公开(公告)号：US07557343B2

公开(公告)日：2009-07-07

申请号：US11224093

申请日：2005-09-13

Applicant: Stuart C. Hansen ,  Gangqiang Li ,  Gavin E. Reid

Inventor： Stuart C. Hansen ,  Gangqiang Li ,  Gavin E. Reid

IPC: H01J49/00

CPC classification number: H01J49/4225

Abstract: A method and apparatus for processing ions in mass spectrometry is provided. The apparatus includes an ion processing cell having segmented multipole rods and a means for admitting reactive reagent ions to the cell. Provision for timed sequence control of RF and DC voltages to the segmented multipole rods is included. Processing includes trapping analyte ions and subjecting them to selected reactions with reactive reagent ions and/or physical manipulation of the ions by changing the characteristics of the electric field and/or creating discrete regions in the field.

Abstract translation: 提供了一种在质谱法中处理离子的方法和装置。 该装置包括具有分段多极棒的离子处理单元和用于将反应性试剂离子引入该单元的装置。 包括对分段多极杆的RF和DC电压的定时序列控制。 处理包括捕获分析物离子并使其与反应性试剂离子进行选择的反应和/或通过改变电场的特性和/或在场中产生离散区域来离子的物理操作。

公开(公告)号：US20090108191A1

公开(公告)日：2009-04-30

申请号：US11927995

申请日：2007-10-30

Applicant: George Yefchak ,  Kenneth L. Staton ,  Gangqiang Li

Inventor： George Yefchak ,  Kenneth L. Staton ,  Gangqiang Li

IPC: G12B13/00 ,  H01J49/00

CPC classification number: H01J49/0009 ,  H01J49/025

Abstract: The gain of the ion detector of a mass spectrometer is calibrated by using the ion detector to measure a ratio of the abundances of at least two ion species having a known abundance ratio. The gain of the ion detector is changed until the measured abundance ratio matches the known abundance ratio.

Abstract translation: 通过使用离子检测器来测量质谱仪的离子检测器的增益，以测量具有已知丰度比的至少两种离子种类的丰度的比率。 改变离子检测器的增益，直到测量的丰度比与已知的丰度比匹配。

公开(公告)号：US07495210B2

公开(公告)日：2009-02-24

申请号：US11429085

申请日：2006-05-04

Applicant: Gangqiang Li

Inventor： Gangqiang Li

IPC: B01D59/44

CPC classification number: G01N30/7266 ,  B01L3/0268 ,  B01L3/5027 ,  B01L2300/0887 ,  B01L2400/0415 ,  B05B5/03 ,  H01J49/165

Abstract: The invention provides a mass spectrometry system, including a microfluidic chip for electrospray ionization having an analyte channel and a gas assist channel that define a spray tip and a detector downstream from the microfluidic chip for detecting ions.The invention also provides a micro fluidic chip for electrospray ionization including a substrate having an analyte channel, a gas channel and an analyte channel wherein the gas channel and analyte channel exit at the first end to define the electrospray tip.Methods of using the system and apparatus are also disclosed.

Abstract translation: 本发明提供一种质谱系统，其包括用于具有分析物通道的电喷雾离子化的微流体芯片和限定喷雾尖端的气体辅助通道以及用于检测离子的微流体芯片下游的检测器。 本发明还提供了一种用于电喷雾离子化的微流体芯片，包括具有分析物通道，气体通道和分析物通道的基底，其中气体通道和分析物通道在第一端处离开以限定电喷雾尖端。 还公开了使用该系统和装置的方法。

公开(公告)号：US07449687B2

公开(公告)日：2008-11-11

申请号：US11151875

申请日：2005-06-13

Applicant: Gangqiang Li

Inventor： Gangqiang Li

IPC: H01J49/26

CPC classification number: H01J49/107 ,  H01J49/0045 ,  H01J49/04

Abstract: The invention provides an apparatus for combining ions and charged particles. In general, the apparatus contains: a) a multipole device having an ion exit end; b) a mass analyzer; and c) a source of charged particles. The apparatus is configured so that charged particles produced by the source of charged particles pass through the mass analyzer and into the multipole device via the ion exit end of the multipole device.

Abstract translation: 本发明提供了一种用于组合离子和带电粒子的装置。 通常，该装置包含：a）具有离子出口端的多极装置; b）质量分析仪; 和c）带电粒子源。 该装置被配置为使得由带电粒子源产生的带电粒子经由质量分析器通过多极装置的离子出口端进入多极装置。

公开(公告)号：US20080067353A1

公开(公告)日：2008-03-20

申请号：US11429085

申请日：2006-05-04

Applicant: Gangqiang Li

Inventor： Gangqiang Li

IPC: H01J49/10

CPC classification number: G01N30/7266 ,  B01L3/0268 ,  B01L3/5027 ,  B01L2300/0887 ,  B01L2400/0415 ,  B05B5/03 ,  H01J49/165

Abstract: The invention provides a mass spectrometry system, including a microfluidic chip for electrospray ionization having an analyte channel and a gas assist channel that define a spray tip and a detector downstream from the microfluidic chip for detecting ions.The invention also provides a micro fluidic chip for electrospray ionization including a substrate having an analyte channel, a gas channel and an analyte channel wherein the gas channel and analyte channel exit at the first end to define the electrospray tip.Methods of using the system and apparatus are also disclosed.

Abstract translation: 本发明提供一种质谱系统，其包括用于具有分析物通道的电喷雾离子化的微流体芯片和限定喷雾尖端的气体辅助通道以及用于检测离子的微流体芯片下游的检测器。 本发明还提供了一种用于电喷雾离子化的微流体芯片，包括具有分析物通道，气体通道和分析物通道的基底，其中气体通道和分析物通道在第一端处离开以限定电喷雾尖端。 还公开了使用该系统和装置的方法。

公开(公告)号：US20070057180A1

公开(公告)日：2007-03-15

申请号：US11224093

申请日：2005-09-13

Applicant: Stuart Hansen ,  Gangqiang Li ,  Gavin Reid

Inventor： Stuart Hansen ,  Gangqiang Li ,  Gavin Reid

IPC: H01J49/42

CPC classification number: H01J49/4225

Abstract: A method and apparatus for processing ions in mass spectrometry is provided. The apparatus includes an ion processing cell having segmented multipole rods and a means for admitting reactive reagent ions to the cell. Provision for timed sequence control of RF and DC voltages to the segmented multipole rods is included. Processing includes trapping analyte ions and subjecting them to selected reactions with reactive reagent ions and/or physical manipulation of the ions by changing the characteristics of the electric field and/or creating discrete regions in the field.

Abstract translation: 提供了一种在质谱法中处理离子的方法和装置。 该装置包括具有分段多极棒的离子处理单元和用于将反应性试剂离子引入该单元的装置。 包括对分段多极杆的RF和DC电压的定时序列控制。 处理包括捕获分析物离子并使其与反应性试剂离子进行选择的反应和/或通过改变电场的特性和/或在场中产生离散区域来离子的物理操作。

公开(公告)号：US20070057175A1

公开(公告)日：2007-03-15

申请号：US11224120

申请日：2005-09-13

Applicant: Alexander Mordehai ,  Gangqiang Li

Inventor： Alexander Mordehai ,  Gangqiang Li

IPC: B01D59/44

CPC classification number: H01J49/4225

Abstract: An apparatus and method for isolation of selected ions of interest in a 2-D ion trap is provided. The 2-D ion trap of the invention has an octopole field which is obtained by modification of the electrodes, modification of the positioning of the electrodes or both. The 2-D ion trap of the invention also includes a means for forcing ion motion in the ion trap in a first and a second direction independently and sequentially.

Abstract translation: 提供了一种用于在2-D离子阱中分离感兴趣的选定离子的装置和方法。 本发明的2-D离子阱具有通过改变电极获得的八极场，电极的定位的修改或两者。 本发明的2-D离子阱还包括用于在第一和第二方向独立且顺序地迫使离子阱中的离子运动强迫的装置。

公开(公告)号：US20070045531A1

公开(公告)日：2007-03-01

申请号：US11217248

申请日：2005-08-31

Applicant: Alex Mordehai ,  Gangqiang Li ,  Stuart Hansen

Inventor： Alex Mordehai ,  Gangqiang Li ,  Stuart Hansen

IPC: H01J49/06

CPC classification number: H01J49/04 ,  H01J43/06 ,  H01J49/10

Abstract: The invention provides a device for introducing ions into the primary ion path of a mass spectrometry system. In general, the device contains an electrical lens having a primary ion passageway and a secondary ion passageway that merges with the primary ion passageway. In certain embodiments, the electrical lens contains a first part and a second part that, together, form the primary ion passageway. The first part of the lens may contain the secondary ion passageway.

Abstract translation: 本发明提供了一种用于将离子引入质谱系统的一次离子路径的装置。 通常，该装置包含具有主离子通道和与主离子通道并入的次级离子通道的电透镜。 在某些实施例中，电透镜包含一起形成主离子通道的第一部分和第二部分。 透镜的第一部分可以包含二次离子通道。

公开(公告)号：US20070023636A1

公开(公告)日：2007-02-01

申请号：US11157907

申请日：2005-06-22

Applicant: Gangqiang Li

Inventor： Gangqiang Li

IPC: H01J49/40

CPC classification number: H01J49/025 ,  H01J49/061 ,  H01J49/40

Abstract: This invention provides an apparatus and method for efficient detection of ions in a time-of-flight mass spectrometer. The apparatus of the invention provides for orthogonal deflection of ions in the flight tube of a time of flight mass spectrometer to a detector or detectors positioned along or in the wall of the flight tube of the mass spectrometer. A method of detecting ions utilizing the apparatus is also provided.

Abstract translation: 本发明提供了一种用于在飞行时间质谱仪中有效检测离子的装置和方法。 本发明的装置提供了飞行时间质谱仪的飞行管中的离子与质谱仪的飞行管的沿着或位于其中的检测器或检测器的正交偏转。 还提供了利用该装置检测离子的方法。

公开(公告)号：US20060043282A1

公开(公告)日：2006-03-02

申请号：US10927874

申请日：2004-08-27

Applicant: August Hidalgo ,  Stuart Hansen ,  Gangqiang Li

Inventor： August Hidalgo ,  Stuart Hansen ,  Gangqiang Li

IPC: H01J49/00

CPC classification number: H01J49/401 ,  H01J49/422 ,  H01J49/424

Abstract: An apparatus for analyzing ions is described. The apparatus includes an ion source, an ion trap positioned to receive ions from the ion source; a time of flight mass analyzer, and a detector operatively coupled to the time of flight. The time of flight mass analyzer includes a pulser region, and the pulser region is positioned to receive ions from the ion trap. The apparatus further includes a scanning delay timing circuit in operable relation to the pulser region. The scanning delay timing circuit is adapted to triggering an extraction pulse at the pulser region. Methods of analyzing ions by mass spectrometry are also described.

Abstract translation: 描述了用于分析离子的装置。 该装置包括离子源，定位成从离子源接收离子的离子阱; 飞行时间质量分析器，以及可操作地耦合到飞行时间的检测器。 飞行时间质量分析器包括脉冲发生器区域，并且脉冲发生器区域被定位成从离子阱接收离子。 该装置还包括与脉冲发生器区域可操作的扫描延迟定时电路。 扫描延迟定时电路适于在脉冲发生器区域触发提取脉冲。 还描述了通过质谱分析离子的方法。