公开(公告)号：US20090035863A1

公开(公告)日：2009-02-05

申请号：US12081999

申请日：2008-04-24

申请人： Tadashi Takahashi ,  Yasuji Koyama

发明人： Tadashi Takahashi ,  Yasuji Koyama

IPC分类号： C12N15/80 ,  C12N1/15

CPC分类号： C12N15/80

摘要： In order to efficiently delete a large chromosomal region with a length of from several tens to hundreds kb such as a cluster of biosynthesis genes encoding a toxic substance such as Aflatoxin, the present invention provides a method for the deletion of a large chromosomal region comprising transforming a transformant having an increased frequency of homologous recombination due to suppression of a Ku gene, which is a mitosporic filamentous fungus belonging to Trichocomaceae with a vector for the deletion of a chromosomal region, which comprises a pair of homologous region arms having a nucleotide sequence that is homologous with a fragment at either end of said chromosomal region, and deleting the chromosomal region by means of homologous recombination between the resulting transformant and said vector.

摘要翻译： 为了有效地删除长度为几十到几百kb的大染色体区域，例如编码毒性物质如黄曲霉毒素的生物合成基因簇，本发明提供了一种删除大染色体区域的方法，包括转化 由于抑制Ku基因而具有增加的同源重组频率的转化体，该Ku基因是具有用于缺失染色体区域的载体的属于三齿科的丝裂霉丝状真菌，其包含一对具有核苷酸序列的同源区域臂， 与所述染色体区域的任一端的片段同源，并通过所得转化体和所述载体之间的同源重组来删除染色体区域。

公开(公告)号：US20070274290A1

公开(公告)日：2007-11-29

申请号：US11751158

申请日：2007-05-21

申请人： Tadashi Takahashi ,  Hiroaki Miyata ,  Takashi Yokoyama ,  Masanori Kamata

发明人： Tadashi Takahashi ,  Hiroaki Miyata ,  Takashi Yokoyama ,  Masanori Kamata

IPC分类号： H04L12/28

CPC分类号： H04L12/4625 ,  H04L49/35 ,  H04L63/0236

摘要： A packet forwarding apparatus with a function of registering packet forwarding control information for each user terminal into a user management table during PPPoE connection and authentication phases in which the apparatus carries out predetermined communication procedures with each user terminal. During DHCP and IP forwarding phases following the authentication phase, the packet forwarding apparatus controls packet forwarding based on the user management table. Packets are forwarded in the form of PPPoE frame until the authentication phase is completed and packets are forwarded in the form of Ethernet frame in the DHCP and IP forwarding phases.

摘要翻译： 一种分组转发装置，其功能是在每个用户终端执行预定的通信过程的PPPoE连接和认证阶段期间，将每个用户终端的分组转发控制信息注册到用户管理表中。 在验证阶段之后的DHCP和IP转发阶段，报文转发装置根据用户管理表控制报文转发。 分组以PPPoE帧的形式转发，直到认证阶段完成，并在DHCP和IP转发阶段以以太网帧的形式转发数据包。

公开(公告)号：US06951750B2

公开(公告)日：2005-10-04

申请号：US10325939

申请日：2002-12-23

申请人： Kotaro Ito ,  Takeharu Nakahara ,  Yasuji Koyama ,  Toshifumi Matsuda ,  Tadashi Takahashi ,  Kenichiro Matsushima ,  Genryou Umitsuki ,  Tsutomu Masuda

发明人： Kotaro Ito ,  Takeharu Nakahara ,  Yasuji Koyama ,  Toshifumi Matsuda ,  Tadashi Takahashi ,  Kenichiro Matsushima ,  Genryou Umitsuki ,  Tsutomu Masuda

IPC分类号： C12N15/09 ,  C12N1/15 ,  C12N1/19 ,  C12N1/21 ,  C12N5/10 ,  C12N9/48 ,  C12N9/62 ,  C12N15/57

CPC分类号： C12Y304/13009 ,  C12N9/48

摘要： Provided are a protein comprising the amino acid sequence as shown in SEQ ID NO: 2 and having prolidase activities, a prolidase gene coding for the protein, a prolidase gene comprising the nucleotide sequence as shown in SEQ ID NO: 1, recombinant DNA having the gene inserted into vector DNA, and a transformant or transductant comprising the recombinant DNA, and a method for producing prolidase using the transformant or transductant.The present invention can improve the prolidase through protein engineering. The present invention can be also used for improving microorganisms used in the production of enzymes for food processing and fermented foods.

摘要翻译： 提供了包含SEQ ID NO：2所示的氨基酸序列并具有唾液酸酶活性的蛋白质，编码该蛋白质的脯氨酶基因，包含SEQ ID NO：1所示的核苷酸序列的唾液酸酶基因，具有SEQ ID NO： 插入到载体DNA中的基因，以及包含重组DNA的转化体或转导体，以及使用转化体或转导体产生唾液酸酶的方法。 本发明可以通过蛋白质工程改善脯氨酸酶。 本发明还可以用于改善用于食品加工和发酵食品酶生产的微生物。

公开(公告)号：US06690409B1

公开(公告)日：2004-02-10

申请号：US09396374

申请日：1999-09-15

申请人： Tadashi Takahashi

发明人： Tadashi Takahashi

IPC分类号： H04N718

CPC分类号： H04N7/183

摘要： In an electronic endoscope system, a flexible scope has a solid image sensor provided at a distal end thereof, to generate image-pixel signals. A proximal end of the scope is detachably connected to a video-signal processing unit, which produces a video signal based on the image-pixel signals. A monitor reproduces an image in accordance with the video signal. A displaying-size changer changes a size of a displaying-area of the image on a screen of the monitor to another size and vice versa. A pointer-image generator generates a pointer image on the monitor screen. A pointer-image controller controls a shifting of the pointer image on the monitor screen, and includes a pointer-image-position converter that converts a position of the pointer image on the monitor screen in accordance with the size-change of the displaying-area of the image on the monitor screen, such that two positions, indicated by the pointer image on the two-sized displaying-areas, correspond to each other.

摘要翻译： 在电子内窥镜系统中，柔性镜具有设置在其远端的实心图像传感器，以产生图像像素信号。 示波器的近端可拆卸地连接到视频信号处理单元，该视频信号处理单元基于图像像素信号产生视频信号。 监视器根据视频信号再现图像。 显示尺寸改变器将监视器的屏幕上的图像的显示区域的大小改变为另一尺寸，反之亦然。 指针图像生成器在监视器屏幕上生成指针图像。 指针图像控制器控制指示器图像在监视器屏幕上的偏移，并且包括指针图像位置转换器，其根据显示区域的尺寸变化而在监视器屏幕上转换指针图像的位置 ，使得由两个尺寸的显示区域上的指针图像指示的两个位置彼此对应。

公开(公告)号：US06544597B2

公开(公告)日：2003-04-08

申请号：US09884845

申请日：2001-06-19

申请人： Tadashi Takahashi ,  Seiya Kunioka ,  Kenji Miyai

发明人： Tadashi Takahashi ,  Seiya Kunioka ,  Kenji Miyai

IPC分类号： C23C412

CPC分类号： C23C4/16 ,  C23C4/08 ,  C23C4/12

摘要： A mixed powder thermal spraying method includes forming a mixed thermal spraying film comprising two kinds of materials having different melting points wherein powder-feeding points are provided for each material; and each powder-feeding port is controlled respectively to externally feed each material, and wherein the thermal powder spraying method is bore thermal spraying carried out with a bent plasma jet.

摘要翻译： 混合粉末热喷涂方法包括形成具有不同熔点的两种材料的混合热喷涂膜，其中为每种材料提供粉末供给点; 每个粉末供给口被分别控制在外部供给每种材料，其中热粉末喷涂方法是用弯曲的等离子体射流进行的内部热喷涂。

公开(公告)号：US06524236B2

公开(公告)日：2003-02-25

申请号：US09867433

申请日：2001-05-31

申请人： Ryoji Honda ,  Makoto Takada ,  Tadashi Takahashi

发明人： Ryoji Honda ,  Makoto Takada ,  Tadashi Takahashi

IPC分类号： A61B1045

CPC分类号： G01J1/08 ,  A61B1/045 ,  A61B1/0638 ,  A61B1/0669 ,  A61B1/07 ,  G01J1/04 ,  G01J1/0437 ,  G01J1/044 ,  G01J1/0492 ,  G02B23/2461 ,  G02B26/02 ,  H04N5/2354 ,  H04N2005/2255

摘要： A device for controlling an amount of light of a lighting unit for use in an endoscope that is used to view an image of an object. A light shielding system shields light generated by a light source and transmitted to the endoscope and a stepping motor drives the light shielding system for a plurality of predetermined time intervals. A system detects a brightness of the image during each of the plurality of predetermined time intervals and an input system inputs one of a plurality of desired brightnesses of the image. A generating system generates a predetermined number of pulses during each of the plurality of predetermined time intervals, the predetermined number of pulses being transmitted to the stepping motor and a system determines an angular position of the light shielding system. A setting system sets one of a plurality of allowed brightness ranges of the image in response to the determined angular position of the light shielding system and a system determines whether the detected brightness is within the set one of the plurality of allowed brightness ranges.

摘要翻译： 一种用于控制用于观察物体的图像的内窥镜中使用的照明单元的光量的装置。 遮光系统屏蔽由光源产生的光并传输到内窥镜，并且步进电机以多个预定时间间隔驱动遮光系统。 系统在多个预定时间间隔的每一个期间检测图像的亮度，并且输入系统输入图像的多个期望亮度中的一个。 生成系统在多个预定时间间隔的每一个期间产生预定数量的脉冲，预定数量的脉冲被发送到步进电机，并且系统确定遮光系统的角度位置。 设置系统响应于所确定的遮光系统的角度位置来设置图像的多个允许的亮度范围中的一个，并且系统确定检测到的亮度是否在多个允许的亮度范围的设定的一个之内。

公开(公告)号：US06414710B1

公开(公告)日：2002-07-02

申请号：US09337338

申请日：1999-06-21

申请人： Tadashi Takahashi ,  Ryo Ozawa

发明人： Tadashi Takahashi ,  Ryo Ozawa

IPC分类号： A61B106

CPC分类号： H04N7/183 ,  A61B1/05

摘要： In an electronic endoscope, a flexible scope has an image sensor provided at a distal end thereof, and an optical light guide extending therethrough. The scope is detachably connectable, at a proximal end thereof, to a processing unit, which processes image-pixel signals successively read from the image sensor. A light source is provided in the processing unit such that light, emitted from the light source, is guided through the guide and radiates from the distal end of the scope. An aperture-stop is associated with the source that regulates the radiation of light from the distal end of the scope. A histogram generator generates a luminance-signal-histogram based on the processed signals. An average luminance level-value is approximately calculated based on luminance signals exhibiting thinned luminance levels extracted from the histogram. The aperture-stop is controlled in accordance with the approximate average luminance level-value, such that an image having a constant brightness level is reproduced based on the processed signals.

摘要翻译： 在电子内窥镜中，柔性镜具有设置在其远端的图像传感器和延伸穿过其中的光学光导。 该范围在其近端可拆卸地连接到处理单元，其处理从图像传感器连续读取的图像像素信号。 在处理单元中提供光源，使得从光源发射的光被引导通过引导件并从示波器的远端辐射。 孔径光阑与调节来自示波器远端的光的辐射源相关联。 直方图生成器基于经处理的信号生成亮度信号直方图。 基于从直方图提取的表现出减薄的亮度水平的亮度信号近似地计算平均亮度水平值。 根据近似平均亮度水平值控制孔径光阑，使得基于处理的信号再现具有恒定亮度水平的图像。

公开(公告)号：US06381152B1

公开(公告)日：2002-04-30

申请号：US09651722

申请日：2000-08-30

申请人： Tadashi Takahashi ,  Kenichi Onda ,  Norikazu Tokunaga ,  Takeshi Onaka ,  Ryouhei Saga ,  Katsunori Hayashi

发明人： Tadashi Takahashi ,  Kenichi Onda ,  Norikazu Tokunaga ,  Takeshi Onaka ,  Ryouhei Saga ,  Katsunori Hayashi

IPC分类号： H02M3335

CPC分类号： H02H7/1206 ,  H02H7/1213 ,  H02H11/003 ,  H02M3/33576 ,  H03K17/166

摘要： A power supply apparatus includes a semiconductor switching device for outputting power and a control circuit for controlling the on/off operation of the semiconductor switching device. The control circuit includes a circuit for applying, when turning on the semiconductor switching device, a first control signal corresponding to the difference between the output voltage of the power supply apparatus and a first reference value to the semiconductor switching device in accordance with the increase in the output voltage from the power supply apparatus thereby to operate the semiconductor switching device in a non-saturated area, so that the semiconductor switching device is turned on gradually.

摘要翻译： 电源装置包括用于输出电力的半导体开关装置和用于控制半导体开关装置的接通/断开操作的控制电路。 控制电路包括电路，当将半导体开关器件接通时，根据电源供应器的增加将与电源装置的输出电压之间的差与第一基准值相对应的第一控制信号作用于半导体开关器件， 来自电源装置的输出电压从而在非饱和区域中操作半导体开关装置，使得半导体开关装置逐渐接通。

公开(公告)号：US06338780B2

公开(公告)日：2002-01-15

申请号：US09756210

申请日：2001-01-09

申请人： Tadashi Takahashi ,  Yukio Aoike ,  Tatsuo Hirayama

发明人： Tadashi Takahashi ,  Yukio Aoike ,  Tatsuo Hirayama

IPC分类号： C30B3002

CPC分类号： C25F7/00 ,  B21C37/047 ,  Y10T428/12333 ,  Y10T428/12424 ,  Y10T428/12431 ,  Y10T428/12444 ,  Y10T428/12465 ,  Y10T428/12486 ,  Y10T428/1259

摘要： A method of manufacturing a metallic fiber in which from a convergent extended wire, which is formed by a metallic fiber and a matrix member which is formed of a metallic material and whose dissolvability is higher than the dissolvability of the metallic fiber, the matrix member is continuously dissolved and removed by an electrolytic processing in a plurality of electrolytic tanks which are arranged in the conveying direction of the convergent extended wire, wherein: the convergent extended wire is passed through electrolytes in the plurality of electrolytic tanks, which are arranged in the shape of a gentle convex arch at the vertical direction upper side which includes the conveying passage of the convergent extended wire, the convergent extended wire is passed above a plurality of feeding devices which are provided at the outer sides of the electrolytes and which are disposed in the same arch-shape so as to correspond to the electrolytic tanks, in each of the plurality of electrolytic tanks, the metallic fiber is maintained in one of a cathode reduction area and a passivation area, or alternatively, anode current is maintained at a predetermined potential which is closer to 0, and the matrix member is anode-electrolyzed. At this time, a method of manufacturing the twine of metallic fibers, further including the step of: intertwining the convergent extended member in the unit of two to four before the electrolytic processing, while the convergent extended member is formed by a forming device in a spiral shape whose diameter is larger than the diameter of a closely-intertwined twine.

摘要翻译： 一种金属纤维的制造方法，其特征在于，从由金属纤维形成的会聚延长线和由金属材料形成的矩阵构件，其溶解性高于金属纤维的溶解性的金属纤维的矩阵构件为 通过在会聚延长线的输送方向上配置的多个电解槽中的电解处理连续地溶解除去，其中：会聚延长线穿过多个电解槽中的电解质，其形状为 在包括会聚延长线的输送通道的垂直方向上侧具有平缓的凸拱，收敛的延伸线在设置在电解质外侧的多个供给装置的上方通过， 相同的拱形，以便在多个电解中的每一个中对应于电解槽 金属纤维保持在阴极还原区域和钝化区域中的一个中，或者，阳极电流保持在更接近0的预定电位，并且基体元件被阳极电解。 此时，制造金属纤维线的方法，还包括以下步骤：在电解处理之前将会聚延伸构件缠绕在二至四单位之间，而会聚延伸构件由成形装置形成在 螺旋形的直径大于紧密缠绕的麻绳的直径。

公开(公告)号：US06322497B1

公开(公告)日：2001-11-27

申请号：US09471380

申请日：1999-12-23

申请人： Tadashi Takahashi

发明人： Tadashi Takahashi

IPC分类号： A61B1045

CPC分类号： G06T11/60 ,  A61B1/00009 ,  A61B1/00039 ,  A61B1/0005

摘要： An electronic endoscope of the present invention includes a video-scope having an image sensor, a video-processor, to which a proximal end of the video-scope and a monitor are respectively connected, a character and mark generation controller, and an area-image changer. The character and mark generation controller generates character signals and indicator-mark signals, and then feeds the character signals and the indicator-mark signals to the monitor. The image-area changer changes a size of an image-area of the object image displayed on the screen of the monitor to another size, thus the object image is selectively displayed within one of plural image-areas on the screen in accordance with a size change of the image-area. The characters and mark generation controller includes a display-position adjuster that determines display-positions of the character information and the indicator-mark on the basis of a reference table, in which a correspondence relationship between each of the image-area and each of the display-positions of the character information and the indicator-mark is indicated.

摘要翻译： 本发明的电子内窥镜包括具有图像传感器，视频处理器的视频范围，视频范围的近端和监视器分别连接到该视频处理器，字符和标记产生控制器， 图像更换器 字符和标记产生控制器产生字符信号和指示标记信号，然后将字符信号和指示标记信号馈送到监视器。 图像区域更换器将显示在监视器的屏幕上的对象图像的图像区域的尺寸改变为另一尺寸，从而根据尺寸在屏幕上的多个图像区域中的一个中选择性地显示对象图像 更改图像区域。 字符和标记生成控制器包括显示位置调整器，其基于参考表确定字符信息和指示符标记的显示位置，其中每个图像区域和每个图像区域之间的对应关系 指示字符信息和指示符标记的显示位置。