公开(公告)号：US07203019B1

公开(公告)日：2007-04-10

申请号：US11243815

申请日：2005-10-05

申请人： Yanning Liu ,  Yanchu Xu ,  Michael McGrath ,  David Tung ,  Mark Heimbaugh

发明人： Yanning Liu ,  Yanchu Xu ,  Michael McGrath ,  David Tung ,  Mark Heimbaugh

IPC分类号： G11B21/02 ,  G11B21/22 ,  G11B5/54 ,  G11B5/596

CPC分类号： G11B21/22 ,  G11B5/54

摘要： A latch apparatus is configured to latch an actuator arm assembly that can position a read/write head relative to a data storage disk in a disk drive. The latch apparatus includes a latch arm, a coil, a permanent magnet, and a latch control circuit. The latch arm is configured to be moved between a closed position that inhibits movement of the actuator arm assembly in a landing zone and an open position that does not inhibit movement of the actuator arm assembly in the landing zone. The coil is configured to generate an electromagnetic force on the latch arm responsive to a coil current. The permanent magnet is configured to generate a magnetic force on the latch arm that is substantially opposed to the electromagnetic force from the coil. The latch control circuit is configured to increase according to defined open current profiles over a defined opening time period the coil current to at least an upper defined level to cause the coil to move the latch arm from the closed position to the open position. The latch control circuit is further configured to decrease according to defined close current profiles over a defined closing time period the coil current to no more than a lower defined level to cause the permanent magnet to move the latch arm from the open position to the closed position.

摘要翻译： 闩锁装置被配置为闩锁致动器臂组件，该致动臂组件可相对于盘驱动器中的数据存储盘定位读/写头。 闩锁装置包括闩锁臂，线圈，永磁体和闩锁控制电路。 闩锁臂构造成在关闭位置之间移动，该关闭位置阻止致动器臂组件在着陆区域中的运动和不阻止致动器臂组件在着陆区域中的运动的打开位置。 线圈构造成响应于线圈电流而在闩锁臂上产生电磁力。 永磁体构造成在闩锁臂上产生与来自线圈的电磁力基本相反的磁力。 闩锁控制电路被配置为根据限定的开启时间周期将线圈电流增加到至少上限确定的电平，以使线圈将闩锁臂从关闭位置移动到打开位置。 闩锁控制电路还被配置为根据限定的闭合时间周期将线圈电流减小到不大于较低限定水平以使永磁体将闩锁臂从打开位置移动到闭合位置 。

公开(公告)号：US20060160087A1

公开(公告)日：2006-07-20

申请号：US10544059

申请日：2004-01-30

申请人： Michael McGrath ,  Kenneth Hadlock

发明人： Michael McGrath ,  Kenneth Hadlock

IPC分类号： C12Q1/68 ,  G01N33/567

CPC分类号： C12Q1/6883 ,  C12Q1/702 ,  C12Q2600/158 ,  G01N33/56983 ,  G01N33/6896 ,  G01N2333/15 ,  G01N2469/10 ,  G01N2469/20 ,  G01N2800/28

摘要： The invention provides methods of monitoring amyotrophic lateral sclerosis (ALS) disease development or progression and monitoring an ALS therapy in an individual by determining the presence or absence of Herv-K/HML-2 expression in a biological sample from the individual. The invention is also directed to methods for aiding diagnosis of ALS by determining expression of Herv-K/HML-2 in a biological sample from the individual. The invention is also directed to methods of reducing Herv-K/HML-2 expression in infected cells and individuals. The invention includes reagents for use in these methods.

摘要翻译： 本发明提供了通过确定来自个体的生物样品中Herv-K / HML-2表达的存在或不存在来监测肌萎缩性侧索硬化（ALS）疾病发展或进展并监测个体中ALS治疗的方法。 本发明还涉及通过确定来自个体的生物样品中Herv-K / HML-2的表达来帮助诊断ALS的方法。 本发明还涉及在感染的细胞和个体中降低Herv-K / HML-2表达的方法。 本发明包括用于这些方法的试剂。

公开(公告)号：US20060091086A1

公开(公告)日：2006-05-04

申请号：US11304523

申请日：2005-12-15

申请人： Mark Canty ,  Michael McGrath

发明人： Mark Canty ,  Michael McGrath

IPC分类号： A47F7/00

CPC分类号： H04Q1/064 ,  G02B6/4459 ,  H02B1/202 ,  H04Q1/062 ,  H04Q1/142 ,  H04Q2201/02 ,  H04Q2201/08 ,  Y10S425/058

摘要： An integrally molded rack-mountable manager for managing the routing of cables along a network rack supporting electrical components having distinct rows of ports. The manager includes an integrally molded channel having a base portion and a pair of slotted side wall portions for retaining cables therein and managing the routing of the cables by providing optional routing through the channel and through slots defined by the slotted sidewalls. The integrally molded manager includes a rack-mounting portion configured for being connected to the network rack.

公开(公告)号：US20050189277A1

公开(公告)日：2005-09-01

申请号：US11071053

申请日：2005-03-02

申请人： Michael McGrath ,  Michael Kenny

发明人： Michael McGrath ,  Michael Kenny

IPC分类号： C02F3/30

CPC分类号： C02F3/302 ,  C02F2203/00 ,  C02F2305/06

摘要： A denitrification system for denitrified wastewater or nitrified water treatment using a detergent or detergent-like compound comprising available carbon. The system comprises a plurality of interconnected tanks including a mixing tank which feeds detention tanks which in combination provide a detention time period for the effluent. A controller determines the amount of detergent dispensed into the mixing tank in accordance with the measured volume of effluent to be treated. The mixing tank comprises a heater for maintaining the nitrified effluent temperature above 50 degrees F. An optional line filter can be added to the output of the system for further reducing organic nitrogen concentration. An alternate embodiment comprises passing the final denitrified effluent through a pump chamber for pumping of the effluent to a sand filter capable of reducing bacterial populations.

公开(公告)号：US20050186560A1

公开(公告)日：2005-08-25

申请号：US10956743

申请日：2004-09-30

申请人： Michael McGrath ,  Brian Herndier

发明人： Michael McGrath ,  Brian Herndier

IPC分类号： G01N33/50 ,  A61K39/00 ,  C07K14/15 ,  C07K16/10 ,  C12N1/15 ,  C12N1/19 ,  C12N1/21 ,  C12N5/10 ,  C12N7/00 ,  C12N7/01 ,  C12N15/09 ,  C12Q1/02 ,  C12Q1/68 ,  C12Q1/70 ,  G01N33/15 ,  G01N33/53 ,  G01N33/566 ,  G01N33/569 ,  C12N9/22

CPC分类号： C07K14/005 ,  A61K39/00 ,  C12N7/00 ,  C12N2740/10021 ,  C12N2740/10022 ,  G01N33/56983 ,  G01N2333/15 ,  Y10S435/81

摘要： The present invention features an isolated, intact virus associated with human lymphoma, and originally isolated from a mantle cell lymphoma, referred to herein as a mantle histiocyte retrovirus (MHRV). The invention also features compositions and methods for detecting MHRV, as well as methods and compositions for propagating MHRV in vitro, screening for anti-MHRV agents, and generation of attenuated MHRV strains.

摘要翻译： 本发明具有与人类淋巴瘤相关的分离的完整病毒，并且最初从外套细胞淋巴瘤（本文称为地幔组织细胞逆转录病毒（MHRV））分离。 本发明还涉及用于检测MHRV的组合物和方法，以及用于在体外传播MHRV的方法和组合物，筛选抗MHRV试剂以及产生减毒的MHRV毒株。

公开(公告)号：US5605311A

公开(公告)日：1997-02-25

申请号：US309119

申请日：1994-09-20

申请人： Michael McGrath ,  Joseph McGrath ,  Josephine McGrath

发明人： Michael McGrath ,  Joseph McGrath ,  Josephine McGrath

IPC分类号： A47B17/02 ,  A47B17/03 ,  A47B21/03 ,  B68G5/00

CPC分类号： A47B17/02 ,  A47B17/033 ,  A47B21/0314 ,  A47B21/0371 ,  A47B2200/0092 ,  A47B2200/13 ,  A47B97/00 ,  Y10S248/918

摘要： An adjustable, sturdy upper body support system for keyboard operators includes a pair of adjustable arm rests mounted on a rigid frame which can be incorporated into a standalone system or into a desk workstation system. In either embodiment, the frame includes a portion extending forward under the arm rests to prevent the device from tipping. The arm rests can be pivoted about two axes relative to a U-shaped frame slidable within a primary frame underneath a keyboard platform. The standalone version includes outwardly diverging feet for added maneuverability and can be positioned underneath an existing desk. In one version, the upper body support is mounted to a height adjustable desk workstation. Another combined upper body support and desk system includes a height adjustable desk positionable with respect to the arm rests.

摘要翻译： 用于键盘操作者的可调节，坚固的上身支撑系统包括一对可调节的扶手，其安装在刚性框架上，该框架可以并入独立系统或台式工作站系统中。 在任一实施例中，框架包括在扶手下方向前延伸的部分，以防止装置倾斜。 扶手可相对于在键盘平台下方的主框架内滑动的U形框架绕两个轴线枢转。 独立版本包括向外发散的脚，增加了机动性，并且可以放置在现有桌子的下面。 在一个版本中，上身支撑件安装到高度可调的桌面工作站。 另一个组合的上身支撑和桌面系统包括相对于扶手可定位的高度可调的桌子。