公开(公告)号：US20110306856A1

公开(公告)日：2011-12-15

申请号：US13156295

申请日：2011-06-08

Applicant: Peter Rule ,  James R. Braig ,  Richard Keenan, II ,  David Callicoat

Inventor： Peter Rule ,  James R. Braig ,  Richard Keenan, II ,  David Callicoat

IPC: A61B5/157 ,  A61B6/00

CPC classification number: G01N33/491 ,  A61B5/1427 ,  A61B5/14532 ,  A61B5/14546 ,  A61B5/1455 ,  A61B5/1495 ,  A61B5/150022 ,  A61B5/15003 ,  A61B5/150221 ,  A61B5/150229 ,  A61B5/150267 ,  A61B5/150755 ,  A61B5/150786 ,  A61B5/150801 ,  A61B5/150862 ,  A61B5/150992 ,  A61B5/153 ,  A61B5/155 ,  A61B5/157 ,  A61B5/4839 ,  A61B5/7275 ,  A61B2560/0223 ,  A61B2560/0233 ,  A61B2560/0437 ,  A61B2560/0443 ,  A61B2562/0238 ,  A61B2562/08 ,  G01N21/35 ,  G01N2021/3174 ,  G01N2201/1215 ,  G01N2201/1293 ,  G06F19/00

Abstract: Systems and methods for analyzing multiple components of a fluid sample are provided. In certain embodiments, a system can include an analyte detection system configured to measure first analyte data in a first component of a fluid sample received from a patient and measure second analyte data in a second component of a fluid sample. In some embodiments, one or more portions of an optical system is movable with respect to other portions of the system in order to optically and/or electrochemically analyze multiple components of a fluid sample. In other embodiments, optical and/or electrochemical analysis can be performed simultaneously on multiple components of a fluid sample. In some embodiments, a first analyte can be measured in a sample (e.g., whole blood) before the sample is separated into its components (e.g., plasma, red blood cells, etc.), and a second analyte can be measured in a component of the sample after separation.

Abstract translation: 提供了用于分析流体样品的多个组分的系统和方法。 在某些实施方案中，系统可以包括分析物检测系统，其被配置为测量从患者接收的流体样品的第一组分中的第一分析物数据，并测量流体样品的第二组分中的第二分析物数据。 在一些实施例中，光学系统的一个或多个部分可相对于系统的其它部分移动，以光学和/或电化学分析流体样品的多个部件。 在其它实施方案中，可以在流体样品的多个组分上同时进行光学和/或电化学分析。 在一些实施方案中，在将样品分离成其组分（例如血浆，红细胞等）之前，可以在样品（例如全血）中测量第一分析物，并且可以在组分 的样品分离后。

公开(公告)号：US20080179530A1

公开(公告)日：2008-07-31

申请号：US11929525

申请日：2007-10-30

Applicant: Xiang Liu ,  Xin Zhou ,  Alfred Feitisch ,  Gregory M. Sanger

Inventor： Xiang Liu ,  Xin Zhou ,  Alfred Feitisch ,  Gregory M. Sanger

IPC: G01N21/37

CPC classification number: G01N21/3504 ,  G01N21/274 ,  G01N21/314 ,  G01N21/39 ,  G01N2201/1215

Abstract: Concentrations of a target analyte in a gas mixture containing one or more background analytes having potentially interfering spectral absorption features can be calculated by compensating for background analyte absorption at a target wavelength used to quantify the target analyte. Absorption can be measured at a reference wavelength chosen to quantify the concentration of the background analyte. Using a background gas adjustment factor or function, the absorption measured at the reference wavelength can be used to calculate absorption due to the background analyte at the target wavelength and thereby compensate for this background absorption to more accurately calculate the target analyte concentration in real or near real time. Additional background analytes can optionally be compensated for by using one or more additional reference wavelengths.

Abstract translation: 含有具有潜在干扰光谱吸收特征的一种或多种背景分析物的气体混合物中的目标分析物的浓度可以通过补偿用于量化目标分析物的目标波长的背景分析物吸收来计算。 可以在选择的参考波长处测量吸光度，以量化背景分析物的浓度。 使用背景气体调节因子或功能，可以使用在参考波长处测量的吸收来计算由于目标波长的背景分析物引起的吸收，从而补偿该背景吸收，以更精确地计算实际或近似的目标分析物浓度 即时的。 可以通过使用一个或多个另外的参考波长来可选地补偿附加的背景分析物。

公开(公告)号：US20060052950A1

公开(公告)日：2006-03-09

申请号：US11243001

申请日：2005-10-04

Applicant: Anthony Pierry ,  David Rich

Inventor： Anthony Pierry ,  David Rich

IPC: G06F19/00 ,  G01N31/00

CPC classification number: A61B5/087 ,  A61B5/0205 ,  A61B5/083 ,  A61B2562/226 ,  G01N21/05 ,  G01N21/3504 ,  G01N33/497 ,  G01N2021/0118 ,  G01N2021/0193 ,  G01N2201/1215

Abstract: A method and apparatus for interfacing a plurality of gas measurement systems, including a mainstream and a sidestream gas measurement system, to a host system via an interface unit. The present invention also pertains to a sidestream gas measurement system that output signals emulating the signals output by a mainstream gas measurement system or portion thereof, so that the sidestream gas measurement system can seamlessly communicate with a host system configured to communicate with a mainstream gas measurement system or a portion thereof.

Abstract translation: 一种用于经由接口单元将多个气体测量系统（包括主流和侧流气体测量系统）连接到主机系统的方法和装置。 本发明还涉及一种侧流气体测量系统，其输出模拟由主流气体测量系统或其一部分输出的信号的信号，使得侧流气体测量系统可以与被配置为与主流气体测量通信的主机系统无缝地通信 系统或其一部分。

公开(公告)号：US20040174821A1

公开(公告)日：2004-09-09

申请号：US10378081

申请日：2003-03-04

Inventor： Christian Eggeling ,  Kaupo Palo ,  Nicolas Fay ,  Maciej Hoffman-Wecker ,  Pierre Ilouga

IPC: G06F011/00

CPC classification number: G01N21/6445 ,  G01N2201/1215

Abstract: The invention provides a method for identifying the impacts of interfering effects on experimental data. In particular, a method is described for identifying the impacts of unwanted auto-fluorescence, fluorescence quenching, and deterioration of a fluorescent sample under study on the collected experimental data. The data are analyzed whether or not said data fulfill certain criteria with respect to a threshold which is indicative for said interfering effect.

Abstract translation: 本发明提供了一种识别干扰效应对实验数据的影响的方法。 特别地，描述了一种用于识别不期望的自动荧光，荧光猝灭和正在研究的荧光样品的劣化对所收集的实验数据的影响的方法。 分析数据是否所述数据是否符合指示所述干扰效应的阈值的某些标准。

公开(公告)号：US5563330A

公开(公告)日：1996-10-08

申请号：US325226

申请日：1994-10-21

Applicant: Ludwig Kimmig

Inventor： Ludwig Kimmig

IPC: G01N21/3504 ,  G01N33/00 ,  G01N21/35

CPC classification number: G01N33/0037 ,  G01N21/3504 ,  G01N33/0006 ,  G01N2201/1215

Abstract: A concentration of a detector gas in a measuring gas containing an interfering gas is measured. A zero gas that is free of the detector gas and/or a test gas having a known concentration of the detector gas are supplied to an analyzer such as a non-dispersive infrared (NDIR) gas analyzer. Interfering gas is added to the measuring gas, the zero gas, and in some instances, to the test gas to an extent which allows the interfering gas to have a same concentration in each case.

Abstract translation: PCT No.PCT / DE93 / 00333 Sec。 371日期：1994年10月21日 102（e）日期1994年10月21日PCT提交1993年4月13日PCT公布。 公开号WO93 / 2151538 日期：1993年10月28日测定含有干扰气体的测量气体中检测器气体的浓度。 没有检测器气体的零气体和/或具有已知浓度的检测器气体的测试气体被提供给诸如非分散红外（NDIR）气体分析仪的分析仪。 干燥气体被添加到测量气体，零气体中，并且在一些情况下，将测试气体添加到允许干扰气体在每种情况下具有相同浓度的程度。

公开(公告)号：US3790798A

公开(公告)日：1974-02-05

申请号：US3790798D

申请日：1972-08-18

Applicant: METRO HYDRAULICS INC

Inventor： LENNINGTON J ,  STERNBERG S ,  YOUNG J

IPC: G01N21/31 ,  G01N21/35 ,  G01N21/26

CPC classification number: G01N21/314 ,  G01N21/3504 ,  G01N2201/1215

Abstract: A dual path analyzer and a single path analyzer are disclosed, each for determining the concentration of one or more gaseous components in a mixture of gases. The preferred analyzer is a single path instrument which includes a source of infrared energy, a detector for the energy, a sample cell for the gas mixture positioned between the source and detector, and a filter wheel having a plurality of filters and a source blocking device positioned between the sample cell and detector for sequentially interposing the filters and the source blocking device between the source and the detector. Means are provided for amplifying the output signal of the detector and for processing the signal to provide a direct readout display which indicates the concentration of the gaseous components being analyzed. The processing electronics preferably include provision for calibrating the analyzer with clean ambient air, for compensating for background levels of radiation, and for correcting the displayed output signal for the effects of absorption band interferences between two or more gases in the gas mixture. The structure of the dual path analyzer includes a source of infrared energy, a detector for the energy, a sample cell for the gas mixture, a cell for a reference gas, and optical path means between the source and detector for sequentially directing the source energy through the sample cell, the reference cell, and through neither cell. Processing electronics similar to the single path instrument can be incorporated to compensate for background radiation and absorption band interferences.

Abstract translation: 公开了双路径分析器和​​单路径分析器，每个用于确定气体混合物中的一种或多种气体组分的浓度。 优选的分析仪是包括红外能量源的单路仪器，用于能量的检测器，用于位于源和检测器之间的气体混合物的样品池，以及具有多个过滤器和源阻挡装置的滤光轮 位于样品池和检测器之间，用于顺序地将滤色器和源阻挡装置插入在源和检测器之间。 提供了用于放大检测器的输出信号并且用于处理信号以提供指示正在分析的气体组分的浓度的直接读出显示的装置。 处理电子器件优选地包括用于用干净的环境空气校准分析器的装置，用于补偿辐射的背景水平，以及用于校正所显示的输出信号以获得气体混合物中两种或更多种气体之间的吸收带干扰的影响。 双路径分析仪的结构包括红外能量源，能量检测器，用于气体混合物的样品池，用于参考气体的池，以及源和检测器之间的光路装置，用于顺序地引导源能量 通过样品池，参比细胞，以及两个细胞。 可以结合类似于单路仪器的处理电子线来补偿背景辐射和吸收带干扰。

公开(公告)号：US20150268095A1

公开(公告)日：2015-09-24

申请号：US14662307

申请日：2015-03-19

Applicant: Servomex Group Limited

Inventor： Richard P. Kovacich ,  Bahram Alizadeh ,  Ian C. Gaskin ,  James D. Hobby ,  Martin Lopez

IPC: G01J3/02 ,  G01N21/39

CPC classification number: G01J3/027 ,  G01J3/0297 ,  G01J3/10 ,  G01J3/433 ,  G01J2003/423 ,  G01N21/274 ,  G01N21/39 ,  G01N2021/399 ,  G01N2201/0612 ,  G01N2201/121 ,  G01N2201/1215

Abstract: A method and system for correcting the effect of intensity fluctuations of the transmitted light in an absorption spectroscopy system used for the detection or measurement of chemical species in a medium, whereby one or more modulation bursts are imposed onto a light beam that passes through the medium. This burst signal may be obtained by modulating the bias current of a tunable diode laser, and the modulation burst signal may be optimally at the second harmonic of the modulation frequency of a wavelength modulated beam to allow usage of the same signal path processing used for the spectroscopic detection of the measurand for a second harmonic detection system. The burst signal can be controlled using a smooth window function to minimise the effects of non-linear perturbations that are inherent in tunable diode laser wavelength modulation spectroscopy systems, of optical interference fringes (etalons) and of the residual light absorption by background chemical species or the measurand at the wavelength coinciding with the modulation burst.

Abstract translation: 一种用于校正用于检测或测量介质中的化学物质的吸收光谱系统中的透射光的强度波动的影响的方法和系统，由此一个或多个调制脉冲串被施加到通过介质的光束 。 可以通过调制可调谐二极管激光器的偏置电流来获得该脉冲串信号，并且调制脉冲串信号可以在波长调制波束的调制频率的二次谐波处最佳地进行，以允许使用与 用于二次谐波检测系统的被测量的光谱检测。 可以使用平滑窗函数来控制突发信号，以最小化可调谐二极管激光波长调制光谱系统固有的非线性扰动，光学干涉条纹（标准具）和背景化学物质的残余光吸收的影响， 在波长上的被测量与调制脉冲串一致。

公开(公告)号：US07606668B2

公开(公告)日：2009-10-20

申请号：US11932119

申请日：2007-10-31

Applicant: Anthony T. Pierry ,  David R. Rich

Inventor： Anthony T. Pierry ,  David R. Rich

IPC: A61B5/08

CPC classification number: A61B5/087 ,  A61B5/0205 ,  A61B5/083 ,  A61B2562/226 ,  G01N21/05 ,  G01N21/3504 ,  G01N33/497 ,  G01N2021/0118 ,  G01N2021/0193 ,  G01N2201/1215

Abstract: A method and apparatus for interfacing a plurality of volumetric measurement systems, each of which includes a gas measurement and a flow measurement system, to a host system via an interface unit.

Abstract translation: 一种用于经由接口单元将多个体积测量系统（每个体积测量系统包括气体测量和流量测量系统）连接到主机系统的方法和装置。

公开(公告)号：US20090213381A1

公开(公告)日：2009-08-27

申请号：US12112401

申请日：2008-04-30

Applicant: Dirk Appel ,  Gaston E. Marzoratti ,  Shrikrishna H. Nabar ,  Robert F. Mouradian

Inventor： Dirk Appel ,  Gaston E. Marzoratti ,  Shrikrishna H. Nabar ,  Robert F. Mouradian

IPC: G01N21/59

CPC classification number: G01N21/3504 ,  G01N21/031 ,  G01N21/274 ,  G01N2021/3133 ,  G01N2021/3174 ,  G01N2201/1215

Abstract: A gas analyzer system includes an optical source, an optical filter assembly, a controller, and an analyzer. The optical source generates an optical signal. The optical filter assembly includes different optical filters in which to filter the optical signal. During operation, the controller selects sequential application of each of the different optical filters in a path of the optical signal to modulate the optical signal using different frequency bands of optical energy. The modulated optical signal passes through an unknown sample. The optical analyzer analyzes the modulated optical signal after passing through the sample to detect which types of multiple different gases are present in the sample.

Abstract translation: 气体分析仪系统包括光源，光学滤光器组件，控制器和分析器。 光源产生光信号。 滤光器组件包括不同的滤光器，用于滤光光信号。 在操作期间，控制器选择在光信号的路径中的每个不同滤光器的顺序应用，以使用不同的光能频带调制光信号。 经调制的光信号通过未知样品。 光学分析仪在通过样品后分析调制的光信号，以检测样品中存在哪种类型的多种不同的气体。

公开(公告)号：US20080255769A1

公开(公告)日：2008-10-16

申请号：US12101890

申请日：2008-04-11

Applicant: Xin Zhou ,  Xiang Liu ,  Alfred Feitisch ,  Gregory M. Sanger

Inventor： Xin Zhou ,  Xiang Liu ,  Alfred Feitisch ,  Gregory M. Sanger

IPC: G01N31/00 ,  B01D53/02

CPC classification number: G01N21/3504 ,  G01N2021/3545 ,  G01N2021/399 ,  G01N2201/1215

Abstract: A differential absorption spectrum for a reactive gas in a gas mixture can be generated for sample absorption data by subtracting background absorption data set from the sample absorption data. The background absorption data can be characteristic of absorption characteristics of the background composition in a laser light scan range that includes a target wavelength. The differential absorption spectrum can be converted to a measured concentration of the reactive gas using calibration data. A determination can be made whether the background composition has substantially changed relative to the background absorption data, and new background absorption data can be used if the background composition has substantially changed. Related systems, apparatus, methods, and/or articles are also described.

Abstract translation: 可以通过从样品吸收数据中减去设置的背景吸收数据，为样品吸收数据产生气体混合物中的反应气体的差分吸收光谱。 背景吸收数据可以是包括目标波长的激光扫描范围中背景组合物的吸收特性的特征。 使用校准数据可以将差示吸收光谱转换为测量的反应气体浓度。 可以确定背景组合物是否相对于背景吸收数据基本上改变，并且如果背景组合物已经基本上改变，则可以使用新的背景吸收数据。 还描述了相关系统，装置，方法和/或制品。