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41.发明授权4-benzylamino-1-carboxylacyl-piperidine derivatives as CETP inhibitors 有权4-苄基氨基-1-羧基 - 哌啶衍生物作为CETP抑制剂公开(公告)号：US08440682B2
公开(公告)日：2013-05-14
申请号：US13490579
申请日：2012-06-07
申请人： Muneto Mogi , Ken Yamada , Kayo Yasoshima , Toshio Kawanami , Ichiro Umemura , Yuki Iwaki , Hongbo Qin , Hidetomo Imase
发明人： Muneto Mogi , Ken Yamada , Kayo Yasoshima , Toshio Kawanami , Ichiro Umemura , Yuki Iwaki , Hongbo Qin , Hidetomo Imase
IPC分类号： A61K31/506 , A61P3/06 , A61P9/10 , A61P9/04 , A61P7/02 , A61P9/12 , A61P3/10 , A61P3/04 , A61P9/00 , C07D401/14
CPC分类号： C07D401/14 , C07D413/14
摘要： The present invention provides a compound of formula (I): wherein the variants R1, R2, R3, R4, R5, R6, R7 are as defined herein, and wherein said compound is an inhibitor of CETP, and thus can be employed for the treatment of a disorder or disease mediated by CETP or responsive to the inhibition of CETP.
摘要翻译： 本发明提供式（I）化合物：其中变体R1，R2，R3，R4，R5，R6，R7如本文所定义，并且其中所述化合物是CETP的抑制剂，因此可用于 治疗由CETP介导的或对CETP的抑制作用的疾病或疾病。
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42.发明授权Method of inhibiting CETP activity with 4-benzylamino-1-carboxylacyl-piperidine derivatives 有权用4-苄氨基-1-羧酰基 - 哌啶衍生物抑制CETP活性的方法公开(公告)号：US08420641B2
公开(公告)日：2013-04-16
申请号：US13449347
申请日：2012-04-18
申请人： Muneto Mogi , Ken Yamada , Kayo Yasoshima , Toshio Kawanami , Ichiro Umemura , Yuki Iwaki , Hongbo Qin , Hidetomo Imase
发明人： Muneto Mogi , Ken Yamada , Kayo Yasoshima , Toshio Kawanami , Ichiro Umemura , Yuki Iwaki , Hongbo Qin , Hidetomo Imase
IPC分类号： A61K31/5377 , C07D401/14 , C07D413/14 , A61K31/506 , A61P9/00 , A61P3/04 , A61P3/00 , A61P9/10 , A61P3/10 , A61P9/12 , A61P3/06
CPC分类号： C07D401/14 , C07D413/14
摘要： The present invention provides a compound of formula (I): wherein the variants R1, R2, R3, R4, R5, R6, R7 are as defined herein, and wherein said compound is an inhibitor of CETP, and thus can be employed for the treatment of a disorder or disease mediated by CETP or responsive to the inhibition of CETP.
摘要翻译： 本发明提供式（I）化合物：其中变体R1，R2，R3，R4，R5，R6，R7如本文所定义，并且其中所述化合物是CETP的抑制剂，因此可用于 治疗由CETP介导的或对CETP的抑制作用的疾病或疾病。
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公开(公告)号：US08263629B2
公开(公告)日：2012-09-11
申请号：US12788794
申请日：2010-05-27
申请人： Gary Mark Coppola , Yuki Iwaki , Rajeshri Ganesh Karki , Toshio Kawanami , Gary Michael Ksander , Muneto Mogi , Robert Sun
发明人： Gary Mark Coppola , Yuki Iwaki , Rajeshri Ganesh Karki , Toshio Kawanami , Gary Michael Ksander , Muneto Mogi , Robert Sun
IPC分类号： A61K31/42 , A61K31/4245 , A61K31/41 , C07D271/04 , C07D271/06 , C07D271/08 , C07D271/10 , C07D263/30 , C07D261/06 , C07D257/02
CPC分类号： A61K31/194 , A61K45/06 , C07C233/47 , C07C233/63 , C07C233/87 , C07C235/52 , C07C235/74 , C07C235/82 , C07C251/12 , C07C257/06 , C07C271/12 , C07C275/16 , C07C311/19 , C07C317/44 , C07C2601/02 , C07C2601/04 , C07C2601/14 , C07D207/34 , C07D209/18 , C07D213/56 , C07D213/81 , C07D213/82 , C07D231/14 , C07D239/28 , C07D261/18 , C07D271/10 , C07D277/64 , C07D285/12 , C07D303/48 , C07D307/68 , C07D309/40 , C07D333/24 , C07D333/40
摘要： The present invention provides a compound of formula I′; or a pharmaceutically acceptable salt thereof, wherein R1, R2, R3, X and n are defined herein. The invention also relates to a method for manufacturing the compounds of the invention, and its therapeutic uses. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition.
摘要翻译： 本发明提供式I'化合物; 或其药学上可接受的盐，其中R1，R2，R3，X和n如本文所定义。 本发明还涉及制备本发明化合物的方法及其治疗用途。 本发明还提供药理活性剂和药物组合物的组合。
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公开(公告)号：US20100305145A1
公开(公告)日：2010-12-02
申请号：US12788794
申请日：2010-05-27
申请人： Gary Mark Coppola , Yuki Iwaki , Rajeshri Ganesh Karki , Toshio Kawanami , Gary Michael Ksander , Muneto Mogi , Robert Sun
发明人： Gary Mark Coppola , Yuki Iwaki , Rajeshri Ganesh Karki , Toshio Kawanami , Gary Michael Ksander , Muneto Mogi , Robert Sun
IPC分类号： A61K31/505
CPC分类号： A61K31/194 , A61K45/06 , C07C233/47 , C07C233/63 , C07C233/87 , C07C235/52 , C07C235/74 , C07C235/82 , C07C251/12 , C07C257/06 , C07C271/12 , C07C275/16 , C07C311/19 , C07C317/44 , C07C2601/02 , C07C2601/04 , C07C2601/14 , C07D207/34 , C07D209/18 , C07D213/56 , C07D213/81 , C07D213/82 , C07D231/14 , C07D239/28 , C07D261/18 , C07D271/10 , C07D277/64 , C07D285/12 , C07D303/48 , C07D307/68 , C07D309/40 , C07D333/24 , C07D333/40
摘要： The present invention provides a compound of formula I′; or a pharmaceutically acceptable salt thereof, wherein R1, R2, R3, X and n are defined herein. The invention also relates to a method for manufacturing the compounds of the invention, and its therapeutic uses. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition.
摘要翻译： 本发明提供式I'化合物; 或其药学上可接受的盐，其中R1，R2，R3，X和n如本文所定义。 本发明还涉及制备本发明化合物的方法及其治疗用途。 本发明还提供药理活性剂和药物组合物的组合。
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公开(公告)号：US20100305131A1
公开(公告)日：2010-12-02
申请号：US12788766
申请日：2010-05-27
申请人： Gary Mark Coppola , Yuki Iwaki , Rajeshri Ganesh Karki , Toshio Kawanami , Gary Michael Ksander , Muneto Mogi , Robert Sun
发明人： Gary Mark Coppola , Yuki Iwaki , Rajeshri Ganesh Karki , Toshio Kawanami , Gary Michael Ksander , Muneto Mogi , Robert Sun
IPC分类号： A61K31/5375 , C07C235/74 , A61K31/24 , C07D317/40 , A61K31/365 , C07D295/15 , C07C255/60 , C07D239/28 , A61K31/275 , A61K31/505 , C07D239/36 , C07D213/82 , A61K31/44 , C07D309/40 , A61K31/351 , C07D239/42 , C07D213/56 , A61K31/4402 , C07D235/16 , A61K31/4184 , C07D207/16 , A61K31/40 , C07D263/38 , A61K31/421 , C07D277/56 , A61K31/426 , C07D271/113 , A61K31/4245 , C07D257/04 , A61K31/41 , C07D237/24 , A61K31/50 , A61K31/195 , A61P3/04 , A61P9/12 , A61P9/00 , A61P13/12 , A61P15/00 , A61P3/10 , A61P9/10 , A61P29/00 , A61P25/00 , A61P25/08 , A61P25/28 , A61P25/18 , A61P35/02 , A61P25/24 , A61P1/00 , A61P17/02 , A61P27/06
CPC分类号： C07D317/34 , A61K31/197 , A61K31/216 , A61K31/325 , A61K31/351 , A61K31/357 , A61K31/41 , A61K31/421 , A61K31/44 , A61K31/505 , A61K31/5375 , A61K45/00 , A61K45/06 , C07B2200/05 , C07C233/47 , C07C233/49 , C07C233/51 , C07C233/56 , C07C233/63 , C07C235/12 , C07C235/78 , C07C237/16 , C07C237/22 , C07C255/60 , C07C271/22 , C07C275/24 , C07C311/08 , C07C311/51 , C07C2601/08 , C07C2601/14 , C07C2602/08 , C07D213/82 , C07D239/28 , C07D239/34 , C07D239/36 , C07D257/04 , C07D261/18 , C07D263/32 , C07D265/30 , C07D271/06 , C07D295/15 , C07D309/32
摘要： The present invention provides a compound of formula I′; or a pharmaceutically acceptable salt thereof, wherein R1, R2, R3, R5, B1, X and n are defined herein. The invention also relates a method for manufacturing the compounds of the invention, and its therapeutic uses. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition.
摘要翻译： 本发明提供式I'化合物; 或其药学上可接受的盐，其中R 1，R 2，R 3，R 5，B 1，X和n如本文所定义。 本发明还涉及制备本发明化合物及其治疗用途的方法。 本发明还提供药理活性剂和药物组合物的组合。
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公开(公告)号：US20090118287A1
公开(公告)日：2009-05-07
申请号：US12265369
申请日：2008-11-05
申请人： Muneto Mogi , Ken Yamada , Kayo Yasoshima , Toshio Kawanami , Ichiro Umemura , Yuki Iwaki , Hongbo Qin , Hidetomo Imase
发明人： Muneto Mogi , Ken Yamada , Kayo Yasoshima , Toshio Kawanami , Ichiro Umemura , Yuki Iwaki , Hongbo Qin , Hidetomo Imase
IPC分类号： A61K31/506 , C07D413/14 , C07D401/14 , A61P9/00 , A61P3/00 , A61K31/5377
CPC分类号： C07D401/14 , C07D413/14
摘要： The present invention provides a compound of formula (I): wherein the variants R1, R2, R3, R4, R5, R6, R7 are as defined herein, and wherein said compound is an inhibitor of CETP, and thus can be employed for the treatment of a disorder or disease mediated by CETP or responsive to the inhibition of CETP.
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