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公开(公告)号：US20080030680A1
公开(公告)日：2008-02-07
申请号：US11770124
申请日：2007-06-28
申请人： Hisashi Tsukada , Tsutomu Kikawa , Yasufumi Fukuma
发明人： Hisashi Tsukada , Tsutomu Kikawa , Yasufumi Fukuma
IPC分类号： A61B3/12
CPC分类号： A61B3/102
摘要： A fundus observation device comprises: an image forming part comprising a first image forming part and a second image forming part, the first image forming part forming a 2-dimensional surface image of fundus oculi of an eye through optical processing, the second image forming part optically scanning a surface region of the fundus oculi corresponding to at least a part of the 2-dimensional surface image to form a tomographic image of the fundus oculi; a controller configured to control the image forming part; and a storage configured to store control information including control instructions to be sent from the controller to the image forming part, when one of the 2-dimensional surface image and the tomographic image is formed. The controller, at the time of formation of new one of the 2-dimensional surface image and the tomographic image of the fundus oculi, instructs the image forming part to form the new one of the 2-dimensional surface image and the tomographic image based on the control information stored in the storage.
摘要翻译： 眼底观察装置包括：图像形成部，包括第一图像形成部和第二图像形成部，所述第一图像形成部通过光学处理形成眼睛的眼底的2维表面图像，第二图像形成部 光学扫描对应于所述二维表面图像的至少一部分的眼底的表面区域，以形成眼底的断层图像; 控制器，被配置为控制图像形成部; 以及存储器，被配置为当形成所述二维表面图像和断层图像中的一个时，存储包括要从所述控制器发送到所述图像形成部分的控制指令的控制信息。 控制器在形成新的二维表面图像和眼底的断层图像时指示图像形成部分形成二维表面图像和断层图像中的新的基于 存储在存储器中的控制信息。
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公开(公告)号：US07248371B2
公开(公告)日：2007-07-24
申请号：US11091653
申请日：2005-03-29
IPC分类号： G01B9/02
CPC分类号： G01N21/49 , A61B3/102 , A61B5/0066 , A61B5/0073 , G01B9/02003 , G01B9/02012 , G01B9/02091 , G01B2290/45 , G01N2021/1782
摘要： Provided is an optical image measuring apparatus capable of easily changing a scanning interval of an object to be measured in a depth direction with high precision. The apparatus includes an interference optical system for superimposing signal light propagating through the object to be measured on reference light subjected to frequency shift to produce interference light, a reference mirror driving unit for driving a mirror to scan the object to be measured in the depth direction, shutters for sampling interference light beams, CCDs for storing charges for only a predetermined storage time and outputting electrical signals, a control unit for changing the storage time of the CCDs, a signal processing portion for calculating intensities and phases of interference light beams corresponding to each depth of the object to be measured which are successively detected by the CCDs during scanning based on the electrical signals successively outputted from the CCDs every changed storage time, and a setting operation unit for setting the storage time of the CCDs by an operator.
摘要翻译： 提供一种能够高精度地容易地在深度方向上变更被测定物的扫描间隔的光学图像测定装置。 该装置包括：干涉光学系统，用于将经过频移的参考光上传播的信号光叠加以产生干涉光;参考镜驱动单元，用于驱动反射镜以沿深度方向扫描被测量物体 用于采集干涉光的百叶窗，仅用于存储预定的存储时间的电荷的CCD和输出电信号;用于改变CCD的存储时间的控制单元，用于计算对应于...的干涉光束的强度和相位的信号处理部分 基于从每个改变的存储时间从CCD连续输出的电信号在扫描期间由CCD连续检测的待测量对象的每个深度，以及设置操作单元，用于设置操作者的CCD的存储时间。
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43.发明授权Optical image measuring apparatus for obtaining a signal intensity and spatial phase distribution of interference light 有权用于获得干涉光的信号强度和空间相位分布的光学图像测量装置公开(公告)号：US07245383B2
公开(公告)日：2007-07-17
申请号：US11062592
申请日：2005-02-23
IPC分类号： G01B9/02
CPC分类号： G01J9/02 , G01B9/02003 , G01B9/02012 , G01B9/02091 , G01B11/2441 , G01B2290/45
摘要： To provide an optical image measuring apparatus capable of calculating an intensity of a direct current component composed of background light based on a result obtained by detection of interference light and obtaining a signal intensity of the interference light using the calculated intensity. The apparatus includes: an optical interference system to divide a light beam into signal light and reference light, and the signal light propagating through an object to be measured and the reference light are superimposed to produce interference light; beam splitters for dividing it into three interference light beams; shutters to perform sampling; photo detectors for detecting the sampled interference light beams and converting them into electrical signals; and a signal processing portion for calculating the signal intensity of the interference light and the spatial phase distribution thereof based on the electrical signals.
摘要翻译： 提供一种光学图像测量装置，其能够基于通过检测干涉光获得的结果来计算由背景光组成的直流分量的强度，并使用所计算的强度来获得干涉光的信号强度。 该装置包括：将光束分成信号光和参考光的光学干涉系统，并且通过被测量物体传播的信号光和参考光被叠加以产生干涉光; 光束分离器，用于将其分为三个干涉光束; 百叶窗进行抽样; 用于检测采样的干涉光束并将其转换成电信号的光电检测器; 以及信号处理部分，用于基于电信号计算干涉光的信号强度及其空间相位分布。
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公开(公告)号：US20070159597A1
公开(公告)日：2007-07-12
申请号：US11621779
申请日：2007-01-10
申请人： Yasufumi Fukuma , Hisashi Tsukada , Tsutomu Kikawa
发明人： Yasufumi Fukuma , Hisashi Tsukada , Tsutomu Kikawa
IPC分类号： A61B3/14
CPC分类号： G01B9/02091 , A61B3/102 , G01B9/0203 , G01B9/02044 , G01B9/02083 , G01B2290/65
摘要： The invention provides an optical image-measuring device that avoids long examination time and reduces some troublesome tasks. A fundus observation device 1 (optical image-measuring device) splits light that is output from a low-coherence light source 160 into a signal light LS directed toward the fundus oculi Ef and a reference light LR directed toward a reference mirror 174, and detects interference light LC that is generated by superimposing the signal light LS passing through the fundus oculi Ef and the reference light LR passing through the reference mirror 174 using a spectrometer 180 to form tomographic images of the fundus oculi Ef. Furthermore, the device comprises a reference mirror drive mechanism 243 shifting the reference mirror 174 toward the optical path direction of the reference light LR and a information storage part 225 storing the reference mirror 174 position information based on previous tomographic images. The controlling part 210 controls the reference mirror drive mechanism 243 so that the reference mirror 174 shifts into a position based on reference mirror position information related to the eye to be examined E that is stored in the information storage part 225.
摘要翻译： 本发明提供了一种光学图像测量装置，其避免了长时间的检查并减少了一些麻烦的任务。 眼底观察装置1（光学图像测量装置）将从低相干光源160输出的光分解成朝向眼底Ef的信号光LS和朝向参照镜174的参考光LR，并且检测 通过使用光谱仪180叠加通过眼底Ef的信号光LS和通过参考镜174的参考光LR产生的干涉光LC，以形成眼底Ef的断层图像。 此外，该装置包括：参考反射镜驱动机构243，使参考镜174朝向参考光LR的光程方向移动;以及信息存储部225，存储基于先前断层图像的参考镜174位置信息。 控制部件210控制参考反射镜驱动机构243，使得参考镜174基于存储在信息存储部分225中的与被检眼E相关的参考镜位置信息而移动到位置。
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公开(公告)号：US20070159596A1
公开(公告)日：2007-07-12
申请号：US11621726
申请日：2007-01-10
申请人： Yasufumi FUKUMA , Hisashi Tsukada , Tsutomu Kikawa
发明人： Yasufumi FUKUMA , Hisashi Tsukada , Tsutomu Kikawa
IPC分类号： A61B3/14
CPC分类号： A61B3/102 , G01N21/359 , G01N21/4795 , G01N2021/1787
摘要： Highly reliable technology is provided with the capable of forming three-dimensional images of fundus oculi. The image forming part 220 of a computational control unit 200 forms images of the surface of fundus oculi Ef based on results of detecting fundus oculi catoptric light of light illuminated by a fundus camera unit 1A, in addition to forming tomographic images of the fundus oculi Ef based on results of detecting interference light LC from the OCT unit 150. The controlling part 210 synchronizes the timing of detecting fundus oculi catoptric light of light illuminated by the fundus camera unit 1A with the timing of detecting interference light LC from the OCT unit 150. The correction processing part 240 corrects the image positions of the tomographic images based on results of detecting interference light LC from the OCT unit 150 on the basis of two-dimensional images based on the results of detecting fundus oculi catoptric light of light illuminated from the fundus camera unit 1A. The image processing part 230 forms three-dimensional images of fundus oculi Ef based on tomographic images for which the image positions have been corrected.
摘要翻译： 提供了高度可靠的技术，能够形成眼底三维图像。 计算控制单元200的图像形成部220除了形成眼底的断层图像之外，还基于由眼底照相机单元1A照射的光的基底眼反射光的检测结果来形成眼底的表面的图像 Ef基于检测来自OCT单元150的干涉光LC的结果。 控制部210使从眼底照相机单元1A照射的光的眼底反射光的检测时间与检测来自OCT单元150的干涉光LC的定时同步。 校正处理部240基于从眼底照射的光的眼底反射光的检测结果，基于二维图像，基于从OCT单元150检测干涉光LC的结果来校正断层图像的图像位置 相机单元1A。图像处理部分230基于已经校正了图像位置的断层图像来形成眼底Ef的三维图像。
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46.发明申请Fundus observation device, fundus image display device and fundus observation program 有权眼底观察装置，眼底图像显示装置和眼底观察程序公开(公告)号：US20070070295A1
公开(公告)日：2007-03-29
申请号：US11521360
申请日：2006-09-15
IPC分类号： A61B3/14
CPC分类号： A61B3/102
摘要： To provide a technology that makes it easy to capture a positional relation of a 2-dimensional image of the surface of a fundus oculi and a tomographic image of the fundus oculi. The fundus observation device 1 is provided with a fundus camera unit 1A for forming a 2-dimensional image of the surface of a fundus oculi Ef of an eye to be examined, an OCT unit 150 for forming a tomographic image of the fundus oculi Ef, a scanning unit 141 as well as an image processing part 220, a display 207, and a controlling part 210 of a computer 200 for displaying the 2-dimensional image formed by the fundus camera unit 1A and a tomographic image formed by the OCT unit, etc. in parallel on the display 207, and also for displaying the cross-sectional position information (attention line L, attention region P) indicating the cross-sectional position of the tomographic image on the surface of the fundus oculi Ef, so as to be overlapped with the 2-dimensional image.
摘要翻译： 提供一种能够容易地捕获眼底表面的二维图像与眼底断层图像的位置关系的技术。 眼底观察装置1设置有用于形成被检眼眼底Ef的表面的二维图像的眼底照相机部1A，形成眼底Ef的断层图像的OCT单元150 ，扫描单元141以及用于显示由眼底照相机单元1A形成的二维图像的计算机200的图像处理部分220，显示器207和控制部分210以及由OCT形成的断层图像 单元等在显示器207上并行显示，并且还用于显示指示眼底Ef的表面上的断层图像的横截面位置的横截面位置信息（注意力线L，注意区域P），因此 以与2维图像重叠。
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公开(公告)号：US20170173105A1
公开(公告)日：2017-06-22
申请号：US15124638
申请日：2015-03-10
申请人： Manav Mehta , Hisashi Tsukada , 3-D MATRIX, LTD.
CPC分类号： A61K38/07 , A61K2121/00 , A61L26/0047 , A61L26/008 , A61L2400/06
摘要： Materials and methods for treatment of pulmonary leakage are provided. A peptide comprising between about 7 amino acids and about 32 amino acids in a solution may be introduced to a target site. A hydrogel barrier may be provided at the target site in order to treat the pulmonary leakage.
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公开(公告)号：US20170072008A1
公开(公告)日：2017-03-16
申请号：US15124636
申请日：2015-03-10
申请人： Manav Mehta , Hisashi Tsukada , 3-D MATRIX, LTD.
CPC分类号： A61K38/16 , A61B17/34 , A61K38/08 , A61K38/10 , A61M16/0463
摘要： Materials and methods for treatment of pulmonary bulla are provided. A peptide comprising between about 7 amino acids and about 32 amino acids in a solution may be introduced to a target site. A hydrogel barrier may be provided at the target site in order to treat the pulmonary bulla.
摘要翻译： 提供了治疗肺泡的材料和方法。 在溶液中含有约7个氨基酸和约32个氨基酸之间的肽可被引入到靶位点。 可以在目标部位提供水凝胶屏障以便治疗肺大疱。
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公开(公告)号：US20080239240A1
公开(公告)日：2008-10-02
申请号：US12055693
申请日：2008-03-26
IPC分类号： A61B3/12
CPC分类号： G01B9/02044 , A61B3/102 , G01B9/0203 , G01B9/02077 , G01B9/02091 , G01B2290/65 , G01N21/4795
摘要： An optical image measurement device has: an interference-light generator configured to generate an interference light by splitting a low-coherence light into a signal light and a reference light and superimposing the signal light having passed through an eye and the reference light having passed through a reference object; a detector configured to detect the generated interference light; and a scanner configured to scan a projection position of the signal light on the eye, and the optical image measurement device is configured to form an image of the eye based on a result of detection by the detector. The optical image measurement device comprises a projector configured to project fixation information for fixing the eye onto a fundus oculi of the eye when the scanner scans with the signal light.
摘要翻译： 光学图像测量装置具有：干涉光发生器，被配置为通过将低相干光分解为信号光和参考光来产生干涉光，并叠加已经穿过眼睛的信号光和已经穿过的参考光 参考对象; 检测器，被配置为检测所产生的干涉光; 以及扫描器，被配置为扫描眼睛上的信号光的投影位置，并且光学图像测量装置被配置为基于检测器的检测结果来形成眼睛的图像。 光学图像测量装置包括：投影仪，配置成当扫描仪用信号光扫描时，将固定信息投影到眼睛的眼底上。
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公开(公告)号：US20100157311A1
公开(公告)日：2010-06-24
申请号：US12733174
申请日：2008-08-01
IPC分类号： G01B11/02
CPC分类号： G01N21/4795 , A61B3/102 , A61B3/1025
摘要： Such an optical image measurement device is provided that is capable of acquiring a clear image even when the intensity of an interference light is low. A fundus oculi observation device 1 is configured to superimpose a signal light LS propagated through a fundus oculi Ef and a reference light LR propagated through a reference mirror 174 to generate an interference light LC, detect the interference light LC, and form an image of the fundus oculi Ef. The device 1 determines whether the intensity of a detection signal of the interference light LC is equal to or more than a predetermined threshold and, when determines that the intensity is less than the predetermined threshold, controls to increase the intensity of the detection signal of the interference light LC. The device 1 forms an image of the fundus oculi Ef based on the detection signal with the increased intensity.
摘要翻译： 提供这样的光学图像测量装置，即使当干涉光的强度低时也能够获得清晰的图像。 眼底观察装置1被配置为叠加通过眼底Ef传播的信号光LS和通过参考反射镜174传播的参考光LR，以产生干涉光LC，检测干涉光LC，并形成图像 眼底眼 设备1确定干涉光LC的检测信号的强度是否等于或大于预定阈值，并且当确定强度小于预定阈值时，控制增加检测信号的强度 干涉光LC。 装置1基于具有增加的强度的检测信号形成眼底Ef的图像。
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