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41.发明授权Methods and pharmaceutical compositions for inhibiting influenza viruses replication 有权用于抑制流感病毒复制的方法和药物组合物公开(公告)号：US09168236B2
公开(公告)日：2015-10-27
申请号：US14110214
申请日：2012-04-10
申请人： Vincent Lotteau , Benoit De Chassey , Patrice Andre , Laurene Meyniel-Schicklin , Anne Aublin-Gex
发明人： Vincent Lotteau , Benoit De Chassey , Patrice Andre , Laurene Meyniel-Schicklin , Anne Aublin-Gex
IPC分类号： A61K39/145 , A61K31/198 , A61K31/122 , A61K31/337 , A61K31/352 , A61K31/404 , A61K31/426 , A61K31/4465 , A61K31/4745 , A61K31/475 , A61K31/55 , A61K31/555 , A61K31/58 , A61K31/7068 , A61K31/7076 , A61K38/06 , A61K45/06 , A61K38/00 , A61K38/21
CPC分类号： A61K31/198 , A61K31/122 , A61K31/337 , A61K31/352 , A61K31/404 , A61K31/426 , A61K31/4465 , A61K31/4745 , A61K31/475 , A61K31/55 , A61K31/555 , A61K31/58 , A61K31/7068 , A61K31/7076 , A61K38/005 , A61K38/063 , A61K38/21 , A61K45/06 , A61K2300/00
摘要： The present invention relates to methods and pharmaceutical compositions for inhibiting influenza virus replication. More particularly, the present invention relates to a compound selected from the group consisting of Gemcitabine, Obatoclax Mesylate, Docetaxel, HA-14, Alsterpaullone, GSK3B inhibitor VIII, GSK3B inhibitor XV, Indirubin 3′-monoxime, L glutathione reduced, Fluocinolone acetonide, Tirofiban, Topotecan hydrochloride, Clofarabine, Vinblastine, Menadione Crystalline and derivatives or analogues thereof for use in the treatment of an influenza infection in a subject in need thereof.
摘要翻译： 本发明涉及用于抑制流感病毒复制的方法和药物组合物。 更具体地说，本发明涉及选自吉西他滨，甲磺酸复方，多西紫杉醇，HA-14，阿司匹伐酮，GSK3B抑制剂VIII，GSK3B抑制剂XV，靛玉红3'-单肟，还原的谷胱甘肽，氟轻松， 替罗非班，盐酸托泊替康，克拉法滨，长春花碱，甲萘醌结晶及其衍生物或类似物，用于治疗有需要的受试者的流感感染。
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公开(公告)号：US08974842B2
公开(公告)日：2015-03-10
申请号：US12460742
申请日：2009-07-23
申请人： Virginie Pecher , Patrice Andre
发明人： Virginie Pecher , Patrice Andre
CPC分类号： A61K8/347 , A61K8/97 , A61Q1/10 , B01D11/0203 , B01D11/0288
摘要： The present invention relates to a method for preparing a lipophilic extract from lignified portions of vine, such as shoots, stock and roots, characterized in that said method comprises a step for extraction from said lignified portions with an apolar solvent; to an extract obtained by such a method; to the use of such an extract as an excipient in a cosmetic composition; and to a cosmetic composition comprising such an extract.
摘要翻译： 本发明涉及一种用于从藤的木质部分制备亲脂性提取物的方法，例如枝条，原料和根，其特征在于所述方法包括用非极性溶剂从所述木质部分提取的步骤; 通过这种方法获得的提取物; 涉及在化妆品组合物中使用这样的提取物作为赋形剂; 以及包含这种提取物的化妆品组合物。
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43.发明申请METHODS AND PHARMACEUTICAL COMPOSITIONS FOR INHIBITING INFLUENZA VIRUSES REPLICATION 有权抑制流感病毒复制的方法和药物组合物公开(公告)号：US20140030224A1
公开(公告)日：2014-01-30
申请号：US14110214
申请日：2012-04-10
申请人： Vincent Lotteau , Benoit De Chassey , Patrice Andre , Laurene Meyniel-Schicklin , Anne Aublin-Gex
发明人： Vincent Lotteau , Benoit De Chassey , Patrice Andre , Laurene Meyniel-Schicklin , Anne Aublin-Gex
IPC分类号： A61K31/7076 , A61K31/404 , A61K31/337 , A61K31/55 , A61K31/352 , A61K45/06 , A61K31/555 , A61K31/198 , A61K31/58 , A61K31/4465 , A61K31/4745 , A61K31/122 , A61K31/7068 , A61K31/426
CPC分类号： A61K31/198 , A61K31/122 , A61K31/337 , A61K31/352 , A61K31/404 , A61K31/426 , A61K31/4465 , A61K31/4745 , A61K31/475 , A61K31/55 , A61K31/555 , A61K31/58 , A61K31/7068 , A61K31/7076 , A61K38/005 , A61K38/063 , A61K38/21 , A61K45/06 , A61K2300/00
摘要： The present invention relates to methods and pharmaceutical compositions for inhibiting influenza virus replication. More particularly, the present invention relates to a compound selected from the group consisting of Gemcitabine, Obatoclax Mesylate, Docetaxel, HA-14, Alsterpaullone, GSK3B inhibitor VIII, GSK3B inhibitor XV, Indirubin 3′- monoxime, L glutathione reduced, Fluocinolone acetonide, Tirofiban, Topotecan hydrochloride, Clofarabine, Vinblastine, Menadione Crystalline and derivatives or analogues thereof for use in the treatment of an influenza infection in a subject in need thereof.
摘要翻译： 本发明涉及用于抑制流感病毒复制的方法和药物组合物。 更具体地说，本发明涉及选自吉西他滨，甲磺酸复方，多西紫杉醇，HA-14，阿司匹帕酮，GSK3B抑制剂VIII，GSK3B抑制剂XV，靛玉红3'-单肟，还原的谷胱甘肽，氟轻松， 替罗非班，盐酸托泊替康，克拉法滨，长春花碱，甲萘醌结晶及其衍生物或类似物，用于治疗有需要的受试者的流感感染。
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公开(公告)号：US20050221464A1
公开(公告)日：2005-10-06
申请号：US10515381
申请日：2003-06-16
CPC分类号： C12N7/00 , C12N2770/24251
摘要： The invention concerns a method for HVC virus culture in vitro comprising steps which consist in: contacting particles containing hepatitis C virus RNA with cells capable of synthesizing and secreting lipoproteins, in a suitable culture environment promoting synthesis and secretion of lipoproteins, and in collecting the virus thus obtained. The invention has diagnostic and therapeutic applications.
摘要翻译： 本发明涉及用于体外HVC病毒培养的方法，包括以下步骤：将含有丙型肝炎病毒RNA的颗粒与能够合成和分泌脂蛋白的细胞接触，在合适的培养环境中促进脂蛋白的合成和分泌，以及收集病毒 从而得到。 本发明具有诊断和治疗应用。
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45.发明授权Products extracted from a plant of the genus Commiphora, particularly the Commiphora mukul plant, extracts containing same and applications thereof, for example in cosmetics 失效从Commiphora属植物提取的产品，特别是Commiphora mukul植物，含有其的提取物及其应用，例如在化妆品
公开(公告)号：US5972341A
公开(公告)日：1999-10-26
申请号：US29851
申请日：1998-05-20
IPC分类号： A61K8/00 , A61K8/35 , A61K8/365 , A61K8/37 , A61K8/96 , A61K8/97 , A61K36/18 , A61K36/328 , A61P17/00 , A61Q1/00 , A61Q1/10 , A61Q19/00 , A61Q19/08 , C07C45/78 , C07C49/743 , C07C59/82 , C07C59/90 , C07C69/007 , C07C69/738 , C07C403/08 , C07C403/20 , A61K35/78 , A61K7/48
CPC分类号： A61Q19/08 , A61K8/35 , A61K8/365 , A61K8/37 , A61K8/97 , C07C45/78 , C07C49/743 , C07C59/90 , C07C69/007 , C07C69/738 , Y10S514/844 , Y10S514/845 , Y10S514/846 , Y10S514/847 , Y10S514/944
摘要： Extracts of the plant Commiphora mukul are used as pigmenting agents and melanocyte culture agents, and for the manufacture of cosmetic and pharmaceutical compositions. Particularly preferred are extracts of the formula IIa, designated Commipherol, and abstracts of the formula IIb designated Commipherin.
摘要翻译： PCT No.PCT / FR96 / 01415 Sec。 371日期：1998年5月20日 102（e）日期1998年5月20日PCT提交1996年9月13日PCT公布。 公开号WO97 / 10196 日期1997年3月20日植物蜱螨属植物提取物作为着色剂和黑素细胞培养剂，用于制造化妆品和药物组合物。 特别优选的是式IIa的提取物，命名为Commipherol，并且称为Commipherin的式IIb的摘要。
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46.发明授权Composition containing pregnenolone or a pregnenolone ester incorporated in liposomes, and a method for regenerating, or revitalizing the skin therewith 失效含有孕烯醇酮或掺入脂质体中的孕烯醇酮的组合物，以及用于再生或使皮肤恢复活力的方法
公开(公告)号：US5202126A
公开(公告)日：1993-04-13
申请号：US737933
申请日：1991-07-29
申请人： Pierre Perrier , Gerard Redziniak , Patrice Andre
发明人： Pierre Perrier , Gerard Redziniak , Patrice Andre
摘要： The present invention relates to a composition based on hydrated lipidic lamellar phases or on liposomes.In this composition, pregnenolone or a pregnenolone ester, such as, in particular, pregnenolone acetate, sulfate or palmitate, is at least partially incorporated in the said hydrated lipidic lamellar phases or the said liposomes.This composition can be applied in particular in the cosmetic or pharmaceutical sector, especially the dermatological sector, for the preparation of compositions with regenerating or revitalizing activity.
摘要翻译： 本发明涉及基于水合脂质层状相或在脂质体上的组合物。 在该组合物中，孕烯醇酮或孕烯醇酮酯，特别是孕烯醇酮乙酸盐，硫酸盐或棕榈酸酯，至少部分地并入所述水合脂质层状相或所述脂质体中。 该组合物可特别用于化妆品或制药领域，特别是皮肤病学领域，用于制备具有再生或活化活性的组合物。
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47.发明授权Cosmetic or dermatological composition, containing kola extracts and method for treatment of cellulitis 失效化妆品或皮肤病学组合物，含有罗拉提取物和治疗蜂窝组织炎的方法
公开(公告)号：US5165935A
公开(公告)日：1992-11-24
申请号：US759827
申请日：1991-09-13
IPC分类号： A61K8/96 , A61K8/00 , A61K8/11 , A61K8/14 , A61K8/97 , A61K9/127 , A61K36/00 , A61K36/18 , A61K36/185 , A61K36/48 , A61Q19/00 , A61Q19/06
CPC分类号： A61Q19/06 , A61K36/185 , A61K36/48 , A61K8/14 , A61K8/97 , A61K9/127 , Y10S514/86
摘要： A cosmetic or dermatological composition comprising an extract of kola seeds substantially free of methylxanthine. Other embodiments include a composition comprising liposomes or hydrated lipidic lamellar phases containing an extract of kola seeds having a methylxanthine content or containing an extract of kola seeds substantially free of methylxanthine. Methods for treating cellulitis deposits present on body parts by application of the compositions of the present invention are also disclosed.
摘要翻译： 一种化妆品或皮肤病学组合物，其包含基本上不含甲基黄嘌呤的科拉拉种子提取物。 其它实施方案包括包含脂质体或水合脂质层状结构的组合物，其含有具有甲基黄嘌呤含量的科拉种子提取物或含有基本上不含甲基黄嘌呤的科拉拉种子提取物。 还公开了通过应用本发明的组合物治疗存在于身体部位的蜂窝织炎沉积物的方法。
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48.发明申请Use of L-alpha-lysophosphatidylcholine to obtain the differentiation of monocytes in mature dendritic cells in vitro 审中-公开使用L-α-溶血磷脂酰胆碱在体外获得成熟树突状细胞中单核细胞的分化公开(公告)号：US20110135684A1
公开(公告)日：2011-06-09
申请号：US12929701
申请日：2011-02-09
申请人： Vincent Lotteau , Patrice Andre
发明人： Vincent Lotteau , Patrice Andre
IPC分类号： A61K39/12 , A61K31/685 , A61K39/00 , A61K31/7088 , A61K39/02 , A61P37/04
CPC分类号： A61K31/4439 , A61K9/0019 , A61K47/10 , A61K47/24
摘要： A method for treating and/or preventing certain ailments by administering to a person in need thereof L-α-lysophosphatidylcholine as an agent for activating the immune system of the person. Also, vaccine compositions that include L-α-lysophosphatidylcholine.
摘要翻译： 一种用于治疗和/或预防某些疾病的方法，其通过向有需要的人施用L-α-溶血磷脂酰胆碱作为激活人的免疫系统的药剂。 而且，包含L-α-溶血磷脂酰胆碱的疫苗组合物。
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49.发明申请METHODS, USES AND COMPOSITIONS FOR MODULATING REPLICATION OF HCV THROUGH THE FARNESOID X RECEPTOR (FXR) ACTIVATION OR INHIBITION 审中-公开方法，用于调节通过FARNESOID X受体（FXR）激活或抑制的HCV复制的用途和组合物公开(公告)号：US20100172870A1
公开(公告)日：2010-07-08
申请号：US12377169
申请日：2007-08-08
IPC分类号： A61K31/7088 , A61K31/57 , A61K31/713 , A61K31/7105 , A61K38/21 , A61P31/14 , A61P35/00 , A61P1/16 , C12N5/071 , C12N7/00 , C12Q1/70
CPC分类号： C12N15/1138 , A61K31/00 , A61K31/57 , C12N5/0018 , C12N2310/11 , C12N2310/12 , C12N2310/14 , C12N2501/38 , C12N2770/24011 , C12N2770/24211 , G01N33/56983 , G01N2333/18
摘要： Uses, methods and compositions for modulating replication of viruses of the Flaviviridae family, such as hepatitis C virus, through the farnesoid X receptor (FXR) activation or inhibition. More specifically, the use of an antagonist of FXR or an inhibitor of expression thereof for the manufacture of a medicament intended for treating a Flaviviridae virus infection in a subject in need thereof. The use of antagonists of FXR, such as guggulsterone, or use of inhibitors of FXR expression. A cell culture system allowing the replication of HCV and to methods for diagnosing HCV infection, screening of anti-viral compounds and vaccine or viral protein production.
摘要翻译： 通过法呢酯X受体（FXR）激活或抑制来调节黄病毒科病毒如丙型肝炎病毒复制的用途，方法和组合物。 更具体地，FXR拮抗剂或其表达抑制剂在制备用于治疗有需要的受试者中的黄病毒科病毒感染的药物中的用途。 使用FXR拮抗剂，如格鲁酮，或使用FXR表达抑制剂。 允许HCV复制的细胞培养系统和用于诊断HCV感染，抗病毒化合物筛选和疫苗或病毒蛋白质生产的方法。
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公开(公告)号：US20100034764A1
公开(公告)日：2010-02-11
申请号：US12460742
申请日：2009-07-23
申请人： Virginie Pecher , Patrice Andre
发明人： Virginie Pecher , Patrice Andre
CPC分类号： A61K8/347 , A61K8/97 , A61Q1/10 , B01D11/0203 , B01D11/0288
摘要： The present invention relates to a method for preparing a lipophilic extract from lignified portions of vine, such as shoots, stock and roots, characterized in that said method comprises a step for extraction from said lignified portions with an apolar solvent; to an extract obtained by such a method; to the use of such an extract as an excipient in a cosmetic composition; and to a cosmetic composition comprising such an extract.
摘要翻译： 本发明涉及一种用于从藤的木质部分制备亲脂性提取物的方法，例如枝条，原料和根，其特征在于所述方法包括用非极性溶剂从所述木质部分提取的步骤; 通过这种方法获得的提取物; 涉及在化妆品组合物中使用这样的提取物作为赋形剂; 以及包含这种提取物的化妆品组合物。
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