公开(公告)号：US06716184B2

公开(公告)日：2004-04-06

申请号：US10166795

申请日：2002-06-07

申请人： Shahram Vaezy ,  Roy W. Martin ,  Stephen J. Carter ,  George W. Keilman ,  Victor Y. Fujimoto ,  Lawrence A. Crum

发明人： Shahram Vaezy ,  Roy W. Martin ,  Stephen J. Carter ,  George W. Keilman ,  Victor Y. Fujimoto ,  Lawrence A. Crum

IPC分类号： A61N700

CPC分类号： A61B8/4488 ,  A61B8/06 ,  A61B8/0833 ,  A61B8/12 ,  A61B8/4209 ,  A61B8/4254 ,  A61B8/445 ,  A61B8/4483 ,  A61B8/481 ,  A61B8/483 ,  A61B2017/4216 ,  A61B2090/378 ,  A61N7/02

摘要： Method and apparatus for the simultaneous use of ultrasound on a probe for imaging and therapeutic purposes. The probe limits the effects of undesirable interference noise in a display by synchronizing high intensity focused ultrasound (HIFU) waves with an imaging transducer to cause the noise to be displayed in an area of the image that does not overlap the treatment site. In one embodiment, the HIFU is first energized at a low power level that does not cause tissue damage, so that the focal point of the HIFU can be identified by a change in the echogenicity of the tissue caused by the HIFU. Once the focal point is properly targeted on a desired treatment site, the power level is increased to a therapeutic level. The location of each treatment site is stored and displayed to the user to enable a plurality of spaced-apart treatment sites to be achieved. As the treatment progresses, any changes in the treatment site can be seen in the real time, noise-free image. A preferred application of the HIFU waves is to cause lesions in blood vessels, so that the supply of nutrients and oxygen to a region, such as a tumor, is interrupted. The tumor will thus eventually be destroyed. In a preferred embodiment, the HIFU is used to treat disorders of the female reproductive system, such as uterine fibroids. The HIFU treatment can be repeated at spaced-apart intervals, until any remaining fibroid tissue is destroyed.

摘要翻译： 用于在探针上同时使用超声波用于成像和治疗目的的方法和装置。 该探针通过将高强度聚焦超声波（HIFU）波与成像换能器同步来将显示中的不期望的干扰噪声的影响限制在使得噪声显示在不与治疗部位重叠的图像区域中。 在一个实施例中，HIFU首先在不会导致组织损伤的低功率水平下通电，使得可以通过由HIFU引起的组织的回波反射性的变化来识别HIFU的焦点。 一旦焦点适当地对准所需的治疗部位，功率水平就提高到治疗水平。 每个治疗部位的位置被存储并显示给使用者，以实现多个间隔开的治疗部位。 随着治疗的进行，治疗部位的任何变化都可以在实时，无噪音的图像中看到。 HIFU波的优选应用是引起血管中的损伤，使得诸如肿瘤等区域的营养物和氧气供应被中断。 因此肿瘤最终将被破坏。 在优选的实施方案中，HIFU用于治疗女性生殖系统的疾病，例如子宫肌瘤。 可以间隔间隔重复HIFU治疗，直到残留的纤维组织被破坏为止。

公开(公告)号：US06398734B1

公开(公告)日：2002-06-04

申请号：US09373445

申请日：1999-08-12

申请人： George E. Cimochowski ,  George W. Keilman

发明人： George E. Cimochowski ,  George W. Keilman

IPC分类号： A61B812

CPC分类号： A61B8/06 ,  A61B5/0031 ,  A61B5/6876 ,  A61B5/6884 ,  A61B8/04 ,  A61B8/12 ,  A61B8/4227 ,  A61B8/4472 ,  A61B8/56 ,  A61B2560/0219 ,  A61M1/3656

摘要： A parameter indicative of the condition of a cardiac valve is determined by monitoring blood flow and/or velocity in a vessel that is coupled to the cardiac valve or in a chamber adjacent to an artificial cardiac valve. One or more ultrasonic transducers are provided either in a wall or a cuff disposed about a cardiac vessel to monitor the parameter in regard to a natural or artificial cardiac valve, or in a support sewing ring of an artificial cardiac valve. A conformal array transducer or a tilted element is used to monitor fluid flow or velocity based on the effect of the blood on ultrasonic waves produced by the transducers. The conformal array transducer comprises a plurality of elements that are excited with an input signal provided by an implantable electronics circuit, producing ultrasonic waves. Transit time or Doppler measurements are made using an appropriate number of these transducers to determine either blood volumetric flow or velocity. Various implantable electronic circuits are disclosed that enable a transducer to be driven and to receive an ultrasonic signal indicative of the status of blood flow and thus, the condition of the cardiac valve. A radio frequency (RF) coil is coupled to an external coil. The external coil is connected to a power supply and monitoring console, conveying power to the ultrasonic transducers and receiving data signals that enable the condition of the cardiac valve to be determined.

摘要翻译： 通过监测联接到心脏瓣膜或邻近人造心脏瓣膜的腔室的血管中的血流和/或速度来确定指示心脏瓣膜状况的参数。 一个或多个超声波换能器设置在围绕心脏血管设置的壁或袖带中，以监测关于天然或人造心脏瓣膜的参数，或在人造心脏瓣膜的支撑缝合环中。 根据血液对由换能器产生的超声波的影响，使用保形阵列换能器或倾斜元件来监测流体流动或速度。 共形阵列换能器包括由可植入电子电路提供的输入信号激励的多个元件，产生超声波。 使用适当数量的这些传感器进行运输时间或多普勒测量，以确定血液体积流量或速度。 公开了各种可植入的电子电路，其能够驱动换能器并接收指示血流状态的超声波信号，并因此接收心脏瓣膜的状况。 射频（RF）线圈耦合到外部线圈。 外部线圈连接到电源和监视控制台，向超声波换能器输送功率，并接收能够确定心脏瓣膜状态的数据信号。

公开(公告)号：US06231516B1

公开(公告)日：2001-05-15

申请号：US09028154

申请日：1998-02-23

申请人： George W. Keilman ,  George E. Cimochowski

发明人： George W. Keilman ,  George E. Cimochowski

IPC分类号： A61B502

CPC分类号： A61B8/06 ,  A61B5/0031 ,  A61B5/14532 ,  A61B5/6862 ,  A61B5/6876 ,  A61B8/04 ,  A61B8/12 ,  A61B8/4483 ,  A61B8/56 ,  A61B2560/0219 ,  A61F2/07 ,  A61F2/82 ,  A61F2002/072 ,  A61F2002/075 ,  A61F2250/0001 ,  A61F2250/0002 ,  A61M1/3656 ,  A61M37/0092 ,  A61N1/306 ,  A61N1/325 ,  A61N5/0601 ,  A61N5/062

摘要： An apparatus includes an endoluminal implant, a RF coupling coil coupled to the endoluminal implant and a therapeutic transducer electrically coupled to the RF coupling coil and physically coupled to the endoluminal implant. The RF coupling coil supplies electrical power to the therapeutic transducer. The therapeutic transducer has a capability for delivering therapeutic energy to a lumen disposed within the endoluminal implant in response to signals coupled via the RF coupling coil.

摘要翻译： 一种装置包括腔内植入物，耦合到腔内植入物的RF耦合线圈和电耦合到RF耦合线圈并物理耦合到腔内植入物的治疗换能器。 RF耦合线圈向治疗换能器提供电力。 所述治疗换能器响应于经由所述RF耦合线圈耦合的信号，具有将治疗能量递送至设置在所述腔内植入物内的内腔的能力。

公开(公告)号：US4475376A

公开(公告)日：1984-10-09

申请号：US445795

申请日：1982-12-01

申请人： George W. Keilman

发明人： George W. Keilman

IPC分类号： G01H3/00 ,  G01N29/30 ,  G10K11/22 ,  G01N29/00 ,  H04R29/00

CPC分类号： G10K11/22 ,  G01H3/005 ,  G01N29/30

摘要： A probe for testing ultrasound transducers is described. The probe is made of a body of material which absorbs ultrasound. There is a conical opening in the body, and a spherical transducer is mounted in the wider opening at the base of the conical opening. When the probe is used as a surface probe, a transducer undergoing tests is placed at the opening at the apex of the cone. Typically the conical opening is filled with a fluid which simulates the absorption qualities of the material with which the tested transducer will ultimately be used. For example, the transducer undergoing the test will be used with human body tissue, so a fluid such as water or light mineral oil would typically fill the cone-shaped opening. The present invention can also be used as a hydrophone, because of the manner in which it generates, or senses, pressure waves at a point in space.

摘要翻译： 描述了用于测试超声换能器的探头。 探头由吸收超声的材料体制成。 体内有一个圆锥形开口，球形换能器安装在锥形开口底部的较宽开口处。 当探针用作表面探针时，经过测试的传感器放置在锥体顶点的开口处。 典型地，圆锥形开口填充有流体，该流体模拟最终将使用所测试的换能器的材料的吸收质量。 例如，经受测试的换能器将与人体组织一起使用，因此诸如水或轻质矿物油的流体通常将填充锥形开口。 本发明也可以用作水听器，因为它在空间中产生或感测压力波的方式。

公开(公告)号：US20100016763A1

公开(公告)日：2010-01-21

申请号：US12505378

申请日：2009-07-17

申请人： George W. Keilman

发明人： George W. Keilman

IPC分类号： A61N1/00 ,  A61B5/00

CPC分类号： A61B8/08 ,  A61B5/076 ,  A61B5/14535 ,  A61B8/06 ,  A61B8/12 ,  A61B8/485 ,  A61N1/08

摘要： Implementations of an intraluminal fluid property status sensing system and method locate an acoustic transducer within a lumen of a biological creature to transmit ultrasound through intraluminal fluid to be reflected or otherwise affected by the fluid with subsequent reception by the same transducer. Reflection or interaction of the ultrasound with an intraluminal fluid depends upon one or more properties of the intraluminal fluid so can be used to determine status of such properties.

摘要翻译： 管腔内液体状态感知系统和方法的实施方法是将生物体内腔内的声换能器定位成通过管腔内液体传输超声波，以便随后由同一换能器进行接收而被流体反射或受其影响。 超声与腔内液体的反射或相互作用取决于腔内液体的一种或多种性质，因此可用于确定这些性质的状态。

公开(公告)号：US06425867B1

公开(公告)日：2002-07-30

申请号：US09397471

申请日：1999-09-17

申请人： Shahram Vaezy ,  Roy W. Martin ,  Stephen J. Carter ,  George W. Keilman ,  Victor Y. Fujimoto ,  Lawrence A. Crum

发明人： Shahram Vaezy ,  Roy W. Martin ,  Stephen J. Carter ,  George W. Keilman ,  Victor Y. Fujimoto ,  Lawrence A. Crum

IPC分类号： A61B800

CPC分类号： A61B8/4488 ,  A61B8/06 ,  A61B8/0833 ,  A61B8/12 ,  A61B8/4209 ,  A61B8/4254 ,  A61B8/445 ,  A61B8/4483 ,  A61B8/481 ,  A61B8/483 ,  A61B2017/4216 ,  A61B2090/378 ,  A61N7/02

摘要： Method and apparatus for the simultaneous use of ultrasound on a probe for imaging and therapeutic purposes. The probe limits the effects of undesirable interference noise in a display by synchronizing high intensity focused ultrasound (HIFU) waves with an imaging transducer to cause the noise to be displayed in an area of the image that does not overlap the treatment site. In one embodiment, the HIFU is first energized at a low power level that does not cause tissue damage, so that the focal point of the HIFU can be identified by a change in the echogenicity of the tissue caused by the HIFU. Once the focal point is properly targeted on a desired treatment site, the power level is increased to a therapeutic level. The location of each treatment site is stored and displayed to the user to enable a plurality of spaced-apart treatment sites to be achieved. As the treatment progresses, any changes in the treatment site can be seen in the real time, noise-free image. A preferred application of the HIFU waves is to cause lesions in blood vessels, so that the supply of nutrients and oxygen to a region, such as a tumor, is interrupted. The tumor will thus eventually be destroyed. In a preferred embodiment, the HIFU is used to treat disorders of the female reproductive system, such as uterine fibroids. The HIFU treatment can be repeated at spaced-apart intervals, until any remaining fibroid tissue is destroyed.

摘要翻译： 用于在探针上同时使用超声波用于成像和治疗目的的方法和装置。 该探针通过将高强度聚焦超声波（HIFU）波与成像换能器同步来将显示中的不期望的干扰噪声的影响限制在使得噪声显示在不与治疗部位重叠的图像区域中。 在一个实施例中，HIFU首先在不会导致组织损伤的低功率水平下通电，使得可以通过由HIFU引起的组织的回波反射性的变化来识别HIFU的焦点。 一旦焦点适当地对准所需的治疗部位，功率水平就提高到治疗水平。 每个治疗部位的位置被存储并显示给使用者，以实现多个间隔开的治疗部位。 随着治疗的进行，治疗部位的任何变化都可以在实时，无噪音的图像中看到。 HIFU波的优选应用是引起血管中的损伤，使得诸如肿瘤等区域的营养物和氧气供应被中断。 因此肿瘤最终将被破坏。 在优选的实施方案中，HIFU用于治疗女性生殖系统的疾病，例如子宫肌瘤。 可以间隔间隔重复HIFU治疗，直到残留的纤维组织被破坏为止。

公开(公告)号：US5967989A

公开(公告)日：1999-10-19

申请号：US79818

申请日：1998-05-15

申请人： George E. Cimochowski ,  George W. Keilman

发明人： George E. Cimochowski ,  George W. Keilman

IPC分类号： A61B5/00 ,  A61B8/04 ,  A61B8/06 ,  A61F2/02 ,  A61M1/36 ,  A61B8/00

CPC分类号： A61B5/6876 ,  A61B5/0031 ,  A61B5/6862 ,  A61B8/06 ,  A61B8/56 ,  A61M1/3656 ,  A61B2560/0219 ,  A61B8/04 ,  A61B8/12 ,  A61F2250/0001 ,  Y10S128/903

摘要： A parameter indicative of the status of fluid flow is remotely monitored in a vessel, a natural graft, or a synthetic graft. One or more transducers are provided either in a wall of a synthetic graft or adjacent to a vessel or natural graft to monitor the parameter. A conformal array transducer or a tilted element is used to monitor fluid flow or velocity through the graft or vessel based on the effect of the fluid on ultrasonic waves produced by the transducers. The conformal array transducer comprises a plurality of elements that curve around the graft or vessel and are excited with an input signal provided by an implantable electronics circuit, producing ultrasonic waves that propagate into the fluid flowing within the graft or vessel. Transit time or Doppler measurements are made using an appropriate number of these transducer to determine either fluid flow or velocity. Various implantable electronic circuits are provided that enable a selected transducer to be driven and to receive an ultrasonic signal or a pressure signal indicative of the status of fluid flow monitored by the transducer. The implanted electronic circuit is connected to an implanted radio frequency (RF) coil. An external coil that is connected to a power supply and monitoring console is coupled to the implanted RF coil to convey power and receive data signals from the transducer that are indicative of the parameter being monitored.

摘要翻译： 在血管，天然移植物或合成移植物中远程监测指示流体流动状态的参数。 一个或多个换能器提供在合成移植物的壁中或邻近血管或天然移植物以监测参数。 基于流体对由换能器产生的超声波的影响，共形阵列换能器或倾斜元件用于监测通过移植物或血管的流体流动或速度。 保形阵列换能器包括在移植物或血管周围弯曲的多个元件，并且由可植入电子电路提供的输入信号激发，产生传播到在移植物或血管内流动的流体的超声波。 使用适当数量的这些传感器进行运输时间或多普勒测量，以确定流体流速或速度。 提供了各种可植入的电子电路，其使得能够驱动所选择的换能器并且接收指示由换能器监测的流体流动的状态的超声波信号或压力信号。 植入的电子电路连接到植入式射频（RF）线圈。 连接到电源和监视控制台的外部线圈耦合到植入的RF线圈以传送功率并从传感器接收指示被监视参数的数据信号。

公开(公告)号：US07722539B2

公开(公告)日：2010-05-25

申请号：US11207554

申请日：2005-08-18

申请人： Stephen J. Carter ,  Shahram Vaezy ,  Roy W. Martin ,  George W. Keilman ,  Lawrence A. Crum

发明人： Stephen J. Carter ,  Shahram Vaezy ,  Roy W. Martin ,  George W. Keilman ,  Lawrence A. Crum

IPC分类号： A61B8/00

CPC分类号： A61N7/02 ,  A61B8/08 ,  A61B8/4209 ,  A61B8/4254 ,  A61B8/4281 ,  A61B34/20 ,  A61B2034/2051 ,  A61B2090/378 ,  A61H23/0245

摘要： A noninvasive technique that can be used to deny blood flow to a particular region of tissue, without the inherent risks associated with invasive procedures such as surgery and minimally-invasive procedures such as embolization. Blood flow in selected portions of the vasculature can be occluded by selectively treating specific portions of the vasculature with high intensity focused ultrasound (HIFU). The occlusion denies undesired tissue the nutrients and oxygen provided by blood flow, causing necrosis in the undesired tissue. An imaging technology (such as magnetic resonance imaging, magnetic resonance angiography, ultrasound imaging, Doppler based ultrasound imaging, or computed tomographic angiography) is used to identify the undesired tissue, and the vascular structures associated with the undesired tissue. A portion of the vasculature providing blood flow to the undesired tissue is selected, and HIFU is administered to the selected portion of the vasculature to occlude blood flow through that portion of the vasculature.

摘要翻译： 一种非侵入性技术，可用于阻止血液流向组织的特定区域，而不会与诸如手术和诸如栓塞的微创手术等侵入性手术相关的固有风险。 通过用高强度聚焦超声（HIFU）选择性处理脉管系统的特定部分，可以阻断脉管系统选定部分的血流。 闭塞阻止不需要的组织由血液流动提供的营养物质和氧气，从而引起不想要的组织中的坏死。 使用成像技术（例如磁共振成像，磁共振血管造影术，超声成像，基于多普勒超声成像或计算机断层造影血管造影术）来鉴别不需要的组织以及与不想要的组织相关的血管结构。 选择向不想要的组织提供血液流动的脉管系统的一部分，并且将HIFU施用于脉管系统的选定部分以阻塞通过脉管系统的那部分的血流。

公开(公告)号：US07427265B1

公开(公告)日：2008-09-23

申请号：US09695748

申请日：2000-10-24

申请人： George W. Keilman ,  George E. Cimochowski

发明人： George W. Keilman ,  George E. Cimochowski

IPC分类号： A61B5/00 ,  A61B5/02 ,  A61B5/05

CPC分类号： A61B8/06 ,  A61B5/0031 ,  A61B5/14532 ,  A61B5/6862 ,  A61B5/6876 ,  A61B8/04 ,  A61B8/12 ,  A61B8/4483 ,  A61B8/56 ,  A61B2560/0219 ,  A61F2/07 ,  A61F2/82 ,  A61F2002/072 ,  A61F2002/075 ,  A61F2250/0001 ,  A61F2250/0002 ,  A61M1/3656 ,  A61M37/0092 ,  A61N1/306 ,  A61N1/325 ,  A61N5/0601 ,  A61N5/062

摘要： An apparatus includes an endoluminal implant, a RF coupling coil coupled to the endoluminal implant and a therapeutic transducer electrically coupled to the RF coupling coil and physically coupled to the endoluminal implant. The RF coupling coil supplies electrical power to the therapeutic transducer. The therapeutic transducer has a capability for delivering therapeutic energy to a lumen disposed within the endoluminal implant in response to signals coupled via the RF coupling coil.

摘要翻译： 一种装置包括腔内植入物，耦合到腔内植入物的RF耦合线圈和电耦合到RF耦合线圈并物理耦合到腔内植入物的治疗换能器。 RF耦合线圈向治疗换能器提供电力。 所述治疗换能器响应于经由所述RF耦合线圈耦合的信号，具有将治疗能量递送至设置在所述腔内植入物内的内腔的能力。

公开(公告)号：US4936303A

公开(公告)日：1990-06-26

申请号：US123218

申请日：1987-11-20

申请人： Sheldon P. Detwiler ,  George W. Keilman ,  Robert F. McConaghy

发明人： Sheldon P. Detwiler ,  George W. Keilman ,  Robert F. McConaghy

IPC分类号： A61N7/02

CPC分类号： A61N7/02

摘要： A method and apparatus for the treatment of tumors by heating with ultrasonic energy. A transducer assembly is provided in a housing having a refractive assembly disposed between the tumor and the transducer. The refractive assembly moves with respect to the transducer assembly. The refractive assembly includes one or more refractive elements. The refractive assembly is interchangeable to provide treatment of different types of tumors using the same transducer assembly and housing. The refractive assembly may focus, deflect or diffuse the ultrasonic energy depending on the arrangement of elements. Motion of the refractive assembly relative to the tumor results in a time-averaging spatial deposition pattern which is more highly uniform due to the averaging of maxima and minima which occurs in the near field.

摘要翻译： 一种用超声能量加热治疗肿瘤的方法和装置。 传感器组件设置在具有设置在肿瘤和换能器之间的折射组件的壳体中。 折射组件相对于换能器组件移动。 折射组件包括一个或多个折射元件。 折射组件是可互换的，以使用相同的换能器组件和壳体来提供治疗不同类型的肿瘤。 根据元件的布置，折射组件可以聚焦，偏转或扩散超声波能量。 折射组件相对于肿瘤的运动导致时间平均空间沉积图案，其由于在近场中发生的最大值和最小值的平均而更加均匀。