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41.发明申请Drug-eluting stent having collagen drug carrier chemically treated with genipin 失效药物洗脱支架用胶原药物载体用京尼平化学处理公开(公告)号：US20050123582A1
公开(公告)日：2005-06-09
申请号：US10811413
申请日：2004-03-26
申请人： Hsing-Wen Sung , Mei-Chin Chen , Peter Tu , Hosheng Tu
发明人： Hsing-Wen Sung , Mei-Chin Chen , Peter Tu , Hosheng Tu
IPC分类号： A61F2/00 , A61F2/06 , A61K36/16 , A61L15/28 , A61L15/32 , A61L24/10 , A61L26/00 , A61L27/20 , A61L27/22 , A61L27/24 , A61L27/34 , A61L27/36 , A61L27/50 , A61L27/54 , A61L29/08 , A61L29/16 , A61L31/10 , A61L31/16 , A61K38/22 , A61K35/78 , A61K38/18 , A61M31/00
CPC分类号： A61L31/16 , A61B2017/22081 , A61F2250/0067 , A61F2310/00365 , A61F2310/00383 , A61L31/042 , A61L31/044 , A61L31/045 , A61L31/047 , A61L31/10 , A61L2300/00 , C08L5/08 , C08L89/00
摘要： A method for treating vulnerable plaques of a patient, comprising: providing a biodegradable stent comprising a first supporting zone made of a first biodegradable material, wherein the supporting zone comprises at least a portion of continuous circumference of the stent; and a second therapeutic zone made of a second biodegradable material, wherein the therapeutic zone comprises at least one bioactive agent; delivering the biodegradable stent to the vulnerable plaques; orienting the therapeutic zone at about the luminal surface of the vulnerable plaque; and releasing the at least one bioactive agent for treating the vulnerable plaques.
摘要翻译： 一种治疗患者脆弱斑块的方法，包括：提供一种生物降解性支架，其包括由第一可生物降解材料制成的第一支撑区域，其中支撑区域包括至少一部分支架的连续圆周; 和由第二可生物降解材料制成的第二治疗区，其中所述治疗区包含至少一种生物活性剂; 将可生物降解的支架递送到易损斑块; 将治疗区域定向在易损斑块的腔表面附近; 以及释放所述至少一种生物活性剂以治疗所述脆弱斑块。
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公开(公告)号：US06624138B1
公开(公告)日：2003-09-23
申请号：US10211656
申请日：2002-08-02
申请人： Hsing-Wen Sung , Hosheng Tu
发明人： Hsing-Wen Sung , Hosheng Tu
IPC分类号： A61K3100
CPC分类号： A61L27/3687 , A61L27/34 , A61L27/3616 , A61L27/507 , A61L29/085 , A61L29/10 , A61L29/16 , A61L31/10 , A61L31/16 , A61L2300/00 , A61L2430/40 , C08L5/08 , C08L89/00
摘要： A method for treating tissue of a patient comprising, in combination, mixing a drug with a solidifiable biological material, chemically treating the drug with the biological material with a crosslinking agent, loading the solidifiable drug-containing biological material onto a medical device, solidifying the drug-containing biological material; and delivering the medical device to a target tissue for treating the tissue.
摘要翻译： 一种治疗患者组织的方法，包括将药物与可凝固的生物材料混合，用生物材料用交联剂化学处理药物，将可凝固药物的生物材料装载到医疗装置上，固化 含药生物材料; 以及将所述医疗装置输送到目标组织以处理所述组织。
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公开(公告)号：US08318198B1
公开(公告)日：2012-11-27
申请号：US13527886
申请日：2012-06-20
申请人： Hsing-Wen Sung , Zi-Xian Liao , Min-Fan Chung , Ko-Jie Chen , Hosheng Tu
发明人： Hsing-Wen Sung , Zi-Xian Liao , Min-Fan Chung , Ko-Jie Chen , Hosheng Tu
IPC分类号： A61L15/00
CPC分类号： A61K9/0004 , A61K9/1272 , A61K9/1278 , A61K9/5146 , A61K9/5153 , A61K9/5161 , A61K31/337 , A61K31/4745 , A61K31/704
摘要： The invention discloses a pharmaceutical composition of liposome nanoparticles for lodging in a target tissue cell in situ of an animal subject, the nanoparticles comprising at least one thermal triggered phase-transition compound as a targeting drug delivery system for physical cancer therapy.
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公开(公告)号：US08187570B1
公开(公告)日：2012-05-29
申请号：US13356583
申请日：2012-01-23
申请人： Hsing-Wen Sung , Zi-Xian Liao , Shu-Fen Peng , Hosheng Tu
发明人： Hsing-Wen Sung , Zi-Xian Liao , Shu-Fen Peng , Hosheng Tu
IPC分类号： A61K51/00
CPC分类号： A61K31/13 , A61K9/0043 , A61K9/5146 , A61K9/5161 , A61K31/445 , A61K31/55
摘要： The invention discloses particulate complexes composed of chitosan, poly-glutamic acid, and at least one bioactive agent, wherein equal moles of the positively charged chitosan and the negatively charged poly-glutamic acid substrate form an electrostatic network enabling improved loading the bioactive agent.
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公开(公告)号：US07998458B2
公开(公告)日：2011-08-16
申请号：US12931935
申请日：2011-02-15
申请人： Hsing-Wen Sung , Hosheng Tu
发明人： Hsing-Wen Sung , Hosheng Tu
CPC分类号： A61K31/13 , A61K9/0043 , A61K9/19 , A61K9/4891 , A61K9/5146 , A61K9/5153 , A61K9/5161 , A61K9/5192 , A61K31/445 , A61K31/55 , A61K38/37 , A61K38/4846 , A61K47/26
摘要： The invention discloses the nanoparticles composed of chitosan, poly-glutamic acid, and at least one anti-hemophilic factor or bioactive agent characterized with a positive surface charge and their enhanced permeability in oral drug delivery.
摘要翻译： 本发明公开了由壳聚糖，聚谷氨酸和至少一种抗血液生成活性剂组成的纳米颗粒，其特征在于阳性表面电荷和它们在口服药物递送中的增强的渗透性。
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公开(公告)号：US07985426B1
公开(公告)日：2011-07-26
申请号：US11975279
申请日：2007-10-18
申请人： Hsing-Wen Sung , Mei-Chin Chen , Hosheng Tu
发明人： Hsing-Wen Sung , Mei-Chin Chen , Hosheng Tu
IPC分类号： A61K9/14
CPC分类号： A61K51/1255 , A61K9/5153 , A61K31/7008 , A61K31/704 , A61K33/24 , A61K45/06 , A61K47/549 , A61K47/6921 , A61K47/6935 , A61K49/0041 , A61K49/0093 , A61K51/0491 , A61K2300/00
摘要： The invention discloses a system, method and pharmaceutical composition of nanoparticles for lodging in a target tissue cell in situ of an animal subject, the nanoparticles comprising PGA-PLA block copolymers that are conjugated with a ligand, wherein the ligand has ligand-receptor binding affinity for the ligand to bind a surface receptor of the tissue cell.
摘要翻译： 本发明公开了纳米颗粒的系统，方法和药物组合物，用于在动物受试者的原位靶向组织细胞中沉积，所述纳米颗粒包含与配体缀合的PGA-PLA嵌段共聚物，其中配体具有配体 - 受体结合亲和力 用于配体结合组织细胞的表面受体。
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公开(公告)号：US20110159083A1
公开(公告)日：2011-06-30
申请号：US12931202
申请日：2011-01-26
申请人： Hsing-Wen Sung , Hosheng Tu
发明人： Hsing-Wen Sung , Hosheng Tu
IPC分类号： A61K9/48 , A61K9/14 , A61K47/36 , A61K9/20 , A61K9/28 , A61K47/42 , A61P25/28 , A61P29/00 , A61P25/08 , A61P31/18 , A61P39/06 , A61P25/00 , A61P3/10 , B82Y5/00
CPC分类号： A61K9/5146 , A61K9/0043 , A61K9/5161 , A61K31/13 , A61K31/445 , A61K31/55
摘要： The invention discloses nanoparticles composed of chitosan, poly-glutamic acid, and at least one bioactive agent characterized with a positive surface charge. The bioactive agent is hydrophobic or lipophilic in nature and is associated with micelles before being encapsulated in nanoparticles.
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公开(公告)号：US20110142926A1
公开(公告)日：2011-06-16
申请号：US12931251
申请日：2011-01-27
申请人： Hsing-Wen Sung , Hosheng Tu
发明人： Hsing-Wen Sung , Hosheng Tu
CPC分类号： A61K9/4891 , A61K9/19 , A61K9/5146 , A61K9/5161 , A61K31/13 , A61K31/445 , A61K31/55 , A61K47/61
摘要： The invention discloses the nanoparticles composed of chitosan, poly-glutamic acid, and at least one antibiotics or equivalent bioactive agent characterized with a positive surface charge and their enhanced permeability in oral drug delivery.
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公开(公告)号：US07901666B1
公开(公告)日：2011-03-08
申请号：US12455339
申请日：2009-06-01
申请人： Hsing-Wen Sung , Hosheng Tu
发明人： Hsing-Wen Sung , Hosheng Tu
CPC分类号： A61K9/4891 , A61K9/19 , A61K9/5146 , A61K9/5161 , A61K31/13 , A61K31/445 , A61K31/55 , A61K33/06 , A61K47/61 , A61K2300/00
摘要： The invention discloses a pharmaceutical composition for treating a subject comprising two or more bioactive nanoparticles, thus treating the subject by co-administering the bioactive nanoparticles to the subject, wherein a first and a second bioactive nanoparticles comprise a shell portion that is dominated by positively charged chitosan, a core portion that contains negatively charged substrate, and at least a first bioactive agent in the first nanoparticle and a second bioactive agent in the second nanoparticle.
摘要翻译： 本发明公开了一种用于治疗包含两种或更多种生物活性纳米颗粒的受试者的药物组合物，从而通过将生物活性纳米颗粒共同施用于受试者来治疗受试者，其中第一和第二生物活性纳米颗粒包含以正电荷为主的壳部分 壳聚糖，含有带负电荷的底物的核心部分，以及第一纳米颗粒中的至少第一生物活性剂和第二纳米颗粒中的第二生物活性剂。
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公开(公告)号：US07879819B1
公开(公告)日：2011-02-01
申请号：US12455388
申请日：2009-06-01
申请人： Hsing-Wen Sung , Hosheng Tu
发明人： Hsing-Wen Sung , Hosheng Tu
CPC分类号： A61K9/4891 , A61K9/19 , A61K9/5146 , A61K9/5161 , A61K31/13 , A61K31/445 , A61K31/55 , A61K47/61
摘要： The invention discloses the nanoparticles composed of chitosan, poly-glutamic acid, and at least one antibiotics or equivalent bioactive agent characterized with a positive surface charge and their enhanced permeability in oral drug delivery.
摘要翻译： 本发明公开了由壳聚糖，聚谷氨酸和至少一种抗生素或等效生物活性剂组成的纳米颗粒，其特征在于具有阳性表面电荷和增加口服药物递送的渗透性。
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