公开(公告)号：US20140221325A1

公开(公告)日：2014-08-07

申请号：US14168688

申请日：2014-01-30

Applicant: Meso Scale Technologies, LLC

Inventor： Eli N. Glezer ,  John Kenten ,  Galina Nikolenko

IPC: G01N33/68 ,  A61M1/36 ,  A61M1/16 ,  A61M1/34

CPC classification number: G01N33/6893 ,  G01N2800/347 ,  G01N2800/52

Abstract: The present invention relates to methods of diagnosing glomerulonephritis (GN) in a patient, as well as methods of monitoring the progression of GN and/or methods of monitoring a treatment protocol of a therapeutic agent or a therapeutic regimen. The invention also relates to assay methods used in connection with the diagnostic methods described herein.

Abstract translation: 本发明涉及诊断患者的肾小球肾炎（GN）的方法以及监测GN进展的方法和/或监测治疗剂或治疗方案的治疗方案的方法。 本发明还涉及结合本文所述的诊断方法使用的测定方法。

公开(公告)号：US12216331B2

公开(公告)日：2025-02-04

申请号：US18596909

申请日：2024-03-06

Applicant: MESO SCALE TECHNOLOGIES, LLC.

Inventor： Ian D. Chamberlin ,  Charles M. Clinton ,  Eli N. Glezer ,  Bandele Jeffrey-Coker ,  Manish Kochar ,  Sandor Kovacs ,  D. T. Le ,  Aaron Leimkuehler ,  George Sigal ,  Leo Tabakin ,  Jon Willoughby

IPC: G02B7/36 ,  G01N21/25 ,  G01N21/64 ,  G01N35/02

Abstract: Apparatuses, systems, method, reagents, and kits for conducting assays as well as process for their preparation are described. They are particularly well suited for conducting automated analysis in a multi-well plate assay format.

公开(公告)号：US20240361322A1

公开(公告)日：2024-10-31

申请号：US18538543

申请日：2023-12-13

Applicant: Meso Scale Technologies, LLC.

Inventor： Anahit Aghvanyan ,  Eli N. Glezer ,  John Kenten ,  Sudeep Kumar ,  Galina Nikolenko ,  Martin Stengelin

IPC: G01N33/574 ,  A61K39/395

CPC classification number: G01N33/57423 ,  A61K39/39533

Abstract: The present invention relates to methods of diagnosing lung cancer in a patient, as well as methods of monitoring the progression of lung cancer and/or methods of monitoring a treatment protocol of a therapeutic agent or a therapeutic regimen. The invention also relates to assay methods used in connection with the diagnostic methods described herein.

公开(公告)号：US11940385B2

公开(公告)日：2024-03-26

申请号：US16270062

申请日：2019-02-07

Applicant: MESO SCALE TECHNOLOGIES, LLC.

Inventor： Charles M. Clinton ,  Eli N. Glezer ,  Sharon West ,  George Sigal ,  Carl Stevens ,  Michael L. Vock

IPC: G01N35/00 ,  G01N21/69 ,  G01N21/76 ,  G01N35/02 ,  G01N35/04 ,  G01N35/10

CPC classification number: G01N21/76 ,  G01N21/69 ,  G01N35/0092 ,  G01N35/028 ,  G01N2035/00524 ,  G01N2035/0425 ,  G01N35/1079 ,  Y10T436/114165

Abstract: We describe apparatuses, systems, method, reagents, and kits for conducting assays as well as process for their preparation. They are particularly well suited for conducting automated sampling, sample preparation, and analysis in a multi-well plate assay format. For example, they may be used for automated analysis of particulates in air and/or liquid samples derived therefrom in environmental monitoring.

公开(公告)号：US11600373B2

公开(公告)日：2023-03-07

申请号：US16555271

申请日：2019-08-29

Applicant: MESO SCALE TECHNOLOGIES, LLC ,  THE HENRY M. JACKSON FOUNDATION FOR THE ADVANCEMENT OF MILITARY MEDICINE, INC.

Inventor： William F. Blakely ,  Eli N. Glezer ,  John Kenten ,  Sudeep Kumar ,  Anu Mathew ,  Natalia I. Ossetrova ,  George Sigal

IPC: G01N33/566 ,  G01N33/569 ,  G01N33/68 ,  G16H20/40 ,  G01T1/02 ,  G01T1/00 ,  G01N27/327 ,  G01N35/00

Abstract: The present invention relates to methods and kits to assess an absorbed dose of ionizing radiation and/or the severity of tissue injury from radiation in a patient. The invention also relates to algorithms used to calculate an absorbed dose of radiation based on biomarker measurements of a plurality of biomarkers that are altered relative to a normal control in the event of radiation exposure.

公开(公告)号：US11525825B2

公开(公告)日：2022-12-13

申请号：US16564208

申请日：2019-09-09

Applicant: MESO SCALE TECHNOLOGIES, LLC.

Inventor： Anahit Aghvanyan ,  Eli N. Glezer ,  John Kenten ,  George Sigal ,  Martin Stengelin ,  David Routenberg

IPC: C12Q1/6832 ,  C12Q1/6837 ,  C12Q1/6844 ,  G01N33/543

Abstract: The present invention is directed to kits for improving assay specificity and performance in binding assays.

公开(公告)号：US20220196638A1

公开(公告)日：2022-06-23

申请号：US17563249

申请日：2021-12-28

Applicant: Meso Scale Technologies, LLC.

Inventor： Ian Chamberlin ,  Charles M. Clinton ,  Eli N. Glezer ,  Bandele Jeffrey-Coker ,  Manish Kochar ,  Sandor Kovacs ,  DT Le ,  Aaron Leimkuehler ,  Greg Pinckney ,  Kristian Roth ,  George Sigal ,  Fei Yin

IPC: G01N33/53 ,  B01L3/00 ,  G01N21/64 ,  G01N33/543 ,  G01N33/569

Abstract: We describe apparatuses, method, reagents, and kits for conducting assays as well as process for their preparation. They are particularly well suited for conducting automated sampling, sample preparation, and analysis in a multi-well plate assay format. For example, they may be used for automated analysis of liquid samples in a clinical point of care setting.

公开(公告)号：US11315662B2

公开(公告)日：2022-04-26

申请号：US16594301

申请日：2019-10-07

Applicant: Meso Scale Technologies, LLC.

Inventor： Charles M. Clinton ,  Xinri Cong ,  Eli N. Glezer ,  Sudeep Kumar ,  Carl Stevens ,  Michael Vock ,  Jon S. Willoughby

IPC: G01N35/00 ,  G16C20/20 ,  G01N33/543 ,  B01L3/00 ,  G16H10/40 ,  G01N33/53

Abstract: The present invention relates to methods, devices and systems for associating assay information with an assay consumable used in a biological assay. Provided are assay systems and associated consumables, wherein the assay system includes a reader adapted to read/erase/write information from/to an assay consumable identifier associated with the assay consumable. Various types of assay information are described, as well as methods of using such information in the conduct of an assay by an assay system.

公开(公告)号：US11300571B2

公开(公告)日：2022-04-12

申请号：US16420724

申请日：2019-05-23

Applicant: Meso Scale Technologies, LLC

Inventor： Charles M. Clinton ,  Eli N. Glezer ,  Bandele Jeffrey-Coker ,  Sandor L. Kovacs ,  Sudeep M. Kumar ,  George Sigal ,  Carl Stevens ,  Michael Vock

IPC: B01L3/00 ,  G01N35/02 ,  G01N33/58 ,  B67B7/00 ,  G01N35/10 ,  G01N21/64 ,  G01N21/66 ,  G01N33/53 ,  G01N35/04

Abstract: We describe apparatuses, systems, method, reagents, and kits for conducting assays as well as process for their preparation. They are particularly well suited for conducting automated sampling, sample preparation, and analysis in a multi-well plate assay format. For example, they may be used for automated analysis of particulates in air and/or liquid samples derived therefrom in environmental monitoring.

公开(公告)号：US20210402390A1

公开(公告)日：2021-12-30

申请号：US17476880

申请日：2021-09-16

Applicant: Meso Scale Technologies, LLC.

Inventor： Eli N. Glezer ,  Sudeep Kumar ,  Pankaj Oberoi ,  George Sigal ,  Michael Tsionsky

IPC: B01L3/00 ,  C12Q1/6876 ,  G01N33/543 ,  C12Q1/6816 ,  C12Q1/6804 ,  G01N33/68

Abstract: The invention relates to methods for conducting solid-phase binding assays. One example is an assay method having improved analyte specificity where specificity is limited by the presence of non-specific binding interactions.