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公开(公告)号:US20170112125A1
公开(公告)日:2017-04-27
申请号:US15282938
申请日:2016-09-30
IPC分类号: A01N25/04 , A01N25/22 , A01N43/90 , A01N43/653 , A23K20/10 , A01N47/38 , A01N43/40 , A01N43/54 , A01N25/30 , A23L33/10 , A01N53/00 , A01N47/02
CPC分类号: A01N25/04 , A01N25/22 , A01N25/30 , A01N43/40 , A01N43/54 , A01N43/653 , A01N43/90 , A01N47/02 , A01N47/38 , A01N53/00 , A23K20/10 , A23L33/10 , A23V2002/00 , A61K9/5138 , A61K9/5146 , A61K9/5161 , A61K9/5192
摘要: The invention provides a method for preparing an improved composition comprising at least one active agent and at least one solid carrier material, wherein the active agent is dispersed through the carrier material in nano-disperse form, which method comprises the steps of: (a) forming a liquid mixture comprising the active agent, the carrier material, a stabilizing agent, a first solvent for the active agent and the stabilizing agent and, a second solvent for the carrier material, and (b) drying the liquid mixture to remove the first and second solvents to obtain a substantially solvent-free nano-dispersion of the active agent with the stabilising agent in the carrier material, wherein the stabilizing agent is capable of stabilizing the active agent in the liquid mixture during drying and in a resultant liquid nano-dispersion of the improved composition.
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42.
公开(公告)号:US20120116347A1
公开(公告)日:2012-05-10
申请号:US13354659
申请日:2012-01-20
申请人: Stefan Weinert , Ajay Thukral , Paul Galley , Siva Chittajallu , Steven Bousamra , James Long
发明人: Stefan Weinert , Ajay Thukral , Paul Galley , Siva Chittajallu , Steven Bousamra , James Long
IPC分类号: A61M5/00
CPC分类号: G06F19/3456 , G06F19/00 , G16H50/50
摘要: A therapy delivery system having an open architecture and method of providing thereof are disclosed. The present invention provides a therapy dosage module having a control algorithm that can be replaced with a predefined or independently defined control algorithm. The tools necessary to create and test such control algorithms in the therapy dosage module in a simulated environment before implementing it in a live therapy system are also disclosed.
摘要翻译: 公开了具有开放结构的治疗递送系统及其提供方法。 本发明提供了具有可以用预定义或独立定义的控制算法替代的控制算法的治疗剂量模块。 还公开了在实时治疗系统中在模拟环境中创建和测试治疗剂量模块中的这种控制算法所必需的工具。
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公开(公告)号:US20100015233A1
公开(公告)日:2010-01-21
申请号:US12309295
申请日:2007-06-29
申请人: David John Duncalf , Asha Hassan Essa , Alison Jayne Foster , James Long , Steven Paul Rannard , Dong Wang
发明人: David John Duncalf , Asha Hassan Essa , Alison Jayne Foster , James Long , Steven Paul Rannard , Dong Wang
IPC分类号: A61K9/14
CPC分类号: A61K9/1617 , A01N25/04 , A61K9/10 , A61K9/1635 , A61K9/1641 , A61K9/1652 , A61K9/19 , A61K31/167 , Y02A50/411 , A01N43/54 , A01N53/00 , A01N31/16 , A01N37/18
摘要: The present invention relates to nanodisperse antiparasitics and provides a composition comprising at least one water insoluble anti-parasitic drug and a water-soluble carrier material, wherein the water-insoluble anti-parasitic drug (preferably an Artemisinin-type drug or a quinine type drug) is dispersed through the carrier material in nano-disperse form having a peak diameter of the nano-disperse form below 1000 nm. The invention further provides an aqueous dispersion of a water insoluble anti-parasitic drug and a water-soluble carrier material, wherein the anti-parasitic drug is in nano-disperse form having a peak diameter of the nano-disperse form below 1000 nm, the invention further subsists in a process for preparing an anti-parasitic composition comprising a water insoluble anti-parasitic agent and a water-soluble carrier, which comprises the steps of either: a) providing an emulsion comprising a solution of the anti-parasitic agent in a water-immiscible solvent for the same, and an aqueous solution of the carrier, or providing a mixture comprising at least one non-aqueous solvent optional water a water-soluble carrier material soluble in the mixture and a water-insoluble anti-parasitic agent soluble in the mixture, and, b) drying the emulsion (preferably by spray drying) to remove water and the water-immiscible solvent to obtain a substantially solvent-free nano-dispersion of the anti-parasitic agent in the carrier.
摘要翻译: 本发明涉及纳米分散抗寄生虫药,并且提供包含至少一种水不溶性抗寄生虫药物和水溶性载体材料的组合物,其中所述水不溶性抗寄生虫药物(优选青蒿素型药物或奎宁型药物 )以纳米分散形式的峰值直径低于1000nm的纳米分散形式分散在载体材料中。 本发明还提供了水不溶性抗寄生虫药物和水溶性载体材料的水性分散体,其中所述抗寄生虫药物为纳米分散形式,其纳米分散体形式的峰值直径低于1000nm, 本发明进一步存在于制备包含水不溶性抗寄生虫剂和水溶性载体的抗寄生物组合物的方法中,其包括以下步骤:a)提供包含抗寄生虫剂溶液的乳液 或与提供包含至少一种非水溶剂任选的水的混合物,可溶于该混合物的水溶性载体材料和水不溶性抗寄生剂 可溶于该混合物,和b)干燥乳液(优选通过喷雾干燥)以除去水和与水不混溶的溶剂,以获得基本上无溶剂的防虫剂纳米分散体 tic代理在承运人。
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公开(公告)号:US20100015229A1
公开(公告)日:2010-01-21
申请号:US12309294
申请日:2007-06-29
CPC分类号: A61K9/1617 , A01N25/04 , A61K9/10 , A61K9/1635 , A61K9/1641 , A61K9/1652 , A61K9/19 , A61K31/167 , Y02A50/411 , A01N43/54 , A01N53/00 , A01N31/16 , A01N37/18
摘要: A process for the production of a composition comprising a water-insoluble statin which comprises the steps of: a) providing a mixture comprising: i) a water-insoluble statin ii) a water soluble carrier, iii) a solvent for each of the statin and the carrier, and b) spray-drying the mixture to remove the or each solvent and obtain a substantially solvent-free nano-dispersion of the statin in the carrier.
摘要翻译: 一种制备包含水不溶性他汀类的组合物的方法,其包括以下步骤:a)提供混合物,其包括:i)不溶于水的他汀类,ii)水溶性载体,iii)每种他汀类的溶剂 和载体,以及b)喷雾干燥混合物以除去或溶解各种溶剂,并获得载体中他汀类药物基本上无溶剂的纳米分散体。
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公开(公告)号:US20100008995A1
公开(公告)日:2010-01-14
申请号:US12309343
申请日:2007-07-13
申请人: David John Duncalf , Paul Rannard , James Long , Dong Wang , Andrew James Elphick , John Staniforth , Alison Jayne Foster
发明人: David John Duncalf , Paul Rannard , James Long , Dong Wang , Andrew James Elphick , John Staniforth , Alison Jayne Foster
IPC分类号: A61K31/454 , A61K31/404 , A61K31/4196 , A61K31/421 , A61K31/403 , A61P25/06 , A61K9/14
CPC分类号: A61K9/1617 , A01N25/04 , A61K9/10 , A61K9/1635 , A61K9/1641 , A61K9/1652 , A61K9/19 , A61K31/167 , Y02A50/411 , A01N43/54 , A01N53/00 , A01N31/16 , A01N37/18
摘要: A process for the production of a composition comprising a water-insoluble triptan which comprises the steps of: a) providing a mixture comprising: i) a water-insoluble triptan, ii) a water soluble carrier, and iii) a solvent for each of the triptan and the carrier, and b) spray-drying the mixture to remove the or each solvent and obtain a substantially solvent-free nano-dispersion of the triptan in the carrier.
摘要翻译: 一种制备包含水不溶性曲坦的组合物的方法,其包括以下步骤:a)提供混合物,其包括:i)不溶于水的曲坦,ii)水溶性载体,和iii) 曲坦和载体,以及b)喷雾干燥混合物以除去或溶解各种溶剂,并获得载体中曲坦的基本上无溶剂的纳米分散体。
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公开(公告)号:US20090304806A1
公开(公告)日:2009-12-10
申请号:US12309292
申请日:2007-06-29
申请人: David John Duncalf , Andrew James Elphick , Alison Jayne Foster , James Long , Steven Paul Rannard , Dong Wang
发明人: David John Duncalf , Andrew James Elphick , Alison Jayne Foster , James Long , Steven Paul Rannard , Dong Wang
CPC分类号: A61K9/1617 , A01N25/04 , A61K9/10 , A61K9/1635 , A61K9/1641 , A61K9/1652 , A61K9/19 , A61K31/167 , Y02A50/411 , A01N43/54 , A01N53/00 , A01N31/16 , A01N37/18
摘要: A process for the production of a composition comprising a water-insoluble sartan which comprises the steps of: a) providing a mixture comprising: i) a water-insoluble sartan, ii) a water soluble carrier, iii) a solvent for each of the sartan and the carrier, and b) spray-drying the mixture to remove the or each solvent and obtain a substantially solvent-free nano-dispersion of the sartan in the carrier.
摘要翻译: 一种制备包含水不溶性沙丁胺的组合物的方法,其包括以下步骤:a)提供混合物,其包含:i)不溶于水的沙坦,ii)水溶性载体,iii) 沙坦和载体,以及b)喷雾干燥该混合物以除去或各种溶剂,并获得载体中沙丁烷的基本上无溶剂的纳米分散体。
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47.
公开(公告)号:US07577749B1
公开(公告)日:2009-08-18
申请号:US11294905
申请日:2005-12-05
申请人: James Long
发明人: James Long
CPC分类号: H04L67/14 , H04L67/02 , H04L67/145
摘要: Systems and methods for emulating a persistent connection using, for example, hypertext transfer protocol (HTTP) transactions over a transmission control protocol (TCP) connection. The persistent connection is maintained by adjusting content length values in HTTP requests and/or HTTP responses. The content length values are associated with methods such as GET and POST actions. The values of the content length are determined in order to keep the connection open for an estimated period of time. Prior to expiration of the time period, a new HTTP request or response is sent in order to keep the connection open for an additional period. If the connection is prematurely closed, the estimated time period is reduced and/or the content length value can be increased. A network conditions detector determines characteristics of the network such as bandwidth for use when determining the estimated time period and the content length value.
摘要翻译: 通过传输控制协议(TCP)连接使用例如超文本传输协议(HTTP)事务来模拟持久连接的系统和方法。 通过调整HTTP请求和/或HTTP响应中的内容长度值来维护持久连接。 内容长度值与GET和POST操作等方法相关联。 确定内容长度的值以便在预计的时间段内保持连接打开。 在该时间段到期之前,发送一个新的HTTP请求或响应,以使连接打开一段时间。 如果连接过早关闭,则估计的时间段减少和/或可以增加内容长度值。 网络条件检测器确定网络的特性,例如在确定估计时间段和内容长度值时使用的带宽。
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48.
公开(公告)号:US20090005728A1
公开(公告)日:2009-01-01
申请号:US12121199
申请日:2008-05-15
申请人: Stefan Weinert , Ajay Thukral , Paul Galley , Siva Chittajallu , Steven Bousamra , James Long
发明人: Stefan Weinert , Ajay Thukral , Paul Galley , Siva Chittajallu , Steven Bousamra , James Long
IPC分类号: A61M5/14
CPC分类号: G06F19/3456 , G06F19/00 , G16H50/50
摘要: A therapy delivery system having an open architecture and method of providing thereof are disclosed. The present invention provides a therapy dosage module having a control algorithm that can be replaced with a predefined or independently defined control algorithm. The tools necessary to create and test such control algorithms in the therapy dosage module in a simulated environment before implementing it in a live therapy system are also disclosed.
摘要翻译: 公开了具有开放结构的治疗递送系统及其提供方法。 本发明提供了具有可以用预定义或独立定义的控制算法替代的控制算法的治疗剂量模块。 还公开了在实时治疗系统中在模拟环境中创建和测试治疗剂量模块中的这种控制算法所必需的工具。
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公开(公告)号:US20080004416A1
公开(公告)日:2008-01-03
申请号:US11852435
申请日:2007-09-10
申请人: Klein Rodrigues , James Long
发明人: Klein Rodrigues , James Long
CPC分类号: C08F220/04 , C03C25/28 , C03C25/40 , C08L33/14 , C08L43/04 , C08L2666/04 , C09J133/04 , Y10T428/2964
摘要: A glass adhesion composition containing a copolymer having an acid and a substituted amide, silanol, or amine oxide functionality. The substituted amide, silanol, or amine oxide functionality provide excellent adhesion of the copolymer to glass, silica, sand and other silicon-based substances. The copolymer is useful as a fiberglass binder, and also useful in providing protective coatings on glass sheets. A fiberglass sizing composition is also provided having a copolymer that includes at least one acid group derived from at least one acid monomer, a hydrophobic comonomer, and a crosslinker. Additives can be added to the compositions to provide other functionality such as corrosion inhibitors, hydrophobic additives, additives for reducing leaching of glass, release agents, acids for lowering pH, anti-oxidants/reducing agents, emulsifiers, dyes, pigments, oils, fillers, colorants, curing agents, anti-migration aids, biocides, plasticizers, waxes, anti-foaming agents, coupling agents, thermal stabilizers, flame retardants, enzymes, wetting agents, and lubricants.
摘要翻译: 含有具有酸和取代酰胺,硅烷醇或胺氧化物官能团的共聚物的玻璃粘合组合物。 取代的酰胺,硅烷醇或胺氧化物官能团提供了共聚物对玻璃,二氧化硅,沙子和其它硅基物质的极好的粘附性。 共聚物可用作玻璃纤维粘合剂,也可用于在玻璃板上提供保护涂层。 还提供了具有包含至少一种衍生自至少一种酸单体,疏水性共聚单体和交联剂的酸基的共聚物的玻璃纤维上胶组合物。 可以向组合物中加入添加剂以提供其它功能,例如腐蚀抑制剂,疏水添加剂,用于减少玻璃浸出的添加剂,脱模剂,用于降低pH的酸,抗氧化剂/还原剂,乳化剂,染料,颜料,油,填料 ,着色剂,固化剂,抗迁移助剂,杀生物剂,增塑剂,蜡,消泡剂,偶联剂,热稳定剂,阻燃剂,酶,润湿剂和润滑剂。
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公开(公告)号:US20070123075A1
公开(公告)日:2007-05-31
申请号:US11598536
申请日:2006-11-13
申请人: Robert Insalaco , James Long
发明人: Robert Insalaco , James Long
IPC分类号: H01R25/00
CPC分类号: H02G3/0437 , H01R13/6633 , H01R25/16 , H01R25/161 , H02G3/0493 , H02G3/34 , H02G3/381 , H02G3/388
摘要: Remote duplex receptacle systems (1600, 16001) are used with power poles (1622), walls, floors or the like. One receptacle system (1600) includes a junction box (1602) with a conduit (1608) and patch cord (1614) extending therefrom. The system (1600) is programmable using a wand (892) to effect control relationships between the system (1600) and controlling devices (967).
摘要翻译: 远程双工插座系统(1600,1600< 1>)与电源极(1622),墙壁,地板等一起使用。 一个插座系统(1600)包括具有从其延伸的导管(1608)和跳线(1614)的接线盒(1602)。 系统(1600)可使用棒(892)来编程,以实现系统(1600)和控制设备(967)之间的控制关系。
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