公开(公告)号：US20050065167A1

公开(公告)日：2005-03-24

申请号：US10950542

申请日：2004-09-24

申请人： Nan Zhang ,  Semiramis Ayral-Kaloustian

发明人： Nan Zhang ,  Semiramis Ayral-Kaloustian

IPC分类号： A61K31/519 ,  A61P35/00 ,  C07D487/02 ,  C07D487/04

CPC分类号： C07D487/04

摘要： This invention relates to certain 6-aryl-7-halo-imidazo[1,2-a]pyrimidines or pharmaceutically acceptable salts thereof, and compositions containing said compounds or pharmaceutically acceptable salts thereof, wherein said compounds are anti-cancer agents useful for the treatment of cancer in mammals by promotion of microtubule polymerization. This invention further relates to a method of treating or inhibiting the growth of cancerous tumor cells and associated diseases in a mammal and further provides a method for the treatment or prevention of cancerous tumors that express multiple drug resistance (MDR) or are resistant because of MDR, in a mammal in need thereof which method comprises administering to said mammal an effective amount of said compounds or pharmaceutically acceptable salts thereof.

摘要翻译： 本发明涉及某些6-芳基-7-卤代咪唑并[1,2-a]嘧啶或其药学上可接受的盐，以及含有所述化合物或其药学上可接受的盐的组合物，其中所述化合物是可用于 通过促进微管聚合治疗哺乳动物的癌症。 本发明还涉及治疗或抑制哺乳动物中癌性肿瘤细胞和相关疾病的生长的方法，并进一步提供了治疗或预防表达多重耐药性（MDR）或耐多药耐药性的癌性肿瘤的方法 在有需要的哺乳动物中，所述方法包括向所述哺乳动物施用有效量的所述化合物或其药学上可接受的盐。

公开(公告)号：US06689772B1

公开(公告)日：2004-02-10

申请号：US10318213

申请日：2002-12-12

申请人： Diane Harris Boschelli ,  Yanong Wang ,  Frank Charles Boschelli ,  Dan Maarten Berger ,  Nan Zhang ,  Dennis William Powell ,  Fei Ye ,  Ayako Yamashita ,  Frenel Fils DeMorin ,  Biqi Wu ,  Hwei-Ru Tsou ,  Elsebe Geraldine Overbeek-Klumpers ,  Allan Wissner

发明人： Diane Harris Boschelli ,  Yanong Wang ,  Frank Charles Boschelli ,  Dan Maarten Berger ,  Nan Zhang ,  Dennis William Powell ,  Fei Ye ,  Ayako Yamashita ,  Frenel Fils DeMorin ,  Biqi Wu ,  Hwei-Ru Tsou ,  Elsebe Geraldine Overbeek-Klumpers ,  Allan Wissner

IPC分类号： A61K3133

CPC分类号： C07D401/04 ,  C07D215/54 ,  C07D401/06 ,  C07D401/12 ,  C07D401/14 ,  C07D405/04 ,  C07D405/12 ,  C07D405/14 ,  C07D409/04 ,  C07D409/12 ,  C07D409/14

摘要： This invention provides compounds of Formula (I), having the structure where T, Z, X, A, R1, R2a, R2b, R2c, R3, R4, and n are defined herein, or a pharmaceutically acceptable salt thereof which are useful as antineoplastic agents and in the treatment of osteoporosis and polycystic kidney disease.

摘要翻译： 本发明提供式（I）化合物，其具有其中T，Z，X，A，R 1，R 2a，R 2b，R 2c，R 3，R 4， 和n在本文中定义，或其药学上可接受的盐，其可用作抗肿瘤剂并用于治疗骨质疏松症和多囊肾病。

公开(公告)号：US06526197B2

公开(公告)日：2003-02-25

申请号：US09829212

申请日：2001-04-09

申请人： Nan Zhang

发明人： Nan Zhang

IPC分类号： G02B626

CPC分类号： G02B6/3518

摘要： An optical switch formed on a substrate with receiving channels defined by alignment grooves formed in the substrate that are offset from alignment grooves that form the inputting channels. The offset receiving channels reduce the output power differentiation from an optical switch in which there is no offset.

摘要翻译： 一种形成在基板上的光学开关，其具有由形成在基板中的对准槽限定的接收通道，该对准槽与形成输入通道的对准槽偏移。 偏移接收通道减少与没有偏移的光开关的输出功率微分。

公开(公告)号：US06469361B2

公开(公告)日：2002-10-22

申请号：US09946390

申请日：2001-09-04

申请人： Nan Zhang

发明人： Nan Zhang

IPC分类号： H01L2900

CPC分类号： H01L21/32139 ,  G03F7/095 ,  G03F7/16 ,  H01L21/0274 ,  H01L21/31144

摘要： Techniques for etching a wafer layer using multiple layers of the same photoresistant material and structures formed using such techniques are provided. In a method, first, multiple layers of the same photoresist material are formed over the wafer layer to form a composite photoresist layer. The composite photoresist layer is patterned and developed to form a patterned photoresist layer. Exposed portions of the wafer layer are then removed using the pattern photoresist layer. Each of the multiple layers of photoresist may, for example, be formed to a maximum rated thickness for the photoresist material. Structures formed using this process may have relatively small dimensions (e.g., widths of 5 microns or less or a spacing or pitch of 5 microns or less). In addition, structures may also have sidewalls which are relatively long, smooth, and/or vertical.

摘要翻译： 提供了使用相同光致抗蚀剂材料的多层蚀刻晶片层的技术和使用这些技术形成的结构。 在一种方法中，首先在晶片层上形成多层相同的光致抗蚀剂材料以形成复合光致抗蚀剂层。 将复合光致抗蚀剂层图案化并显影以形成图案化的光致抗蚀剂层。 然后使用图案光致抗蚀剂层去除晶片层的暴露部分。 例如，可以将多层光致抗蚀剂中的每一层形成为光致抗蚀剂材料的最大额定厚度。 使用该方法形成的结构可以具有相对小的尺寸（例如，5微米或更小的宽度或5微米或更小的间距或间距）。 此外，结构还可以具有相对长，平滑和/或垂直的侧壁。

公开(公告)号：US06229640B1

公开(公告)日：2001-05-08

申请号：US09372265

申请日：1999-08-11

申请人： Nan Zhang

发明人： Nan Zhang

IPC分类号： G02B2600

CPC分类号： G02B6/357 ,  B81B2201/033 ,  B81B2201/045 ,  B81C1/00182 ,  B81C2201/0109 ,  B81C2203/0136 ,  G02B6/3514 ,  G02B6/3518 ,  G02B6/3544 ,  G02B6/3584 ,  H02N1/008

摘要： A MEMS-based optical switch having improved characteristics and methods for manufacturing the same are provided. In accordance with one embodiment, an optical switch includes a single comb drive actuator having a deflecting beam structure and a mirror coupled to the actuator. The mirror is capable of being moved between an extended position interposed between waveguide channels and a retracted position apart from the waveguide channels. The actuator applies a force capable of deflecting the beam structure and moving the mirror to one of the extended positions or the retracted position and the beam structure returns the mirror to the other of the extended position or the retracted position in the absence of the application of force.

摘要翻译： 提供了具有改进的特性的MEMS基光开关及其制造方法。 根据一个实施例，光学开关包括具有偏转梁结构的单个梳状驱动致动器和耦合到致动器的反射镜。 镜子能够在介于波导通道之间的延伸位置与离开波导通道的缩回位置之间移动。 致动器施加能够使梁结构偏转并且将反射镜移动到延伸位置或缩回位置中的一个的力，并且梁结构在没有应用的情况下将反射镜返回到延伸位置或缩回位置中的另一个 力。

公开(公告)号：US5908840A

公开(公告)日：1999-06-01

申请号：US965217

申请日：1997-11-06

申请人： Michael P. Trova ,  Nan Zhang

发明人： Michael P. Trova ,  Nan Zhang

IPC分类号： C07D471/04 ,  A61K31/505 ,  A61K31/55

CPC分类号： C07D471/04

摘要： This invention provides a compound having the formula: ##STR1## wherein: (A) n=2-4;(B) R.sub.1 and R.sub.2 are the same or different and selected from the group consisting of H, (C.sub.1 -C.sub.3) alkyl, --CH.sub.2 CH.sub.2 OH, --CH.sub.2 CH.sub.2 NH.sub.2, and --CH.sub.2 CH.sub.2 N(CH.sub.3).sub.2 or R.sub.1 and R.sub.2 are alkyl moieties which are taken together to form a 4- to 7- membered ring;(C) R.sub.3 is selected from the group consisting of H, --CH.sub.3, --CH.sub.2 CH.sub.3, and --CH.sub.2 CH.sub.2 NH.sub.2 ;(D) Y is a heterocyclic radical having 5-14 atoms, located at the 2- or 3- position of the pyridoquinazolinone nucleus, in which 1-3 of the heterocyclic ring atoms are independently nitrogen, oxygen, or sulfur; wherein Y may be optionally mono-, di-, or tri- substituted with --OR.sub.4, --NR.sub.5 R.sub.6, --CO.sub.2 H, --CO.sub.2 R.sub.4, or phenyl;R.sub.4 is H or (C.sub.1 -C.sub. 4) straight-chain alkyl;R.sub.5 and R.sub.6 are the same or different and are selected from the group consisting of H, (C.sub.1 -C.sub.4) straight-chain alkyl, --CH.sub.2 CH.sub.2 OH, --CH.sub.2 CH.sub.2 NH.sub.2, and --CH.sub.2 CH.sub.2 N(CH.sub.3).sub.2 or R.sub.5 and R.sub.6 are alkyl moieties which are taken together to form a 4-7 membered ring;or a pharmaceutically acceptable salt thereof which is useful as an antineoplastic agent.

摘要翻译： 本发明提供具有下式的化合物：其中：（A）n = 2-4; （B）R 1和R 2相同或不同，选自H，（C 1 -C 3）烷基，-CH 2 CH 2 OH，-CH 2 CH 2 NH 2和-CH 2 CH 2 N（CH 3）2或R 1和R 2为被取代的烷基部分 一起形成4-至7-元环; （C）R 3选自H，-CH 3，-CH 2 CH 3和-CH 2 CH 2 NH 2; （D）Y是位于吡啶并喹啉酮核的2-或3-位的具有5-14个原子的杂环基，其中1-3个杂环环原子独立地是氮，氧或硫; 其中Y可任选被-OR 4，-NR 5 R 6，-CO 2 H，-CO 2 R 4或苯基单，二或三取代; R4是H或（C1-C4）直链烷基; R5和R6相同或不同，选自H，（C1-C4）直链烷基，-CH2CH2OH，-CH2CH2NH2和-CH2CH2N（CH3）2或R5和R6是烷基部分，它们是 一起形成4-7元环; 或其药学上可接受的盐，其可用作抗肿瘤剂。

公开(公告)号：US09091771B2

公开(公告)日：2015-07-28

申请号：US13539915

申请日：2012-07-02

申请人： Debora Henseler ,  Ronald Grazioso ,  Nan Zhang ,  Matthias J. Schmand ,  Sanghee Cho

发明人： Debora Henseler ,  Ronald Grazioso ,  Nan Zhang ,  Matthias J. Schmand ,  Sanghee Cho

IPC分类号： G01T1/29 ,  A61B6/03 ,  G01T1/00 ,  A61B6/00

CPC分类号： G01T1/2985 ,  A61B6/00 ,  A61B6/037 ,  G01T1/00

摘要： A system and method are provided for determining the onset of gamma interactions for positron emission tomography (PET) imaging more accurately than with existing techniques. The timing of a sequence of primary trigger events is obtained and used to determine a weighted combination, which mixes the timing information from the various primary trigger events to compute an overall event trigger timing with improved time resolution. Numerical simulations demonstrate that the invention improves time resolution by approximately 10% over state-of-the-art methods. This improved time resolution directly benefits the imaging performance of the PET scanner, especially in time-of-flight (TOF) mode, where a high time resolution directly translates to a reduction in image noise at the same dose—or, alternatively, a reduction of dose to the patient or scan time for the same image quality.

摘要翻译： 提供了一种系统和方法，用于比现有技术更准确地确定正电子发射断层摄影（PET）成像的γ相互作用的发生。 获得主要触发事件序列的定时并用于确定加权组合，其混合来自各种主要触发事件的定时信息以通过改进的时间分辨率计算总体事件触发时序。 数值模拟表明，本发明使用最先进的方法将时间分辨率提高约10％。 这种改进的时间分辨率直接有利于PET扫描仪的成像性能，特别是在飞行时间（TOF）模式下，其中高时间分辨率直接转换为以相同剂量降低图像噪声，或者替代地，减少 给予患者剂量或扫描时间相同的图像质量。

公开(公告)号：US09020797B2

公开(公告)日：2015-04-28

申请号：US13523492

申请日：2012-06-14

申请人： Qingyu Lin ,  Prabal Kanti Bhattacharya ,  Nan Zhang ,  Zhong Fan

发明人： Qingyu Lin ,  Prabal Kanti Bhattacharya ,  Nan Zhang ,  Zhong Fan

IPC分类号： G06F17/50 ,  G06G7/62

CPC分类号： G06F17/5081 ,  G06F17/5009 ,  G06F17/5022 ,  G06F17/5036 ,  G06F17/5045 ,  G06F2217/78 ,  Y02E60/76 ,  Y04S40/22

摘要： A method is provided that comprises a circuit design that includes multiple design blocks; a power intent specification file that defines a power domain within the circuit design and that identifies design instances within the power domain and that defines a control function to selectively transition the defined power domain between multiple respective power supply values; using a digital simulator to simulate operation of the digital representation while using an analog simulator to simulate operation of the analog representation; wherein simulating the digital representation includes transitioning the defined power domain between supply values from among the multiple respective supply values; wherein simulating the analog representation includes periodically storing in a storage location a power supply value currently in use during digital simulation of the digital representation; and wherein simulating the analog representation includes using the stored currently in use power supply value to supply voltage to the analog representation.

摘要翻译： 提供一种包括包括多个设计块的电路设计的方法; 功率意图规范文件，其定义电路设计内的功率域，并且识别功率域内的设计实例，并定义控制功能以选择性地在多个相应的电源值之间转换所定义的功率域; 使用数字模拟器来模拟数字表示的操作，同时使用模拟仿真器来模拟模拟表示的操作; 其中模拟所述数字表示包括在所述多个相应电源值中的电源值之间转换所述定义的电源域; 其中模拟所述模拟表示包括在所述数字表示的数字模拟期间周期性地存储在存储位置中当前正在使用的电源值; 并且其中模拟所述模拟表示包括使用所存储的当前使用中的电源值为所述模拟表示提供电压。

公开(公告)号：US20130273374A1

公开(公告)日：2013-10-17

申请号：US13989595

申请日：2011-12-19

申请人： Kashiko Kawai ,  Yusuke Obu ,  Tomohiro Miyai ,  Shunya Nangou ,  Nan Zhang

发明人： Kashiko Kawai ,  Yusuke Obu ,  Tomohiro Miyai ,  Shunya Nangou ,  Nan Zhang

IPC分类号： B32B27/08 ,  B05D5/00

CPC分类号： B32B27/08 ,  B05D5/00 ,  C08J7/04 ,  C08J7/042 ,  C08J2367/02 ,  C08J2433/02 ,  C08J2475/06 ,  Y10T428/31547 ,  Y10T428/31551 ,  Y10T428/31573

摘要： A gas barrier laminate having an undercoating (A) which comprises a main resin, an isocyanate type curing agent and an alkaline compound of a polyvalent metal; and a barrier layer (B) of a polycarboxylic acid polymer forming an ionic crosslinking due to the polyvalent metal among the carboxyl groups; formed on at least one surface of a plastic base material (P), wherein a region (b) free of the alkaline compound of the polyvalent metal is formed in the undercoating (A) on the side of the barrier layer (B), the content of nitrogen in the region (b) being larger than the content of nitrogen in the undercoating (A) other than the region (b), the gas barrier laminate having excellent gas barrier property, retort resistance, producibility as well as excellent flexibility without developing interlayer peeling even if it is folded and featuring excellent interlayer adhesion.

摘要翻译： 一种具有底涂层（A）的阻气性层压体，其包含主要树脂，异氰酸酯型固化剂和多价金属的碱性化合物; 和由羧基中的多价金属形成离子交联的多元羧酸聚合物的阻挡层（B）; 形成在塑料基材（P）的至少一个表面上，其中在阻挡层（B）侧的底涂层（A）中形成有不含多价金属的碱性化合物的区域（b）， 区域（b）中的氮含量比除了区域（b）以外的底涂层（A）中的氮含量大，阻气性层压体具有优异的阻气性，耐蒸煮性，可生产性以及优异的柔韧性， 即使被折叠也发展了层间剥离，并具有优异的层间粘合性。

公开(公告)号：US08551422B2

公开(公告)日：2013-10-08

申请号：US13608408

申请日：2012-09-10

申请人： Zhiliang Wan ,  Nan Zhang

发明人： Zhiliang Wan ,  Nan Zhang

IPC分类号： G01N33/00

CPC分类号： G01N33/558 ,  B01L3/502746 ,  B01L3/502753 ,  B01L2200/04 ,  B01L2200/0631 ,  B01L2200/16 ,  B01L2300/0654 ,  B01L2300/069 ,  B01L2300/0819 ,  B01L2300/0883 ,  B01L2300/0887 ,  B01L2300/165 ,  B01L2400/0406 ,  Y10T137/0318

摘要： Analytical cartridges, systems and methods of processing a sample for analysis using capillary flows. Vertical gradient sample filtration provides filtrate to an incubation chamber for a time controlled by a flow modulator at the outlet of the incubation chamber. The flow modulator can include a serpentine capillary flow path without side walls. Incubated filtrate can flow from the incubation chamber to a detection channel after a predetermined time. The detection chamber can include one or more analytical regions in a porous substrate for detection of two or more analytes on the same cartridge from the same sample.

摘要翻译： 使用毛细管流分析样品的分析柱，系统和方法。 垂直梯度样品过滤将滤液提供到孵育室，由孵育室出口处的流动调节器控制一段时间。 流量调节器可以包括没有侧壁的蛇形毛细管流动路径。 孵育的滤液可以在预定时间后从孵育室流出到检测通道。 检测室可以在多孔基底中包括一个或多个分析区域，用于从相同的样品检测相同盒上的两种或更多种分析物。