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![Substituted acetylenic imidazo[1,2-A]pyridine compounds as kinase inhibitors](/abs-image/US/2013/06/25/US08470851B2/abs.jpg.150x150.jpg)
41.发明授权Substituted acetylenic imidazo[1,2-A]pyridine compounds as kinase inhibitors 有权取代的炔属咪唑并[1,2-A]吡啶化合物作为激酶抑制剂公开(公告)号：US08470851B2
公开(公告)日：2013-06-25
申请号：US13357745
申请日：2012-01-25
申请人： Dong Zou , Wei-Sheng Huang , R. Mathew Thomas , Jan Antoinette C. Romero , Jiwei Qi , Yihan Wang , Xiaotian Zhu , William C. Shakespeare , Rajeswari Sundaramoorthi , Chester A. Metcalf, III , David C. Dalgarno , Tomi K. Sawyer
发明人： Dong Zou , Wei-Sheng Huang , R. Mathew Thomas , Jan Antoinette C. Romero , Jiwei Qi , Yihan Wang , Xiaotian Zhu , William C. Shakespeare , Rajeswari Sundaramoorthi , Chester A. Metcalf, III , David C. Dalgarno , Tomi K. Sawyer
IPC分类号： A61K31/44
CPC分类号： C07D471/04 , C07D473/34 , C07D487/04
摘要： This invention relates to compounds of the general formula: in which the variable groups are as defined herein, and to their preparation and use.
摘要翻译： 本发明涉及以下通式的化合物：其中可变基团如本文所定义，及其制备和用途。
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公开(公告)号：US20120178716A1
公开(公告)日：2012-07-12
申请号：US13311106
申请日：2011-12-05
申请人： Yihan Wang , Wei-Sheng Huang , Rajeswari Sundaramoorthi , Xiaotian Zhu , R. Mathew Thomas , William C. Shakespeare , David C. Dalgarno , Tomi K. Sawyer
发明人： Yihan Wang , Wei-Sheng Huang , Rajeswari Sundaramoorthi , Xiaotian Zhu , R. Mathew Thomas , William C. Shakespeare , David C. Dalgarno , Tomi K. Sawyer
IPC分类号： A61K31/675 , A61P35/00 , C07F9/6561 , A61K31/52 , C07D473/32
CPC分类号： C07F9/65616
摘要： This invention relates to compounds of the general formula: in which the variable groups are as defined herein, and to their preparation and use.
摘要翻译： 本发明涉及以下通式的化合物：其中可变基团如本文所定义，以及其制备和用途。
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公开(公告)号：US08071609B2
公开(公告)日：2011-12-06
申请号：US11990299
申请日：2006-08-11
申请人： Yihan Wang , Wei-Sheng Huang , Rajeswari Sundaramoorthi , Xiaotian Zhu , R. Mathew Thomas , William C. Shakespeare , David C. Dalgarno , Tomi K. Sawyer
发明人： Yihan Wang , Wei-Sheng Huang , Rajeswari Sundaramoorthi , Xiaotian Zhu , R. Mathew Thomas , William C. Shakespeare , David C. Dalgarno , Tomi K. Sawyer
IPC分类号： C07D473/16 , C07D473/34 , A61K31/52 , C07F9/6561 , C07D473/40 , A61P35/00
CPC分类号： C07F9/65616
摘要： This invention relates to compounds of the general formula: in which Q is an ethynyl or ethenyl moiety; Ring A is an aryl, heteroaryl or heterocyclic ring or ring system; and the remaining variable groups are as defined herein, and to their preparation and use.
摘要翻译： 本发明涉及下列通式的化合物：其中Q是乙炔基或乙烯基部分; 环A是芳基，杂芳基或杂环或环系; 并且其余的可变基团如本文所定义，以及其制备和使用。
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公开(公告)号：US07115589B2
公开(公告)日：2006-10-03
申请号：US09740393
申请日：2000-12-18
申请人： Manfred Weigele , Tomi K. Sawyer , Regine Bohacek , William C. Shakespeare , Rajeswari Sundaramoorthi , Yihan Wang , David C. Dalgarno , Chester A. Metcalf, III
发明人： Manfred Weigele , Tomi K. Sawyer , Regine Bohacek , William C. Shakespeare , Rajeswari Sundaramoorthi , Yihan Wang , David C. Dalgarno , Chester A. Metcalf, III
IPC分类号： C07F9/6561 , A61K31/675 , A61P19/10 , A61P19/08 , A61P35/00
CPC分类号： C07D471/04 , A61K47/548 , C07D487/04 , C07F9/4012 , C07F9/405 , C07F9/58 , C07F9/65583 , C07F9/6561 , C07F9/65616
摘要： This invention relates to compounds of the general formula: in which RA, RB, RC and RD are as defined herein, and to their preparation and use. In these compounds, RB is an aliphatic, heteroaliphatic, aryl, or heteroaryl moiety which comprises one or more phosphorus-containing moieties.
摘要翻译： 本发明涉及以下通式的化合物：其中R A，R B，R C和R D D均为 >如本文所定义，以及其制备和使用。 在这些化合物中，R B是包含一个或多个含磷部分的脂族，杂脂族，芳基或杂芳基部分。
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公开(公告)号：US07009054B2
公开(公告)日：2006-03-07
申请号：US10716239
申请日：2003-11-17
申请人： Yihan Wang , Chester A. Metcalf, III , William C. Shakespeare , Tomi K. Sawyer , Regine Bohacek , Rajeswari Sundaramoorthi
发明人： Yihan Wang , Chester A. Metcalf, III , William C. Shakespeare , Tomi K. Sawyer , Regine Bohacek , Rajeswari Sundaramoorthi
IPC分类号： C07D215/38 , A61K31/66
CPC分类号： C07F9/3821 , C07F9/4012 , C07F9/60 , C07F9/65583
摘要： This invention relates to compounds of the general formula: in which RA, RB, RC and RD are as defined herein, and to their preparation and use.
摘要翻译： 本发明涉及以下通式的化合物：其中R A，R B，R C和R D D均为 >如本文所定义，以及其制备和使用。
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公开(公告)号：US06960572B2
公开(公告)日：2005-11-01
申请号：US10177472
申请日：2002-06-21
申请人： William C. Shakespeare , Tomi K. Sawyer , Chester A. Metcalf, III , Yihan Wang , Regine Bohacek
发明人： William C. Shakespeare , Tomi K. Sawyer , Chester A. Metcalf, III , Yihan Wang , Regine Bohacek
IPC分类号： C07B61/00 , C07D209/30 , C07D209/34 , C07D209/40 , C07D401/04 , C07D401/06 , C07D403/06 , C07D405/06 , C07D409/06 , C07F9/38 , C07F9/572 , C07F9/58 , C07F9/6509 , C07F9/6558 , A61K31/66
CPC分类号： C07D401/04 , C07B2200/11 , C07D209/30 , C07D209/34 , C07D209/40 , C07D401/06 , C07D403/06 , C07D405/06 , C07D409/06 , C07F9/3821 , C07F9/5728 , C07F9/58 , C07F9/650952 , C07F9/65583 , C40B40/00
摘要： This invention relates to compounds of the general formula: in which RA, RB, RC, RD, RE, p, q and X are as defined herein, and to their preparation and use.
摘要翻译： 本发明涉及下列通式的化合物：其中R A，R B，R C，R D， >，R，E，P，q和X如本文所定义，以及它们的制备和用途。
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公开(公告)号：US06878697B2
公开(公告)日：2005-04-12
申请号：US10177469
申请日：2002-06-21
申请人： Chester A. Metcalf, III , William C. Shakespeare , Tomi K. Sawyer , Yihan Wang , Regine Bohacek
发明人： Chester A. Metcalf, III , William C. Shakespeare , Tomi K. Sawyer , Yihan Wang , Regine Bohacek
IPC分类号： C07D239/42 , C07D401/04 , C07D403/04 , C07F9/6512 , C07F9/6558 , A61K31/506
CPC分类号： C07D239/42 , C07D401/04 , C07D403/04 , C07F9/6512 , C07F9/65583
摘要： This invention relates to compounds of the general formula: in which RA, RB, RC, RD, w, x, y, and z are as defined herein, and to their preparation and use.
摘要翻译： 本发明涉及以下通式的化合物：其中R A，R B，R C，R D，W，x，y和z如本文所定义，以及它们的制备和 使用。
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公开(公告)号：US06573295B2
公开(公告)日：2003-06-03
申请号：US09990637
申请日：2001-11-21
申请人： William C. Shakespeare , Michael G. Yang , Rajeswari Sundaramoorthi , Regine Bohacek , Charles Joseph Eyermann , Tomi K. Sawyer
发明人： William C. Shakespeare , Michael G. Yang , Rajeswari Sundaramoorthi , Regine Bohacek , Charles Joseph Eyermann , Tomi K. Sawyer
IPC分类号： A61K31335
CPC分类号： C07F9/65527 , C07C237/48 , C07C2601/14 , C07C2602/12 , C07D313/08 , C07F9/12 , C07F9/3834 , C07F9/3873 , C07F9/3882 , C07F9/4021
摘要： This invention concerns compounds for inhibiting intracellular signal transduction, especially intracellular signal transduction mediated by one or more molecular interactions involving a phosphotyrosine-containing protein. This invention also relates to pharmaceutical compositions containing the compounds and prophylactic and therapeutic methods involving pharmaceutical and veterinary administration of the compounds. The compounds are of the formula as defined herein.
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