公开(公告)号：US08926523B2

公开(公告)日：2015-01-06

申请号：US13794898

申请日：2013-03-12

Applicant: Medtronic, Inc.

Inventor： Zhendong Song ,  Xiaohong Zhou

IPC: A61B5/02 ,  A61N1/00 ,  A61B5/0215 ,  A61N1/365 ,  A61B5/0245 ,  A61N1/362 ,  A61B7/04 ,  A61N1/05

CPC classification number: A61B7/04 ,  A61B5/02158 ,  A61B5/0245 ,  A61B6/12 ,  A61B6/487 ,  A61N1/056 ,  A61N1/362 ,  A61N1/36564 ,  A61N1/36578 ,  A61N1/36585

Abstract: An implantable medical device that includes a first elongated lead body having an outer surface and an opening along the outer surface, a sensor positioned along the lead body and configured to receive acoustic signals through the opening of the first lead body and generate an electrical signal representative of sounds produced at a targeted location along a patient's cardiovascular system. A therapy delivery module is capable of delivering a cardiac therapy via predetermined electrodes of a plurality of electrodes, and a processor is configured to detect a cardiac event in response to the sensed cardiac electrical signals, determine a plurality of time intervals between the electrical signals and acoustic signals, determine a correlation between the electrical signals and the acoustic signals, and control the therapy delivery module to deliver therapy in response to the determined correlation.

Abstract translation: 一种可植入医疗装置，其包括具有外表面和沿着外表面的​​开口的第一细长引线本体，沿着引线本体定位并被配置为通过第一引线体的开口接收声信号并产生电信号代表 在沿着患者心血管系统的目标位置产生的声音。 治疗递送模块能够通过多个电极的预定电极递送心脏治疗，并且处理器被配置为响应于所感测的心脏电信号来检测心脏事件，确定电信号与电信号之间的多个时间间隔 声信号，确定电信号和声信号之间的相关性，并且响应于确定的相关性来控制治疗递送模块递送治疗。

公开(公告)号：US08764674B2

公开(公告)日：2014-07-01

申请号：US13786736

申请日：2013-03-06

Applicant: Medtronic, Inc.

Inventor： Zhendong Song ,  Xiaohong Zhou

IPC: A61B5/02

CPC classification number: A61B5/0205 ,  A61B5/021 ,  A61B5/0215 ,  A61B5/0456 ,  A61B5/7285 ,  A61B7/00 ,  A61B7/003 ,  A61M5/1723 ,  A61N1/36585

Abstract: A medical device system and method that includes receiving an A2 heart sound signal from a first external acoustic sensor, receiving a P2 heart sound signal from a second external acoustic sensor, determining at least one A2 heart sound signal parameter from the A2 heart sound signal, determining at least one P2 heart sound signal parameter from the P2 heart sound signal, and based on the at least one P2 heart sound signal parameter, estimating pulmonary arterial pressure.

Abstract translation: 一种医疗装置系统和方法，包括从第一外部声学传感器接收A2心音信号，从第二外部声学传感器接收P2心音信号，从A2心音信号确定至少一个A2心音信号参数， 从所述P2心音信号确定至少一个P2心音信号参数，并且基于所述至少一个P2心音信号参数估计肺动脉压。

公开(公告)号：US20130289377A1

公开(公告)日：2013-10-31

申请号：US13794869

申请日：2013-03-12

Applicant: MEDTRONIC, INC.

Inventor： Zhendong Song ,  Xiaohong Zhou

IPC: A61B7/04

CPC classification number: A61B7/04 ,  A61B5/02158 ,  A61B5/0245 ,  A61B6/12 ,  A61B6/487 ,  A61B7/00 ,  A61N1/056 ,  A61N1/362 ,  A61N1/36564 ,  A61N1/36578 ,  A61N1/36585

Abstract: An implantable medical device system includes an elongated lead body carrying a hydrophone. In some embodiments, the elongated lead body has outer surface and an opening along the outer surface. The hydrophone is configured to receive acoustical signals through the opening of the lead body and generate an electrical signal representative of sounds produced at a targeted location along a patient's cardiovascular system. In some examples, the lead body outer surface has a shaped contour for directing the opening for receiving the sounds from a direction of the targeted location. A processor is enabled to receive signals from the hydrophone and detect a cardiac condition in response to the signals.

Abstract translation: 一种植入式医疗装置系统，包括承载水听器的细长引线体。 在一些实施例中，细长引线体具有外表面和沿着外表面的​​开口。 水听器被配置为通过引线体的开口接收声信号，并产生代表沿着患者心血管系统的目标位置产生的声音的电信号。 在一些示例中，引线体外表面具有用于引导开口以从目标位置的方向接收声音的成形轮廓。 处理器能够从水听器接收信号并且响应于信号来检测心脏状况。

公开(公告)号：US11298547B2

公开(公告)日：2022-04-12

申请号：US16521963

申请日：2019-07-25

Applicant: Medtronic, Inc.

Inventor： Zhendong Song ,  Todd M. Zielinski ,  Brian B. Lee

IPC: A61B5/352 ,  A61N1/365 ,  A61B5/11 ,  A61B5/00 ,  A61B5/283 ,  A61B5/0537 ,  A61B5/0538

Abstract: A medical device is configured to generate fluid status signal data of a patient by determining impedance metrics from an impedance signal, determining cardiac electrical signal amplitudes from a cardiac electrical signal and determining a calibration relationship between the impedance metrics and cardiac electrical signal amplitudes. The medical device generates a fluid status signal data by adjusting cardiac electrical signal amplitudes according to the determined calibration relationship. The fluid status signal data may be displayed or monitored for detecting a change in the patient's fluid status.

公开(公告)号：US20130289379A1

公开(公告)日：2013-10-31

申请号：US13794973

申请日：2013-03-12

Applicant: MEDTRONIC, INC.

Inventor： Zhendong Song ,  Xiaohong Zhou

IPC: A61B5/0215 ,  A61N1/365

CPC classification number: A61B7/04 ,  A61B5/02158 ,  A61B5/0245 ,  A61B6/12 ,  A61B6/487 ,  A61N1/056 ,  A61N1/362 ,  A61N1/36564 ,  A61N1/36578 ,  A61N1/36585

Abstract: An implantable medical device that includes an elongated lead body having an outer surface and a first opening along the outer surface, a first sensor positioned along the lead body and configured to receive first acoustic signals through the first opening of the lead body and generate an electrical signal representative of sounds produced at a first targeted location along a patient's cardiovascular system, and a processor configured to determine an intensity of the first acoustic signals, and determine changes in blood pressure in response to the determined intensity.

Abstract translation: 一种可植入医疗装置，其包括具有外表面和沿外表面的第一开口的细长引线本体，沿着引线本体定位的第一传感器，并且被配置为通过引线主体的第一开口接收第一声信号，并产生电 表示沿着患者心血管系统在第一目标位置产生的声音的信号，以及被配置为确定第一声信号的强度并响应于所确定的强度来确定血压变化的处理器。

公开(公告)号：US20130237862A1

公开(公告)日：2013-09-12

申请号：US13786736

申请日：2013-03-06

Applicant: MEDTRONIC, INC.

Inventor： Zhendong Song ,  Xiaohong Zhou

IPC: A61B5/0205 ,  A61B5/021

CPC classification number: A61B5/0205 ,  A61B5/021 ,  A61B5/0215 ,  A61B5/0456 ,  A61B5/7285 ,  A61B7/00 ,  A61B7/003 ,  A61M5/1723 ,  A61N1/36585

Abstract: A medical device system and method that includes receiving an A2 heart sound signal from a first external acoustic sensor, receiving a P2 heart sound signal from a second external acoustic sensor, determining at least one A2 heart sound signal parameter from the A2 heart sound signal, determining at least one P2 heart sound signal parameter from the P2 heart sound signal, and based on the at least one P2 heart sound signal parameter, estimating pulmonary arterial pressure.

Abstract translation: 一种医疗装置系统和方法，包括从第一外部声学传感器接收A2心音信号，从第二外部声学传感器接收P2心音信号，从A2心音信号确定至少一个A2心音信号参数， 从所述P2心音信号确定至少一个P2心音信号参数，并且基于所述至少一个P2心音信号参数估计肺动脉压。

公开(公告)号：US10130267B2

公开(公告)日：2018-11-20

申请号：US13786778

申请日：2013-03-06

Applicant: Medtronic, Inc.

Inventor： Zhendong Song ,  Xiaohong Zhou

IPC: A61B5/0205 ,  A61M5/172 ,  A61N1/365 ,  A61B7/00 ,  A61B5/021 ,  A61B5/00 ,  A61B5/0215 ,  A61B5/0456

Abstract: A medical device system and method that includes sensing a heart sound signal from a first external sensor, determining whether a pulmonary hypertension signature is detected in response to the sensed heart sound signal, sensing a lung sound signal from a second external sensor, determining whether a heart failure signature is detected in response to the sensed lung sound signal, and determining therapy parameters in response to determining whether a pulmonary hypertension signature is detected and determining whether a heart failure signature is detected.

公开(公告)号：US09675315B2

公开(公告)日：2017-06-13

申请号：US13794973

申请日：2013-03-12

Applicant: Medtronic, Inc.

Inventor： Zhendong Song ,  Xiaohong Zhou

IPC: A61B5/0215 ,  A61B7/04 ,  A61N1/365 ,  A61B5/0245 ,  A61N1/362 ,  A61N1/05 ,  A61B6/12 ,  A61B6/00

CPC classification number: A61B7/04 ,  A61B5/02158 ,  A61B5/0245 ,  A61B6/12 ,  A61B6/487 ,  A61N1/056 ,  A61N1/362 ,  A61N1/36564 ,  A61N1/36578 ,  A61N1/36585

Abstract: An implantable medical device that includes an elongated lead body having an outer surface and a first opening along the outer surface, a first sensor positioned along the lead body and configured to receive first acoustic signals through the first opening of the lead body and generate an electrical signal representative of sounds produced at a first targeted location along a patient's cardiovascular system, and a processor configured to determine an intensity of the first acoustic signals, and determine changes in blood pressure in response to the determined intensity.

公开(公告)号：US20130289378A1

公开(公告)日：2013-10-31

申请号：US13794918

申请日：2013-03-12

Applicant: MEDTRONIC, INC.

Inventor： Zhendong Song ,  Xiaohong Zhou

IPC: A61N1/365 ,  A61B7/04

CPC classification number: A61B7/04 ,  A61B5/02158 ,  A61B5/0245 ,  A61B6/12 ,  A61B6/487 ,  A61B7/00 ,  A61N1/056 ,  A61N1/362 ,  A61N1/36564 ,  A61N1/36578 ,  A61N1/36585

Abstract: An implantable medical device that includes an elongated lead body having an outer surface and an opening along the outer surface, a first sensor positioned along the lead body and configured to receive acoustic signals through the opening of the first lead body and generate an electrical signal representative of sounds produced at a targeted location along a patient's cardiovascular system, and a processor configured to detect change in an S-T segment of sensed cardiac signals, and receive the acoustic signal and determine whether the sensed cardiac signals correspond to one of acute myocardial infarct and myocardial ischemia in response to the detected change.

Abstract translation: 一种植入式医疗装置，其包括具有外表面和沿着外表面的​​开口的细长引线体，沿着引线本体定位的第一传感器，并且被构造成通过第一引线体的开口接收声信号，并产生电信号代表 在患者的心血管系统的目标位置处产生的声音以及被配置为检测感测到的心脏信号的ST段的变化并且接收声信号并且确定所感测的心脏信号是否对应于急性心肌梗死和心肌中的一个的处理器 响应于检测到的变化的缺血。

公开(公告)号：US20200030612A1

公开(公告)日：2020-01-30

申请号：US16521963

申请日：2019-07-25

Applicant: Medtronic, Inc.

Inventor： Zhendong Song ,  Todd M. Zielinski ,  Brian B. Lee

IPC: A61N1/365 ,  A61B5/042 ,  A61B5/00 ,  A61B5/0456 ,  A61B5/11

Abstract: A medical device is configured to generate fluid status signal data of a patient by determining impedance metrics from an impedance signal, determining cardiac electrical signal amplitudes from a cardiac electrical signal and determining a calibration relationship between the impedance metrics and cardiac electrical signal amplitudes. The medical device generates a fluid status signal data by adjusting cardiac electrical signal amplitudes according to the determined calibration relationship. The fluid status signal data may be displayed or monitored for detecting a change in the patient's fluid status.