公开(公告)号：US4657916A

公开(公告)日：1987-04-14

申请号：US772693

申请日：1985-09-05

申请人： Masayuki Teranishi ,  Koji Suzuki ,  Hiroshi Kase ,  Shigeto Kitamura ,  Katsuichi Shuto ,  Kenji Omori

发明人： Masayuki Teranishi ,  Koji Suzuki ,  Hiroshi Kase ,  Shigeto Kitamura ,  Katsuichi Shuto ,  Kenji Omori

IPC分类号： A61K31/47 ,  A61P43/00 ,  C07D215/60 ,  C07D405/12 ,  C07F7/18

CPC分类号： C07D405/12 ,  C07D215/60

摘要： A quinoline-N-oxide derivative represented by the formula: ##STR1## wherein X is hydroxy, lower alkoxy, lower alkylthio, unsubstituted or substituted aralkyloxy, or unsubstituted or substituted aralkylthio; Y is a hydrogen atom or halogen atom; R.sub.1 is alkylene or alkenylene having 3 to 15 carbon atom; Z is hydroxymethyl, lower alkoxymethyl, unsubstituted or substituted aryloxymethyl, tetrahydropyranyloxymethyl, tetrahydrofuranyloxymethyl, unsubstituted or substituted arylsulfonyloxymethyl, lower alkylthiomethyl, unsubstituted or substituted arylthiomethyl, lower alkylsulfinylmethyl, unsubstituted or substituted arylsulfinylmethyl, lower alkylsulfonylmethyl, unsubstituted or substituted arylsulfonylmethyl, aminomethyl, --CH.sub.2 NHR.sub.2 (wherein R.sub.2 is lower alkyl, unsubstituted or substituted aralkyl, or unsubstituted or substituted aryl), --CH.sub.2 NR.sub.3 R.sub.4 (wherein R.sub.3 and R.sub.4 are lower alkyl, unsubstituted or substituted aralkyl, or unsubstituted or substituted aryl), --CH.sub.2 N.sup.+ R.sub.5 R.sub.6 R.sub.7 (wherein R.sub.5, R.sub.6, and R.sub.7 are lower alkyl, unsubstituted or substituted aralkyl, or unsubstituted or substituted aryl, where the counterion is an anion of acid or a hydroxyl ion), --COR.sub.8 (wherein R.sub.8 is a hydrogen atom, lower alkyl or hydroxy), --CH(OR.sub.9).sub.2 (wherein R.sub.9 is lower alkyl), iminomethyl, hydroxyiminomethyl, or a halogen atom and its salts, can very strongly inhibit the lipoxygenase and considerably suppress production and release of its metabolites, and thus are useful as preventive and healing agents for the diseases caused by the lipoxygenase metabolites.

摘要翻译： 由下式表示的喹啉-N-氧化物衍生物：其中X为羟基，低级烷氧基，低级烷硫基，未取代或取代的芳烷氧基，或未取代或取代的芳烷硫基; Y是氢原子或卤素原子; R1是具有3至15个碳原子的亚烷基或亚烯基; Z是羟甲基，低级烷氧基甲基，未取代或取代的芳氧基甲基，四氢吡喃氧基甲基，四氢呋喃氧基甲基，未取代或取代的芳基磺酰氧基甲基，低级烷硫基甲基，未取代或取代的芳基硫代甲基，低级烷基亚磺酰基甲基，未取代或取代的芳基亚磺酰基甲基，低级烷基磺酰基甲基，未取代或取代的芳基磺酰基甲基，氨基甲基，-CH2NHR2（ 其中R 2是低级烷基，未取代或取代的芳烷基或未取代或取代的芳基），-CH 2 NR 3 R 4（其中R 3和R 4是低级烷基，未取代或取代的芳烷基，或未取代或取代的芳基），-CH 2 N + R 5 R 6 R 7（其中R 5，R 6 ，R 7为低级烷基，未取代或取代的芳烷基或未取代或取代的芳基，其中抗衡离子为酸或羟基离子的阴离子），-COR8（其中R8为氢原子，低级烷基或羟基），-CH （OR 9）2（其中R 9为低级烷基），亚氨基甲基，羟基亚氨基甲基或卤素 原子及其盐可以非常强烈地抑制脂氧合酶，并显着抑制其代谢物的产生和释放，因此可用作由脂氧合酶代谢物引起的疾病的预防和治疗剂。

公开(公告)号：US4521950A

公开(公告)日：1985-06-11

申请号：US403543

申请日：1982-07-30

申请人： Hiroshi Kase ,  Yoshiaki Matsumoto ,  Kouji Ohkawa

发明人： Hiroshi Kase ,  Yoshiaki Matsumoto ,  Kouji Ohkawa

IPC分类号： B23B39/20 ,  B23Q3/155 ,  B23Q3/157

CPC分类号： B23B39/205 ,  B23Q3/15506 ,  Y10T408/37 ,  Y10T483/1726 ,  Y10T483/1809 ,  Y10T82/2511

摘要： An automatic tool change machine tool having a vertical column on which a tool stock receiving therein a vertically movable tool bar is mounted. The tool bar is provided with a toolholder receiving means at the lowermost end for the attachment of a toolholder having a cutting tool. The machine tool further has a toolholder magazine storing a plurality of toolholders. The magazine is turned around the vertical column so that one of the toolholders is indexed to a predetermined position where toolholders are attached to and detached from the tool bar in one reciprocal vertical movement of the tool bar.

摘要翻译： 一种自动换刀机床，具有垂直柱，其上安装有可垂直移动的工具杆的工具坯料。 工具杆在最下端设置有用于附接具有切割工具的刀夹的刀架接收装置。 机床还具有存储多个刀架的刀夹。 刀库围绕垂直柱转动，使得其中一个刀架被索引到预定位置，在该预定位置，工具杆在工具栏的一个往复垂直运动中附接到刀具杆并从刀具上拆下。

公开(公告)号：US20120131649A1

公开(公告)日：2012-05-24

申请号：US13388127

申请日：2010-10-26

申请人： Hiroshi Kase

发明人： Hiroshi Kase

IPC分类号： G06F21/00

CPC分类号： H04N5/765 ,  H04N21/6334

摘要： In a method of registering an access permission from a first device to a second device to the second device over a network, when receiving via the network a connection request from the first device of which access permission is not registered, the second device rejects connection from the first device, and shifts to the first mode. In the first mode, the second device detects user's operation on the second device, and judges whether the detected user's operation is an operation regarding viewing of a reproduction signal from the second device. If the user's operation is not the operation regarding viewing, the second device shifts to the second mode for registering an access permission. If the user's operation is the operation regarding viewing, the second device does not shift to the second mode.

摘要翻译： 在通过网络将从第一设备到第二设备的访问许可登记到第二设备的方法中，当经由网络接收到来自未登记访问许可的第一设备的连接请求时，第二设备拒绝 第一个设备，并转移到第一个模式。 在第一模式中，第二设备检测用户在第二设备上的操作，并且判断检测到的用户的操作是否是关于从第二设备观看再现信号的操作。 如果用户的操作不是关于观看的操作，则第二设备转移到用于注册访问许可的第二模式。 如果用户的操作是关于观看的操作，则第二设备不转移到第二模式。

公开(公告)号：US08054996B2

公开(公告)日：2011-11-08

申请号：US12364693

申请日：2009-02-03

申请人： Sako Asayama ,  Hiroshi Kase ,  Mitsuteru Kataoka

发明人： Sako Asayama ,  Hiroshi Kase ,  Mitsuteru Kataoka

IPC分类号： H02B1/00 ,  H04R29/00

CPC分类号： H04R3/12 ,  H04N5/60 ,  H04N5/63 ,  H04N21/436 ,  H04N21/4396 ,  H04N21/44227 ,  H04N21/44231 ,  H04R27/00 ,  H04R2499/15

摘要： An external speaker control apparatus causes only one of an internal speaker and an external speaker to output audio when a power supply of the external speaker control apparatus which controls the external speaker changes from an off state to an on state, the external speaker being a speaker outside a video and audio output apparatus. The external speaker control apparatus includes a microcomputer for detecting the change of the power supply of an amplifier from an off state to an on state and a HDMI/CEC communication unit or outputting an instruction requesting output of information which indicates the audio output mode to the video and audio output apparatus while at the same time receiving the information indicating the audio detects the change of the power supply from an off state to an on state, wherein the microcomputer controls the output of the audio from the external speaker according to the information indicating the audio output mode.

公开(公告)号：US07727993B2

公开(公告)日：2010-06-01

申请号：US11326414

申请日：2006-01-06

申请人： Hiroshi Kase ,  Akihisa Mori ,  Yutaka Waki ,  Yutaka Ohsawa ,  Akira Karasawa ,  Yoshihisa Kuwana

发明人： Hiroshi Kase ,  Akihisa Mori ,  Yutaka Waki ,  Yutaka Ohsawa ,  Akira Karasawa ,  Yoshihisa Kuwana

IPC分类号： A61K31/522 ,  A61K31/505

CPC分类号： A61K31/522 ,  A61K9/0019 ,  A61K9/20 ,  A61K9/48 ,  A61K31/198 ,  A61K45/06

摘要： The present invention is directed to methods of treating movement disorders by administering an effective amount of one or more adenosine A2A receptor antagonists to a patient in need thereof. The present invention also provides methods of decreasing the adverse effects of L-DOPA in patients receiving L-DOPA therapy in the treatment of Parkinson's disease. The present invention further provides methods and compositions for treating Parkinson's disease patients with sub-clinically effective doses of L-DOPA by combining L-DOPA treatment with an effective amount of one or more adenosine A2A receptor antagonists (i.e., L-DOPA sparing effect). The present invention further provides methods of effective treatment of Parkinson's disease by co-administering at least one adenosine A2A receptor antagonist, L-DOPA and a dopamine agonist and/or a COMT inhibitor and/or a MAO inhibitor. The present invention further provides methods of prolonging effective treatment of Parkinson's disease by administering an adenosine A2A receptor antagonist singly or together with a dopamine agonist, and/or a COMT inhibitor, and/or a MAO inhibitor without prior or subsequent administration of L-DOPA, delaying or removing on-set of L-DOPA motor complication.

摘要翻译： 本发明涉及通过向有需要的患者施用有效量的一种或多种腺苷A 2A受体拮抗剂来治疗运动障碍的方法。 本发明还提供降低L-DOPA在接受L-DOPA治疗的帕金森病治疗中的不良反应的方法。 本发明进一步提供了通过将L-DOPA治疗与有效量的一种或多种腺苷A 2A受体拮抗剂组合（即L-DOPA备用效应）来治疗具有亚临床有效剂量的L-DOPA的帕金森病患者的方法和组合物， 。 本发明还提供了通过共同施用至少一种腺苷A 2A受体拮抗剂，L-DOPA和多巴胺激动剂和/或COMT抑制剂和/或MAO抑制剂来有效治疗帕金森病的方法。 本发明还提供了延长帕金森病有效治疗的方法，通过单独或与多巴胺激动剂和/或COMT抑制剂和/或MAO抑制剂一起施用腺苷A2A受体拮抗剂，而无需先前或随后给予L-DOPA ，延迟或消除L-DOPA电机并发症。

公开(公告)号：US07668842B2

公开(公告)日：2010-02-23

申请号：US11168060

申请日：2005-06-28

申请人： Kevin Leigh LaChapelle ,  Brian James Walker ,  Ian Cameron Mercer ,  Hiroshi Kase ,  Harutoshi Miyamoto ,  Tomotaka Yagi ,  Yasuyuki Torii ,  Nobuyasu Takeguchi

发明人： Kevin Leigh LaChapelle ,  Brian James Walker ,  Ian Cameron Mercer ,  Hiroshi Kase ,  Harutoshi Miyamoto ,  Tomotaka Yagi ,  Yasuyuki Torii ,  Nobuyasu Takeguchi

IPC分类号： G06F17/00 ,  G06F7/00

CPC分类号： G06F17/30056 ,  G06F17/30772 ,  G11B19/025 ,  G11B27/034 ,  G11B27/105 ,  G11B27/329 ,  G11B27/34 ,  G11B2220/218 ,  G11B2220/2545 ,  G11B2220/2562 ,  G11B2220/61 ,  G11B2220/90 ,  Y10S707/913 ,  Y10S707/916 ,  Y10S707/954

摘要： Enabling efficient navigation of a playlist of media files stored on a computer-readable medium. Aspects of the invention define a playlist structure to have one or more playlist units. Each playlist unit identifies one or more media files in the playlist and includes metadata for the media files. A consumer electronic device retrieves the playlist units and displays the metadata contained therein to a user to enable navigation of the playlist. Aspects of the invention reduce the memory requirements of the consumer electronic devices and reduce the quantity of disk seek operations needed for playlist navigation.

摘要翻译： 启用存储在计算机可读介质上的媒体文件的播放列表的有效导航。 本发明的方面定义了具有一个或多个播放列表单元的播放列表结构。 每个播放列表单元识别播放列表中的一个或多个媒体文件，并且包括媒体文件的元数据。 消费者电子设备检索播放列表单元并将包含在其中的元数据显示给用户以启用播放列表的导航。 本发明的各方面减少了消费电子设备的存储器需求，并减少了播放列表导航所需的磁盘寻道操作的数量。

公开(公告)号：US20060148827A1

公开(公告)日：2006-07-06

申请号：US11326516

申请日：2006-01-06

申请人： Hiroshi Kase ,  Akihisa Mori ,  Yutaka Waki ,  Yutaka Ohsawa ,  Akira Karasawa ,  Yoshihisa Kuwana

发明人： Hiroshi Kase ,  Akihisa Mori ,  Yutaka Waki ,  Yutaka Ohsawa ,  Akira Karasawa ,  Yoshihisa Kuwana

IPC分类号： A61K31/522 ,  A61K31/198 ,  A61K31/137

CPC分类号： A61K31/522 ,  A61K9/0019 ,  A61K9/20 ,  A61K9/48 ,  A61K31/198 ,  A61K45/06

摘要： The present invention is directed to methods of treating movement disorders by administering an effective amount of one or more adenosine A2A receptor antagonists to a patient in need thereof. The present invention also provides methods of decreasing the adverse effects of L-DOPA in patients receiving L-DOPA therapy in the treatment of Parkinson's disease. The present invention further provides methods and compositions for treating Parkinson's disease patients with sub-clinically effective doses of L-DOPA by combining L-DOPA treatment with an effective amount of one or more adenosine A2A receptor antagonists (i.e., L-DOPA sparing effect). The present invention further provides methods of effective treatment of Parkinson's disease by co-administering at least one adenosine A2A receptor antagonist, L-DOPA and a dopamine agonist and/or a COMT inhibitor and/or a MAO inhibitor. The present invention further provides methods of prolonging effective treatment of Parkinson's disease by administering an adenosine A2A receptor antagonist singly or together with a dopamine agonist, and/or a COMT inhibitor, and/or a MAO inhibitor without prior or subsequent administration of L-DOPA, delaying or removing on-set of L-DOPA motor complication.

摘要翻译： 本发明涉及通过向有需要的患者施用有效量的一种或多种腺苷A 2A 2受体拮抗剂来治疗运动障碍的方法。 本发明还提供降低L-DOPA在接受L-DOPA治疗的帕金森病治疗中的不良反应的方法。 本发明进一步提供了通过将L-DOPA治疗与有效量的一种或多种腺苷A 2A受体拮抗剂组合（用于治疗患有亚临床有效剂量的L-DOPA）的帕金森病患者的方法和组合物 即L-DOPA保护作用）。 本发明还提供了通过共同施用至少一种腺苷A 2A受体拮抗剂，L-DOPA和多巴胺激动剂和/或COMT抑制剂和/或MAO来有效治疗帕金森病的方法 抑制剂。 本发明还提供了通过单独或与多巴胺激动剂和/或COMT抑制剂和/或MAO抑制剂一起施用腺苷A 2A受体拮抗剂而延长帕金森病有效治疗的方法，而没有 之前或之后的L-DOPA给药，延迟或去除L-DOPA运动并发症。

公开(公告)号：US20050219980A1

公开(公告)日：2005-10-06

申请号：US11083266

申请日：2005-03-17

申请人： Hiroshi Kase ,  Yoshiho Gotoh ,  Harutoshi Miyamoto

发明人： Hiroshi Kase ,  Yoshiho Gotoh ,  Harutoshi Miyamoto

IPC分类号： G11B20/12 ,  G11B20/18 ,  G11B27/36 ,  G11B5/09

CPC分类号： G11B20/18 ,  G11B20/12 ,  G11B27/36

摘要： To record video data or audio data on an optical disc on which a defective area exists, there is a method of determining an allowable number of defects in proportion to a recording size and skipping the defective area to use an adjacent area thereto. This method has a problem that the size of the recording area becomes larger by an equivalent of the skipped defective area so as to take a longer time for recording a file, and so convenience for a user is damaged. The size of the defective area allowed in a recording area is limited regardless of the size of the recording area.

摘要翻译： 为了在存在缺陷区域的光盘上记录视频数据或音频数据，存在与记录尺寸成比例地确定允许的缺陷数量并跳过缺陷区域以使用相邻区域的方法。 这种方法存在的问题是记录区域的尺寸变得相当于跳过的缺陷区域，从而需要更长的时间来记录文件，因此用户的便利被损坏。 记录区域允许的缺陷区域的大小受限于记录区域的大小。

公开(公告)号：US06449668B1

公开(公告)日：2002-09-10

申请号：US09380745

申请日：1999-09-13

申请人： Shinji Hamai ,  Hiroshi Kase ,  Yoshihiro Morioka ,  Hiroshi Mitani

发明人： Shinji Hamai ,  Hiroshi Kase ,  Yoshihiro Morioka ,  Hiroshi Mitani

IPC分类号： G06F1314

CPC分类号： H04N21/21 ,  G11B20/10 ,  G11B20/10527 ,  G11B27/034 ,  H04N5/781 ,  H04N21/23 ,  H04N21/2381 ,  H04N21/4363 ,  H04N21/4381

摘要： A controller issues a command to an HDD interface to transfer AV data stored in HDDs to a memory. The HDD interface, in compliance with the command, transfers the AV data stored in the HDDs to a memory mapped on a bus. A memory controller reads the AV data out of the bus, and writes the AV data into the memory. The controller outputs the address of the AV data to be outputted to the memory controller. The memory controller reads out the AV data of the designated address, and outputs them to an AV data output interface. And the AV data output interface outputs the AV data. The controller issues a command to the HDD interface memory to record the AV data stored in the memory into the HDDs. The HDD interface, in compliance with the command, reads the data out of a memory mapped on the bus, and stores them in the HDDs. The memory controller reads the AV data out of the memory, and outputs them to the bus. At the same time, the controller designates to the memory controller the address in the memory into which the AV data inputted from the AV data input interface are to be written. The memory controller reads the AV data out of the AV data input interface, and writes them into the designated memory. By accomplishing this series of actions in synchronism with the frame period, AV data are stored in the HDDs, and also AV data stored in the HDDs are outputted.

摘要翻译： 控制器向HDD接口发出命令以将存储在HDD中的AV数据传送到存储器。 HDD接口根据该命令将存储在HDD中的AV数据传送到映射在总线上的存储器。 存储器控制器从总线读出AV数据，并将AV数据写入存储器。 控制器将要输出的AV数据的地址输出到存储器控制器。 存储器控制器读出指定地址的AV数据，并将其输出到AV数据输出接口。 并且AV数据输出接口输出AV数据。 控制器向HDD接口存储器发出命令，将存储在存储器中的AV数据记录到HDD中。 根据该命令，HDD接口从映射在总线上的存储器读出数据，并将其存储在HDD中。 存储器控制器将AV数据从存储器中读出，并将其输出到总线。 同时，控制器向存储器控制器指定要从AV数据输入接口输入的AV数据被写入的存储器中的地址。 存储器控制器从AV数据输入接口读出AV数据，并将它们写入指定的存储器。 通过与帧周期同步地完成这一系列动作，AV数据被存储在HDD中，并且还输出存储在HDD中的AV数据。

公开(公告)号：US06292878B1

公开(公告)日：2001-09-18

申请号：US09017675

申请日：1998-02-03

申请人： Yoshihiro Morioka ,  Naohisa Motomura ,  Hiroshi Kase ,  Shinji Hamai

发明人： Yoshihiro Morioka ,  Naohisa Motomura ,  Hiroshi Kase ,  Shinji Hamai

IPC分类号： G06F1200

CPC分类号： G06F3/0613 ,  G06F3/064 ,  G06F3/0656 ,  G06F3/0689

摘要： The present invention relates to a data recorder which chronologically records continuous data such as image data without interruption at high speed, a medium which stores the procedure of recording or reproducing in the data recorder as a program, and a method of accessing the data recorder. In one embodiment, the data recorder is equipped with a group of recording units, and each group unit has a SCSI adaptor and a hard disk. The hard disk is connected to the SCSI bus and the SCSI adaptor is connected to a PCI bus. With this construction, data to be recorded in the data recorder is split into units of a prescribed size and assigned and recorded on the group of recording units so as to utilize a plurality of hard disks as a single logical recording space.

摘要翻译： 本发明涉及一种数据记录器，其按时间顺序记录高速无中断的连续数据如图像数据，将数据记录器中记录或再现的过程作为程序存储的介质以及访问数据记录器的方法。 在一个实施例中，数据记录器配备有一组记录单元，并且每个组单元具有SCSI适配器和硬盘。 硬盘连接到SCSI总线，SCSI适配器连接到PCI总线。 利用这种结构，要记录在数据记录器中的数据被分割为规定尺寸的单位，并被分配并记录在记录单元组上，以便利用多个硬盘作为单个逻辑记录空间。