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41.发明申请公开(公告)号：US20220088390A1
公开(公告)日：2022-03-24
申请号：US17468058
申请日：2021-09-07
Applicant: Medtronic, Inc.
Inventor： Robert W. Stadler , Subham Ghosh , Jian Cao , Andrea Grammatico , Sarah Meloni , Xiaohong Zhou
Abstract: An implantable medical device system is configured to generate signals representing activity of a heart of a patient; determine, based on the signals, an intrinsic delay of the heart of the patient; determine whether the intrinsic delay is indicative of a first-degree heart block being present in the heart of the patient; determine a patient-specific timing regime for conduction system pacing based on whether the intrinsic delay is indicative of the first-degree heart block being present in the heart of the patient; and administer cardiac pacing to a native conduction system of the heart of the patient based on the timing regime.
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公开(公告)号：US11129988B2
公开(公告)日：2021-09-28
申请号：US16278476
申请日：2019-02-18
Applicant: Medtronic, Inc.
Inventor： Xiaohong Zhou , John Edward Burnes , Lilian Kornet , Richard N.M. Cornelussen
Abstract: Methods of nerve signal differentiation, methods of delivering therapy using such nerve signal differentiation, and to systems and devices for performing such methods. Nerve signal differentiation may include locating two electrodes proximate nerve tissue and differentiating between efferent and afferent components of nerve signals monitored using the two electrodes.
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公开(公告)号：US20190175914A1
公开(公告)日：2019-06-13
申请号：US16278476
申请日：2019-02-18
Applicant: Medtronic, Inc.
Inventor： Xiaohong Zhou , John Edward Burnes , Lilian Kornet , Richard N.M. Cornelussen
Abstract: Methods of nerve signal differentiation, methods of delivering therapy using such nerve signal differentiation, and to systems and devices for performing such methods. Nerve signal differentiation may include locating two electrodes proximate nerve tissue and differentiating between efferent and afferent components of nerve signals monitored using the two electrodes.
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Patent Agency Ranking
公开(公告)号：US10130267B2
公开(公告)日：2018-11-20
申请号：US13786778
申请日：2013-03-06
Applicant: Medtronic, Inc.
Inventor： Zhendong Song , Xiaohong Zhou
IPC: A61B5/0205 , A61M5/172 , A61N1/365 , A61B7/00 , A61B5/021 , A61B5/00 , A61B5/0215 , A61B5/0456
Abstract: A medical device system and method that includes sensing a heart sound signal from a first external sensor, determining whether a pulmonary hypertension signature is detected in response to the sensed heart sound signal, sensing a lung sound signal from a second external sensor, determining whether a heart failure signature is detected in response to the sensed lung sound signal, and determining therapy parameters in response to determining whether a pulmonary hypertension signature is detected and determining whether a heart failure signature is detected.
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公开(公告)号：US09681809B2
公开(公告)日：2017-06-20
申请号：US13794352
申请日：2013-03-11
Applicant: Medtronic, Inc.
Inventor： Vinod Sharma , Xiaohong Zhou
IPC: C12Q1/68 , A61B5/00 , A61B5/0452
CPC classification number: A61B5/0071 , A61B5/0084 , A61B5/0452
Abstract: An implantable medical device for optically sensing action potential signals in excitable body tissue. The device includes an elongated tubular lead body carrying an optical fiber extending from a proximal lead end to a distal lead end to position the optical fiber at a target site. The lead body additionally carries a conduit for dispensing a voltage-sensitive fluorescent dye into tissue surrounding the target site. The optical fiber transmits excitation light to the fluorescent dye to cause the dye to fluoresce with varying intensity as the transmembrane potentials of local tissue cells vary due to passing depolarization wavefronts. The optical fiber transmits the fluorescence signal to the device to generate an action potential signal or fiducial points of an action potential signal for use in accurately measuring and characterizing electrical activity of excitable tissue.
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公开(公告)号：US09675315B2
公开(公告)日：2017-06-13
申请号：US13794973
申请日：2013-03-12
Applicant: Medtronic, Inc.
Inventor： Zhendong Song , Xiaohong Zhou
IPC: A61B5/0215 , A61B7/04 , A61N1/365 , A61B5/0245 , A61N1/362 , A61N1/05 , A61B6/12 , A61B6/00
CPC classification number: A61B7/04 , A61B5/02158 , A61B5/0245 , A61B6/12 , A61B6/487 , A61N1/056 , A61N1/362 , A61N1/36564 , A61N1/36578 , A61N1/36585
Abstract: An implantable medical device that includes an elongated lead body having an outer surface and a first opening along the outer surface, a first sensor positioned along the lead body and configured to receive first acoustic signals through the first opening of the lead body and generate an electrical signal representative of sounds produced at a first targeted location along a patient's cardiovascular system, and a processor configured to determine an intensity of the first acoustic signals, and determine changes in blood pressure in response to the determined intensity.
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公开(公告)号：US20170028204A1
公开(公告)日：2017-02-02
申请号：US15295727
申请日：2016-10-17
Applicant: Medtronic, Inc.
Inventor： Xiaohong Zhou , John Edward Burnes , Lilian Kornet , Richard N.M. Cornelussen
CPC classification number: A61N1/36139 , A61N1/36053 , A61N1/36114 , A61N1/3621 , A61N1/36514 , A61N1/3937 , A61N1/3987
Abstract: Methods of nerve signal differentiation, methods of delivering therapy using such nerve signal differentiation, and to systems and devices for performing such methods. Nerve signal differentiation may include locating two electrodes proximate nerve tissue and differentiating between efferent and afferent components of nerve signals monitored using the two electrodes.
Abstract translation: 神经信号分化方法，使用这种神经信号分化的治疗方法，以及用于执行这些方法的系统和装置。 神经信号分化可能包括将两个电极定位在神经组织附近，并使用两个电极来监测神经信号的传出和传入分量。
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公开(公告)号：US20130289378A1
公开(公告)日：2013-10-31
申请号：US13794918
申请日：2013-03-12
Applicant: MEDTRONIC, INC.
Inventor： Zhendong Song , Xiaohong Zhou
CPC classification number: A61B7/04 , A61B5/02158 , A61B5/0245 , A61B6/12 , A61B6/487 , A61B7/00 , A61N1/056 , A61N1/362 , A61N1/36564 , A61N1/36578 , A61N1/36585
Abstract: An implantable medical device that includes an elongated lead body having an outer surface and an opening along the outer surface, a first sensor positioned along the lead body and configured to receive acoustic signals through the opening of the first lead body and generate an electrical signal representative of sounds produced at a targeted location along a patient's cardiovascular system, and a processor configured to detect change in an S-T segment of sensed cardiac signals, and receive the acoustic signal and determine whether the sensed cardiac signals correspond to one of acute myocardial infarct and myocardial ischemia in response to the detected change.
Abstract translation: 一种植入式医疗装置，其包括具有外表面和沿着外表面的开口的细长引线体，沿着引线本体定位的第一传感器，并且被构造成通过第一引线体的开口接收声信号，并产生电信号代表 在患者的心血管系统的目标位置处产生的声音以及被配置为检测感测到的心脏信号的ST段的变化并且接收声信号并且确定所感测的心脏信号是否对应于急性心肌梗死和心肌中的一个的处理器 响应于检测到的变化的缺血。
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