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    Heat-developable silver halide infrared ray-sensitive material
    42.
    发明授权
    Heat-developable silver halide infrared ray-sensitive material 失效
    可热显影卤化银红外线感光材料

    公开(公告)号：US5677121A

    公开(公告)日：1997-10-14

    申请号：US651499

    申请日：1996-05-22

    申请人： Hirohiko Tsuzuki

    发明人： Hirohiko Tsuzuki

    IPC分类号： G03C1/00 ,  G03C1/12 ,  G03C1/26 ,  G03C1/498 ,  G03C1/76 ,  G03C1/825 ,  G03C5/16

    CPC分类号： G03C1/49809 ,  G03C1/127 ,  G03C1/26 ,  G03C1/7614 ,  G03C5/164 ,  Y10S430/145

    摘要： A silver halide photographic material which is useful for photography and diagnostic imaging and exhibits excellent storability to ordinary aging, excellent image storability, high sensitivity and low D.sub.min is disclosed. The heat-developable silver halide infrared ray-sensitive material comprises a support having on one side of the support an emulsion layer containing a binder, a nonsensitive silver salt, a reducing agent for silver ion and silver halide grains spectrally sensitized at a wavelength within the region of from 750 to 1,400 nm, wherein the nonsensitive silver salt comprises a mixture of silver salts of at least three kinds of acids, one of the acids is behenic acid, and the content of the behenic acid in the acids is from not less than 35 to less than 90 mol %.

    摘要翻译： 公开了一种可用于摄影和诊断成像并且对普通老化显示出优异的储存性，优异的图像保存性，高灵敏度和低Dmin的卤化银照相材料。 可热显影的卤化银红外线感光材料包括在载体的一侧具有包含粘合剂的乳剂层，非敏感性银盐，用于银离子的还原剂和在其内的波长处光谱致敏的卤化银颗粒的载体 750nm至1400nm的区域，其中非敏感性银盐包含至少三种酸的银盐的混合物，一种酸是山萮酸，并且酸中的山萮酸含量不小于 35〜小于90摩尔％。

    Process for producing a carrier
    43.
    发明授权
    Process for producing a carrier 有权
    制造载体的方法

    公开(公告)号：US08137733B2

    公开(公告)日：2012-03-20

    申请号：US12276004

    申请日：2008-11-21

    申请人： Koichi Minami ,  Hirohiko Tsuzuki

    发明人： Koichi Minami ,  Hirohiko Tsuzuki

    IPC分类号： G01N1/31

    CPC分类号： C07K17/00 ,  G01N21/553

    摘要： A complex, which has been formed by at least two pieces of a ligand and a first metal ion, is bound with a carrier. A second metal ion is then added onto the carrier, a new complex being thereby formed. A substance that contains a Group-15 or Group-16 atom, which has metal coordinating capability, is then fixed to the first metal ion and the second metal ion.

    摘要翻译： 由至少两个配体和第一金属离子形成的络合物与载体结合。 然后将第二金属离子加入到载体上，从而形成新的络合物。 含有具有金属配位能力的第15族或第16族原子的物质然后固定在第一金属离子和第二金属离子上。

    Method for measuring dissociation constant by surface plasmon resonance analysis
    45.
    发明授权
    Method for measuring dissociation constant by surface plasmon resonance analysis 有权
    通过表面等离子体共振分析测量解离常数的方法

    公开(公告)号：US07602495B2

    公开(公告)日：2009-10-13

    申请号：US11660958

    申请日：2005-08-24

    申请人： Koji Kuruma ,  Hirohiko Tsuzuki

    发明人： Koji Kuruma ,  Hirohiko Tsuzuki

    IPC分类号： G01N21/55

    CPC分类号： G01N21/553 ,  G01N33/542 ,  G01N33/543

    摘要： An object to be solved by the present invention is to determine the dissociation constant of an analyte molecule immobilized on a metal surface and a molecule that interacts therewith in surface plasmon resonance (SPR) analysis via an analytical method that produces a low noise level (i.e., a noise width of a reference chip), small baseline fluctuations (i.e., signal changes of a reference chip), and highly reliable results of measurement. The present invention provides a method for determining a dissociation constant of an analyte molecule immobilized on a metal surface and a molecule that interacts therewith, wherein changes in surface plasmon resonance signals are measured by using a surface plasmon resonance measurement device comprising a flow channel system having a cell formed on a metal film and a light-detecting means for detecting the state of surface plasmon resonance by measuring the intensity of a light beam totally reflected on the metal film; wherein a change in surface plasmon resonance signals is measured in a state where the flow of the liquid has been stopped, after the liquid contained in the above flow channel system has been exchanged; and wherein the dissociation constant is determined based on the results of measurement of signal changes.

    摘要翻译： 本发明要解决的一个目的是通过产生低噪声水平的分析方法来确定固定在金属表面上的分析物分子和与其相互作用的分子在表面等离子体共振（SPR）分析中的解离常数（即 ，参考芯片的噪声宽度），小的基线波动（即，参考芯片的信号变化）以及高度可靠的测量结果。 本发明提供了一种确定固定在金属表面上的分析物分子和与其相互作用的分子的解离常数的方法，其中通过使用表面等离子体共振测量装置测量表面等离子体共振信号的变化，所述表面等离子体共振测量装置包括具有 形成在金属膜上的电池和光检测装置，用于通过测量在金属膜上全反射的光束的强度来检测表面等离子体共振的状态; 其中在已经更换了上述流道系统中所含的液体之后，在已经停止液体流动的状态下测量表面等离子体共振信号的变化; 并且其中基于信号变化的测量结果确定解离常数。

    BIOSENSOR CHIP
    46.
    发明申请
    BIOSENSOR CHIP 审中-公开
    生物传感器芯片

    公开(公告)号：US20090042745A1

    公开(公告)日：2009-02-12

    申请号：US12188508

    申请日：2008-08-08

    申请人： Koichi MINAMI ,  Yohsuke Takeuchi ,  Hirohiko Tsuzuki

    发明人： Koichi MINAMI ,  Yohsuke Takeuchi ,  Hirohiko Tsuzuki

    IPC分类号： C40B60/12

    CPC分类号： G01N33/54353 ,  G01N33/54393 ,  G01N33/553 ,  G01N2610/00

    摘要： A biosensor chip is constituted by: a substrate; a metal film which is physically attached to the substrate; and a self assembled monolayer constituted by alkyl chains, which is physically attached to the metal film. Ligands and at least one functional group, selected from a group consisting of a hydroxyl group, a carboxyl group, an alkoxy group, a methyl group, and hydrogen atoms are physically attached to the self assembled monolayer. The ratio between the total number of alkyl chains physically attached to the metal film and the number of alkyl chains which are covalently bonded with the ligands is within a range of 0.40 to 0.99.

    摘要翻译： 生物传感器芯片由以下部分构成：基板; 物理地附接到基底的金属膜; 以及由金属膜物理附着的烷基链构成的自组装单层。 配体和选自羟基，羧基，烷氧基，甲基和氢原子的至少一个官能团物理连接到自组装单层。 与金属膜物理连接的烷基链的总数与与配体共价键合的烷基链的数量之间的比例在0.40至0.99的范围内。

    Carrier for cell culture
    47.
    发明授权
    Carrier for cell culture 有权
    细胞培养载体

    公开(公告)号：US07267982B2

    公开(公告)日：2007-09-11

    申请号：US10612955

    申请日：2003-07-07

    申请人： Hirohiko Tsuzuki ,  Kazuhiro Aikawa ,  Makoto Kato ,  Akiko Matsuura

    发明人： Hirohiko Tsuzuki ,  Kazuhiro Aikawa ,  Makoto Kato ,  Akiko Matsuura

    IPC分类号： C12N5/00

    CPC分类号： C12N5/0068 ,  C12N2533/12 ,  C12N2533/54 ,  C12N2533/72 ,  C12N2533/74 ,  C12N2533/80

    摘要： A carrier for cell culture comprising a carrier having a cationic group and polypeptide-modified portions formed on a surface of the carrier in a sea-island structure, and a carrier for cell culture comprising a water-containing gel comprising alginic acid, wherein a surface of the carrier is coated with collagen, and wherein the collagen is bound to a surface of the water-containing gel by means of chitosan.

    摘要翻译： 一种用于细胞培养的载体，其包含具有阳离子基团的载体和形成在海岛结构中的载体表面上的多肽改性部分，以及包含含有海藻酸的含水凝胶的载体，其中表面 的载体涂覆有胶原，并且其中胶原蛋白通过壳聚糖结合到含水凝胶的表面。

    Carrier for cell culture
    50.
    发明授权
    Carrier for cell culture 有权

    公开(公告)号：US07041505B2

    公开(公告)日：2006-05-09

    申请号：US10384651

    申请日：2003-03-11

    申请人： Hirohiko Tsuzuki ,  Akiko Matsuura

    发明人： Hirohiko Tsuzuki ,  Akiko Matsuura

    IPC分类号： C12N5/00

    CPC分类号： C12N5/0688 ,  C12N5/0068 ,  C12N2533/54 ,  C12N2533/74

    摘要： A carrier for cell culture comprising an alginic acid gel layer laminated with a gel layer containing a cell adhesion substance, wherein the gel layer containing a cell adhesion substance has a dry thickness of less than 0.3 μm. The carrier for cell culture enables reproducible and convenient cell layer lamination without inhibiting growth and proliferation of cells upon solubilization of the carrier for preparation of a cell sheet.