Patent search ap:("FOUNDATION MEDICINE Page INC.") AND inv:"Philip James Stephens"

41.

发明授权
Methods of treating urothelial carcinoma 有权

公开(公告)号：US09610288B2

公开(公告)日：2017-04-04

申请号：US14333368

申请日：2014-07-16

Applicant: FOUNDATION MEDICINE, INC.

Inventor： Siraj Mahamed Ali , Matthew J. Hawryluk , Jeffrey S. Ross , Philip James Stephens

IPC: C12Q1/68 , A61K31/517 , A61K47/48 , A61K31/5365 , C07K14/82 , C07K16/32 , A61K45/06 , A61K31/475 , A61K31/519 , A61K31/704 , A61K31/7105 , A61K31/713 , A61K33/24

Abstract: Methods and compositions for treating a urothelial and/or a micropapillary carcinoma, such as a micropapillary urothelial carcinoma are disclosed.

42.

发明授权
Human papilloma virus as predictor of cancer prognosis 有权
Title translation: 人乳头状瘤病毒作为癌症预后的预测因子

公开(公告)号：US09410954B2

公开(公告)日：2016-08-09

申请号：US14177615

申请日：2014-02-11

Applicant: FOUNDATION MEDICINE, INC. , UCL Business PLC

Inventor： Chris Hendrik Boshoff , Timothy Robert Fenton , Matthias Alexander Lechner , Philip James Stephens , Matthew J. Hawryluk , Garrett Michael Frampton , Roman Yelensky

IPC: A61K31/513 , A61K31/555 , A61K31/337 , A61K33/24 , G01N33/571 , C07K16/28 , C12Q1/68 , C12Q1/70 , A61K31/506 , A61K31/519 , A61K31/454 , A61K31/52 , A61K31/404 , A61K31/4196 , A61K31/282 , A61K39/395 , A61K31/436 , A61K31/05 , A61K31/4709 , A61K31/496 , A61K31/5377 , A61K31/352 , A61N5/00 , A61K31/366 , A61K31/505 , A61K31/439 , A61K31/4745 , A61K39/00

CPC classification number: A61K31/519 , A61K31/05 , A61K31/282 , A61K31/337 , A61K31/352 , A61K31/366 , A61K31/404 , A61K31/4196 , A61K31/436 , A61K31/439 , A61K31/454 , A61K31/4709 , A61K31/4745 , A61K31/496 , A61K31/505 , A61K31/506 , A61K31/513 , A61K31/52 , A61K31/5377 , A61K31/555 , A61K33/24 , A61K39/39558 , A61K2039/505 , A61N5/00 , A61N5/10 , C07K16/2863 , C12Q1/6883 , C12Q1/6886 , C12Q1/708 , C12Q2600/106 , C12Q2600/118 , C12Q2600/156 , C12Q2600/158 , C12Q2600/16 , G01N33/571 , A61K2300/00

Abstract: Methods of treating a head and neck cancer are disclosed.

Abstract translation: 公开了治疗头颈癌的方法。

43.

发明申请
METHODS OF TREATING CHOLANGIOCARCINOMA 审中-公开
Title translation: 治疗胆囊癌的方法

公开(公告)号：US20150366866A1

公开(公告)日：2015-12-24

申请号：US14761518

申请日：2014-01-17

Applicant: Vincent A. Miller , FOUNDATION MEDICINE, INC.

Inventor： Siraj Mahamed Ali , Matthew J. Hawryluk , Jie He , Doron Lipson , Vincent A. Miller , Jeffrey S. Ross , Philip James Stephens

IPC: A61K31/5025 , C07K16/40 , C12Q1/68 , G01N33/573 , C12N9/12 , A61K31/4412 , C12N15/113

CPC classification number: A61K31/5025 , A61K31/404 , A61K31/435 , A61K31/4412 , A61K31/4439 , A61K31/47 , A61K31/496 , A61K31/498 , A61K31/506 , A61K31/517 , A61K31/519 , A61K31/53 , A61K31/5383 , A61K31/553 , A61K45/06 , C07K14/705 , C07K14/71 , C07K16/40 , C07K2319/00 , C12N9/12 , C12N15/1137 , C12N2310/11 , C12N2310/12 , C12N2310/14 , C12Q1/6883 , C12Q1/6886 , C12Q2600/156 , C12Q2600/158 , C12Y207/10001 , G01N33/573 , G01N2333/912 , G01N2500/04

Abstract: Methods and compositions for treating cholangiocarcinoma.

Abstract translation: 治疗胆管癌的方法和组合物。

44.

发明申请
SYSTEM AND METHOD FOR MANAGING GENOMIC INFORMATION 审中-公开

公开(公告)号：US20150046191A1

公开(公告)日：2015-02-12

申请号：US14463073

申请日：2014-08-19

Applicant: FOUNDATION MEDICINE, INC.

Inventor： Helena Futscher de Deus , Rachel Lauren Erlich , Ronald David Collette , Alexander N. Parker , Michael Pellini , Gary Palmer , Mary Pat Lancelotta , Matthew J. Hawryluk , Philip James Stephens , Eric Karl Neumann , Jeffrey B. Collemer

IPC: G06F19/00

CPC classification number: G16H10/60 , G06F19/3456 , G06Q50/24 , G16C99/00 , G16H15/00

Abstract: Various embodiments provide interfaces to access genomic testing information and incorporate it into daily physician practice. According to one aspect, a graph-based data model is used that may be used to organizes and revise precision medicine knowledge. In one example structure, gene states are abstracted into alteration groups, where alteration groups are built using reverse engineering actionable information and storing that information within the graph-based data structure. Volumes of genomic alterations and associated information (e.g., journal articles, clinical trial information, therapies, etc.) are analyzed and synthesized into actionable information items viewable on an alteration system in a graph-based data format. According to one embodiment, the system can be configured to focus practitioners on discrete portions of the alteration information on which they can act. According to other aspects, curated information is provided on the system to enable practitioners to make informed decisions regarding the implications of the presence of specific genomic alterations.

45.

发明申请
SYSTEM AND METHOD FOR MANAGING GENOMIC INFORMATION 审中-公开
Title translation: 用于管理基因信息的系统和方法

公开(公告)号：US20150046180A1

公开(公告)日：2015-02-12

申请号：US14463068

申请日：2014-08-19

Applicant: FOUNDATION MEDICINE, INC.

Inventor： Helena Futscher de Deus , Rachel Lauren Erlich , Ronald David Collette , Alexander N. Parker , Michael Pellini , Gary Palmer , Mary Pat Lancelotta , Matthew J. Hawryluk , Philip James Stephens , Eric Karl Neumann

IPC: G06F19/00

CPC classification number: G16H50/20 , G06Q50/24 , G16C99/00 , G16H10/60 , G16H15/00

Abstract: Various embodiments provide interfaces to access genomic testing information and incorporate it into daily physician practice. According to one aspect, a graph-based data model is used that may be used to organizes and revise precision medicine knowledge. In one example structure, gene states are abstracted into alteration groups, where alteration groups are built using reverse engineering actionable information and storing that information within the graph-based data structure. Volumes of genomic alterations and associated information (e.g., journal articles, clinical trial information, therapies, etc.) are analyzed and synthesized into actionable information items viewable on an alteration system in a graph-based data format. According to one embodiment, the system can be configured to focus practitioners on discrete portions of the alteration information on which they can act. According to other aspects, curated information is provided on the system to enable practitioners to make informed decisions regarding the implications of the presence of specific genomic alterations.

Abstract translation: 各种实施方案提供了接口以访问基因组测试信息并将其并入日常医师实践中。根据一个方面，使用可用于组织和修改精密医学知识的基于图的数据模型。在一个示例结构中，基因状态被抽象为变更组，其中使用反向工程可操作信息构建变更组，并将该信息存储在基于图的数据结构内。将基因组变化和相关信息（例如，期刊文章，临床试验信息，治疗等）的卷分析并合成为以基于图表的数据格式在变更系统上可见的可操作的信息项。根据一个实施例，系统可以被配置为将从业者聚焦在它们可以作用于其上的变更信息的离散部分上。根据其他方面，在系统上提供了策划的信息，以使从业者就具体基因组改变的存在的含义做出明智的决定。