公开(公告)号：US20230270719A1

公开(公告)日：2023-08-31

申请号：US18059806

申请日：2022-11-29

Applicant: Gilead Sciences, Inc.

Inventor： Jinfa Du ,  Joshua A. Kaplan ,  Thorsten A. Kirschberg ,  Tetsuya Kobayashi ,  Scott E. Lazerwith ,  Rick Andrew Lee ,  Jonathan William Medley ,  Michael L. Mitchell ,  Philip Anthony Morganelli ,  Hyung-Jung Pyun ,  Sophia L. Shevick ,  Neil H. Squires ,  William J. Watkins

IPC: A61K31/403 ,  C07D487/04 ,  C07D519/00 ,  A61P31/20 ,  A61K31/03 ,  A61K31/16 ,  A61K31/38 ,  A61K31/4192

CPC classification number: A61K31/403 ,  C07D487/04 ,  C07D519/00 ,  A61P31/20 ,  A61K31/03 ,  A61K31/16 ,  A61K31/38 ,  A61K31/4192

Abstract: This application relates generally to certain substituted pyrrolizine compounds, and pharmaceutical compositions which inhibit HBV replication, and methods of making and using them.

公开(公告)号：US20230002407A1

公开(公告)日：2023-01-05

申请号：US17317041

申请日：2021-05-11

Applicant: Gilead Sciences, Inc.

Inventor： Elizabeth M. Bacon ,  Gayatri Balan ,  Chien-Hung Chou ,  Christopher T. Clark ,  Jeromy J. Cottell ,  Musong Kim ,  Thorsten A. Kirschberg ,  John O. Link ,  Gary Phillips ,  Scott D. Schroeder ,  Neil H. Squires ,  Kirk L. Stevens ,  James G. Taylor ,  William J. Watkins ,  Nathan E. Wright ,  Sheila M. Zipfel

IPC: C07D498/04 ,  C07D405/14 ,  C07D413/14 ,  C07D401/12 ,  C07D409/14 ,  C07D417/14 ,  C07D471/04 ,  C07D495/04 ,  C07D401/14 ,  C07B59/00

Abstract: The present disclosure relates generally to modulators of Cot (cancer Osaka thyroid) and methods of use and manufacture thereof.

公开(公告)号：US20210171543A1

公开(公告)日：2021-06-10

申请号：US17094447

申请日：2020-11-10

Applicant: Gilead Sciences, Inc.

Inventor： Hang Chu ,  Juan A. Guerrero ,  Anna E. Hurtley ,  Lan Jiang ,  Darryl Kato ,  Tetsuya Kobayashi ,  David W. Lin ,  Jonathan William Medley ,  Devan Naduthambi ,  Vickie H. Tsui ,  Chandrasekar Venkataramani ,  William J. Watkins ,  Hong Yang ,  QingMing Zhu

IPC: C07D513/18 ,  C07D519/00 ,  C07D513/20 ,  C07D513/08 ,  C07D513/22 ,  A61K45/06 ,  C07K16/28

Abstract: The present disclosure generally relates to compounds of Formula (I) and pharmaceutical compositions that may be used in methods of treating cancer.

公开(公告)号：US20210024494A1

公开(公告)日：2021-01-28

申请号：US16923750

申请日：2020-07-08

Applicant: Gilead Sciences, Inc.

Inventor： Evangelos Aktoudianakis ,  Aesop Cho ,  Michael Graupe ,  Lateshkumar Thakorlal Lad ,  Paulo A. Machicao Tello ,  Jonathan William Medley ,  Samuel E. Metobo ,  Devan Naduthambi ,  Barton W. Phillips ,  Scott Preston Simonovich ,  Peiyuan Wang ,  William J. Watkins ,  Jie Xu ,  Kin Shing Yang ,  Christopher Allen Ziebenhaus

IPC: C07D401/14 ,  A61K31/444 ,  A61K31/497 ,  A61K31/704 ,  A61K31/7068 ,  A61K39/395 ,  C07D471/08

Abstract: Compounds and methods of using said compounds singly or in combination with additional agents and compositions of said compounds for the treatment of cancer are disclosed.

公开(公告)号：US20200331870A1

公开(公告)日：2020-10-22

申请号：US16857021

申请日：2020-04-23

Applicant: Gilead Sciences, Inc.

Inventor： Hang Chu ,  Juan A. Guerrero ,  Anna E. Hurtley ,  Tae H. Hwang ,  Lan Jiang ,  Darryl Kato ,  Tetsuya Kobayashi ,  John E. Knox ,  Scott E. Lazerwith ,  Xiaofen Li ,  David W. Lin ,  Jonathan W. Medley ,  Michael L. Mitchell ,  Devan Naduthambi ,  Zachary Newby ,  Neil H. Squires ,  Vickie H. Tsui ,  Chandrasekar Venkataramani ,  William J. Watkins ,  Hong Yang

IPC: C07D267/20 ,  C07D413/12 ,  C07D413/14 ,  C07D417/12 ,  C07D471/04 ,  C07D487/04 ,  C07D498/04

Abstract: The present disclosure generally relates to compounds and pharmaceutical compositions that may be used in methods of treating cancer.

公开(公告)号：US20200255418A1

公开(公告)日：2020-08-13

申请号：US16741101

申请日：2020-01-13

Applicant: Gilead Sciences, Inc.

Inventor： Peter A. Blomgren ,  Kevin S. Currie ,  Morin Mae Frick ,  Elizabeth M. Horstman ,  Joshua A. Kaplan ,  Jeffrey E. Kropf ,  William J. Watkins

IPC: C07D413/14

Abstract: The present disclosure relates generally to compounds that bind to FXR and act as agonists of FXR. The disclosure further relates to the use of the compounds for the preparation of a medicament for the treatment of diseases and/or conditions through binding of said nuclear receptor by said compounds and to a process for the synthesis of said compounds.

公开(公告)号：US10059695B2

公开(公告)日：2018-08-28

申请号：US15634314

申请日：2017-06-27

Applicant: Gilead Sciences, Inc.

Inventor： Gayatri Balan ,  Chien-Hung Chou ,  Musong Kim ,  Thorsten A. Kirschberg ,  John O. Link ,  Gary Phillips ,  Roland D. Saito ,  Neil H. Squires ,  James G. Taylor ,  William J. Watkins ,  Nathan E. Wright

IPC: C07D403/12 ,  C07D401/14 ,  C07D405/14 ,  C07D417/14

CPC classification number: C07D403/12 ,  C07D401/14 ,  C07D405/14 ,  C07D417/14

Abstract: The present disclosure relates generally to modulators of Cot (cancer Osaka thyroid) and methods of use and manufacture thereof.

公开(公告)号：US20180237455A1

公开(公告)日：2018-08-23

申请号：US15891163

申请日：2018-02-07

Applicant: Gilead Sciences, Inc.

Inventor： Elizabeth M. Bacon ,  Gayatri Balan ,  Chien-Hung Chou ,  Christopher T. Clark ,  Jeromy J. Cottell ,  Musong Kim ,  Thorsten A. Kirschberg ,  John O. Link ,  Gary Phillips ,  Scott D. Schroeder ,  Neil H. Squires ,  Kirk L. Stevens ,  James G. Taylor ,  William J. Watkins ,  Nathan E. Wright ,  Sheila M. Zipfel

IPC: C07D498/04 ,  C07D495/04 ,  C07D471/04 ,  C07D417/14 ,  C07D409/14 ,  C07D401/12 ,  C07B59/00 ,  C07D405/14 ,  C07D401/14 ,  C07D413/14

CPC classification number: C07D498/04 ,  C07B59/002 ,  C07B2200/05 ,  C07D401/12 ,  C07D401/14 ,  C07D405/14 ,  C07D409/14 ,  C07D413/14 ,  C07D417/14 ,  C07D471/04 ,  C07D495/04

Abstract: The present disclosure relates generally to modulators of Cot (cancer Osaka thyroid) and methods of use and manufacture thereof.

公开(公告)号：US20180133203A1

公开(公告)日：2018-05-17

申请号：US15796195

申请日：2017-10-27

Applicant: Gilead Sciences, Inc.

Inventor： David Gordon Clarkson Breckenridge ,  Grant Raymond Budas ,  John T. Liles ,  William J. Watkins

IPC: A61K31/4439 ,  A61P1/16

CPC classification number: A61K31/4439 ,  A61K2300/00 ,  A61P1/16

Abstract: The present disclosure relates to a method of preventing and/or treating liver disease comprising administering an ASK1 inhibitor in combination with a FXR agonist to a patient in need thereof.

公开(公告)号：US09878995B2

公开(公告)日：2018-01-30

申请号：US15429086

申请日：2017-02-09

Applicant: Gilead Sciences, Inc.

Inventor： Elizabeth M. Bacon ,  Gayatri Balan ,  Chien-Hung Chou ,  Christopher T. Clark ,  Jeromy J. Cottell ,  Musong Kim ,  Thorsten A. Kirschberg ,  John O. Link ,  Gary Phillips ,  Scott D. Schroeder ,  Neil H. Squires ,  Kirk L. Stevens ,  James G. Taylor ,  William J. Watkins ,  Nathan E. Wright ,  Sheila M. Zipfel

IPC: C07D401/14

CPC classification number: C07D498/04 ,  C07B59/002 ,  C07B2200/05 ,  C07D401/12 ,  C07D401/14 ,  C07D405/14 ,  C07D409/14 ,  C07D413/14 ,  C07D417/14 ,  C07D471/04 ,  C07D495/04

Abstract: The present disclosure relates generally to modulators of Cot (cancer Osaka thyroid) and methods of use and manufacture thereof.