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公开(公告)号：US08173704B2
公开(公告)日：2012-05-08
申请号：US12083509
申请日：2006-10-09
申请人： Stephan Bartel , Michael Hahn , Wahed Ahmed Moradi , Eva-Maria Becker , Thomas Rölle , Johannes-Peter Stasch , Karl-Heinz Schlemmer , Frank Wunder , Andreas Knorr
发明人： Stephan Bartel , Michael Hahn , Wahed Ahmed Moradi , Eva-Maria Becker , Thomas Rölle , Johannes-Peter Stasch , Karl-Heinz Schlemmer , Frank Wunder , Andreas Knorr
IPC分类号： A61K31/19 , A61K31/195 , C07C59/00 , C07C65/03 , C07C321/00
CPC分类号： C07C59/68 , C07C229/14 , C07D249/12 , C07D257/04 , C07D271/07 , C07D271/113
摘要： The present application relates to novel difluorophenol derivatives, processes for their preparation, their use for the treatment and/or prophylaxis of diseases, and their use for producing medicaments for the treatment and/or prophylaxis of diseases, especially for the treatment and/or prevention of cardiovascular disorders.
摘要翻译： 本申请涉及新型二氟苯酚衍生物，其制备方法，其用于治疗和/或预防疾病的用途及其用于治疗和/或预防疾病，特别是用于治疗和/或预防的药物的用途 的心血管疾病。
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42.发明授权公开(公告)号：US08129378B2
公开(公告)日：2012-03-06
申请号：US12494879
申请日：2009-06-30
申请人： Alexander Straub , Thomas Lampe , Jens Pohlmann , Susanne Röhrig , Elisabeth Perzborn , Karl-Heinz Schlemmer , Joseph Pernerstorfer
发明人： Alexander Straub , Thomas Lampe , Jens Pohlmann , Susanne Röhrig , Elisabeth Perzborn , Karl-Heinz Schlemmer , Joseph Pernerstorfer
IPC分类号： A61K31/5377 , A61K31/42 , C07D409/14
CPC分类号： C07D498/04 , A61K31/5377 , C07D333/38 , C07D409/12 , C07D413/10 , C07D413/12 , C07D413/14 , C07D417/14 , C07D495/04
摘要： The invention relates to the field of blood coagulation. Novel oxazolidinone derivatives of the general formula (I) processes for their preparation and their use as medicinally active compounds for the prophylaxis and/or treatment of disorders are described.
摘要翻译： 本发明涉及血液凝固领域。 描述了通式（I）的新型恶唑烷酮衍生物的制备及其作为用于预防和/或治疗病症的药物活性化合物的用途。
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公开(公告)号：US20100048548A1
公开(公告)日：2010-02-25
申请号：US11919020
申请日：2006-04-08
IPC分类号： A61K31/422 , C12N5/00 , A61K31/5377 , A61K31/506 , A61K31/445 , A61K31/44 , C07D413/14 , C07D413/10 , A61P7/00 , A61P7/02
CPC分类号： C07D413/14
摘要： The present invention relates to novel iminooxazolidines, to processes for their preparation, to their use for the treatment and/or prophylaxis of diseases and also to their use for preparing medicaments for the treatment and/or prophylaxis of diseases, in particular thromboembolic disorders.
摘要翻译： 本发明涉及新的亚氨基恶唑烷，其制备方法，其用于治疗和/或预防疾病的用途，以及其用于制备用于治疗和/或预防疾病，特别是血栓栓塞障碍的药物的用途。
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44.发明申请Tetrazole Derivatives and Their Use for the Treatment of Cardiovascular Diseases 有权四唑衍生物及其用于治疗心血管疾病的用途公开(公告)号：US20090215843A1
公开(公告)日：2009-08-27
申请号：US12085543
申请日：2006-10-09
申请人： Stephan Bartel , Michael Hahn , Wahed Ahmed Moradi , Eva-Maria Becker , Thomas Rölle , Johannes-Peter Stasch , Karl-Heinz Schlemmer , Frank Wunder , Andreas Knorr
发明人： Stephan Bartel , Michael Hahn , Wahed Ahmed Moradi , Eva-Maria Becker , Thomas Rölle , Johannes-Peter Stasch , Karl-Heinz Schlemmer , Frank Wunder , Andreas Knorr
IPC分类号： A61K31/395 , C07D257/04 , A61P9/00
CPC分类号： C07D257/04
摘要： The present application relates to novel tetrazole derivatives, processes for their preparation, their use for the treatment and/or prophylaxis of diseases, and their use for producing medicaments for the treatment and/or prophylaxis of diseases, especially for the treatment and/or prevention of cardiovascular disorders.
摘要翻译： 本申请涉及新型四唑衍生物，其制备方法，其用于治疗和/或预防疾病的用途及其用于治疗和/或预防疾病特别是用于治疗和/或预防的药物的用途 的心血管疾病。
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45.发明授权公开(公告)号：US07576111B2
公开(公告)日：2009-08-18
申请号：US11932082
申请日：2007-10-31
申请人： Alexander Straub , Thomas Lampe , Jens Pohlmann , Susanne Rohrig , Elisabeth Perzborn , Karl-Heinz Schlemmer , Joseph Pernerstorfer
发明人： Alexander Straub , Thomas Lampe , Jens Pohlmann , Susanne Rohrig , Elisabeth Perzborn , Karl-Heinz Schlemmer , Joseph Pernerstorfer
IPC分类号： A61K31/42 , C07D409/14
CPC分类号： C07D498/04 , A61K31/5377 , C07D333/38 , C07D409/12 , C07D413/10 , C07D413/12 , C07D413/14 , C07D417/14 , C07D495/04
摘要： The invention relates to the field of blood coagulation. Novel oxazolidinone derivatives of the general formula (I) processes for their preparation and their use as medicinally active compounds for the prophylaxis and/or treatment of disorders are described.
摘要翻译： 本发明涉及血液凝固领域。 描述了通式（I）的新型恶唑烷酮衍生物的制备及其作为用于预防和/或治疗病症的药物活性化合物的用途。
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公开(公告)号：US20080090815A1
公开(公告)日：2008-04-17
申请号：US11932082
申请日：2007-10-31
申请人： Alexander Straub , Thomas Lampe , Jens Pohlmann , Susanne Rohrig , Elisabeth Perzborn , Karl-Heinz Schlemmer , Joseph Pernerstorfer
发明人： Alexander Straub , Thomas Lampe , Jens Pohlmann , Susanne Rohrig , Elisabeth Perzborn , Karl-Heinz Schlemmer , Joseph Pernerstorfer
IPC分类号： A61K31/541 , A61K31/421 , A61K31/4453 , A61P9/10 , C07D401/14 , C07D417/14 , C07D413/14 , C07D263/02 , A61P9/00 , A61K31/5355
CPC分类号： C07D498/04 , A61K31/5377 , C07D333/38 , C07D409/12 , C07D413/10 , C07D413/12 , C07D413/14 , C07D417/14 , C07D495/04
摘要： The invention relates to the field of blood coagulation. Novel oxazolidinone derivatives of the general formula (I) processes for their preparation and their use as medicinally active compounds for the prophylaxis and/or treatment of disorders are described.
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公开(公告)号：US20060189615A1
公开(公告)日：2006-08-24
申请号：US11409417
申请日：2006-04-21
申请人： Ulrich Niewohner , Mazen Es-Sayed , Helmut Haning , Thomas Schenke , Karl-Heinz Schlemmer , Jorg Keldenich , Erwin Bischoff , Elisabeth Perzborn , Klaus Dembowsky , Peter Serno , Marc Nowakowski
发明人： Ulrich Niewohner , Mazen Es-Sayed , Helmut Haning , Thomas Schenke , Karl-Heinz Schlemmer , Jorg Keldenich , Erwin Bischoff , Elisabeth Perzborn , Klaus Dembowsky , Peter Serno , Marc Nowakowski
IPC分类号： A61K31/53 , C07D487/04
CPC分类号： C07D487/04 , C07F9/6561
摘要： The 2-phenyl-substituted imidazotriazinones having short, unbranched alkyl radicals in the 9-position are prepared from the corresponding 2-phenyl-imidazotriazinones by chlorosulphonation and subsequent reaction with the amines. The compounds inhibit cGMP-metabolizing phosphodiesterases and are suitable for use as active compounds in pharmaceuticals, for the treatment of cardiovascular and cerebrovascular disorders and/or disorders of the urogenital system, in particular for the treatment of erectile dysfunction.
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公开(公告)号：US20060166992A1
公开(公告)日：2006-07-27
申请号：US10519134
申请日：2003-06-25
申请人： Martin Hendrix , David Bruckner , Arno Friedl , Irene Gerlach , Volker Hinz , Jorg Keldenich , Frank Mauler , Ulrich Niewohner , Maria Niewohner , Dagmar Karthaus , Karl-Heinz Schlemmer , Adrian Tersteeger , Ozkan Yalkinoglu
发明人： Martin Hendrix , David Bruckner , Arno Friedl , Irene Gerlach , Volker Hinz , Jorg Keldenich , Frank Mauler , Ulrich Niewohner , Maria Niewohner , Dagmar Karthaus , Karl-Heinz Schlemmer , Adrian Tersteeger , Ozkan Yalkinoglu
IPC分类号： A61K31/53 , C07D487/04
CPC分类号： C07D487/04 , A61K31/53
摘要： The invention relates to new heterocyclically substituted imidazotriazines, processes for their preparation and their use for the production of medicaments for the treatment and/or prophylaxis of cancer and neurodegenerative disorders, in particular of Parkinson's disease and of schizophrenia.
摘要翻译： 本发明涉及新的杂环取代的咪唑三嗪，其制备方法及其用于生产用于治疗和/或预防癌症和神经变性疾病，特别是帕金森病和精神分裂症的药物的用途。
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公开(公告)号：US07022709B2
公开(公告)日：2006-04-04
申请号：US09911277
申请日：2001-07-23
申请人： Frank-Gerhard Böss , Martin Hendrix , Gerhard König , Ulrich Niewöhner , Karl-Heinz Schlemmer , Rudy Schreiber , Franz-Josef Van Der Staay , Dagmar Schauss
发明人： Frank-Gerhard Böss , Martin Hendrix , Gerhard König , Ulrich Niewöhner , Karl-Heinz Schlemmer , Rudy Schreiber , Franz-Josef Van Der Staay , Dagmar Schauss
IPC分类号： A61K31/519
CPC分类号： A61K31/505
摘要： The invention relates to the use of selective phosphodiesterase 2 (PDE 2) inhibitors for producing pharmaceuticals for improving perception, concentration, learning and/or memory.
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公开(公告)号：US20050096320A1
公开(公告)日：2005-05-05
申请号：US10728180
申请日：2003-12-04
申请人： Ulrich Niewohner , Helmut Haning , Thomas Lampe , Mazen Es-Sayed , Gunter Schmidt , Erwin Bischoff , Klaus Dembowsby , Elisabeth Perzborn , Karl-Heinz Schlemmer
发明人： Ulrich Niewohner , Helmut Haning , Thomas Lampe , Mazen Es-Sayed , Gunter Schmidt , Erwin Bischoff , Klaus Dembowsby , Elisabeth Perzborn , Karl-Heinz Schlemmer
IPC分类号： A61K31/53 , A61K31/55 , A61K31/551 , A61P7/04 , A61P9/00 , A61P9/06 , A61P9/10 , A61P9/12 , A61P13/00 , A61P13/08 , A61P15/00 , A61P15/10 , A61P25/28 , A61P43/00 , C07D487/04
CPC分类号： C07D487/04
摘要： The invention relates to novel triazolotriazinones of the general formula and to a method for their production and pharmaceutical use thereof.
摘要翻译： 本发明涉及通式的新型三唑并三氮嗪酮及其制备方法和药物用途。
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