中科微点-全球专利检索

  1. Login
  2. Sign Up

Search Results

90 records (took 0.028 seconds)

    Prevention of tumors with monoclonal antibodies against neu
    42.
    发明授权
    Prevention of tumors with monoclonal antibodies against neu 失效
    使用针对neu的单克隆抗体预防肿瘤

    公开(公告)号：US06733752B1

    公开(公告)日：2004-05-11

    申请号：US08525800

    申请日：1995-11-20

    Applicant: Mark I. Greene ,  Makoto Katsumato

    Inventor： Mark I. Greene ,  Makoto Katsumato

    IPC: A61K39395

    CPC classification number: C07K16/32 ,  A61K38/00 ,  A61K2039/505

    Abstract: Prevention of transformation of a normal cell into a tumour cell in an individual at risk of developing a tumour having tumours which have p185 on their surfaces comprises: (a) identifying the individual and (b) administering to the individual an antibody which specifically binds to p185. Also claimed is a method of preventing transformation of a normal cell into a tumour cell that has p185 on its surface in an individual who has had a tumour that has p185 on its cell surfaces removed or who has had a cancer characterised by tumour cells that have p185 on their surfaces enter remission, comprising (a) identifying the individual and (b) administering to the individual an antibody which specifically binds to p185.

    Abstract translation: 预防将正常细胞转化到患有肿瘤的个体的肿瘤细胞中，所述肿瘤细胞具有在其表面上具有p185的肿瘤的肿瘤，其包括：（a）鉴定个体和（b）向个体施用特异性结合 p185。 还要求保护的是防止正常细胞转化成肿瘤细胞的方法，该肿瘤细胞在其表面上具有在其细胞表面上具有p185的肿瘤的个体的表面上具有p185或具有肿瘤细胞特征的癌症的肿瘤细胞 其表面上的p185进入缓解，包括（a）鉴定个体和（b）向个体施用特异性结合p185的抗体。

    Compounds that bind to p185 and methods of using the same
    44.
    发明授权
    Compounds that bind to p185 and methods of using the same 失效

    公开(公告)号：US5919764A

    公开(公告)日：1999-07-06

    申请号：US922048

    申请日：1997-09-02

    Applicant: Mark I. Greene ,  Xin Zhang

    Inventor： Mark I. Greene ,  Xin Zhang

    IPC: A61K38/00 ,  C07K7/08 ,  A61K38/03 ,  C07K4/00

    CPC classification number: C07K7/08 ,  A61K38/00

    Abstract: Novels peptides and pharmaceutical compositions comprising the same are disclosed. Conjugated compositions peptides linked to detectable agents and/or cytotoxic agents. are disclosed. Method of detecting tumors that have p185 on tumor cell surfaces are disclosed. Methods of preventing transformation of a normal cell into a tumor cell in an individual at risk of developing a tumor having tumor cells which have p185 on their surfaces are disclosed. Methods of treating an individual who has cancer characterized by tumor cells that have a p185 on their cell surfaces are disclosed.

    Saccular collagen and compositions and methods for making and using the same
    45.
    发明授权
    Saccular collagen and compositions and methods for making and using the same 失效
    囊状胶原及其制备和使用方法

    公开(公告)号：US5891850A

    公开(公告)日：1999-04-06

    申请号：US999336

    申请日：1997-12-29

    Applicant: Mark I. Greene ,  James G. Davis

    Inventor： Mark I. Greene ,  James G. Davis

    IPC: A61K38/00 ,  C07K14/78 ,  G03C1/047 ,  A61K38/39 ,  C07K14/47 ,  C07K16/00

    CPC classification number: C07K14/78 ,  A01K2217/05 ,  A61K38/00 ,  G03C1/047

    Abstract: A substantially purified saccular collagen protein and compositions, including pharmaceutical compositions, that comprise the saccular collagen protein are disclosed. Methods of using the saccular collagen which comprise injecting the saccular collagen into the tissue of an individual are disclosed. Antibodies which bind to the saccular collagen protein, nucleic acid molecules which encode the saccular collagen protein, and oligonucleotides which are identical or complementary to at least a portion of the sequence that encodes the saccular collagen proteins are disclosed. Recombinant expression vector that comprise nucleic acid molecules that encode the saccular collagen protein and host cells, including the cells of transgenic animals, which comprise the recombinant expression vectors are disclosed.

    Abstract translation: 公开了包含囊状胶原蛋白的基本上纯化的囊状胶原蛋白和包括药物组合物的组合物。 公开了将包括将囊状胶原注射到个体组织中的囊状胶原蛋白的使用方法。 公开了与囊状胶原蛋白结合的抗体，编码囊状胶原蛋白的核酸分子和与编码囊状胶原蛋白的序列的至少一部分相同或互补的寡核苷酸。 公开了包含编码囊状胶原蛋白和包含重组表达载体的转基因动物细胞的宿主细胞的核酸分子的重组表达载体。

    Treatment of tumors with monoclonal antibodies against oncogene antigens
    46.
    发明授权
    Treatment of tumors with monoclonal antibodies against oncogene antigens 失效
    用针对癌基因抗原的单克隆抗体治疗肿瘤

    公开(公告)号：US5824311A

    公开(公告)日：1998-10-20

    申请号：US347019

    申请日：1994-11-30

    Applicant: Mark I. Greene ,  Jeffrey A. Drebin

    Inventor： Mark I. Greene ,  Jeffrey A. Drebin

    IPC: A61K38/00 ,  C07K16/32 ,  C07K16/30 ,  C07K16/28

    CPC classification number: C07K16/32 ,  A61K38/00

    Abstract: A method of treating certain mammalian tumors with monoclonal antibodies is provided. Monoclonal antibodies specific to distinct epitopes of p185, the translation production of the neu oncongene, are provided, and these are then contacted with the tumor antigen under conditions which allow binding of the antibodies to a degree sufficient to inhibit tumor growth. The monoclonal antibodies act synergistically thus enhancing their anti-tumorigenic effect upon the tumor. An injectable composition for treating certain mammalian tumors with monoclonal antibodies and methods for diagnosing mammalian cancer tumors which express the protein p185 on the surface of the cells are also disclosed.

    Abstract translation: 提供了用单克隆抗体治疗某些哺乳动物肿瘤的方法。 提供了对p185的不同表位特异性的单克隆抗体，即neu oncongene的翻译生产，然后在允许抗体结合足够抑制肿瘤生长的程度的条件下将其与肿瘤抗原接触。 单克隆抗体协同作用，从而增强其对肿瘤的抗致瘤作用。 还公开了用单克隆抗体治疗某些哺乳动物肿瘤的可注射组合物和用于诊断在细胞表面上表达蛋白质p185的哺乳动物癌症肿瘤的方法。

Patent Agency Ranking