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41.发明授权Methods and compositions for increasing replication capacity of an influenza virus 失效增加流感病毒复制能力的方法和组合物公开(公告)号：US08097459B2
公开(公告)日：2012-01-17
申请号：US12552018
申请日：2009-09-01
IPC: C12N1/36 , A61K39/145
CPC classification number: C12N7/00 , A61K39/12 , A61K39/145 , C07K14/005 , C12N2760/16121 , C12N2760/16122 , C12N2760/16134
Abstract: In certain aspects, the present invention provides methods for increasing the replication capacity of influenza viruses in hens' eggs and/or cell culture, recombinant and/or reassortant influenza viruses with increased replication capacity, and immunogenic and vaccine compositions comprising such recombinant and/or reassortant influenza viruses. In other aspects, the invention further provides nucleic acids encoding influenza genes associated with increased replication capacity, expression vectors comprising the nucleic acids of the invention, methods for making influenza viruses with increased replication capacity, and kits useful for practice of the methods.
Abstract translation: 在某些方面，本发明提供了增加在具有增加的复制能力的母鸡卵和/或细胞培养物，重组和/或重配流感病毒中的流感病毒的复制能力的方法，以及包含这种重组和/或 重配流感病毒。 在其它方面，本发明还提供编码与增加的复制能力相关的流感基因的核酸，包含本发明的核酸的表达载体，具有增加的复制能力的制备流感病毒的方法，以及可用于实施该方法的试剂盒。
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42.发明申请公开(公告)号：US20100322969A1
公开(公告)日：2010-12-23
申请号：US12599761
申请日：2008-06-18
Applicant: Hong Jin , Zhongying Chen
Inventor： Hong Jin , Zhongying Chen
IPC: A61K39/145 , C12N7/01 , A61P31/16
CPC classification number: G01N33/56983 , A61K39/12 , A61K39/145 , A61K2039/5254 , C07K14/005 , C12N7/00 , C12N2760/16122 , C12N2760/16222 , C12N2760/16234 , C12N2760/16243 , C12N2760/16261
Abstract: The present invention encompasses methods of producing influenza B viruses in cell culture. The influenza B viruses may have desirable characteristics, such as enhanced replication in eggs and may be used, for example, in vaccines and in methods of treatment to protect against influenza B virus infection.
Abstract translation: 本发明包括在细胞培养物中产生乙型流感病毒的方法。 乙型流感病毒可能具有期望的特征，例如在卵中增强的复制，并且可以用于例如疫苗和治疗方法以防止乙型流感病毒感染。
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公开(公告)号：US20090298073A1
公开(公告)日：2009-12-03
申请号：US12308918
申请日：2007-06-28
Applicant: David L. Gerhold , Daniel J. Holder , Hong Jin , David J. Figueroa , Wendy J. Bailey , Josef S. Ozer , Ming Su
Inventor： David L. Gerhold , Daniel J. Holder , Hong Jin , David J. Figueroa , Wendy J. Bailey , Josef S. Ozer , Ming Su
IPC: C12Q1/68 , C07H21/04 , C07K14/435 , C12Q1/02 , G01N33/00
CPC classification number: C12Q1/6883 , C12Q2600/142 , C12Q2600/158
Abstract: Novel biomarkers for kidney toxicity. Said biomarkers may be useful for optimization of lead compounds, or in safety assessment.
Abstract translation: 肾毒性的新型生物标志物。 所述生物标志物可用于优化铅化合物或安全性评估。
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公开(公告)号：US20090297554A1
公开(公告)日：2009-12-03
申请号：US12090435
申请日：2006-10-17
IPC: A61K39/145 , C12Q1/70 , C12N7/00
CPC classification number: C12N7/00 , A61K35/76 , A61K38/00 , A61K39/12 , A61K39/145 , A61K39/295 , A61K2039/5254 , C07K14/005 , C12N15/86 , C12N2760/16122 , C12N2760/16134 , C12N2760/16143 , C12N2760/16151 , C12N2760/16222 , C12N2760/16234 , C12N2760/16243 , C12N2760/16251
Abstract: Vectors and methods for the production of influenza viruses suitable as recombinant influenza vaccines in cell culture are provided. Bi-directional expression vectors for use in a multi-plasmid influenza virus expression system are provided. Additionally, the invention provides methods of producing influenza viruses with enhanced ability to replicate in embryonated chicken eggs and/or cells (e.g., Vero and/or MDCK) and further provides influenza viruses with enhanced replication characteristics.
Abstract translation: 提供了用于在细胞培养中生产适合作为重组流感疫苗的流感病毒的载体和方法。 提供了用于多质粒流感病毒表达系统的双向表达载体。 另外，本发明提供了生产能够在含胚鸡蛋和/或细胞（例如Vero和/或MDCK）中复制的流感病毒的方法，并进一步提供具有增强的复制特征的流感病毒。
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公开(公告)号：US20090175907A1
公开(公告)日：2009-07-09
申请号：US12254131
申请日：2008-10-20
Applicant: Erich Hoffman , Hong Jin , Bin Lu , Gregory Duke , George Kemble , Zhongying Chen
Inventor： Erich Hoffman , Hong Jin , Bin Lu , Gregory Duke , George Kemble , Zhongying Chen
IPC: A61K39/145 , C12N7/01 , C12N15/74 , A61P31/16
CPC classification number: C12N15/86 , A61K2039/5254 , C07K14/005 , C12N7/00 , C12N15/85 , C12N2760/16122 , C12N2760/16134 , C12N2760/16143 , C12N2760/16162 , C12N2760/16222 , C12N2760/16234 , C12N2760/16243 , C12N2760/16262 , C12N2840/20
Abstract: Vectors and methods for the production of influenza viruses suitable as recombinant influenza vaccines in cell culture are provided. Bi-directional expression vectors for use in a multi-plasmid influenza virus expression system are provided. Additionally, the invention provides methods of producing influenza viruses with enhanced ability to replicate in embryonated chicken eggs and/or cells (e.g., Vero and/or MDCK) and further provides influenza viruses with enhanced replication characteristics. A method of producing a cold adapted (ca) influenza virus that replicates efficiently at, e.g., 25° C. (and immunogenic compositions comprising the same) is also provided.
Abstract translation: 提供了用于在细胞培养中生产适合作为重组流感疫苗的流感病毒的载体和方法。 提供了用于多质粒流感病毒表达系统的双向表达载体。 另外，本发明提供了生产能够在含胚鸡蛋和/或细胞（例如Vero和/或MDCK）中复制的流感病毒的方法，并进一步提供具有增强的复制特征的流感病毒。 还提供了生产在例如25℃下有效复制的冷适应（ca）流感病毒的方法（和包含其的免疫原性组合物）。
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Patent Agency Ranking
公开(公告)号：US07465574B2
公开(公告)日：2008-12-16
申请号：US11078900
申请日：2005-03-11
Applicant: Hong Jin , Roderick Tang , Shengqiang Li , Martin Bryant
Inventor： Hong Jin , Roderick Tang , Shengqiang Li , Martin Bryant
CPC classification number: C07K14/005 , A61K39/00 , A61K2039/51 , A61K2039/5254 , A61K2039/5256 , C12N7/00 , C12N15/86 , C12N2760/16022 , C12N2760/16122 , C12N2760/18522 , C12N2760/18543 , C12N2760/18561 , C12N2840/20
Abstract: The present invention relates to genetically engineered recombinant RS viruses and viral vectors which contain heterologous genes which for the use as vaccines. In accordance with the present invention, the recombinant RS viral vectors and viruses are engineered to contain heterologous genes, including genes of other viruses, pathogens, cellular genes, tumor antigens, or to encode combinations of genes from different strains of RSV.
Abstract translation: 本发明涉及遗传工程重组RS病毒和含有用作疫苗的异源基因的病毒载体。 根据本发明，重组RS病毒载体和病毒被工程化以包含异源基因，包括其他病毒，病原体，细胞基因，肿瘤抗原的基因，或编码来自不同RSV病毒株的基因的组合。
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公开(公告)号：US07465456B2
公开(公告)日：2008-12-16
申请号：US11133345
申请日：2005-05-20
Applicant: Erich Hoffmann , Hong Jin , Bin Lu , Gregory Duke , George Kemble , Zhongying Chen
Inventor： Erich Hoffmann , Hong Jin , Bin Lu , Gregory Duke , George Kemble , Zhongying Chen
IPC: A61K39/145 , C12Q1/70 , C12P19/34
CPC classification number: C12N15/86 , A61K2039/5254 , C07K14/005 , C12N7/00 , C12N15/85 , C12N2760/16122 , C12N2760/16134 , C12N2760/16143 , C12N2760/16162 , C12N2760/16222 , C12N2760/16234 , C12N2760/16243 , C12N2760/16262 , C12N2840/20
Abstract: Vectors and methods for the production of influenza viruses suitable as recombinant influenza vaccines in cell culture are provided. Bi-directional expression vectors for use in a multi-plasmid influenza virus expression system are provided. Additionally, the invention provides methods of producing influenza viruses with enhanced ability to replicate in embryonated chicken eggs and/or cells (e.g., Vero and/or MDCK) and further provides influenza viruses with enhanced replication characteristics. A method of producing a cold adapted (ca) influenza virus that replicates efficiently at, e.g., 25° C. (and immunogenic compositions comprising the same) is also provided.
Abstract translation: 提供了用于在细胞培养中生产适合作为重组流感疫苗的流感病毒的载体和方法。 提供了用于多质粒流感病毒表达系统的双向表达载体。 另外，本发明提供了生产能够在含胚鸡蛋和/或细胞（例如Vero和/或MDCK）中复制的流感病毒的方法，并进一步提供具有增强的复制特征的流感病毒。 还提供了生产在例如25℃下有效复制的冷适应（ca）流感病毒的方法（和包含其的免疫原性组合物）。
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公开(公告)号：US20080279892A1
公开(公告)日：2008-11-13
申请号：US11690957
申请日：2007-03-26
Applicant: Hong Jin , Roderick Tang , Shengqiang Li , Martin Bryant
Inventor： Hong Jin , Roderick Tang , Shengqiang Li , Martin Bryant
CPC classification number: C12N7/00 , A61K39/00 , A61K39/12 , A61K39/155 , A61K2039/51 , A61K2039/5254 , A61K2039/5256 , A61K2039/543 , C07K14/005 , C12N15/86 , C12N2760/16022 , C12N2760/18522 , C12N2760/18534 , C12N2760/18543 , C12N2760/18561 , C12N2840/20
Abstract: The present invention relates to genetically engineered recombinant respiratory syncytial viruses and viral vectors which contain deletions of various viral accessory gene(s) either singly or in combination. In accordance with the present invention, the recombinant respiratory syncytial viral vectors and viruses are engineered to contain complete deletions of the M2-2, NS1, NS2, or SH viral accessory genes or various combinations thereof. In addition, the present invention relates to the attenuation of respiratory syncytial virus by mutagenisis of the M2-1 gene.
Abstract translation: 本发明涉及遗传工程重组呼吸道合胞病毒和病毒载体，其含有单独或组合的各种病毒辅助基因的缺失。 根据本发明，重组呼吸道合胞病毒载体和病毒被工程化以含有M2-2，NS1，NS2或SH病毒附属基因或其各种组合的完全缺失。 此外，本发明涉及通过M2-1基因的诱变来减轻呼吸道合胞病毒。
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49.发明申请System and method for limiting access to features in a mobile telecommunications device 审中-公开用于限制对移动电信设备中的特征的访问的系统和方法公开(公告)号：US20080254767A1
公开(公告)日：2008-10-16
申请号：US11786094
申请日：2007-04-10
Applicant: Hong Jin
Inventor： Hong Jin
IPC: H04M1/66
CPC classification number: H04M1/667 , H04M1/6775 , H04M1/72544 , H04M1/72563 , H04M1/72583 , H04M2250/52
Abstract: A mobile telecommunications device with a processor, memory in electronic communication with the processor, and instructions stored in the memory, the instructions being executable to implement a method for childproof operation wherein the user's access is limited to a subset of applications and services while the device is in childproof mode. A preferred embodiment includes providing a default set of applications and services to enable while in childproof mode and allowing the user to individually specify the applications and services to enable while in childproof mode.
Abstract translation: 具有处理器，与处理器电子通信的存储器和存储在存储器中的指令的移动电信设备，所述指令可执行以实现用于儿童安全操作的方法，其中用户的访问被限制为应用和服务的子集，而设备 处于儿童防护模式。 优选实施例包括提供默认的应用程序和服务集合，以在儿童安全模式下实现，并允许用户单独指定在儿童安全模式下启用的应用和服务。
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公开(公告)号：US20050158340A1
公开(公告)日：2005-07-21
申请号：US11079002
申请日：2005-03-11
Applicant: Hong Jin , Roderick Tang , Shengqiang Li , Martin Bryant , David Clarke , Peter Palese
Inventor： Hong Jin , Roderick Tang , Shengqiang Li , Martin Bryant , David Clarke , Peter Palese
IPC: A61K39/00 , C07K14/11 , C07K14/135 , C12N7/04 , C12N15/86 , C12Q1/70 , C07H21/02 , C12N7/00 , C12Q1/68
CPC classification number: C07K14/005 , A61K39/00 , A61K2039/51 , A61K2039/5254 , A61K2039/5256 , C12N7/00 , C12N15/86 , C12N2760/16022 , C12N2760/18522 , C12N2760/18543 , C12N2760/18561 , C12N2840/20
Abstract: The present invention relates to genetically engineered recombinant RS viruses and viral vectors which contain heterologous genes which for the use as vaccines. In accordance with the present invention, the recombinant RS viral vectors and viruses are engineered to contain heterologous genes, including genes of other viruses, pathogens, cellular genes, tumor antigens, or to encode combinations of genes from different strains of RSV.
Abstract translation: 本发明涉及遗传工程重组RS病毒和含有用作疫苗的异源基因的病毒载体。 根据本发明，重组RS病毒载体和病毒被工程化以包含异源基因，包括其他病毒，病原体，细胞基因，肿瘤抗原的基因，或编码来自不同RSV病毒株的基因的组合。
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