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132 条记录 (耗时 0.046 秒)

    SEQUENCES CHARACTERISTIC OF HYPOXIA-REGULATED GENE TRANSCRIPTION
    43.
    发明申请
    SEQUENCES CHARACTERISTIC OF HYPOXIA-REGULATED GENE TRANSCRIPTION 审中-公开
    HYPOXIA调控基因转录的序列特征

    公开(公告)号：US20090264634A1

    公开(公告)日：2009-10-22

    申请号：US12269722

    申请日：2008-11-12

    申请人： Paz EINAT ,  Rami Skaliter ,  Elena Feinstein ,  Aviv Regev ,  Hagar Ralinski

    发明人： Paz EINAT ,  Rami Skaliter ,  Elena Feinstein ,  Aviv Regev ,  Hagar Ralinski

    IPC分类号： C07H21/04

    CPC分类号： C12Q1/6883 ,  A61K38/00 ,  A61K48/00 ,  C07K14/47 ,  C07K14/4702 ,  C07K14/4747 ,  C12N9/0004 ,  C12Q2600/158 ,  C12Y114/11004

    摘要： There are provided polynucleotides that are modulated by hypoxic conditions. The disclosure includes such genes and proteins as well as analogs, salts and functional derivatives of such proteins, and DNA encoding such analogs, and methods of use. Methods for treating the effects of stroke, hypoxia and/or ischemia by regulating such genes or proteins are also disclosed. The presence of hypoxia or a hypoxia-associated pathology may be diagnosed by screening for the presence of at least one polynucleotide having the nucleic acid sequence according to the present invention. Methods of regulating hypoxia associated pathologies are also provided.

    摘要翻译： 提供了由缺氧条件调节的多核苷酸。 本公开包括此类基因和蛋白质以及此类蛋白质的类似物，盐和功能性衍生物，以及编码此类类似物的DNA及其使用方法。 还公开了通过调节这些基因或蛋白质治疗中风，缺氧和/或缺血的作用的方法。 可以通过筛选至少一种具有本发明的核酸序列的多核苷酸的存在来诊断缺氧或缺氧相关病理的存在。 还提供了调节缺氧相关病变的方法。

    Methods of treatment of renal disease
    44.
    发明申请
    Methods of treatment of renal disease 审中-公开
    肾病治疗方法

    公开(公告)号：US20090075923A1

    公开(公告)日：2009-03-19

    申请号：US11827198

    申请日：2007-07-10

    申请人： Orna Mor ,  Elena Feinstein

    发明人： Orna Mor ,  Elena Feinstein

    IPC分类号： A61K31/7105 ,  A61P13/12

    CPC分类号： G01N33/6893 ,  C12Q1/485 ,  G01N2500/00 ,  G01N2500/04 ,  G01N2500/10 ,  G01N2800/042 ,  G01N2800/347

    摘要： The invention is directed to a process of identifying a compound capable of inhibiting the activity of a human Ax1 receptor that comprises contacting the Ax1 receptor or cells expressing the Ax1 receptor with the compound; measuring the Ax1 receptor activity in the presence of the compound; and comparing the activity measured to that measured in the absence of the compound under controlled conditions, wherein a decrease identifies the compound as being capable of inhibiting the activity. Therapeutic and diagnostic applications are also described.

    摘要翻译： 本发明涉及鉴定能够抑制人Ax1受体活性的化合物的方法，其包括使Ax1受体或表达Ax1受体的细胞与化合物接触; 在化合物存在下测量Ax1受体活性; 并将测量的活性与在控制条件下不存在化合物时测量的活性进行比较，其中减少将该化合物鉴定为能够抑制该活性。 还描述了治疗和诊断应用。

    Use of the endo-180 gene and polypeptide for diagnosis and treatment
    46.
    发明申请
    Use of the endo-180 gene and polypeptide for diagnosis and treatment 审中-公开
    使用endo-180基因和多肽进行诊断和治疗

    公开(公告)号：US20070072244A1

    公开(公告)日：2007-03-29

    申请号：US10557089

    申请日：2005-11-16

    申请人： Orna Mor ,  Elena Feinstein ,  Alexander Faerman

    发明人： Orna Mor ,  Elena Feinstein ,  Alexander Faerman

    IPC分类号： G01N33/567 ,  A61K38/17

    CPC分类号： G01N33/5032 ,  G01N33/6872 ,  G01N2333/4724 ,  G01N2333/78

    摘要： This application is directed to a process of identifying a compound capable of modulating activity of a human ENDO180 receptor that comprises the steps of measuring the binding of the ENDO180 receptor to an interactor with which the ENDO180 receptor interacts specifically in vivo, in the absence or presence of a compound, and determining whether the binding of the ENDO180 receptor to the interactor is affected by the compound. This application is also directed to use of a compound identified by that process in the preparation of a medicament for therapy of disease, in particular fibrosis. This application also relates to the use of ENDO180 modulators in treatment of disease.

    摘要翻译： 本申请涉及鉴定能够调节人ENDO180受体活性的化合物的方法，该方法包括以下步骤：在不存在或存在下测量ENDO180受体与ENDO180受体在体内特异性相互作用的相互作用因子的结合 的化合物，并确定ENDO180受体与相互作用体的结合是否受化合物的影响。 本申请还涉及通过该方法鉴定的化合物在制备用于治疗疾病，特别是纤维化的药物中的用途。 本申请还涉及使用ENDO180调节剂治疗疾病。