-
公开(公告)号：US06862534B2
公开(公告)日：2005-03-01
申请号：US10366540
申请日：2003-02-12
申请人： Bernhard B. Sterling , James R. Braig , Daniel S. Goldberger , Philip C. Hartstein , Robert D. Gaffney
发明人： Bernhard B. Sterling , James R. Braig , Daniel S. Goldberger , Philip C. Hartstein , Robert D. Gaffney
CPC分类号： A61B5/14532 , A61B5/14546 , A61B5/1455 , A61B2562/0295 , G01N21/274 , G01N21/314 , G01N21/35 , G01N27/3271
摘要： A method determines an analyte concentration in a sample including the analyte and a substance. The method includes providing an absorption spectrum of the sample. The absorption spectrum has an absorption baseline. The method further includes shifting the absorption spectrum so that the absorption baseline approximately equals a selected absorption value in a selected absorption wavelength range. The method further includes subtracting a substance contribution from the absorption spectrum. Thus, the method provides a corrected absorption spectrum substantially free of a contribution from the substance.
-
公开(公告)号：US06196046B1
公开(公告)日：2001-03-06
申请号：US09382273
申请日：1999-08-25
申请人： James R. Braig , Bernhard B. Sterling , Daniel S. Goldberger , Joan C. Godfrey , Kamrava Azizi , David J. Correia , Charles E. Kramer
发明人： James R. Braig , Bernhard B. Sterling , Daniel S. Goldberger , Joan C. Godfrey , Kamrava Azizi , David J. Correia , Charles E. Kramer
IPC分类号： G01N100
CPC分类号： A61B5/1495 , A61B5/14532 , A61B2560/0233 , A61B2560/0271
摘要： A calibration standard for calibrating a thermal gradient spectrometer. The calibration standard is a structure having a particular glucose concentration which a thermal gradient spectrometer reads for determining whether the spectrometer is in calibration. The structure of the calibration standard properly mimics the physiology of human tissue. A number of such standards, each containing a different concentration of glucose are provided in kit form with a thermal gradient spectrometer for use in calibrating the spectrometer. The spectrometer is provided with a display and internal circuitry for performing self-calibrating adjustments and a communications port for electronically coupling to a remote computer and database for supplying external calibration commands to said spectrometer.
摘要翻译： 用于校准热梯度光谱仪的校准标准。 校准标准是具有特定葡萄糖浓度的结构，热梯度光谱仪读取以确定光谱仪是否在校准中。 校准标准的结构恰当地模拟了人体组织的生理。 提供了许多这样的标准，每种含有不同浓度的葡萄糖的试剂盒形式与用于校准光谱仪的热梯度光谱仪一起提供。 光谱仪具有用于执行自校准调节的显示器和内部电路，以及用于电子耦合到远程计算机和数据库的通信端口，用于向所述光谱仪提供外部校准命令。
-
公开(公告)号：US5515847A
公开(公告)日：1996-05-14
申请号：US247311
申请日：1994-05-23
IPC分类号： A61B5/145 , A61B5/00 , A61B5/1455 , G01N21/35
CPC分类号： A61B5/1455 , A61B5/14532 , A61B5/14546 , A61B5/6826 , G01N21/35 , G01N21/3581
摘要： A method and apparatus for monitoring glucose, ethyl alcohol and other blood constituents in a noninvasive manner. The measurements are made by monitoring infrared absorption of the desired blood constituent in the long infrared wavelength range where the blood constituent has a strong and distinguishable absorption spectrum. The long wavelength infrared energy emitted by the person as heat is monitored and the infrared absorption of particular constituents in the blood (such as glucose or blood alcohol) is measured at characteristic infrared absorption wavelengths for those constituents. The measurements are preferably synchronized with systole and diastole of the cardiac cycle so that the signal contribution caused by veins and tissues (which do not pulse) may be cancelled when a ratio of the detected signals is taken. The concentration of the blood constituents are then determined in accordance with a polynomial equation.
摘要翻译： 一种以非侵入性方式监测葡萄糖，乙醇和其他血液成分的方法和装置。 通过监测血液成分具有强烈且可区分的吸收光谱的长红外波长范围内的所需血液成分的红外吸收来进行测量。 监测由人发射的长波长红外能量作为热，并且对于那些成分在特征红外吸收波长处测量血液中特定成分（如葡萄糖或血液酒精）的红外吸收。 所述测量优选与心动周期的收缩和心律舒张同步，使得当检测到的信号的比率被采取时，可以消除由静脉和组织引起的信号贡献（其不脉冲）。 然后根据多项式方程确定血液成分的浓度。
-
44.发明授权Method and apparatus for determining an analyte concentration in a sample having interferents 有权用于确定具有干扰物的样品中的分析物浓度的方法和装置公开(公告)号：US08620397B2
公开(公告)日：2013-12-31
申请号：US12573821
申请日：2009-10-05
申请人： Bernhard B. Sterling , W. Dale Hall , Kenneth G. Witte , Mark Wechsler , Peng Zheng , Richard Keenan
发明人： Bernhard B. Sterling , W. Dale Hall , Kenneth G. Witte , Mark Wechsler , Peng Zheng , Richard Keenan
IPC分类号： A61B5/1455 , G01N21/00
CPC分类号： G01N21/274 , A61B5/14532 , A61B5/14535 , A61B5/14546 , A61B5/1459 , A61B5/1495 , A61B2560/0223 , A61M5/14212 , A61M2230/20 , G01N21/35 , G01N35/00693 , G01N35/00712 , G01N2201/1215 , G01N2201/127
摘要： A method and apparatus are described that permit an analyte concentration to be estimated from a measurement in the presence of compounds that interfere with the measurement. The method reduces the error in the analyte concentration in the presence of interferents. The method includes the use of a set of measurements obtained for a large population having a range of known analyte and interfering compound concentrations. From a sample measurement, which may or may not be one of the population, likely present interferents are identified, and a calibration vector is calculated.
摘要翻译： 描述了允许在干扰测量的化合物存在下从测量估计分析物浓度的方法和装置。 该方法减少了在存在干扰物的情况下分析物浓度的误差。 该方法包括使用对具有已知分析物范围和干扰化合物浓度的大群体获得的一组测量。 从可能或可能不是其中一个群体的样本测量中，可能存在干扰物被识别，并且计算校准向量。
-
公开(公告)号：US20110112383A1
公开(公告)日：2011-05-12
申请号：US12930377
申请日：2011-01-04
IPC分类号： A61B5/07
CPC分类号： A61F5/003 , A61B5/073 , A61B5/4238
摘要： An ingestible gastric device comprising a formed body that is adapted to expand upon exposure to a hydration medium and then degrade after a first residence time in the stomach cavity, allowing the device to be passed by the patient's normal digestive process, and monitoring means for monitoring the gastric device. In some embodiments, the monitoring means comprises a biocompatible RFID tag.
摘要翻译： 一种可摄入的胃装置，其包括成形体，其适于在暴露于水合介质后膨胀，然后在第一停留时间后在胃腔中降解，允许该装置通过患者的正常消化过程，以及用于监测的监测装置 胃装置。 在一些实施例中，监测装置包括生物相容性RFID标签。
-
公开(公告)号：US20100049007A1
公开(公告)日：2010-02-25
申请号：US12229080
申请日：2008-08-20
申请人： Bernhard B. Sterling , Andrew R. Lawrence , Gregory I. Voss , James M. Perry , Rankin A. Clinton, III
发明人： Bernhard B. Sterling , Andrew R. Lawrence , Gregory I. Voss , James M. Perry , Rankin A. Clinton, III
IPC分类号： A61B5/00
CPC分类号： A61B5/14552 , A61B5/0261 , A61B5/14551 , A61B5/1491 , A61B5/6806 , A61B5/6816 , A61B5/6843
摘要： A physiological sensor apparatus, system and method for determining a physiological characteristic, comprising providing at least one physiological sensor that is adapted to measure at least one physiological characteristic at a target measurement site on a subject's body, heating an extended tissue region on the subject's body, whereby blood perfusion of the tissue region is enhanced, and measuring at least one physiological characteristic at the target measurement site with the physiological sensor during or within a predetermined period after heating the extended tissue region. In one embodiment, the sensor system includes at least one temperature algorithm that is adapted to adjust the heat applied to the extended tissue region based on the body's response to the heat stimuli.
摘要翻译： 一种用于确定生理特征的生理传感器装置，系统和方法，包括提供至少一个生理传感器，所述生理传感器适于测量被检体的目标测量部位上的至少一个生理特征，加热被检体的延伸的组织区域 从而增强组织区域的血液灌注，并且在加热延伸的组织区域之后或期间的预定时间段内，用生理传感器测量目标测量部位的至少一个生理特征。 在一个实施例中，传感器系统包括至少一个温度算法，其适于基于身体对热刺激的响应来调节施加到延伸的组织区域的热量。
-
公开(公告)号：US20080183232A1
公开(公告)日：2008-07-31
申请号：US11700328
申请日：2007-01-30
IPC分类号： A61N1/00
CPC分类号： A61B5/02255 , A61B5/02028 , A61B5/02125 , A61B5/024 , A61B5/029 , A61B5/0295 , A61B5/1455
摘要： A method for determining a physiologic characteristic associated with cardiac function in a subject comprising the steps of providing at least one electromagnetic radiation absorption measurement, providing demographic information reflecting the subject's physical condition, determining a temporal plethysmographic value from the electromagnetic radiation absorption measurement, and determining at least one physiologic characteristic from the temporal plethysmographic value and demographic information by using a predetermined phenomenological model that is adapted to provide an estimate of a blood volume-time relationship proximate the heart and compute at least one physiologic characteristic associated with cardiac function based on the estimated blood volume-time relationship.
摘要翻译： 一种用于确定与受试者的心脏功能相关的生理特征的方法，包括以下步骤：提供至少一个电磁辐射吸收测量，提供反映受试者的身体状况的人口统计信息，从电磁辐射吸收测量确定时间体积描记值，以及确定 通过使用适于提供邻近心脏的血液体积 - 时间关系的估计并计算与心脏功能相关联的至少一个生理特征的预定的现象学模型，来自时间体积描记值和人口统计信息的至少一个生理特征，基于 估计血容量 - 时间关系。
-
公开(公告)号：US20100152547A1
公开(公告)日：2010-06-17
申请号：US12459570
申请日：2009-07-02
申请人： Bernhard B. Sterling , Andrew R. Lawrence , Gregory I. Voss , James M. Perry , Rankin A. Clinton, III
发明人： Bernhard B. Sterling , Andrew R. Lawrence , Gregory I. Voss , James M. Perry , Rankin A. Clinton, III
IPC分类号： A61B5/02
CPC分类号： A61B5/029
摘要： Methods and associated algorithms for determining cardiac and/or cardiovascular performance that are based on at least one cardiac function determinant associated with or at least in part, reflective of preload, contractility and afterload.
摘要翻译： 基于与预负荷，收缩性和后负荷相关联或至少部分地反映预负荷，收缩性和后负荷的至少一个心脏功能决定因素来确定心脏和/或心血管性能的方法和相关算法。
-
49.发明授权Method and apparatus for processing signals reflecting physiological characteristics 失效用于处理反映生理特征的信号的方法和装置公开(公告)号：US07215987B1
公开(公告)日：2007-05-08
申请号：US11270241
申请日：2005-11-08
IPC分类号： A61B5/00
CPC分类号： A61B5/14551
摘要： The invention comprises a method and apparatus for processing signals reflecting a physiological characteristic by detecting the intensity of light following tissue absorption at two wavelengths and subtracting the best estimate of the desired signal from the difference between the signals. Corrected first and second intensity signals are determined by applying a residual derived from a combination of the first and second intensity signals as multiplied by a residual factor and subtracted from a difference between the first and second intensity signals to the first and second intensity signals. In one embodiment, the method and apparatus are used to determine arterial oxygen saturation.
摘要翻译： 本发明包括一种用于通过检测在两个波长的组织吸收之后的光的强度来处理反映生理特征的信号的方法和装置，并且从信号之间的差中减去所需信号的最佳估计。 通过将从第一和第二强度信号的组合导出的残差乘以残差因子并从第一和第二强度信号之间的差减去第一和第二强度信号来确定校正的第一和第二强度信号。 在一个实施例中，使用该方法和装置来确定动脉血氧饱和度。
-
公开(公告)号：US07184809B1
公开(公告)日：2007-02-27
申请号：US11270240
申请日：2005-11-08
IPC分类号： A61B5/00
CPC分类号： A61B5/14551
摘要： The invention is method and apparatus for determining a physiological characteristic by detecting the intensity of light following tissue absorption at two wavelengths, estimating the pulse amplitude and indexing a calculated physiological characteristic to the estimated pulse amplitude. In one embodiment, the ratio of logarithms of absorbance signal amplitude is indexed to the pulse amplitude to improve the accuracy of arterial oxygen saturation as determined by a pulse oximeter.
摘要翻译： 本发明是通过检测在两个波长的组织吸收之后的光的强度来确定生理特性的方法和装置，估计脉冲幅度并将计算的生理特征指数与估计的脉冲幅度相关。 在一个实施例中，将吸光度信号幅度的对数比率指数为脉冲幅度，以提高由脉搏血氧计确定的动脉血氧饱和度的准确度。
-
-
-
-
-
-
-
-
-
搜索结果
62 条记录 (耗时 0.036 秒)
