公开(公告)号：US20100292920A1

公开(公告)日：2010-11-18

申请号：US12834580

申请日：2010-07-12

Applicant: Matthew D. Pierce ,  Matthew Rabinowitz

Inventor： Matthew D. Pierce ,  Matthew Rabinowitz

IPC: G01C21/00

CPC classification number: G01S5/0036 ,  A63F2300/205 ,  G01C21/206 ,  G01S5/0054 ,  G01S5/0081 ,  G01S5/021 ,  G01S5/0215 ,  G01S5/0221 ,  G01S5/14 ,  G01S5/145 ,  G01S19/46 ,  H04N21/25841 ,  H04N21/2662 ,  H04N21/2668 ,  H04N21/41422 ,  H04N21/615 ,  H04N21/8126

Abstract: A service depends on the location of a device. The device location is determined using DTV signals. More specifically, the device location is determined based on pseudo-ranges between the device and a plurality of digital television (DTV) transmitters and the pseudo-ranges are determined based on broadcast DTV signals received by the device from the DTV transmitters. Examples of DTV signals include the American Television Standards Committee (ATSC) signals, the European Telecommunications Standards Institute Digital Video Broadcasting-Terrestrial (DVB-T) signals and the Japanese Integrated Service Digital Broadcasting-Terrestrial (ISDB-T) signals.

Abstract translation: 服务取决于设备的位置。 设备位置使用DTV信号确定。 更具体地，基于设备和多个数字电视（DTV）发射机之间的伪距来确定设备位置，并且基于由设备从DTV发射机接收的广播DTV信号来确定伪距离。 DTV信号的示例包括美国电视标准委员会（ATSC）信号，欧洲电信标准协会数字视频广播地面（DVB-T）信号和日本综合业务数字广播地面（ISDB-T）信号。

公开(公告)号：US07463195B2

公开(公告)日：2008-12-09

申请号：US10159478

申请日：2002-05-31

Applicant: Matthew Rabinowitz ,  James J. Spilker, Jr.

Inventor： Matthew Rabinowitz ,  James J. Spilker, Jr.

IPC: G01S3/02

CPC classification number: G01S19/46 ,  A63F2300/205 ,  G01S5/0036 ,  G01S5/0054 ,  G01S5/0081 ,  G01S5/02 ,  G01S5/021 ,  G01S5/0215 ,  G01S5/0221 ,  G01S5/14 ,  G01S5/145 ,  G01S19/05 ,  G01S19/11 ,  G01S19/254 ,  G01S19/256 ,  G01S19/258 ,  H04N21/25841 ,  H04N21/2668 ,  H04N21/41422 ,  H04N21/615 ,  H04N21/8126

Abstract: A method, apparatus, and computer-readable media for determining the position of a user terminal comprises receiving at the user terminal a broadcast television signal from a television signal transmitter; determining a first pseudo-range between the user terminal and the television signal transmitter based on a known component of the broadcast television signal; receiving at the user terminal a global positioning signal from a global positioning satellite; determining a second pseudo-range between the user terminal and the global positioning satellite based on the global positioning signal; and determining a position of the user terminal based on the first and second pseudo-ranges, a location of the television signal transmitter, and a location of the global positioning satellite.

Abstract translation: 一种用于确定用户终端的位置的方法，装置和计算机可读介质包括在用户终端接收来自电视信号发射机的广播电视信号; 基于所述广播电视信号的已知分量，确定所述用户终端和所述电视信号发射机之间的第一伪距; 在用户终端接收来自全球定位卫星的全球定位信号; 基于全球定位信号确定用户终端和全球定位卫星之间的第二伪距; 以及基于第一和第二伪距，电视信号发射机的位置和全球定位卫星的位置来确定用户终端的位置。

公开(公告)号：US20070184467A1

公开(公告)日：2007-08-09

申请号：US11603406

申请日：2006-11-22

Applicant: Matthew Rabinowitz ,  Milena Banjevic ,  Zachary Demko ,  David Johnson

Inventor： Matthew Rabinowitz ,  Milena Banjevic ,  Zachary Demko ,  David Johnson

IPC: C12Q1/68 ,  G06F19/00

CPC classification number: G06F19/20 ,  G06F19/18

Abstract: A system and method for determining the genetic data for one or a small set of cells, or from fragmentary DNA, where a limited quantity of genetic data is available. Genetic data for the target individual is acquired and amplified using known methods, and poorly measured base pairs, missing alleles and missing regions are reconstructed using expected similarities between the target genome and the genome of genetically related subjects. In accordance with one embodiment of the invention, incomplete genetic data from an embryonic cell is reconstructed using the more complete genetic data from a larger sample of diploid cells from one or both parents, with or without genetic data from haploid cells from one or both parents, and/or genetic data taken from other related individuals. In accordance with another embodiment of the invention, incomplete genetic data from a fetus is acquired from fetal cells, or cell-free fetal DNA isolated from the mother's blood, and the incomplete genetic data is reconstructed using the more complete genetic data from a larger sample diploid cells from one or both parents, with or without genetic data from haploid cells from one or both parents, and/or genetic data taken from other related individuals. In one embodiment, the genetic data can be reconstructed for the purposes of making phenotypic predictions. In another embodiment, the genetic data can be used to detect for aneuploides and uniparental disomy.

Abstract translation: 用于确定有限数量的遗传数据可用的一个或一小组细胞或来自片段DNA的遗传数据的系统和方法。 使用已知方法获取和扩增目标个体的遗传数据，并且使用目标基因组与基因相关受试者的基因组之间的预期相似性重建差测量的碱基对，缺失的等位基因和缺失区域。 根据本发明的一个实施方案，使用来自一个或两个亲本的二倍体细胞的较大样本的更完整的遗传数据重建来自胚胎细胞的不完整遗传数据，具有或不具有来自一个或两个亲本的单倍体细胞的遗传数据 ，和/或从其他相关个体获取的遗传数据。 根据本发明的另一个实施方案，从胎儿细胞或从母体血液中分离的无细胞胎儿DNA获得来自胎儿的不完整遗传数据，并且使用来自较大样本的更完整的遗传数据重建不完全遗传数据 来自一个或两个父母的二倍体细胞，具有或不具有来自一个或两个亲本的单倍体细胞的遗传数据和/或从其他相关个体获取的遗传数据。 在一个实施方案中，为了进行表型预测的目的，可以重建遗传数据。 在另一个实施方案中，遗传数据可以用于检测非整倍体和单亲二倍体。

公开(公告)号：US20070178501A1

公开(公告)日：2007-08-02

申请号：US11634550

申请日：2006-12-06

Applicant: Matthew Rabinowitz ,  Jonathan Sheena ,  Zachary Demko ,  Christopher Clark ,  Nigam Shah

Inventor： Matthew Rabinowitz ,  Jonathan Sheena ,  Zachary Demko ,  Christopher Clark ,  Nigam Shah

IPC: C12Q1/68 ,  G06F19/00 ,  G06Q50/00

CPC classification number: G06Q50/22 ,  G06Q50/24

Abstract: The system described herein enables clinicians and researchers to use aggregated genetic and phenotypic data from clinical trials and medical records to make the safest, most effective treatment decisions for each patient. This involves (i) the creation of a standardized ontology for genetic, phenotypic, clinical, pharmacokinetic, pharmacodynamic and other data sets, (ii) the creation of a translation engine to integrate heterogeneous data sets into a database using the standardized ontology, and (iii) the development of statistical methods to perform data validation and outcome prediction with the integrated data. The system is designed to interface with patient electronic medical records (EMRs) in hospitals and laboratories to extract a particular patient's relevant data. The system may also be used in the context of generating phenotypic predictions and enhanced medical laboratory reports for treating clinicians. The system may also be used in the context of leveraging the huge amount of data created in medical and pharmaceutical clinical trials. The ontology and validation rules are designed to be flexible so as to accommodate a disparate set of clients. The system is also designed to be flexible so that it can change to accommodate scientific progress and remain optimally configured.

Abstract translation: 本文描述的系统使临床医师和研究人员能够使用来自临床试验和医疗记录的综合遗传和表型数据，为每位患者做出最安全，最有效的治疗决定。 这涉及（i）为遗传，表型，临床，药代动力学，药效学和其他数据集创建标准化本体，（ii）创建翻译引擎以将异构数据集合集成到使用标准化本体的数据库中，以及（ iii）开发统计方法，使用综合数据进行数据验证和结果预测。 该系统旨在与医院和实验室中的患者电子病历（EMR）进行接口，以提取特定患者的相关数据。 该系统也可用于产生表型预测和增强的用于治疗临床医师的医学实验室报告。 该系统也可以在利用在医疗和药物临床试验中创造的大量数据的背景下使用。 本体和验证规则被设计为灵活的，以容纳不同的客户端集合。 该系统还被设计为灵活的，以便它可以改变以适应科学进步并保持最佳配置。

公开(公告)号：US20070131079A1

公开(公告)日：2007-06-14

申请号：US11554765

申请日：2006-10-31

Applicant: Guttorm Opshaug ,  David Burgess ,  George Flammer ,  Scott Furman ,  Andy Lee ,  Matthew Rabinowitz ,  Harvind Samra

Inventor： Guttorm Opshaug ,  David Burgess ,  George Flammer ,  Scott Furman ,  Andy Lee ,  Matthew Rabinowitz ,  Harvind Samra

IPC: G10H3/18

CPC classification number: G01S11/02 ,  G01S5/0263 ,  G01S5/12

Abstract: Apparatus having corresponding methods and computer-readable media comprises a receiver to receive a wireless stereo frequency-modulation (FM) signal comprising a plurality of spectral signal components including a first tone and one or more frequency bands; one or more tone generators each to generate a respective second tone based on a respective one of the frequency bands; a plurality of phase circuits each to measure a phase of a respective one of the first and second tones; and a difference element to determine a phase difference between two of the phases.

Abstract translation: 具有相应方法和计算机可读介质的装置包括：接收器，用于接收包括包括第一音调和一个或多个频带的多个频谱信号分量的无线立体声调频（FM）信号; 一个或多个音调发生器，每个音调发生器基于相应的一个频带产生相应的第二音调; 多个相位电路，各自测量第一和第二音调中的相应一个的相位; 以及差分元件，以确定两相之间的相位差。

公开(公告)号：US06753812B2

公开(公告)日：2004-06-22

申请号：US10209578

申请日：2002-07-31

Applicant: Matthew Rabinowitz ,  James J. Spilker, Jr.

Inventor： Matthew Rabinowitz ,  James J. Spilker, Jr.

IPC: G01S302

CPC classification number: G01C21/206 ,  A63F2300/205 ,  G01S5/0036 ,  G01S5/0054 ,  G01S5/0081 ,  G01S5/02 ,  G01S5/0205 ,  G01S5/021 ,  G01S5/0215 ,  G01S5/0221 ,  G01S5/0226 ,  G01S5/145 ,  G01S19/46 ,  H04N21/25841 ,  H04N21/2662 ,  H04N21/2668 ,  H04N21/41422 ,  H04N21/615 ,  H04N21/8126

Abstract: A computer program product, apparatus, and method for use in determining the position of a user terminal includes receiving at the user terminal a digital television (DTV) broadcast signal transmitted by a DTV transmitter; tracking a periodic component of the DTV signal using a delay-lock loop (DLL), including selecting an observation interval based on the timing of the periodic component, and turning on a portion of the DLL during the observation interval, and turning the portion off otherwise; and determining a pseudo-range between the user terminal and the DTV transmitter based on the DTV broadcast signal; and wherein the position of the user terminal is determined based on the pseudo-range and a location of the DTV transmitter.

Abstract translation: 用于确定用户终端的位置的计算机程序产品，装置和方法包括在用户终端处接收由DTV发送器发送的数字电视（DTV）广播信号; 使用延迟锁定循环（DLL）跟踪DTV信号的周期分量，包括基于周期性分量的定时选择观察间隔，以及在观察间隔期间打开DLL的一部分，并且将部分关闭 除此以外; 以及基于所述DTV广播信号确定所述用户终端和所述DTV发射机之间的伪距离; 并且其中，基于所述DTV发射机的伪距和位置确定所述用户终端的位置。

公开(公告)号：US06717547B2

公开(公告)日：2004-04-06

申请号：US10232142

申请日：2002-08-29

Applicant: James J. Spilker, Jr. ,  Jimmy K. Omura ,  Matthew Rabinowitz

Inventor： James J. Spilker, Jr. ,  Jimmy K. Omura ,  Matthew Rabinowitz

IPC: G01S302

CPC classification number: G01S19/46 ,  A63F2300/205 ,  G01S5/0036 ,  G01S5/0054 ,  G01S5/0081 ,  G01S5/021 ,  G01S5/0215 ,  G01S5/0221 ,  G01S5/0226 ,  G01S5/0236 ,  G01S5/0268 ,  G01S5/14 ,  G01S5/145 ,  G01S19/09 ,  G01S19/10 ,  H04N21/25841 ,  H04N21/2668 ,  H04N21/41422 ,  H04N21/615 ,  H04N21/8126

Abstract: A method, apparatus, and computer-readable media for determining the position of a user terminal comprises receiving at the user terminal a broadcast television signal from a television signal transmitter; determining a first pseudo-range between the user terminal and the television signal transmitter based on a known component of the broadcast television signal; receiving at the user terminal a mobile telephone signal from a mobile telephone base station; determining a second pseudo-range between the user terminal and the mobile telephone base station based on a known component of the mobile telephone signal; and determining a position of the user terminal based on the first and second pseudo-ranges, a location of the television signal transmitter, and a location of the mobile telephone base station.

Abstract translation: 一种用于确定用户终端的位置的方法，装置和计算机可读介质包括在用户终端接收来自电视信号发射机的广播电视信号; 基于所述广播电视信号的已知分量，确定所述用户终端和所述电视信号发射机之间的第一伪距; 在用户终端接收来自移动电话基站的移动电话信号; 基于所述移动电话信号的已知组件确定所述用户终端与所述移动电话基站之间的第二伪距; 以及基于第一和第二伪距，电视信号发射机的位置和移动电话基站的位置来确定用户终端的位置。

公开(公告)号：US08825412B2

公开(公告)日：2014-09-02

申请号：US13110685

申请日：2011-05-18

Applicant: Matthew Rabinowitz ,  George Gemelos ,  Milena Banjevic ,  Allison Ryan ,  Zachary Demko ,  Matthew Hill ,  Bernhard Zimmermann ,  Johan Baner

Inventor： Matthew Rabinowitz ,  George Gemelos ,  Milena Banjevic ,  Allison Ryan ,  Zachary Demko ,  Matthew Hill ,  Bernhard Zimmermann ,  Johan Baner

IPC: G01N33/48 ,  G06F19/00 ,  G01N31/00 ,  G06G7/48 ,  G06G7/58 ,  G06F19/12 ,  C12Q1/68

CPC classification number: C12Q1/6883 ,  C12Q1/6827 ,  C12Q1/6869 ,  C12Q2537/161 ,  C12Q2537/165 ,  C12Q2600/112 ,  C12Q2600/156 ,  C12Q2600/16 ,  C12Q2600/172 ,  G06F19/00 ,  G06F19/12 ,  G06F19/18 ,  G06F19/22 ,  G06F19/34 ,  G16H50/30

Abstract: Methods for non-invasive prenatal ploidy calling are disclosed herein. Methods for determining the ploidy status of a chromosome in a gestating fetus from genotypic data measured from a sample of DNA from the mother of the fetus and from the fetus, and from genotypic data from the mother and optionally also from the father are disclosed herein. The ploidy state is determined by using a joint distribution model to create a set of expected allele distributions for different possible fetal ploidy states given the parental genotypic data, and comparing the expected allelic distributions to the pattern of measured allelic distributions measured in the mixed sample, and choosing the ploidy state whose expected allelic distribution pattern most closely matches the observed allelic distribution pattern. In an embodiment, the mixed sample of DNA may be preferentially enriched at a plurality of polymorphic loci in a way that minimizes the allelic bias.

Abstract translation: 本文公开了非侵入性产前倍性呼叫的方法。 本文公开了从胎儿母体和胎儿的DNA样本以及来自母亲和任选也来自父亲的基因型数据测量的基因型数据中确定妊娠胎儿染色体倍性状态的方法。 通过使用联合分布模型来确定给定父母基因型数据的不同可能胎儿倍性状态的一组预期等位基因分布，并将预期等位基因分布与在混合样品中测量的测量等位基因分布的模式进行比较来确定倍性状态， 并选择其预期等位基因分布模式与观察到的等位基因分布模式最接近的倍性状态。 在一个实施方案中，DNA的混合样品可以以使等位基因偏倚最小化的方式优先富集在多个多态位点。

公开(公告)号：US08754807B2

公开(公告)日：2014-06-17

申请号：US12741346

申请日：2009-06-02

Applicant: Ju-Yong Do ,  Guttorm Opshaug ,  James J. Spilker, Jr. ,  Matthew Rabinowitz

Inventor： Ju-Yong Do ,  Guttorm Opshaug ,  James J. Spilker, Jr. ,  Matthew Rabinowitz

IPC: G01S19/46 ,  G01S19/38

CPC classification number: H04W64/00 ,  H04W64/003 ,  H04W84/045

Abstract: Apparatus having corresponding methods and tangible computer-readable media comprise: a measurement module adapted to generate measurements of a wireless television signal received by the apparatus and measurements of a wireless satellite positioning signal received by the apparatus; a location module adapted to determine a location of the apparatus based on the measurements of the wireless television signal and the measurements of the wireless satellite positioning signal; and a time module adapted to provide a clock control signal for the apparatus based on at least one of the measurements of the wireless television signal, and the measurements of the wireless satellite positioning signal.

Abstract translation: 具有相应方法和有形计算机可读介质的装置包括：测量模块，其适于产生由所述装置接收的无线电视信号的测量值和由所述装置接收的无线卫星定位信号的测量值; 位置模块，其适于基于所述无线电视信号的测量结果和所述无线卫星定位信号的测量来确定所述设备的位置; 以及时间模块，其适于基于所述无线电视信号的所述测量中的至少一个以及所述无线卫星定位信号的测量来为所述装置提供时钟控制信号。

公开(公告)号：US08682341B1

公开(公告)日：2014-03-25

申请号：US11865881

申请日：2007-10-02

Applicant: Guttorm Opshaug ,  Matthew Rabinowitz ,  Scott Furman

Inventor： Guttorm Opshaug ,  Matthew Rabinowitz ,  Scott Furman

IPC: H04W24/00

CPC classification number: H04W64/00 ,  G01S5/10

Abstract: Apparatus having corresponding methods and computer-readable media comprise: an input module adapted to receive a plurality of pseudoranges each determined by a receiver based on one of a plurality of wireless single-frequency network (SFN) signals transmitted at a predetermined frequency from a corresponding plurality of transmitters; and a transmitter identification module adapted to identify one of the transmitters for each of the pseudoranges based on the pseudoranges and a plurality of ranges each predetermined between one of the transmitters and one of a plurality of predetermined geographic locations.

Abstract translation: 具有相应方法和计算机可读介质的装置包括：输入模块，适于接收由接收机基于从预定频率从相应的发射的多个无线单频网络（SFN）信号中的一个信号确定的多个伪距 多个发射机; 以及发射机识别模块，其适于基于所述伪距识别每个所述伪距并识别所述发射机之一，以及在所述发射机之一和所述多个预定地理位置中的一个之间预定的多个范围。