公开(公告)号：US20220362557A1

公开(公告)日：2022-11-17

申请号：US17663350

申请日：2022-05-13

Applicant: Medtronic, Inc.

Inventor： Shailesh Kumar V. Musley ,  Maneesh Shrivastav ,  Abhijit Kadrolkar ,  Todd J. Sheldon ,  Vinod Sharma

IPC: A61N1/365 ,  A61N1/372 ,  A61B5/00 ,  A61B5/053 ,  A61B5/07

Abstract: A system comprises an implantable medical device configured to generate temperature data and impedance data associated with temperature and impedance of a patient proximate to the implantable medical device. The system further comprises processing circuitry configured to determine whether a first one or more infection criteria are satisfied by temperature data and impedance data generated by the implantable medical device during a first time interval, wherein the first one or more infection criteria include at least one criterion indicative of decreased impedance, determine whether a second one or more infection criteria are satisfied by the temperature data and impedance data generated by the implantable medical device during a second time interval subsequent to the first time interval, wherein the second one or more infection criteria include at least one criterion indicative of increased impedance, and output, based on satisfaction of the first and second infection criteria, an indication of infection.

公开(公告)号：US20220266028A1

公开(公告)日：2022-08-25

申请号：US17651705

申请日：2022-02-18

Applicant: Medtronic, Inc.

Inventor： Hank Bink ,  Erik J. Peterson ,  Louis Vera-Portocarrero ,  Vinod Sharma ,  Jiashu Li

IPC: A61N1/36

Abstract: An example method of cycling electric stimulation includes delivering, via an implantable device, electric stimulation to a patient in accordance with a first therapy program; monitoring, via the implantable device and while the electric stimulation is being delivered in accordance with the first therapy program, a biomarker; and responsive to determining the biomarker satisfies a threshold, delivering, via the implantable device, electric stimulation to the patient in accordance with a second therapy program that is different than the first therapy program.

公开(公告)号：US20220257954A1

公开(公告)日：2022-08-18

申请号：US17734958

申请日：2022-05-02

Applicant: Medtronic, Inc.

Inventor： Vinod Sharma ,  Teresa A. Whitman ,  Troy E. Jackson

IPC: A61N1/365 ,  A61N1/362

Abstract: A method and device apparatus to deliver a pacing therapy capable of remodeling a patient's heart over a period of time that includes monitoring one or more parameters in response to a delivered cardiac remodeling pacing, determining whether the cardiac remodeling pacing has an effect on cardiac normalization in response to the monitoring, and adjusting the cardiac remodeling pacing in response to the determined effect on cardiac normalization. The method and device may also perform short-term monitoring of one or more parameters in response to the delivered cardiac remodeling pacing, monitor one or more long-term parameter indicative of a long-term effect of the delivered cardiac remodeling pacing, determine the long-term effect of the delivered cardiac remodeling pacing on cardiac normalization in response to the monitoring, and adjust the cardiac remodeling pacing in response to one or both of the short-term monitoring and the determined long-term effect on cardiac normalization.

公开(公告)号：US20220211332A1

公开(公告)日：2022-07-07

申请号：US17647314

申请日：2022-01-06

Applicant: Medtronic, Inc.

Inventor： Wade M. Demmer ,  Vinod Sharma ,  Shantanu Sarkar ,  James R Peichel

IPC: A61B5/00 ,  A61B5/11 ,  A61B7/00 ,  A61B5/361 ,  A61B5/0538 ,  A61B5/0205 ,  A61B5/024 ,  G16H40/67 ,  G16H10/20 ,  G16H50/30

Abstract: A method of monitoring a patient using a system includes a medical device, a peripheral device configured to wirelessly communicate with the medical device, and processing circuitry. The method includes, by the processing circuitry, receiving sensor data collected by the medical device and evaluating the sensor data. The method further includes, based on the evaluation of the sensor data, outputting for display via the peripheral device at least one question relating to the sensor data collected by the medical device for a patient to answer. The method further includes receiving at least one answer via the peripheral device and determining, based on a combination of the sensor data and the at least one answer, a risk-level of the patient's health associated with at least one condition such as at least one of infection, stroke, sepsis, chronic obstructive pulmonary disease, cardiac arrhythmia, or myocardial infarction.

公开(公告)号：US11318314B2

公开(公告)日：2022-05-03

申请号：US16441738

申请日：2019-06-14

Applicant: Medtronic, Inc.

Inventor： Vinod Sharma ,  Teresa A. Whitman ,  Troy E. Jackson

IPC: A61N1/365 ,  A61N1/362 ,  A61N1/36 ,  A61N1/368

Abstract: A method and device apparatus to deliver a pacing therapy capable of remodeling a patient's heart over a period of time that includes monitoring one or more parameters in response to a delivered cardiac remodeling pacing, determining whether the cardiac remodeling pacing has an effect on cardiac normalization in response to the monitoring, and adjusting the cardiac remodeling pacing in response to the determined effect on cardiac normalization. The method and device may also perform short-term monitoring of one or more parameters in response to the delivered cardiac remodeling pacing, monitor one or more long-term parameter indicative of a long-term effect of the delivered cardiac remodeling pacing, determine the long-term effect of the delivered cardiac remodeling pacing on cardiac normalization in response to the monitoring, and adjust the cardiac remodeling pacing in response to one or both of the short-term monitoring and the determined long-term effect on cardiac normalization.

公开(公告)号：US20220111211A1

公开(公告)日：2022-04-14

申请号：US17067231

申请日：2020-10-09

Applicant: Medtronic, Inc.

Inventor： Jiashu Li ,  Jeffery Kramer ,  Vinod Sharma

IPC: A61N1/36 ,  A61B5/024 ,  A61B5/0472 ,  A61B5/00

Abstract: Techniques are disclosed for using a cardiac signal sensed via a plurality of electrodes disposed on one or more leads implanted within an epidural space of a patient to control spinal cord stimulation (SCS) therapy. In one example, an implantable medical device (IMD) senses an electrical signal via a plurality of electrodes disposed on one or more leads implanted within an epidural space of a patient. Processing circuitry determines, from the electrical signal, one or more cardiac features indicative of activity of a heart of the patient. The processing circuitry controls, based on the one or more cardiac features, delivery of SCS therapy to the patient.

公开(公告)号：US10952681B2

公开(公告)日：2021-03-23

申请号：US16119329

申请日：2018-08-31

Applicant: Medtronic, Inc.

Inventor： Vinod Sharma ,  Joel R. Lauer ,  Holly S. Norman ,  Kevin L. Wong

IPC: A61B5/00 ,  A61B5/02 ,  A61B5/24 ,  A61B5/339 ,  A61B5/349 ,  A61N1/39 ,  A61N1/02 ,  A61N1/37 ,  A61N1/372

Abstract: A method for differentiating heart failure risk scores that includes receiving a current data transmission and acquiring patient metrics from a remote device, determining a daily heart failure risk score for each day occurring during a time period from a previous received data transmission to the current received data transmission based on the acquired patient metrics, determining a maximum daily heart failure risk score of the determined daily heart failure risk scores during a lookback window prior to the current received data transmission, determining a heart failure risk status alert for the received data transmission based on the temporal proximity of the determined maximum heart failure risk score and receipt of the current data transmission, selecting a type of notification based on the heart failure risk status differentiation, and indicating the transmission heart failure risk status and the heart failure risk status differentiation via the selected type of notification.

公开(公告)号：US10736516B2

公开(公告)日：2020-08-11

申请号：US14172378

申请日：2014-02-04

Applicant: Medtronic, Inc.

Inventor： Vinod Sharma

IPC: A61B5/024 ,  A61B5/0205 ,  A61B5/11 ,  A61B5/04 ,  A61B5/00 ,  A61B5/0464 ,  A61B5/0408 ,  A61B5/0432

Abstract: An implantable monitoring device is disclosed for monitoring a patient's heart rate variability over time. The device includes a cardiac electrogram amplifier, a sensing electrode coupled to an input of the amplifier, timing circuitry, processing circuitry and a memory. The timing circuitry defines successive shorter time periods during each monitoring period. The processing circuitry relies upon electrogram activity that occurs during rest periods that extend as long as T1, all of which is stored into memory. Active periods are not considered as part of the heart rate variability calculation. The processing circuitry calculates median intervals between depolarizations of the patient's heart sensed by the amplifier during the shorter time periods and calculates a standard deviation of the median intervals during T2, a longer monitoring period.

公开(公告)号：US20170027474A1

公开(公告)日：2017-02-02

申请号：US15222461

申请日：2016-07-28

Applicant: Medtronic, Inc.

Inventor： Vinod Sharma ,  Jodi L Redemske

IPC: A61B5/053 ,  A61N1/365 ,  A61N1/372 ,  A61B5/00

CPC classification number: A61B5/0537 ,  A61B5/0538 ,  A61B5/7275 ,  A61N1/36521 ,  A61N1/3702 ,  A61N1/37258

Abstract: A health care system acquires data determines whether a patient is at risk of hypervolemia or hypovolemia. The method comprises (a) acquiring from a device memory a patient's absolute intrathoracic impedance data over a pre-specified time period, (b) determining a running average of the intrathoracic impedance data over the pre-specified time period, and (c) determining by the system whether the running average of the intrathoracic impedance data over the pre-specified time period exceeds one of a first and second range, the first range being a higher value boundary of intrathoracic electrical impedance and the second range being a lower value boundary of intrathoracic electrical impedance.

Abstract translation: 卫生保健系统获取数据确定患者是否处于高血容量或血容量不足的风险之中。 该方法包括：（a）从设备存储器获取患者在预定时间段内的绝对胸内阻抗数据，（b）在预定时间段内确定胸内阻抗数据的运行平均值，以及（c）确定 通过系统，经预先确定的时间段内的胸内阻抗数据的运行平均值是否超过第一和第二范围之一，第一范围是胸内电阻抗的较高值边界，第二范围是下限值边界 胸内电阻抗。

公开(公告)号：US20130197373A1

公开(公告)日：2013-08-01

申请号：US13794352

申请日：2013-03-11

Applicant: MEDTRONIC, INC.

Inventor： Vinod Sharma ,  Xiaohong Zhou

IPC: A61B5/00

CPC classification number: A61B5/0071 ,  A61B5/0084 ,  A61B5/0452

Abstract: An implantable medical device for optically sensing action potential signals in excitable body tissue. The device includes an elongated tubular lead body carrying an optical fiber extending from a proximal lead end to a distal lead end to position the optical fiber at a target site. The lead body additionally carries a conduit for dispensing a voltage-sensitive fluorescent dye into tissue surrounding the target site. The optical fiber transmits excitation light to the fluorescent dye to cause the dye to fluoresce with varying intensity as the transmembrane potentials of local tissue cells vary due to passing depolarization wavefronts. The optical fiber transmits the fluorescence signal to the device to generate an action potential signal or fiducial points of an action potential signal for use in accurately measuring and characterizing electrical activity of excitable tissue.

Abstract translation: 一种用于在可兴奋的身体组织中光学感测动作电位信号的可植入医疗装置。 该装置包括细长的管状引线体，其承载从近侧引线端延伸到远端引线端的光纤，以将光纤定位在目标部位。 引线体还带有用于将电压敏感的荧光染料分配到靶区域周围的组织中的导管。 光纤将激发光透射到荧光染料，以使得染料以不同的强度发荧光，因为局部组织细胞的跨膜电位由于通过去极化波前而变化。 光纤将荧光信号传输到设备以产生动作电位信号或动作电位信号的基准点，用于精确测量和表征可兴奋组织的电活动。