公开(公告)号：USRE43374E1

公开(公告)日：2012-05-08

申请号：US11084870

申请日：2005-03-18

Applicant: James W. Kronberg

Inventor： James W. Kronberg

IPC: A61N1/34

CPC classification number: A61N1/36021 ,  A61N1/326 ,  A61N1/36071 ,  A61N1/36178

Abstract: An apparatus for generating an electrical signal for use in biomedical applications, including two timing blocks for generating timing intervals T1-T7, an interconnection block for combining these intervals into an output signal having predetermined relationships among the intervals, an output block for transmitting the output signal to a load, and, optionally, a filter for removing unwanted frequency components from the output signal and an adjustment block for selecting from among a plurality of output signals with predetermined characteristics. The output is a repeating succession of a burst of rectangular waves, an equalizing pulse (if needed) to cancel net DC, and a rest period of no signal.

Abstract translation: 一种用于生成用于生物医学应用的电信号的装置，包括用于产生定时间隔T1-T7的两个定时块，用于将这些间隔组合为具有间隔之间的预定关系的输出信号的互连块，用于发送输出的输出块 信号到负载，以及可选地用于从输出信号中去除不需要的频率分量的滤波器和用于从具有预定特性的多个输出信号中进行选择的调整块。 输出是矩阵波的重复序列，消除净DC的均衡脉冲（如果需要）和无信号的休止周期。

公开(公告)号：US07840272B2

公开(公告)日：2010-11-23

申请号：US11444916

申请日：2006-05-22

Applicant: James W. Kronberg ,  Timothy Ganey ,  Stephen L. Gordon

Inventor： James W. Kronberg ,  Timothy Ganey ,  Stephen L. Gordon

IPC: A61N1/00 ,  A61N1/36

CPC classification number: C12M35/02 ,  A61N1/326 ,  A61N1/40 ,  C12M21/08

Abstract: Compositions and methods are provided for modulating the growth, development and repair of bone, cartilage or other connective tissue. Devices and stimulus waveforms are provided to differentially modulate the behavior of osteoblasts, chondrocytes and other connective tissue cells to promote proliferation, differentiation, matrix formation or mineralization for in vitro or in vivo applications. Continuous-mode and pulse-burst-mode stimulation of cells with charge-balanced signals may be used. Bone, cartilage and other connective tissue growth is stimulated in part by nitric oxide release through electrical stimulation and may be modulated through co-administration of NO donors and NO synthase inhibitors. Bone, cartilage and other connective tissue growth is stimulated in part by release of BMP-2 and BMP-7 in response to electrical stimulation to promote differentiation of cells. The methods and devices described are useful in promoting repair of bone fractures, cartilage and connective tissue repair as well as for engineering tissue for transplantation.

Abstract translation: 提供组合物和方法用于调节骨，软骨或其它结缔组织的生长，发育和修复。 提供装置和刺激波形以差异调节成骨细胞，软骨细胞和其他结缔组织细胞的行为，以促进体外或体内应用的增殖，分化，基质形成或矿化。 可以使用具有电荷平衡信号的单元的连续模式和脉冲突发模式刺激。 骨骼，软骨和其他结缔组织生长部分由一氧化氮通过电刺激释放而被刺激，并且可以通过共同给予NO供体和NO合酶抑制剂来调节。 骨骼，软骨和其他结缔组织生长部分通过释放BMP-2和BMP-7而受到刺激，以响应电刺激以促进细胞分化。 描述的方法和装置可用于促进骨折，软骨和结缔组织修复以及用于移植的工程组织的修复。

公开(公告)号：US06417651B1

公开(公告)日：2002-07-09

申请号：US09847815

申请日：2001-05-02

Applicant: James W. Kronberg

Inventor： James W. Kronberg

IPC: G05F114

CPC classification number: G05F1/14

Abstract: A voltage stabilizer apparatus with digitally-controlled emulation of servotransformer operation to provide smooth voltage control. Tap-switching on both the primary and the secondary sides of a transformer allows a small number of relays to provide a large number of voltage step-up and step-down ratios. The maximum number of achievable ratios is equal to Nmax=(m*n−p+1) where m is the number of primary taps, n the number of secondary taps, and p the number of taps which are common to both sets. The taps are preferably placed at approximately logarithmic intervals along the transformer winding to provide evenly-spaced step-up and step-down ratios. Additional components may include devices for sensing under- or over-voltages, preventing unwanted cycling under load, rectifiers, arc-suppression devices, circuitry for interfacing with the user's electronic equipment, and LEDs or other indicators for providing feedback on the operational state of the apparatus.

Abstract translation: 具有伺服变压器运行的数字控制仿真的电压稳定器装置，以提供平稳的电压控制。 变压器的主侧和次侧的分接开关允许少量继电器提供大量的升压和降压比。 可达到的最大比例数等于Nmax =（m * n-p + 1）其中m是主抽头数，n次级抽头数，p是两组共同的抽头数。 抽头优选地沿变压器绕组以大约对数的间隔放置，以提供均匀间隔的升压和降压比。 附加组件可以包括用于感测欠压或过电压的装置，防止负载下的不期望的循环，整流器，灭弧装置，用于与用户电子设备接口的电路，以及用于提供对用户电子设备的操作状态的反馈的LED或其他指示器 仪器。

公开(公告)号：US06321119B1

公开(公告)日：2001-11-20

申请号：US09478103

申请日：2000-01-04

Applicant: James W. Kronberg

Inventor： James W. Kronberg

IPC: A61N108

CPC classification number: A61N1/326

Abstract: A pulsed signal generator for biomedical applications, including electrical stimulation of fracture healing, treatment of osteoporosis, strengthening of freshly-healed bone after removal of a cast or other fixation device, and iontophoresis. The generator includes dual asymmetric oscillators and associated circuitry to deliver signals efficiently throughout the area to be treated. The components of the generator are selected so as to produce any desired output signal, including fixed and variable amplitude, fixed, variable, and swept frequency signals, and optional DC biasing. The pulse frequency and/or interval can be fixed or adjustable. In a preferred embodiment of the invention, the generator is powered by readily-available, inexpensive batteries.

Abstract translation: 用于生物医学应用的脉冲信号发生器，包括骨折愈合的电刺激，骨质疏松症的治疗，去除铸造或其它固定装置之后加强新鲜愈合的骨骼以及离子电渗疗法。 该发生器包括双重非对称振荡器和相关联的电路，用于在待处理的整个区域内有效地传递信号。 选择发生器的组件以产生任何期望的输出信号，包括固定和可变幅度，固定，可变和扫频信号，以及可选的直流偏置。 脉冲频率和/或间隔可以是固定的或可调节的。 在本发明的优选实施例中，发电机由容易获得的廉价电池供电。

公开(公告)号：US5547283A

公开(公告)日：1996-08-20

申请号：US332068

申请日：1994-11-01

Applicant: James W. Kronberg

Inventor： James W. Kronberg

IPC: G01K1/14 ,  G01K11/14 ,  G01K11/12

CPC classification number: B23K37/006 ,  G01K1/14 ,  G01K11/14 ,  Y10S252/962

Abstract: An optical temperature measuring device utilizes thermochromic semiconductors which vary in color in response to changes in temperature. The thermochromic material is sealed in a glass matrix which allows the temperature sensor to detect high temperatures without breakdown. Cuprous oxide and cadmium sulfide are among the semiconductor materials which provide the best results. The changes in color may be detected visually or by utilizing an optical fiber and an electrical sensing circuit.

Abstract translation: 光学温度测量装置利用响应于温度变化而变色的热变色半导体。 热变色材料被密封在玻璃基质中，允许温度传感器检测高温而不破裂。 氧化亚铜和硫化镉是提供最佳效果的半导体材料之一。 颜色的变化可以通过视觉检测或利用光纤和电感测电路来检测。

公开(公告)号：US5431148A

公开(公告)日：1995-07-11

申请号：US240474

申请日：1994-05-10

Applicant: James W. Kronberg

Inventor： James W. Kronberg

IPC: F24J2/04 ,  F24J2/02

CPC classification number: F24J2/0461 ,  Y02E10/44

Abstract: An immersible solar heater comprising a light-absorbing panel attached to a frame for absorbing heat energy from the light and transferring the absorbed heat energy directly to the fluid in which the heater is immersed. The heater can be used to heat a swimming pool, for example, and is held in position and at a preselected angle by a system of floats, weights and tethers so that the panel can operate efficiently. A skid can be used in one embodiment to prevent lateral movement of the heater along the bottom of the pool. Alternative embodiments include different arrangements of the weights, floats and tethers and methods for making the heater.

Abstract translation: 一种浸入式太阳能加热器，其包括附接到框架的吸光板，用于从光吸收热能并将吸收的热能直接传递到加热器浸入的流体。 加热器可以用于加热游泳池，例如，通过浮子，重物和系绳系统将其保持就位并以预选的角度，使得面板可以有效地操作。 在一个实施例中可以使用防滑装置来防止加热器沿池底部的横向移动。 替代实施例包括重量，浮子和系绳的不同布置以及用于制造加热器的方法。

公开(公告)号：US5317253A

公开(公告)日：1994-05-31

申请号：US798785

申请日：1991-11-27

Applicant: James W. Kronberg

Inventor： James W. Kronberg

IPC: G01R19/155 ,  G01R19/165 ,  G01R19/00

CPC classification number: G01R19/155 ,  G01R19/16561

Abstract: An apparatus and method that combines a signal generator and a passive signal receiver to detect and record the path of partially or completely concealed electrical wiring without disturbing the concealing surface. The signal generator applies a series of electrical pulses to the selected wiring of interest. The applied pulses create a magnetic field about the wiring that can be detected by a coil contained within the signal receiver. An audible output connected to the receiver and driven by the coil reflects the receivers position with respect to the wiring. The receivers audible signal is strongest when the receiver is directly above the wiring and the long axis of the receivers coil is parallel to the wiring. A marking means is mounted on the receiver to mark the location of the wiring as the receiver is directed over the wiring's concealing surface. Numerous marks made on various locations of the concealing surface will trace the path of the wiring of interest.

Abstract translation: 一种组合信号发生器和无源信号接收器的装置和方法，用于检测和记录部分或完全隐藏的电线的路径，而不会干扰隐藏表面。 信号发生器将一系列电脉冲施加到所选择的感兴趣的布线。 施加的脉冲产生围绕线路的磁场，该磁场可由包含在信号接收器内的线圈检测。 连接到接收器并由线圈驱动的可听输出反映了接收器相对于布线的位置。 当接收器直接在布线上方时，接收器的声音信号最强，接收器线圈的长轴平行于布线。 当接收器被引导到布线的隐蔽表面上时，标记装置安装在接收器上以标记布线的位置。 在隐蔽表面的各个位置上形成的许多标记将跟踪感兴趣的布线的路径。

公开(公告)号：US5314735A

公开(公告)日：1994-05-24

申请号：US730423

申请日：1991-07-16

Applicant: James W. Kronberg

Inventor： James W. Kronberg

IPC: B32B3/12

CPC classification number: B32B3/12 ,  Y10T428/233 ,  Y10T428/234 ,  Y10T428/236 ,  Y10T428/24149 ,  Y10T428/24157 ,  Y10T428/24165 ,  Y10T428/2495 ,  Y10T428/24992 ,  Y10T428/3154 ,  Y10T442/176

Abstract: A flexible surface coating which promotes the removal of deposits as they reach the surface by preventing adhesion and crust formation. Flexible layers are attached to each side of a flexible mesh substrate comprising of a plurality of zones composed of one or more neighboring cells, each zone having a different compressibility than its adjacent zones. The substrate is composed of a mesh made of strands and open cells. The cells may be filled with foam. Studs or bearings may also be positioned in the cells to increase the variation in compressibility and thus the degree of flexing of the coating. Surface loading produces varying amounts of compression from point to point causing the coating to flex as deposits reach it, breaking up any hardening deposits before a continuous crust forms. Preferably one or more additional layers are also used, such as an outer layer of a non-stick material such as TEFLON, which may be pigmented, and an inner, adhesive layer to facilitate applying the coating to a surface.

Abstract translation: 柔性表面涂层，通过防止粘附和地壳形成，促进沉积物到达表面时的去除。 柔性层附着到柔性网状基底的每一侧，包括由一个或多个相邻细胞组成的多个区域，每个区域具有与其相邻区域不同的可压缩性。 基底由由丝束和开放细胞构成的网构成。 细胞可以填充泡沫。 螺柱或轴承也可以定位在电池中，以增加压缩性的变化，从而增加涂层的弯曲度。 表面加载产生不同数量的压缩点，导致涂层在沉积物到达时产生挠曲，在形成连续的地壳之前破坏任何硬化沉积物。 还优选地，还使用一个或多个附加层，例如可以着色的不粘材料的外层，例如TEFLON，以及内部粘合剂层，以便于将涂层施加到表面。

公开(公告)号：US5296715A

公开(公告)日：1994-03-22

申请号：US993553

申请日：1992-12-21

Applicant: James W. Kronberg

Inventor： James W. Kronberg

IPC: H04B10/00 ,  H01J40/14

CPC classification number: H04B10/802

Abstract: An optocoupler for isolating electrical signals that translates an electrical input signal linearly to an electrical output signal. The optocoupler comprises a light emitter, a light receiver, and a light transmitting medium. The light emitter, preferably a blue, silicon carbide LED, is of the type that provides linear, electro-optical conversion of electrical signals within a narrow wavelength range. Correspondingly, the light receiver, which converts light signals to electrical signals and is preferably a cadmium sulfide photoconductor, is linearly responsive to light signals within substantially the same wavelength range as the blue LED.

Abstract translation: 用于隔离电信号的光耦合器，其将电输入信号线性地转换为电输出信号。 光耦合器包括光发射器，光接收器和透光介质。 光发射器，优选蓝色碳化硅LED，是提供在窄波长范围内的电信号的线性电光转换的类型。 相应地，将光信号转换为电信号并且优选为硫化镉光电导体的光接收器对与蓝色LED基本相同的波长范围内的光信号线性地响应。

公开(公告)号：US5259382A

公开(公告)日：1993-11-09

申请号：US663518

申请日：1991-03-04

Applicant: James W. Kronberg

Inventor： James W. Kronberg

IPC: A61B5/103 ,  A61B5/00

CPC classification number: A61B5/0059 ,  A61B5/443

Abstract: A transcutaneous bilirubin detector comprising a source of light having spectral components absorbable and not absorbable by bilirubin, a handle assembly, electronic circuitry and a fiber optic bundle connecting the assembly to the light source and circuitry. Inside the assembly is a prism that receives the light from one end of the fiber optic bundle and directs it onto the skin and directs the reflected light back into the bundle. The other end of the bundle is trifucated, with one end going to the light source and the other two ends going to circuitry that determines how much light of each kind has been reflected. A relatively greater amount absorbed by the skin from the portion of the spectrum absorbable by bilirubin may indicate the presence of the illness. Preferably, two measurements are made, one on the kneecap and one on the forehead, and compared to determine the presence of bilirubin. To reduce the impact of light absorption by hemoglobin in the blood carried by the skin, pressure is applied with a plunger and spring in the handle assembly, the pressure limited by points of a button slidably carried in the assembly that are perceived by touch when the pressure applied is sufficient.

Abstract translation: 一种经皮胆红素检测器，包括具有可吸收和不被胆红素吸收的光谱成分的光源，手柄组件，电子电路和将组件连接到光源和电路的光纤束。 在组件内部是棱镜，其接收来自光纤束的一端的光并将其引导到皮肤上并将反射光引导回束。 束的另一端是三角形的，一端到达光源，另外一端到达确定每种类型的光被反射多少的电路。 由可被胆红素吸收的光谱部分吸收的皮肤相对较大的量可能表示存在疾病。 优选地，进行两次测量，一次在膝盖上，一个在前额上，并进行比较以确定胆红素的存在。 为了减少由皮肤携带的血液中的血红蛋白引起的光吸收的影响，用手柄组件中的柱塞和弹簧施加压力，该压力受到可滑动地携带在组件中的按钮的限制，该按钮被触摸感知时 施加压力就足够了。