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41.发明授权公开(公告)号：US09682021B2
公开(公告)日：2017-06-20
申请号：US14189559
申请日：2014-02-25
发明人： Dov Tamarkin , Doron Friedman , Enbal Ziv , Meir Eini , Tal Berman , Jorge Danziger , Rita Keynan , David Schuz
CPC分类号： A61K8/046 , A61K8/31 , A61K9/0014 , A61K9/107 , A61K9/122 , A61K47/06 , A61K2800/31 , A61Q19/00 , Y10S514/859
摘要： The present invention relates to stable substantially non-aqueous, non-alcoholic, non-silicone, foamable carrier compositions comprising petrolatum or mixtures thereof, at least one foam agent, at least one propellant, and with and without the addition of an active agent. The formulations may contain a solvent substantially miscible therein. The present invention further provides a method of treating, alleviating or preventing a disorder of mammalian subject in need thereof, comprising administering the above-mentioned compositions to an afflicted target site of said mammalian subject.
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42.发明授权Non surfactant hydro-alcoholic foamable compositions, breakable foams and their uses 有权非表面活性剂水醇发泡组合物，易碎泡沫及其用途公开(公告)号：US09572775B2
公开(公告)日：2017-02-21
申请号：US14857282
申请日：2015-09-17
发明人： Dov Tamarkin , Enbal Ziv , Yohan Hazot , David Schuz
CPC分类号： A61K31/7056 , A01N25/16 , A61K9/0014 , A61K9/122 , A61K31/196 , A61K31/327 , A61K31/573 , A61K31/58 , A61K47/10 , A61K47/38
摘要： A substantially surface active agent-free foamable composition which includes short-chain alcohol, water, polymer, fatty alcohol or fatty acid or a combination of fatty alcohol and fatty acid and propellant. A substantially surface active agent-free foamable composition which includes, water, polymer, fatty alcohol or fatty acid and propellant. A method of treatment using a substantially surface active agent-free foamable compositions.
摘要翻译： 一种基本上无表面活性剂的可发泡组合物，其包括短链醇，水，聚合物，脂肪醇或脂肪酸，或脂肪醇和脂肪酸与推进剂的组合。 一种基本上无表面活性剂的可发泡组合物，其包括水，聚合物，脂肪醇或脂肪酸和推进剂。 一种使用基本上无表面活性剂的可发泡组合物的处理方法。
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43.发明申请Non Surface Active Agent Non Polymeric Agent Hydro-Alcoholic Foamable Compositions, Breakable Foams And Their Uses 审中-公开非表面活性剂非聚合物水性可发泡组合物，可破坏泡沫及其用途公开(公告)号：US20150374625A1
公开(公告)日：2015-12-31
申请号：US14733418
申请日：2015-06-08
发明人： Dov Tamarkin , Enbal Ziv , Yohan Hazot , David Schuz
CPC分类号： A61K9/122 , A61K8/046 , A61K8/34 , A61K8/342 , A61K9/12 , A61K31/573 , A61K47/10 , A61K47/12 , A61K47/44 , A61Q19/00
摘要： A substantially surface active agent-free and substantially polymeric agent-free foamable composition which includes short-chain alcohol, water, fatty alcohol or fatty acid or a combination of fatty alcohol and fatty acid and propellant. A substantially surface active agent-free and substantially polymeric agent-free foamable composition which includes water, fatty alcohol or fatty acid and propellant. A method of treatment using a substantially surface active agent-free and substantially polymeric agent-free foamable composition.
摘要翻译： 一种基本上无表面活性剂和基本上无聚合物的可发泡组合物，其包括短链醇，水，脂肪醇或脂肪酸，或脂肪醇和脂肪酸与推进剂的组合。 一种基本上无表面活性剂和基本上无聚合物的可发泡组合物，其包括水，脂肪醇或脂肪酸和推进剂。 一种使用基本上无表面活性剂和基本上不含聚合物的可发泡组合物进行处理的方法。
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44.发明申请公开(公告)号：US20150239645A1
公开(公告)日：2015-08-27
申请号：US14634208
申请日：2015-02-27
发明人： Meir Eini , Tami Winitz , David Schuz
IPC分类号： B65D83/54
CPC分类号： B01F15/0087 , B01F3/04446 , B01F5/0606 , B01F5/0607 , B01F13/0022 , B05B7/08 , B65D83/14 , B65D83/16 , B65D83/201 , B65D83/202 , B65D83/205 , B65D83/206 , B65D83/207 , B65D83/40 , B65D83/48 , B65D83/525 , B65D83/54 , B65D83/546 , B65D83/68 , B65D83/682
摘要： A apparatus for delivering a predetermined quantity of content from a pressurized container includes a dispensing assembly which sits on the container and connects with an upper portion of a valve stem of the valve assembly, wherein the dispensing assembly includes a) an actuator cap having a discharge passage, which is open or obstructed and wherein the actuator cap acts as a metering chamber in combination with b) an adaptor which fits inside the cap and also snuggly engages the valve stem. The cap fits snuggly over the adjuster to define a metering chamber which depending on its position can close off the metered chamber or open it to the dispensing conduit\nozzle. When the cap is depressed it pushes down on the adjuster which depresses the valve. The chamber fills, but nothing is released until the upstroke.
摘要翻译： 用于从加压容器输送预定量的内容物的装置包括分配组件，其位于容器上并与阀组件的阀杆的上部连接，其中分配组件包括：a）具有放电的致动器盖 通道，其是敞开的或阻塞的，并且其中致动器盖用作计量室，其结合b）适配器，其适配在盖内并且紧密地接合阀杆。 盖子紧紧地配合在调节器上以限定计量室，其根据其位置可以关闭计量室或将其打开到分配管道\喷嘴。 当盖子被压下时，按下压下阀门的调节器。 房间填满，但是直到上冲才释放。
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公开(公告)号：US20210038517A1
公开(公告)日：2021-02-11
申请号：US17072243
申请日：2020-10-16
发明人： Dov Tamarkin , Doron Friedman , Tal Berman , Enbal Ziv , David Schuz
IPC分类号： A61K9/12 , A01N25/16 , A61K8/04 , A61K8/362 , A61Q19/00 , A61K8/49 , A61K8/86 , A61K9/00 , A61K8/37
摘要： The present invention teaches a foamable pharmaceutical carrier comprising a benefit agent, selected from the group consisting of a dicarboxylic acid and a dicarboxylic acid ester; a stabilizer selected from the group consisting of at least one surface-active agent; at least one polymeric agent and mixtures thereof; a solvent selected from the group consisting of water, a hydrophilic solvent, a hydrophobic solvent, a potent solvent, a polar solvent, a silicone, an emollient, and mixtures thereof, wherein the benefit agent, stabilizer and solvent are selected to provide a composition that is substantially resistant to aging and to phase separation and or can substantially stabilize other active ingredients. The invention further relates to a foamable composition further containing a liquefied hydrocarbon gas propellant.
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公开(公告)号：US20210023226A1
公开(公告)日：2021-01-28
申请号：US17066752
申请日：2020-10-09
发明人： Dov Tamarkin , Elana Gazal , Irakliy Papiashvili , Yohan Hazot , David Schuz , Rita Keynan
IPC分类号： A61K47/44 , A61K47/06 , A61K9/00 , A61K9/12 , A61K8/31 , A61Q17/04 , A61Q19/00 , A61Q19/10 , A61K31/137 , A61K31/192 , A61K31/4164 , A61K31/57 , A61K31/573 , A61K31/593 , A61K31/65 , A61K8/34 , A61K8/36 , A61K47/10 , A61K47/12 , A61K45/06 , A61K47/02 , A61K47/24
摘要： A substantially surface active agent-free and foam adjuvant-free composition which includes a hydrophobic solvent, a wax and a propellant. A substantially surface active agent-free and foam adjuvant-free composition, further comprising, a tetracycline antibiotic, or one or more other active agents. A method of treatment, using a substantially surface active agent-free and substantially foam adjuvant-free composition.
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公开(公告)号：US10821187B2
公开(公告)日：2020-11-03
申请号：US16280921
申请日：2019-02-20
发明人： Dov Tamarkin , Elana Gazal , Yohan Hazot , David Schuz , Irakliy Papiashvili
IPC分类号： A61K31/65 , A61K47/44 , A61K9/12 , A61P31/04 , A61P17/10 , A61K47/06 , A61K9/00 , A61K8/31 , A61Q17/04 , A61Q19/00 , A61Q19/10 , A61K31/137 , A61K31/192 , A61K31/4164 , A61K31/57 , A61K31/573 , A61K31/593 , A61K8/34 , A61K8/36 , A61K47/10 , A61K47/12 , A61K45/06 , A61K47/02 , A61K47/24
摘要： The present disclosure relates generally to compositions for cosmetic or pharmaceutical application. The compositions include a carrier and rheology modulators.
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公开(公告)号：US10821077B2
公开(公告)日：2020-11-03
申请号：US15903275
申请日：2018-02-23
发明人： Dov Tamarkin , Doron Friedman , Tal Berman , Enbal Ziv , David Schuz
IPC分类号： A61K9/12 , A01N25/16 , A61K8/04 , A61K8/362 , A61K8/37 , A61K8/49 , A61K8/86 , A61K9/00 , A61Q19/00
摘要： The present invention teaches a foamable pharmaceutical carrier comprising a benefit agent, selected from the group consisting of a dicarboxylic acid and a dicarboxylic acid ester; a stabilizer selected from the group consisting of at least one surface-active agent; at least one polymeric agent and mixtures thereof; a solvent selected from the group consisting of water, a hydrophilic solvent, a hydrophobic solvent, a potent solvent, a polar solvent, a silicone, an emollient, and mixtures thereof, wherein the benefit agent, stabilizer and solvent are selected to provide a composition that is substantially resistant to aging and to phase separation and or can substantially stabilize other active ingredients. The invention further relates to a foamable composition further containing a liquefied hydrocarbon gas propellant.
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公开(公告)号：US10463742B2
公开(公告)日：2019-11-05
申请号：US16387407
申请日：2019-04-17
发明人： Dov Tamarkin , Elana Gazal , Irakliy Papiashvili , Yohan Hazot , David Schuz , Rita Keynan
IPC分类号： A61K8/18 , A61K35/50 , A61K31/65 , C07C50/36 , C07C237/26 , A61K47/44 , A61K8/31 , A61Q17/04 , A61K9/12 , A61K31/4164 , A61K31/57 , A61K31/573 , A61K31/593 , A61K47/12 , A61K31/137 , A61K31/192 , A61K47/02 , A61K9/00 , A61Q19/00 , A61Q19/10 , A61K8/34 , A61K8/36 , A61K47/10 , A61K45/06 , A61K47/24 , A61K47/06
摘要： A topical therapeutic hydrophobic breakable composition includes a carrier comprising (a) about 60% to about 99% by weight of at least one hydrophobic oil; (b) at least one viscosity-modifying agents selected from the group consisting of a fatty alcohol, a fatty acid and a wax; and (c) a tetracycline antibiotic, characterized in that at least part of the tetracycline antibiotic is suspended in the composition; the viscosity of the composition is at least about 30% higher than the viscosity of the carrier without the tetracycline antibiotic; and is higher than the viscosity or the hydrophobic oil and the tetracycline antibiotic without the viscosity modifying agents. The tetracycline is chemically stable in the composition for at least six months; wherein more than about 90% of the tetracycline has not broken down. The composition is packaged as a breakable foam that breaks easily upon application of shear force.
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公开(公告)号：US20190240239A1
公开(公告)日：2019-08-08
申请号：US16384589
申请日：2019-04-15
发明人： Dov Tamarkin , Elana Gazal , Irakliy Papiashvili , Yohan Hazot , David Schuz
IPC分类号： A61K31/65 , A61Q19/00 , A61K9/12 , A61K8/34 , A61K47/44 , A61K47/12 , A61K47/10 , A61K47/06 , A61K8/31 , A61K9/06 , A61K9/00 , A61K8/92 , A61K8/42 , A61K8/36
CPC分类号： A61K31/65 , A61K8/31 , A61K8/342 , A61K8/361 , A61K8/42 , A61K8/922 , A61K9/0014 , A61K9/06 , A61K9/122 , A61K47/06 , A61K47/10 , A61K47/12 , A61K47/44 , A61K2800/10 , A61K2800/48 , A61Q19/00
摘要： The present disclosure relates generally to compositions for cosmetic or pharmaceutical application. The compositions include a carrier and rheology modulators.
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