公开(公告)号：US20220184030A1

公开(公告)日：2022-06-16

申请号：US17121558

申请日：2020-12-14

申请人： Christopher Thompson

发明人： Christopher Thompson

IPC分类号： A61K31/40 ,  A61K31/05 ,  A61K9/00 ,  A61K31/685 ,  A61K31/7072 ,  A61K31/522 ,  A61K9/68 ,  A23L33/105 ,  A23G4/06 ,  A23G4/12

摘要： A composition comprising a combination of N-Phenylacetyl-L-prolylglycine ethyl ester and cannabidiol for oral administration to humans and other animals and a method for administering said composition are described. The composition provides synergistic nootropic benefits to the user, resulting in enhanced cognitive functions, such as increased focus, creativity, memory recall, and memory consolidation, among other cognitive functions. The composition generally does not cause side effects in the users and generally does not cause the user to develop tolerance to its nootropic effects. The composition optionally comprises a compound containing choline or a choline prodrug to supply choline to the brain of the user for the production of the neurotransmitter acetylcholine, and may also optionally comprise caffeine.

公开(公告)号：US09038507B2

公开(公告)日：2015-05-26

申请号：US11726263

申请日：2007-03-21

申请人： Christopher Thompson ,  Michael Foster

发明人： Christopher Thompson ,  Michael Foster

IPC分类号： B25B13/46

CPC分类号： B25B13/463

摘要： A dual-pawl ratchet wrench mechanism is disclosed having a stop mechanism for limiting over-travel of a reversing lever for selecting drive directions. The stop mechanism is formed on a disc is selectively engageable with first and second pawls to move the pawls into and out of engagement with a ratchet gear to determine a torque drive direction, the ratchet gear capable of providing torque to a working piece in the selected drive direction. The design simplifies manufacturing. Additionally, the reversing lever is assembled with the mechanism in a manner to improve sealing.

摘要翻译： 公开了一种双棘爪棘轮扳手机构，其具有用于限制用于选择驱动方向的换向杆的超行程的停止机构。 止动机构形成在盘上，其可选择性地与第一爪和第二爪接合，以将棘爪移动到与棘轮啮合的啮合中，以确定扭矩驱动方向，该棘轮能够向所选择的工件中的工件提供扭矩 驱动方向。 该设计简化了制造。 此外，换向杆与机构组装以提高密封性。

公开(公告)号：US08499666B2

公开(公告)日：2013-08-06

申请号：US11726262

申请日：2007-03-21

申请人： Richard Hopper ,  Michael Foster ,  Christopher Thompson

发明人： Richard Hopper ,  Michael Foster ,  Christopher Thompson

IPC分类号： B25B13/46

CPC分类号： B25B13/463

摘要： A dual-pawl ratchet wrench mechanism is disclosed having a stop mechanism for limiting over-travel of a reversing lever for selecting drive directions. In one form, the wrench mechanism includes a ball and spring assembly that cooperate with recesses to define proper positions for the reversing lever, and one or more ramps are provided between the recesses to promote tactile feel and to promote the reversing lever being rotated to a proper position. In some forms, the stop mechanism is formed on a stationary portion, such as a spacer or the wrench body, and a portion of the reversing lever. The design simplifies manufacturing, such as by simplifying assembly and minimizing the need for securements. Additionally, the reversing lever is assembled with the mechanism in a manner to improve sealing.

摘要翻译： 公开了一种双棘爪棘轮扳手机构，其具有用于限制用于选择驱动方向的换向杆的超行程的停止机构。 在一种形式中，扳手机构包括球和弹簧组件，其与凹部协作以限定用于换向杆的适当位置，并且在凹部之间设置一个或多个斜面以促进触觉，并且促使换向杆旋转到 适当的位置 在一些形式中，止动机构形成在诸如间隔件或扳手主体的固定部分和反转杆的一部分上。 该设计简化了制造，例如通过简化组装和最小化对固定的需求。 此外，换向杆与机构组装以提高密封性。

公开(公告)号：US08193365B2

公开(公告)日：2012-06-05

申请号：US12815146

申请日：2010-06-14

申请人： Amjad Ali ,  Joann Bohn ,  Qiaolin Deng ,  Zhijian Lu ,  Peter J. Sinclair ,  Gayle Taylor ,  Christopher Thompson ,  Nazia Quraishi

发明人： Amjad Ali ,  Joann Bohn ,  Qiaolin Deng ,  Zhijian Lu ,  Peter J. Sinclair ,  Gayle Taylor ,  Christopher Thompson ,  Nazia Quraishi

IPC分类号： C07D261/02 ,  C07D209/04 ,  C07D307/93 ,  A01N57/26 ,  A01N57/00

CPC分类号： A61K31/343 ,  A61K31/381 ,  A61K31/404 ,  A61K31/42 ,  A61K31/44 ,  A61K31/4412 ,  A61K31/455 ,  A61K31/47 ,  A61K31/472 ,  A61K38/00 ,  A61K45/06 ,  C07C233/16 ,  C07C271/16 ,  C07C271/20 ,  C07C271/22 ,  C07C275/32 ,  C07C311/04 ,  C07C311/08 ,  C07C317/32 ,  C07D209/08 ,  C07D213/54 ,  C07D215/12 ,  C07D217/02 ,  C07D261/08 ,  C07D271/10 ,  C07D307/14 ,  C07D307/79 ,  C07D333/20 ,  C07D333/22 ,  C07D333/28 ,  A61K2300/00

摘要： Compounds of Formula I, including pharmaceutically acceptable salts of the compounds, are CETP inhibitors, and are useful for raising HDL-cholesterol, reducing LDL-cholesterol, and for treating or preventing atherosclerosis. In the compounds of Formula 1, A1 and A2 are each an aromatic ring, a 5-6-membered heterocyclic ring, an aromatic ring fused to a heterocyclic ring, a phenyl ring fused to a heterocyclic ring, or a cycloalkyl ring.

摘要翻译： 式I化合物，包括化合物的药学上可接受的盐，是CETP抑制剂，可用于培养HDL-胆固醇，降低LDL-胆固醇，以及治疗或预防动脉粥样硬化。 在式1化合物中，A1和A2各自为芳环，5-6元杂环，稠合于杂环的芳环，稠合于杂环的苯环或环烷基环。

公开(公告)号：US08100815B2

公开(公告)日：2012-01-24

申请号：US12968181

申请日：2010-12-14

申请人： Matt Balaker ,  Christopher Thompson

发明人： Matt Balaker ,  Christopher Thompson

IPC分类号： A63B22/00 ,  A63B21/00

CPC分类号： A63B21/156 ,  A63B21/00185 ,  A63B21/008 ,  A63B21/0083 ,  A63B21/023 ,  A63B21/4034 ,  A63B21/4035 ,  A63B21/4043 ,  A63B21/4045 ,  A63B22/203 ,  A63B23/03541 ,  A63B23/03575 ,  A63B69/182 ,  A63B2225/10

摘要： An exercise device comprising a frame; and a plurality of platforms for accommodating an exerciser's feet, each platform of the plurality of platforms including at least one moving member for facilitating both a divergent movement and a convergent movement. The device includes a tensioning structure for providing adjustable resistance.

摘要翻译： 一种健身器具，包括一个框架; 以及用于容纳锻炼脚的多个平台，所述多个平台中的每个平台包括至少一个移动构件，以便于发散运动和收敛运动。 该装置包括用于提供可调电阻的张紧结构。

公开(公告)号：US20110222327A1

公开(公告)日：2011-09-15

申请号：US12722129

申请日：2010-03-11

申请人： Christopher Thompson

发明人： Christopher Thompson

IPC分类号： H02M7/515

CPC分类号： H02J3/383 ,  Y02E10/563

摘要： A photovoltaic system may include a DC to AC inverter including a minimum operating power setting and a microprocessor for calculating a maximum available power output for a photovoltaic array.

摘要翻译： 光伏系统可以包括DC至AC逆变器，其包括最小工作功率设置和用于计算光伏阵列的最大可用功率输出的微处理器。

公开(公告)号：US20110222242A1

公开(公告)日：2011-09-15

申请号：US12722181

申请日：2010-03-11

申请人： Christopher Thompson

发明人： Christopher Thompson

IPC分类号： H05K7/20

CPC分类号： H05K7/20945 ,  Y10T307/62 ,  Y10T307/625

摘要： A DC to AC inverter used in a solar cell power system can include an improved control scheme for cooling itself and optimizing power output.

摘要翻译： 在太阳能电池电力系统中使用的直流到交流逆变器可以包括用于冷却自身并优化功率输出的改进的控制方案。

公开(公告)号：US20110078840A1

公开(公告)日：2011-04-07

申请号：US12897712

申请日：2010-10-04

申请人： Christopher Thompson

发明人： Christopher Thompson

IPC分类号： A41D7/00 ,  A41D1/06 ,  A41D1/00 ,  A41D1/14 ,  A41D1/22 ,  A41D3/02 ,  A41B9/00 ,  A42B1/04 ,  A43B17/00 ,  A41C3/00 ,  A41D27/20

CPC分类号： A41D27/20 ,  A41D2300/30

摘要： The clothes, apparel, or garment, whether it be pants, jeans, trousers, shorts, a skirt, a dress, a shirt, a hat, socks, sweatshirt, jacket, bikini, swim suit, bra, or any other possible item of clothing that has, or could have a pocket as part of the clothing, whereby a pocket as part of a garment has an opening for gaining access to the interior of the pocket. The pocket may include optional closure means or flap for closing the exterior of the pocket. The interior of the pocket may provide the full functionality of a normal pocket, but in addition, may have a second opening (which may take any number of forms, shapes, or sizes) within the interior of the pocket for gaining access to the wearer's body, and wherein the second opening may be closed using one or more buttons, snaps, clasps, zippers and/or laces or other closure means.

摘要翻译： 衣服，服装或服装，无论是裤子，牛仔裤，裤子，短裤，裙子，连衣裙，衬衫，帽子，袜子，运动衫，夹克，比基尼泳衣，泳衣，胸罩或任何其他可能的项目 具有或可以具有作为衣服的一部分的口袋的衣服，其中作为服装的一部分的口袋具有用于进入口袋内部的开口。 口袋可以包括用于封闭口袋外部的可选闭合装置或瓣。 口袋的内部可以提供普通口袋的全部功能，但是另外也可以在口袋内部具有第二开口（其可以采取任何数量的形式，形状或尺寸），以便进入穿戴者的位置 身体，并且其中可以使用一个或多个按钮，按扣，扣子，拉链和/或鞋带或其他闭合装置来关闭第二开口。

公开(公告)号：US20090312645A1

公开(公告)日：2009-12-17

申请号：US12482081

申请日：2009-06-10

申请人： Barry Weitzner ,  Christopher Thompson

发明人： Barry Weitzner ,  Christopher Thompson

IPC分类号： A61B1/018 ,  A61B6/00

CPC分类号： A61B17/29 ,  A61B1/00098 ,  A61B1/00149 ,  A61B1/018 ,  A61B2017/00331 ,  A61B2017/2926 ,  A61B2017/306 ,  A61B2017/3445

摘要： Described herein are methods and devices for performing endoscopic retrograde cholangiopancreatography (ERCP). A system comprising an elongate body housing a front-viewing endoscope and a tissue grasping instrument can be used to facilitate the insertion of a catheter into the ampulla of Vater. The distal end of the elongate body can be positioned such that the operator of the system can view the ampulla while manipulating the surrounding tissue to ease cannulation of the opening with the catheter. As a result, the procedure can be performed faster and more reliably than in the past.

摘要翻译： 本文描述了用于进行内窥镜逆行胰胆管造影（ERCP）的方法和装置。 可以使用包括容纳前视内窥镜和组织夹持器具的细长主体的系统以便于将导管插入Vater的壶腹中。 细长体的远端可以被定位成使得系统的操作者可以在操纵周围组织的同时观察壶腹，以便放开导管插管。 因此，可以比过去更快，更可靠地执行该过程。

公开(公告)号：US07473671B2

公开(公告)日：2009-01-06

申请号：US10631883

申请日：2003-07-31

申请人： Daniel Kahne ,  Robert Kerns ,  Seketsu Fukuzawa ,  Min Ge ,  Christopher Thompson

发明人： Daniel Kahne ,  Robert Kerns ,  Seketsu Fukuzawa ,  Min Ge ,  Christopher Thompson

IPC分类号： C40B40/14

CPC分类号： C07K9/008

摘要： A glycopeptide of the formula A1-A2-A3-A4-A5-A6-A7, in which each dash represents a covalent bond; wherein A1 comprises a modified or unmodified α-amino acid residue, alkyl, aryl, aralkyl, alkanoyl, aroyl, aralkanoyl, heterocyclic, heterocyclic-carbonyl, heterocyclic-alkyl, heterocyclic-alkyl-carbonyl, alkylsulfonyl, arylsulfonyl, guanidinyl, carbamoyl, or xanthyl; wherein each of A2 to A7 comprises a modified or unmodified α-amino acid residue, whereby (i) A1 is linked to an amino group on A2, (ii) each of A2, A4 and A6 bears an aromatic side chain, which aromatic side chains are cross-linked together by two or more covalent bonds, and (iii) A7 bears a terminal carboxyl, ester, amide, or N-substituted amide group; and wherein one or more of A1 to A7 is linked via a glycosidic bond to one or more glycosidic groups each having one or more sugar residues, at least one of the sugar residues bearing one or more substituents of the formula YXR, N+(R1)=CR2R3, N=PR1R2R3, N+R1R2R3 or P+R1R2R3 in which Y is a single bond, O, NR, or S; X is O, NR1, S, SO2, C(O)O, C(O)S, C(S)O, C(S)S, C(NR1)O, C(O)NR1, or halo (in which case Y and R are absent). A chemical library comprising a plurality of the glycopeptides of the invention.A method for preparing a glycopeptide by glycosylation of an aglycone derived from a glycopeptide antibiotic.A method for preparing a glycopeptide by preparing a pseudoaglycone from a glycopeptide antibiotic and glycosylating the pseudoaglycone.

摘要翻译： 式A1-A2-A3-A4-A5-A6-A7的糖肽，其中每个短划线代表共价键; 其中A1包含经修饰或未修饰的α-氨基酸残基，烷基，芳基，芳烷基，烷酰基，芳酰基，芳烷酰基，杂环，杂环羰基，杂环烷基，杂环 - 烷基 - 羰基，烷基磺酰基，芳基磺酰基，胍基，氨基甲酰基或 呫吨 其中A2至A7各自包含经修饰或未修饰的α-氨基酸残基，由此（i）A1与A2上的氨基连接，（ii）每个A2，A4和A6均带有芳香侧链，该芳族侧 链通过两个或更多个共价键交联在一起，和（iii）A7具有末端羧基，酯，酰胺或N-取代的酰胺基; 并且其中A1至A7中的一个或多个通过糖苷键与一个或多个各自具有一个或多个糖残基的糖苷基连接，至少一个具有一个或多个式YXR，N +（R1）的取代基的糖残基， = CR2R3，N = PR1R2R3，N + R1R2R3或P + R1R2R3，其中Y为单键，O，NR或S; X是O，NR1，S，SO2，C（O）O，C（O）S，C（S）O，C（S）S，C（NR1）O，C（O）NR1或卤素 哪种情况下Y和R不存在）。 包含本发明多种糖肽的化学文库。 通过糖衍生自糖肽抗生素的糖苷配基制备糖肽的方法。 一种通过从糖肽抗生素制备假糖苷配基并糖基化假糖苷配基来制备糖肽的方法。