公开(公告)号：US4981966A

公开(公告)日：1991-01-01

申请号：US295439

申请日：1989-01-10

申请人： Istvan Hermecz ,  Geza Kereszturi ,  Lelle Vasvari nee Debreczy ,  Agnes Horvath ,  Maria Balogh ,  Gabor Kovacs ,  Tamas Szuts ,  Peter Ritli ,  Judit Sipos ,  Aniko Pajor

发明人： Istvan Hermecz ,  Geza Kereszturi ,  Lelle Vasvari nee Debreczy ,  Agnes Horvath ,  Maria Balogh ,  Gabor Kovacs ,  Tamas Szuts ,  Peter Ritli ,  Judit Sipos ,  Aniko Pajor

IPC分类号： C07D401/10 ,  A61K31/47 ,  A61P31/04 ,  C07D215/56 ,  C07D295/067 ,  C07D295/155 ,  C07F5/02 ,  C07F5/04

CPC分类号： C07D215/56 ,  C07F5/022 ,  C07F5/04

摘要： The invention relates to a new process for the preparation of compounds of the Formula I ##STR1## (wherein R stands for hydrogen or methyl) and pharmaceutically acceptable salts thereof which comprises reacting a compound of the Formula V ##STR2## (wherein R.sup.1 and R.sup.2 stand for an aliphatic acyloxy group comprising 2-6 carbon atoms and optionally substituted by halogen; or for an aromatic acyloxy group comprising 7-11 carbon atoms) with an amine of the Formula VI ##STR3## (wherein R has the same meaning as stated above) or a salt thereof and subjecting the compound of the Formula VII ##STR4## thus obtained (wherein R, R.sup.1 and R.sup.2 are as stated above) to hydrolysis after or without isolation and if desired converting the compound of the Formula I thus obtained into a salt thereof or setting free the same from its salt.The compounds of the Formula I are known antibacterial agents.The advantage of the process of the present invention is that it makes the desired compounds of the Formula I available in a simple manner, with high yields and in a short reaction time.

摘要翻译： 本发明涉及制备式I化合物（I）（其中R代表氢或甲基）及其药学上可接受的盐的新方法，其包括使式V化合物（V ）（其中R 1和R 2表示包含2-6个碳原子并且任选被卤素取代的脂族酰氧基或对于包含7-11个碳原子的芳族酰氧基）与式VI的胺VI， （其中R具有与上述相同的含义）或其盐，并且如此获得的式VII（VII）化合物（其中R，R 1和R 2如上所述）在分离之后或在不分离之前进行水解，以及 如果需要将由此获得的式I的化合物转化成其盐或使其与其盐相同。 式I的化合物是已知的抗菌剂。 本发明方法的优点在于使得所需的式I化合物可以简单的方式得到，产率高，反应时间短。

公开(公告)号：US4840949A

公开(公告)日：1989-06-20

申请号：US107693

申请日：1987-10-09

申请人： Dezso Korbonits ,  Emil Minker ,  Zoltan Vargai ,  Gergely Heja ,  Gabor Kovacs ,  Agnes Gottsegen ,  Sandor Antus ,  Sandor Virag ,  Andrea Bolehovszky ,  Jeno Marton ,  Katalin Marmarosi nee Kellner ,  Lorand Debreczeni ,  Laszlo Tardos ,  Peter Kormoczy ,  Vera Gergely ,  Gabor Horvath

发明人： Dezso Korbonits ,  Emil Minker ,  Zoltan Vargai ,  Gergely Heja ,  Gabor Kovacs ,  Agnes Gottsegen ,  Sandor Antus ,  Sandor Virag ,  Andrea Bolehovszky ,  Jeno Marton ,  Katalin Marmarosi nee Kellner ,  Lorand Debreczeni ,  Laszlo Tardos ,  Peter Kormoczy ,  Vera Gergely ,  Gabor Horvath

IPC分类号： C07D473/04 ,  A61K31/52 ,  A61K31/522 ,  A61P11/04 ,  A61P11/14 ,  C07D271/06 ,  C07D273/02 ,  C07D473/06

CPC分类号： C07D473/06

摘要： The invention relates to new oxidiazole-alkyl-purine-derivatives of the Formula I ##STR1## and pharmaceutically acceptable salts thereof wherein A stands for C.sub.1-4 alkylene andR.sup.1 represents C.sub.1-6 alkyl, hydroxyalkyl, halogenoalkyl, carboxyalkyl, C.sub.5-6 cycloalkyl or aminoalkyl of the Formula --(CH.sub.2).sub.n --NR.sup.2 R.sup.3 in which group n is an integer 1-3; R.sup.2 and R.sup.3 each stand for hydrogen or C.sub.1-4 alkyl or together with the adjacent nitrogen atom they are attached to form a 5- or 6-membered nitrogen containing heterocyclic ring which may optionally comprise a further nitrogen atom or an oxygen atom as heteroatom; orR.sup.1 stands for phenyl, hydroxyphenyl, carboxyphenyl, benzyl or dimethoxybenzylThe compounds of the Formula I can be prepared by methods known per se and can be used in therapy as antitussive agents.

摘要翻译： 本发明涉及式I的新型氧化噻唑烷基嘌呤衍生物及其药学上可接受的盐，其中A代表C1-4亚烷基，R1代表C1-6烷基，羟基烷基，卤代烷基，羧基烷基，C5-6环烷基 或其中基团n为整数1-3的式 - （CH 2）n -NR 2 R 3的氨基烷基; R 2和R 3各自代表氢或C 1-4烷基或与它们相连的相邻氮原子一起形成5-或6-元含氮杂环，其可以任选地包含另外的氮原子或氧原子作为杂原子; 或R 1代表苯基，羟基苯基，羧基苯基，苄基或二甲氧基苄基。式I化合物可以通过本身已知的方法制备，并且可用于作为止咳剂的治疗。

公开(公告)号：US4588713A

公开(公告)日：1986-05-13

申请号：US691340

申请日：1985-01-14

申请人： Peter Gyory ,  Geza Galambos ,  Karoly Kanay ,  Jozsef Ivanics ,  Gyorgy Dorman ,  Gabor Kovacs ,  Istvan Stadler ,  Sandor Virag ,  Istvan Tomoskozi ,  Peter Kormoczky ,  Marianna Kovacs

发明人： Peter Gyory ,  Geza Galambos ,  Karoly Kanay ,  Jozsef Ivanics ,  Gyorgy Dorman ,  Gabor Kovacs ,  Istvan Stadler ,  Sandor Virag ,  Istvan Tomoskozi ,  Peter Kormoczky ,  Marianna Kovacs

IPC分类号： C07D307/935 ,  A61K31/557 ,  A61P7/02 ,  A61P9/00 ,  A61P9/08 ,  A61P43/00 ,  C07C405/00 ,  C07D307/937 ,  A61K31/34

CPC分类号： C07D307/937

摘要： Compounds of the formula ##STR1## are disclosed wherein R.sup.1 stands for hydrogen, C.sub.1-4 straight or branched alkyl or pharmacologically acceptable cation,R.sup.2 stands for hydrogen, C.sub.1-4 alkanoyl, benzoyl, or benzoyl substituted by C.sub.1-4 alkyl or halogen, and R.sup.2 can further represent tetrahydropyranyl, trialkylsilyl or alkoxyalkyl,A stands for ethylene, cis or trans-vinylene or --C.dbd.C--,n may represent 2, 3 or 4. The compounds are highly effective in the inhibition of thrombocyte aggregation while at the same time exert only a very small hypotensive effect.

摘要翻译： 公开了其中R1代表氢，C1-4直链或支链烷基或药理学上可接受的阳离子的式I的化合物，R2代表被C1-4烷基或卤素取代的氢，C1-4烷酰基，苯甲酰基或苯甲酰基 ，R 2可以进一步代表四氢吡喃基，三烷基甲硅烷基或烷氧基烷基，A代表乙烯，顺式或反式亚乙烯基或-C = C-，n可以代表2,3或4.这些化合物在抑制血小板聚集方面是非常有效的， 同时只会产生非常小的降血压作用。

公开(公告)号：US3988684A

公开(公告)日：1976-10-26

申请号：US450432

申请日：1974-03-12

申请人： Willi Muller ,  Hans-Joachim Freygang ,  Gabor Kovacs

发明人： Willi Muller ,  Hans-Joachim Freygang ,  Gabor Kovacs

IPC分类号： H01F38/20 ,  G01R15/16 ,  H01F27/42 ,  H01F38/24 ,  H01F38/38 ,  H02B13/02 ,  H02M11/00 ,  G01R15/06

CPC分类号： G01R15/16 ,  H02M11/00

摘要： A voltage transformer for a fully insulated high-voltage installation containing several conductors includes a plurality of electrodes corresponding to respective ones of the conductors. The electrodes are disposed outside of the arrangement of the conductors in such a manner that each one of the electrodes is disposed directly adjacent a corresponding one of the conductors. Each of the electrodes and the conductor directly adjacent thereto conjointly define a high-voltage capacitor. A plurality of low-voltage capacitors are disposed outside of the region occupied by the electrodes and are connected to corresponding ones of the high-voltage capacitors so as to conjointly define therewith respective capacitive voltage dividers.

摘要翻译： 用于具有多个导体的完全绝缘的高压设备的变压器包括对应于各个导体的多个电极。 电极以这样的方式设置在导体的布置之外，使得每个电极直接邻近相应的一个导体设置。 每个电极和与其直接相邻的导体共同限定高压电容器。 多个低电压电容器设置在由电极占据的区域的外部，并且连接到相应的高压电容器，以便与其相应地限定各自的电容分压器。

公开(公告)号：US3942099A

公开(公告)日：1976-03-02

申请号：US470907

申请日：1974-05-17

申请人： Hans-Joachim Freygang ,  Gabor Kovacs

发明人： Hans-Joachim Freygang ,  Gabor Kovacs

IPC分类号： H02B13/02 ,  G01R15/14 ,  H01B17/28 ,  H01F38/20 ,  H01F38/38 ,  H01G2/00 ,  H01F27/06 ,  H01B9/06

CPC分类号： H01G2/00 ,  G01R15/14 ,  H01B17/28 ,  H02B13/0356 ,  H02G5/068 ,  Y10S174/10

摘要： A measuring transformer arrangement with a capacitor bushing and devices for measuring voltage and current associated with the capacitor bushing is suitable for use in a high-voltage installation with metal encapsulation carrying several high-voltage conductors. The capacitor bushing provided for each high-voltage conductor is arranged in a bulkhead partition of the metal encapsulation and carries a current measuring device which includes at the periphery of the bushing at least one current transformer core with a secondary winding system mounted thereon.

摘要翻译： 具有电容器衬套的测量变压器装置和用于测量与电容器套管相关的电压和电流的装置适用于具有承载几个高压导体的金属封装的高压安装。 为每个高电压导体提供的电容器衬套被布置在金属封装的隔板分隔件中并且承载电流测量装置，该电流测量装置在衬套的外围包括至少一个电流互感器芯，其上安装有次级绕组系统。

公开(公告)号：US09193559B2

公开(公告)日：2015-11-24

申请号：US13580681

申请日：2011-02-24

申请人： Zsolt Rumy ,  Gabor Kovacs

发明人： Zsolt Rumy ,  Gabor Kovacs

IPC分类号： B65H69/06

CPC分类号： B65H69/065 ,  B65H2701/314 ,  B65H2701/37 ,  Y10T428/2918

摘要： A spliced fiber tow (40) having a uniform density along its entire length is provided. The spliced fiber tow is manufactured by rarefying the ends (22, 32) of the two fiber tow segments to be joined, aligning the rarefied regions (26, 36) and then applying pressurized gas to entangle the filaments in the rarefied regions. An apparatus (50) for forming the spliced fiber tow includes a pair of rarefying blades (86, 92) and an entanglement element (58).

摘要翻译： 提供具有沿整个长度均匀密度的拼接纤维束（40）。 接合的纤维束通过稀薄待连接的两个纤维束段的端部（22,32）而制造，使稀薄区域（26,36）对齐，然后施加加压气体以使细丝缠绕在稀薄区域中。 用于形成拼接纤维丝束的装置（50）包括一对稀薄刀片（86,92）和缠结元件（58）。

公开(公告)号：US08746416B2

公开(公告)日：2014-06-10

申请号：US12719048

申请日：2010-03-08

申请人： Stefan Glück ,  Gabor Kovacs

发明人： Stefan Glück ,  Gabor Kovacs

IPC分类号： F16C29/10

CPC分类号： F16D57/002 ,  F16C29/10 ,  F16D63/008 ,  F16D2121/28

摘要： A linear guide with a guide carriage longitudinally movably arranged on a guide rail, which is preferably U-shaped and a braking device effectively arranged between the guide rail and the guide carriage. An actuator for actuating the braking device is provided and the actuator has an electro-active polymer effectively arranged in the longitudinal axis of the linear guide which engages around the guide rail for actuating the braking device.

摘要翻译： 一种直线引导件，其具有纵向可移动地布置在导轨上的引导托架，其优选为U形，并且制动装置有效地布置在导轨和引导托架之间。 提供了用于致动制动装置的致动器，并且致动器具有有效地布置在线性引导件的纵向轴线上的电活性聚合物，其接合围绕导轨以致动制动装置。

公开(公告)号：US20090294582A1

公开(公告)日：2009-12-03

申请号：US11918333

申请日：2006-04-07

申请人： Silvain Michel ,  Gabor Kovacs ,  Patrick Lochmatter

发明人： Silvain Michel ,  Gabor Kovacs ,  Patrick Lochmatter

IPC分类号： B64B1/24

CPC分类号： B64B1/58 ,  B64B1/24

摘要： A lighter-than-air aircraft is propelled via a bending-rotating tail whip. Two actuating areas located on opposite sides in a rear area of a lifting gas body are shortened by activated actuators. A vertical plane of symmetry of the lifting gas body and thus, the lifting gas body itself, are pivoted in an area of bending zones about angles a and β. An activated state exists when the actuator performs work for propelling the aircraft. Propulsion can be provided by deformation of the lifting gas body. Changes in direction can also be effected by asymmetrical sequences of movements.

摘要翻译： 一架轻型的飞机是通过弯曲的鞭子推动的。 位于提升气体的后部区域相对两侧的两个致动区域被激活的致动器缩短。 提升气体的垂直对称平面以及提升气体本身在弯曲区域围绕角度α和β枢转。 当执行器执行用于推进飞行器的工作时，存在激活状态。 可以通过提升气体的变形来提供推进。 方向的改变也可以通过不对称的运动顺序来实现。

公开(公告)号：US5294712A

公开(公告)日：1994-03-15

申请号：US583296

申请日：1990-09-14

申请人： Istvan Hermecz ,  Geza Keresturi ,  Lelle V. Debreczy ,  Agnes Horvath ,  Maria Balogh ,  Gabor Kovacs ,  Tamas Szuts ,  Peter Ritli ,  Judit Sipos ,  Aniko Pajor

发明人： Istvan Hermecz ,  Geza Keresturi ,  Lelle V. Debreczy ,  Agnes Horvath ,  Maria Balogh ,  Gabor Kovacs ,  Tamas Szuts ,  Peter Ritli ,  Judit Sipos ,  Aniko Pajor

IPC分类号： C07D215/56 ,  C07F5/02 ,  C07D401/04

CPC分类号： C07D215/56 ,  C07F5/022

摘要： The invention relates to a new process for the preparation of compounds of the Formula I ##STR1## (wherein R stands for hydrogen or methyl) and pharmaceutically acceptable salts thereof which comprises reacting a compound of the Formula V ##STR2## (wherein R.sup.1 and R.sup.2 stand for an aliphatic acyloxy group comprising 2-6 carbon atoms and optionally substituted by halogen: or for an aromatic acyloxy group comprising 7-11 carbon atoms) with an amine of the Formula VI ##STR3## (wherein R has the same meaning as stated above) or a salt thereof and subjecting the compound of the Formula VII ##STR4## thus obtained (wherein R, R.sup.1 and R.sup.2 are as stated above) to hydrolysis after or without isolation and if desired converting the compound of the Formula I thus obtained into a salt thereof or setting free the same from its salt.The compounds of the Formula I are known antibacterial agents.

摘要翻译： 本发明涉及制备式I化合物（I）（其中R代表氢或甲基）及其药学上可接受的盐的新方法，其包括使式V化合物（V ）（其中R 1和R 2表示包含2-6个碳原子并且任选被卤素取代的脂族酰氧基或用于包含7-11个碳原子的芳族酰氧基）与式VI的胺（VI） （其中R具有与上述相同的含义）或其盐，并且如此获得的式VII（VII）化合物（其中R，R 1和R 2如上所述）在分离之后或在不分离之前进行水解，以及 如果需要将由此获得的式I的化合物转化成其盐或使其与其盐相同。 式I的化合物是已知的抗菌剂。

公开(公告)号：US5284950A

公开(公告)日：1994-02-08

申请号：US691633

申请日：1991-04-25

申请人： Istvan Hermecz ,  Geza Kereszturi ,  Lelle Vasvari nee Debreczy ,  Agnes Horvath ,  Maria Balogh ,  Gabor Kovacs ,  Tamas Szuts ,  Peter Ritli ,  Judit Sipos ,  Aniko Pajor

发明人： Istvan Hermecz ,  Geza Kereszturi ,  Lelle Vasvari nee Debreczy ,  Agnes Horvath ,  Maria Balogh ,  Gabor Kovacs ,  Tamas Szuts ,  Peter Ritli ,  Judit Sipos ,  Aniko Pajor

IPC分类号： C07D215/56 ,  C07F5/02 ,  C07F5/04 ,  C07D403/04

CPC分类号： C07D215/56 ,  C07F5/022 ,  C07F5/04

摘要： A method of using a compound of the Formula (V) ##STR1## or a pharmaceutically acceptable salt thereof is disclosed, wherein R.sup.1 and R.sup.2 are each C.sub.1 to C.sub.6 aliphatic acyloxy, unsubstituted or substituted by halogen, or are each C.sub.7 to C.sub.11 aromatic acyloxy,for preventing amination of the 6-position when a compound of the Formula (I) ##STR2## or a pharmaceutically acceptable salt thereof is to be formed, which comprises the steps of:(a) aminating the compound of the Formula (V) or a pharmaceutically acceptable salt thereof with piperazine in an inert organic solvent to yield a compound of the Formula (VII) ##STR3## or a pharmaceutically acceptable salt thereof, and (b) hydrolyzing the compound of the Formula (VII) or a pharmaceutically acceptable salt thereof, after or without isolation, to obtain the compound of the Formula (I), and if desired, converting the compound of the Formula (I) into a pharmaceutically acceptable salt thereof, or setting free the compound of the Formula (I) from its pharmaceutically acceptable salt.

摘要翻译： 公开了使用式（V）的化合物或其药学上可接受的盐的方法，其中R 1和R 2各自是未被取代或被卤素取代的C 1至C 6脂族酰氧基，或各自为C7至 C11芳族酰氧基，用于防止当式（I）化合物或其药学上可接受的盐形成时，6-位的胺化，其包括以下步骤：（a）胺化化合物 （VII）化合物或其药学上可接受的盐，和（b）将式（Ⅴ）化合物或其药学上可接受的盐与哌嗪在惰性有机溶剂中反应，得到式 式（VII）化合物或其药学上可接受的盐在得到式（I）化合物后，如果需要，将式（I）化合物转化为其药学上可接受的盐，或设定 释放式的化合物 （I）的药学上可接受的盐。