Maimon ,  Ron Sharoni ,  Tamir S. Levi ,  Emil Karapetian ,  Tri D. Tran ,  Tung T. Le

IPC: A61F2/24

CPC classification number: A61F2/2427 ,  A61B50/30 ,  A61F2/0095 ,  A61F2/243 ,  A61F2/2433 ,  A61F2002/9522 ,  B21D41/04 ,  B23P19/04 ,  B25B27/10 ,  Y10T29/53552 ,  Y10T29/53578 ,  Y10T29/5367

Abstract: A device for crimping a radially expandable and collapsible prosthetic valve comprises a coiled wire frame having a longitudinal opening extending from a proximal end to a distal end thereof. The opening has a first state and a second state, the opening in the first state having a first diameter dimensioned to receive the prosthetic valve in an expanded or partially crimped configuration therein, and the opening in the second state having a second diameter dimensioned to receive the prosthetic valve in a crimped configuration. The coiled wire frame has a first end coupled to a first member and a second end coupled to a second member. The first member is movable relative to the second member to convert the coiled wire frame from the first state to the second state.

Abstract translation: 用于压缩可径向膨胀和可折叠的人工瓣膜的装置包括具有从近端延伸到其远端的纵向开口的螺旋线框架。 所述开口具有第一状态和第二状态，所述第一状态下的开口具有第一直径，所述第一直径的尺寸被设计成接收处于其中的膨胀或部分卷曲构造的所述人造瓣膜，并且所述第二状态中的所述开口的尺寸设计成接收 人造瓣膜处于卷曲结构。 盘绕的线框架具有联接到第一构件的第一端和联接到第二构件的第二端。 第一构件可相对于第二构件移动，以将盘绕的线框架从第一状态转换到第二状态。

公开(公告)号：US20150320556A1

公开(公告)日：2015-11-12

申请号：US14704861

申请日：2015-05-05

Applicant: Edwards Lifesciences Corporation

Inventor： Tamir S. Levi ,  Ron Sharoni ,  Elena Sherman ,  Oren H. Wintner ,  Kevin D. Rupp ,  Son V. Nguyen ,  Ajay Chadha ,  Jeff Lindstrom

IPC: A61F2/24

CPC classification number: A61F2/2418 ,  A61F2/2412 ,  A61F2/2427 ,  A61F2002/9522 ,  A61F2220/0025 ,  A61F2220/0075 ,  A61F2230/0054 ,  A61F2250/0018 ,  A61F2250/0039 ,  A61F2250/0069 ,  Y10T29/49927

Abstract: Embodiments of a radially collapsible and expandable prosthetic heart valve are disclosed. The prosthetic valve can comprise an annular frame, leaflets, an inner skirt, and an outer skirt. The outer skirt can be secured to the outside of the inflow end portion of the frame, the outer skirt having longitudinal slack that buckles outward radially when the valve is in the expanded configuration and which lies flat when the valve is in the collapsed configuration. In some embodiments, the outer skirt is stiffer in the axial direction of the valve than in the circumferential direction of the valve. In additional embodiments, the outer skirt comprises a self-expandable fabric comprising fibers made of a shape memory material having a shape memory set to enhance the radially outward buckling of the outer skirt. Methods of crimping such valves to a collapsed or partially collapsed configuration are also disclosed.

Abstract translation: 公开了径向可折叠和可扩张的假体心脏瓣膜的实施例。 假体瓣膜可包括环形框架，小叶，内裙部和外裙部。 外裙部可以固定到框架的流入端部分的外部，外裙部具有纵向松弛，当阀处于膨胀构型时在径向向外弯曲，并且当阀处于折叠构型时它处于平坦状态。 在一些实施例中，外裙部在阀的轴向方向上比阀的圆周方向更硬。 在另外的实施例中，外裙部包括自膨胀织物，其包括由形状记忆材料制成的纤维，该形状记忆材料具有设置成增强外裙部径向向外屈曲的形状记忆。 还公开了将这种阀压接成折叠或部分收缩的构造的方法。

公开(公告)号：US08652145B2

公开(公告)日：2014-02-18

申请号：US13715605

申请日：2012-12-14

Applicant: Edwards Lifesciences Corporation

Inventor： David Maimon ,  Ron Sharoni ,  Tamir S. Levi ,  Emil Karapetian ,  Tri D. Tran ,  Tung Le

IPC: B21D41/00 ,  A61B17/06 ,  B23P11/00

CPC classification number: A61F2/2427 ,  A61B50/30 ,  A61F2/0095 ,  A61F2/243 ,  A61F2/2433 ,  A61F2002/9522 ,  B21D41/04 ,  B23P19/04 ,  B25B27/10 ,  Y10T29/53552 ,  Y10T29/53578 ,  Y10T29/5367

Abstract: An exemplary system for crimping a prosthetic valve comprises a radially expandable and compressible prosthetic valve, a crimping device positioned around the valve and configured to reduce the diameter of the valve to a delivery configuration, and a sterile package enclosing the valve and the crimping device. The valve can be pre-assembled in a partially crimped configuration within the crimping device. After removing the sterile packaging, the crimping device can be used to crimp the valve from the partially crimped configuration to the delivery configuration, such as by twisting a knob on the crimping device. The system can further comprise at least a portion of a delivery catheter within the sterile package, wherein the valve is pre-mounted on or adjacent to an inflatable balloon of the delivery catheter, such that the valve can be crimped onto the delivery catheter using the crimping device.

Abstract translation: 用于卷曲假体瓣膜的示例性系统包括径向可膨胀和可压缩的人造瓣膜，围绕阀门定位并构造成将阀的直径减小到输送构造的压接装置，以及封闭阀和压接装置的无菌包装。 阀可以在压接装置内以部分压接构造预先组装。 在去除无菌包装之后，卷曲装置可以用于将阀从部分压接构型压接到输送构型，例如通过扭曲压接装置上的旋钮。 所述系统还可以包括在无菌包装内的输送导管的至少一部分，其中所述瓣膜被预先安装在所述输送导管的可充气球囊上或邻近所述输送导管的可充气气囊，使得所述阀可以使用 压接装置。