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    ENDOGENOUS RETROVIRUS POLYPEPTIDES LINKED TO ONCOGENIC TRANSFORMATION
    1.
    发明申请
    ENDOGENOUS RETROVIRUS POLYPEPTIDES LINKED TO ONCOGENIC TRANSFORMATION 审中-公开
    与内源性转化相关的内源性逆转录酶多肽

    公开(公告)号：US20140135384A1

    公开(公告)日：2014-05-15

    申请号：US14156167

    申请日：2014-01-15

    申请人： NOVARTIS VACCINES & DIAGNOSTICS, INC.

    发明人： Pablo GARCIA ,  Stephen F. HARDY ,  Lewis T. WILLIAMS ,  Jaime ESCOBEDO

    IPC分类号： C07K14/005

    CPC分类号： C07K14/005 ,  A61K39/00 ,  C12N7/00 ,  C12N2740/10021 ,  C12N2740/10022 ,  C12Q1/6886 ,  C12Q1/702 ,  C12Q2600/136 ,  C12Q2600/158 ,  G01N33/57434 ,  G01N2333/15

    摘要： HERV-K human endogenous retroviruses show up-regulated expression in tumors. In particular, splicing events in the env region generate a series of transcripts which utilize the +2 reading frame, relative to the env reading frame. The proteins show activity typical of transcriptional regulators, and they also have oncogenic potential. Two related proteins, PCAP2 and PCAP3, are strongly associated with breast cancer and prostate cancer, respectively. PCAP4 stimulates cell division. These proteins can be used in cancer diagnosis and therapy, and are also drug targets e.g. for adjuvant therapy. The identification of these splice products is remarkable because full sequence information has been available for HERV-K viruses since 1986.

    摘要翻译： HERV-K人内源性逆转录病毒在肿瘤中表达上调。 特别地，env区域中的拼接事件产生一系列相对于env阅读框使用+2阅读框的抄本。 蛋白质表现出转录调节因子的典型活性，并且具有致癌潜力。 两种相关蛋白，PCAP2和PCAP3分别与乳腺癌和前列腺癌密切相关。 PCAP4刺激细胞分裂。 这些蛋白质可用于癌症诊断和治疗，也是药物靶标。 用于辅助治疗。 鉴于这些拼接产品是非常显着的，因为自1986年以来，全序列信息已经可用于HERV-K病毒。

    Endogenous retrovirus polypeptides linked to oncogenic transformation
    3.
    发明申请
    Endogenous retrovirus polypeptides linked to oncogenic transformation 审中-公开
    与致癌转化相关的内源性逆转录病毒多肽

    公开(公告)号：US20070037147A1

    公开(公告)日：2007-02-15

    申请号：US10497786

    申请日：2002-12-09

    申请人： Pablo Garcia ,  Stephen Hardy ,  Lewis Williams ,  Jaime Escobedo

    发明人： Pablo Garcia ,  Stephen Hardy ,  Lewis Williams ,  Jaime Escobedo

    IPC分类号： C12Q1/70 ,  C12Q1/68

    CPC分类号： C07K14/005 ,  A61K39/00 ,  C12N7/00 ,  C12N2740/10021 ,  C12N2740/10022 ,  C12Q1/6886 ,  C12Q1/702 ,  C12Q2600/136 ,  C12Q2600/158 ,  G01N33/57434 ,  G01N2333/15

    摘要： HERV-K human endogenous retroviruses show up-regulated expression in tumors. In particular, splicing events in the env region generate a series of transcripts which utilise the +2 reading frame, relative to the env reading frame. The proteins show activity typical of transcriptional regulators, and they also have oncogenic potential. Two related proteins, PCAP2 and PCAP3, are strongly associated with breast cancer and prostate cancer, respectively. PCAP4 stimulates cell division. These proteins can be used in cancer diagnosis and therapy, and are also drug target e.g. for adjuvant therapy. The identification of these splice products is remarkable because full sequence information has been available for HERV-K viruses since 1986.

    摘要翻译： HERV-K人内源性逆转录病毒在肿瘤中表达上调。 特别地，env区域中的拼接事件产生一系列相对于env阅读框使用+2阅读框的抄本。 蛋白质表现出转录调节因子的典型活性，并且具有致癌潜力。 两种相关蛋白，PCAP2和PCAP3分别与乳腺癌和前列腺癌密切相关。 PCAP4刺激细胞分裂。 这些蛋白质可用于癌症诊断和治疗，也是药物靶标。 用于辅助治疗。 鉴于这些拼接产品是非常显着的，因为自1986年以来，全序列信息已经可用于HERV-K病毒。

    Novel retrovirus associated with myelodysplastic syndromers and uses thereof
    8.
    发明申请
    Novel retrovirus associated with myelodysplastic syndromers and uses thereof 有权
    与骨髓增生异常综合征相关的新型逆转录病毒及其用途

    公开(公告)号：US20040106103A1

    公开(公告)日：2004-06-03

    申请号：US10433244

    申请日：2003-05-28

    发明人： Azra Raza ,  Harvey Preisler

    IPC分类号： C12Q001/70 ,  C12Q001/68

    CPC分类号： C12N7/00 ,  C12N2740/10021 ,  C12Q1/702 ,  G01N33/56983 ,  G01N2333/15 ,  G01N2469/10

    摘要： The present invention relates first, to the identification of a novel retrovirus and the novel nucleotide sequences encoding a retroviral polymerase gene (POL nucleotides) associated with the existence of MDS and MDS associated disorders. The present invention further relates to methods for using the MDS associated retroviral nucleotides for the detection of MDS and MDS associated disorders in patient samples. The present invention also relates to methods for using and targeting the MDS associated retroviral POL nucleotides in gene therapy protocols for the treatment of MDS and MDS associated disorders in patients in need of such treatment. The present invention further relates to diagnostic protocols and kits for the detection of MDS and MDS associated disorders in tissue samples.

    摘要翻译： 本发明首先涉及新型逆转录病毒的鉴定和编码与存在MDS和MDS相关疾病相关的逆转录病毒聚合酶基因（POL核苷酸）的新型核苷酸序列。 本发明还涉及使用MDS相关逆转录病毒核苷酸来检测患者样品中MDS和MDS相关疾病的方法。 本发明还涉及在需要这种治疗的患者中用于治疗MDS和MDS相关疾病的基因治疗方案中使用和靶向MDS相关逆转录病毒POL核苷酸的方法。 本发明还涉及用于检测组织样品中MDS和MDS相关疾病的诊断方案和试剂盒。