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    Tissue site markers for in vivo imaging
    43.
    发明授权
    Tissue site markers for in vivo imaging 有权
    用于体内成像的组织位点标记

    公开(公告)号：US08224424B2

    公开(公告)日：2012-07-17

    申请号：US12460052

    申请日：2009-07-13

    申请人： Fred H. Burbank ,  Paul Lubock ,  Michael L. Jones ,  Richard L. Quick ,  Frank Louw ,  Stephen A. De Santis

    发明人： Fred H. Burbank ,  Paul Lubock ,  Michael L. Jones ,  Richard L. Quick ,  Frank Louw ,  Stephen A. De Santis

    IPC分类号： A61B5/00 ,  A61B6/00 ,  A61B19/00

    CPC分类号： A61M37/0069 ,  A61B6/12 ,  A61B8/0833 ,  A61B10/02 ,  A61B90/39 ,  A61B2017/00004 ,  A61B2090/08021 ,  A61B2090/3908 ,  A61B2090/3925 ,  A61B2090/3987 ,  A61K49/006 ,  A61K49/222

    摘要： The invention is directed biopsy site markers and methods of marking a biopsy site, so that the location of the biopsy cavity is readily visible by conventional imaging methods, particularly by ultrasonic imaging. The biopsy site markers of the invention have high ultrasound reflectivity, presenting a substantial acoustic signature from a small marker, so as to avoid obscuring diagnostic tissue features in subsequent imaging studies, and can be readily distinguished from biological features. The several disclosed embodiments of the biopsy site marker of the invention have a high contrast of acoustic impedance as placed in a tissue site, so as to efficiently reflect and scatter ultrasonic energy, and preferably include gas-filled internal pores. The markers may have a non-uniform surface contour to enhance the acoustic signature. The markers have a characteristic form which is recognizably artificial during medical imaging. The biopsy site marker may be accurately fixed to the biopsy site so as to resist migration from the biopsy cavity when a placement instrument is withdrawn, and when the marked tissue is subsequently moved or manipulated.

    摘要翻译： 本发明涉及活检部位标记和标记活组织检查部位的方法，使得活检腔的位置通过常规成像方法，特别是通过超声成像容易看到。 本发明的活检部位标记物具有高的超声反射率，从小标记物呈现出实质的声学特征，以避免在随后的成像研究中掩盖诊断组织特征，并且可以容易地与生物特征区别开来。 本发明的活检部位标记物的几个公开的实施方案具有放置在组织部位中的声阻抗的高对比度，以便有效地反射和散射超声能量，并且优选地包括气体填充的内部孔。 标记可以具有不均匀的表面轮廓以增强声学特征。 标记具有在医学成像期间可识别人造的特征形式。 可以将活检部位标记物精确地固定到活检部位，以便当放置放置器械被取出时以及随后标记的组织被移动或操纵时抵抗从活检腔的迁移。

    Marker or filler forming fluid
    45.
    发明授权
    Marker or filler forming fluid 有权
    标记或填料成型液

    公开(公告)号：US07877133B2

    公开(公告)日：2011-01-25

    申请号：US10444428

    申请日：2003-05-23

    申请人： Fred H. Burbank ,  Michael L. Jones ,  Frank Louw ,  Paul Lubock

    发明人： Fred H. Burbank ,  Michael L. Jones ,  Frank Louw ,  Paul Lubock

    IPC分类号： A61B6/00 ,  A61B10/00

    CPC分类号： A61B90/39 ,  A61B2090/3908 ,  A61B2090/3925 ,  A61B2090/3933 ,  A61B2090/3987 ,  A61K49/226

    摘要： A solution for forming a marker or filler mass for an intracorporeal site. The solution contains a polar, water soluble non-aqueous solvent such as dimethyl sulfoxide and a bioabsorbable, essentially water insoluble polymer such as polylactic acid, or copolymers of lactic acid and glycolic acid. The solution may be delivered to the biopsy site by a suitable syringe and delivery tube. The delivery tube is preferably provided with a releasable radiopaque element on the distal tip which can be released within the polymeric marker mass formed in the biopsy cavity.

    摘要翻译： 用于形成体内部位的标记物或填充剂块的溶液。 该溶液含有极性的水溶性非水溶剂如二甲基亚砜和生物可吸收的，基本上不溶于水的聚合物如聚乳酸，或乳酸和乙醇酸的共聚物。 溶液可以通过合适的注射器和输送管递送到活检部位。 输送管优选地设置在远端上的可释放的不透射线元件，其可以在形成于活检腔内的聚合物标记块内释放。

    Cavity-filling biopsy site markers
    46.
    发明授权
    Cavity-filling biopsy site markers 有权
    腔填充活检部位标记

    公开(公告)号：US07792569B2

    公开(公告)日：2010-09-07

    申请号：US10990327

    申请日：2004-11-16

    申请人： Fred H. Burbank ,  Paul Lubock ,  Michael L. Jones

    发明人： Fred H. Burbank ,  Paul Lubock ,  Michael L. Jones

    IPC分类号： A61B19/00

    CPC分类号： A61B8/481 ,  A61B6/12 ,  A61B8/0833 ,  A61B10/02 ,  A61B90/39 ,  A61B2017/00004 ,  A61B2090/3908 ,  A61B2090/392 ,  A61B2090/3925 ,  A61B2090/395 ,  A61B2090/3954 ,  A61B2090/3966 ,  A61B2090/3987 ,  A61B2090/3995 ,  A61K49/006 ,  A61K49/222 ,  A61M37/0069

    摘要： The invention provides materials, devices and methods for marking biopsy sites for a limited time. The biopsy-marking materials are ultrasound-detectable bio-resorbable powders, with powder particles typically between about 20 microns and about 800 microns in maximum dimension, more preferably between about 300 microns and about 500 microns. The powders may be formed of polymeric materials containing cavities sized between about 10 microns and about 500 microns, and may also contain binding agents, anesthetic agents, hemostatic agents, and radiopaque markers. Devices for delivering the powders include tubes configured to contain the powders and to fit within a biopsy cannula, the powders being ejected by action of a syringe. Systems may include a tube containing powder, and a syringe containing sterile saline. The tube may be configured to fit within a biopsy cannula such as a Mammotome® or SenoCor 360™ cannula.

    摘要翻译： 本发明提供用于在有限时间内标记活检部位的材料，装置和方法。 活检标记材料是可超声检测的生物可再吸收粉末，粉末颗粒通常在最大尺寸为约20微米至约800微米之间，更优选为约300微米至约500微米。 粉末可以由含有大约10微米至约500微米的空腔的聚合材料形成，并且还可以含有粘合剂，麻醉剂，止血剂和不透射线的标记物。 用于递送粉末的装置包括被配置为容纳粉末并且装配在活检插管内的管，粉末通过注射器的作用喷射。 系统可以包括含有粉末的管和含有无菌盐水的注射器。 管可以被配置成装配在活检插管内，例如Mammotome或SenoCor 360 TM插管。

    Imageable biopsy site marker
    48.
    发明授权
    Imageable biopsy site marker 有权
    可成像的活检部位标记

    公开(公告)号：US06996433B2

    公开(公告)日：2006-02-07

    申请号：US10719448

    申请日：2003-11-21

    申请人： Fred H. Burbank ,  Paul Lubock ,  Michael L. Jones ,  Nancy Forcier

    发明人： Fred H. Burbank ,  Paul Lubock ,  Michael L. Jones ,  Nancy Forcier

    IPC分类号： A61B1/00 ,  A61B1/04 ,  A61B6/00

    CPC分类号： A61K49/006 ,  A61B10/02 ,  A61B90/39 ,  A61B2017/00004 ,  A61B2090/3908 ,  A61B2090/3933 ,  A61B2090/395 ,  A61B2090/3987 ,  A61M37/0069

    摘要： A biopsy site marker comprises small bodies or pellets of gelatin which enclose substantially in their interior a radio (X-ray) opaque object. The gelatin pellets are deposited into the biopsy site, typically a cylindrical opening in the tissue created by the recent use of a vacuum assisted large core biopsy device, by an applicator device that includes an elongated cylindrical body that forms a flexible tube and a piston slidable in the tube. One end of the tube is placed into the biopsy site. Typically, several gelatin pellets, only some of which typically do, but all of which may contain the radio opaque object, are deposited sequentially into the site through the tube. The radio opaque objects contained in the gelatin bodies are of a non-biological configuration and readily identifiable as man-made object, so that in observation by typical mammography equipment they do not assume the shape of a line, whereby they are readily distinguishable from granules and lines of calcification.

    摘要翻译： 活检部位标记物包括明胶的小体或小丸，其基本上在其内部封闭无线电（X射线）不透明物体。 凝胶颗粒沉积到活检部位，通常是通过最近使用真空辅助的大芯活检装置产生的组织中的圆柱形开口，该施用装置包括形成柔性管的细长圆柱形主体和可滑动的活塞 在管中。 将管的一端放入活检部位。 通常，几个明胶丸粒，其中仅一些通常可以，但都可以包含无线电不透明物体，通过管子依次沉积到该部位。 包含在明胶体中的无线电不透明物体具有非生物构型，并且易于被识别为人造物体，因此在通过典型的乳房X射线摄影术设备的观察中，它们不呈现线的形状，由此它们容易与颗粒区分开 和钙化线。