-
公开(公告)号:US09006249B2
公开(公告)日:2015-04-14
申请号:US13490562
申请日:2012-06-07
申请人: Gary Mark Coppola , Yuki Iwaki , Rajeshri Ganesh Karki , Toshio Kawanami , Gary Michael Ksander , Muneto Mogi , Robert Sun
发明人: Gary Mark Coppola , Yuki Iwaki , Rajeshri Ganesh Karki , Toshio Kawanami , Gary Michael Ksander , Muneto Mogi , Robert Sun
IPC分类号: A61K31/505 , A61K31/44 , A61K31/415 , A61K31/40 , A61K31/38 , A61K31/34 , A61K31/335 , A61K31/195 , C07D239/24 , C07D211/00 , C07D213/81 , C07D233/54 , C07D231/10 , C07D207/30 , C07D333/38 , C07D229/02 , C07C233/87 , C07C233/47 , C07C233/63 , C07C235/52 , C07C251/12 , C07C257/06 , C07C271/12 , C07C275/16 , C07C311/19 , C07C317/44 , C07D207/34 , C07D209/18 , C07D213/56 , C07D213/82 , C07D231/14 , C07D239/28 , C07D271/10 , C07D277/64 , C07D285/12 , C07D303/48 , C07D307/68 , C07D309/40 , C07D333/24 , C07D333/40 , C07D261/18
CPC分类号: A61K31/194 , A61K45/06 , C07C233/47 , C07C233/63 , C07C233/87 , C07C235/52 , C07C235/74 , C07C235/82 , C07C251/12 , C07C257/06 , C07C271/12 , C07C275/16 , C07C311/19 , C07C317/44 , C07C2601/02 , C07C2601/04 , C07C2601/14 , C07D207/34 , C07D209/18 , C07D213/56 , C07D213/81 , C07D213/82 , C07D231/14 , C07D239/28 , C07D261/18 , C07D271/10 , C07D277/64 , C07D285/12 , C07D303/48 , C07D307/68 , C07D309/40 , C07D333/24 , C07D333/40
摘要: The present invention provides a compound of formula I′; or a pharmaceutically acceptable salt thereof, wherein R1, R2, R3, X and n are defined herein. The invention also relates to a method for manufacturing the compounds of the invention, and its therapeutic uses. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition.
摘要翻译: 本发明提供式I'化合物; 或其药学上可接受的盐,其中R1,R2,R3,X和n如本文所定义。 本发明还涉及制备本发明化合物的方法及其治疗用途。 本发明还提供药理活性剂和药物组合物的组合。
-
2.
公开(公告)号:US08394853B2
公开(公告)日:2013-03-12
申请号:US12788766
申请日:2010-05-27
申请人: Gary Mark Coppola , Yuki Iwaki , Rajeshri Ganesh Karki , Toshio Kawanami , Gary Michael Ksander , Muneto Mogi , Robert Sun
发明人: Gary Mark Coppola , Yuki Iwaki , Rajeshri Ganesh Karki , Toshio Kawanami , Gary Michael Ksander , Muneto Mogi , Robert Sun
IPC分类号: A61K31/235 , C07C229/34
CPC分类号: C07D317/34 , A61K31/197 , A61K31/216 , A61K31/325 , A61K31/351 , A61K31/357 , A61K31/41 , A61K31/421 , A61K31/44 , A61K31/505 , A61K31/5375 , A61K45/00 , A61K45/06 , C07B2200/05 , C07C233/47 , C07C233/49 , C07C233/51 , C07C233/56 , C07C233/63 , C07C235/12 , C07C235/78 , C07C237/16 , C07C237/22 , C07C255/60 , C07C271/22 , C07C275/24 , C07C311/08 , C07C311/51 , C07C2601/08 , C07C2601/14 , C07C2602/08 , C07D213/82 , C07D239/28 , C07D239/34 , C07D239/36 , C07D257/04 , C07D261/18 , C07D263/32 , C07D265/30 , C07D271/06 , C07D295/15 , C07D309/32
摘要: The present invention provides a compound of formula I′; or a pharmaceutically acceptable salt thereof, wherein R1, R2, R3, R5, B1, X and n are defined herein. The invention also relates a method for manufacturing the compounds of the invention, and its therapeutic uses. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition.
摘要翻译: 本发明提供式I'化合物; 或其药学上可接受的盐,其中R 1,R 2,R 3,R 5,B 1,X和n如本文所定义。 本发明还涉及制备本发明化合物及其治疗用途的方法。 本发明还提供药理活性剂和药物组合物的组合。
-
公开(公告)号:US08263629B2
公开(公告)日:2012-09-11
申请号:US12788794
申请日:2010-05-27
申请人: Gary Mark Coppola , Yuki Iwaki , Rajeshri Ganesh Karki , Toshio Kawanami , Gary Michael Ksander , Muneto Mogi , Robert Sun
发明人: Gary Mark Coppola , Yuki Iwaki , Rajeshri Ganesh Karki , Toshio Kawanami , Gary Michael Ksander , Muneto Mogi , Robert Sun
IPC分类号: A61K31/42 , A61K31/4245 , A61K31/41 , C07D271/04 , C07D271/06 , C07D271/08 , C07D271/10 , C07D263/30 , C07D261/06 , C07D257/02
CPC分类号: A61K31/194 , A61K45/06 , C07C233/47 , C07C233/63 , C07C233/87 , C07C235/52 , C07C235/74 , C07C235/82 , C07C251/12 , C07C257/06 , C07C271/12 , C07C275/16 , C07C311/19 , C07C317/44 , C07C2601/02 , C07C2601/04 , C07C2601/14 , C07D207/34 , C07D209/18 , C07D213/56 , C07D213/81 , C07D213/82 , C07D231/14 , C07D239/28 , C07D261/18 , C07D271/10 , C07D277/64 , C07D285/12 , C07D303/48 , C07D307/68 , C07D309/40 , C07D333/24 , C07D333/40
摘要: The present invention provides a compound of formula I′; or a pharmaceutically acceptable salt thereof, wherein R1, R2, R3, X and n are defined herein. The invention also relates to a method for manufacturing the compounds of the invention, and its therapeutic uses. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition.
摘要翻译: 本发明提供式I'化合物; 或其药学上可接受的盐,其中R1,R2,R3,X和n如本文所定义。 本发明还涉及制备本发明化合物的方法及其治疗用途。 本发明还提供药理活性剂和药物组合物的组合。
-
公开(公告)号:US20100305145A1
公开(公告)日:2010-12-02
申请号:US12788794
申请日:2010-05-27
申请人: Gary Mark Coppola , Yuki Iwaki , Rajeshri Ganesh Karki , Toshio Kawanami , Gary Michael Ksander , Muneto Mogi , Robert Sun
发明人: Gary Mark Coppola , Yuki Iwaki , Rajeshri Ganesh Karki , Toshio Kawanami , Gary Michael Ksander , Muneto Mogi , Robert Sun
IPC分类号: A61K31/505
CPC分类号: A61K31/194 , A61K45/06 , C07C233/47 , C07C233/63 , C07C233/87 , C07C235/52 , C07C235/74 , C07C235/82 , C07C251/12 , C07C257/06 , C07C271/12 , C07C275/16 , C07C311/19 , C07C317/44 , C07C2601/02 , C07C2601/04 , C07C2601/14 , C07D207/34 , C07D209/18 , C07D213/56 , C07D213/81 , C07D213/82 , C07D231/14 , C07D239/28 , C07D261/18 , C07D271/10 , C07D277/64 , C07D285/12 , C07D303/48 , C07D307/68 , C07D309/40 , C07D333/24 , C07D333/40
摘要: The present invention provides a compound of formula I′; or a pharmaceutically acceptable salt thereof, wherein R1, R2, R3, X and n are defined herein. The invention also relates to a method for manufacturing the compounds of the invention, and its therapeutic uses. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition.
摘要翻译: 本发明提供式I'化合物; 或其药学上可接受的盐,其中R1,R2,R3,X和n如本文所定义。 本发明还涉及制备本发明化合物的方法及其治疗用途。 本发明还提供药理活性剂和药物组合物的组合。
-
5.
公开(公告)号:US20100305131A1
公开(公告)日:2010-12-02
申请号:US12788766
申请日:2010-05-27
申请人: Gary Mark Coppola , Yuki Iwaki , Rajeshri Ganesh Karki , Toshio Kawanami , Gary Michael Ksander , Muneto Mogi , Robert Sun
发明人: Gary Mark Coppola , Yuki Iwaki , Rajeshri Ganesh Karki , Toshio Kawanami , Gary Michael Ksander , Muneto Mogi , Robert Sun
IPC分类号: A61K31/5375 , C07C235/74 , A61K31/24 , C07D317/40 , A61K31/365 , C07D295/15 , C07C255/60 , C07D239/28 , A61K31/275 , A61K31/505 , C07D239/36 , C07D213/82 , A61K31/44 , C07D309/40 , A61K31/351 , C07D239/42 , C07D213/56 , A61K31/4402 , C07D235/16 , A61K31/4184 , C07D207/16 , A61K31/40 , C07D263/38 , A61K31/421 , C07D277/56 , A61K31/426 , C07D271/113 , A61K31/4245 , C07D257/04 , A61K31/41 , C07D237/24 , A61K31/50 , A61K31/195 , A61P3/04 , A61P9/12 , A61P9/00 , A61P13/12 , A61P15/00 , A61P3/10 , A61P9/10 , A61P29/00 , A61P25/00 , A61P25/08 , A61P25/28 , A61P25/18 , A61P35/02 , A61P25/24 , A61P1/00 , A61P17/02 , A61P27/06
CPC分类号: C07D317/34 , A61K31/197 , A61K31/216 , A61K31/325 , A61K31/351 , A61K31/357 , A61K31/41 , A61K31/421 , A61K31/44 , A61K31/505 , A61K31/5375 , A61K45/00 , A61K45/06 , C07B2200/05 , C07C233/47 , C07C233/49 , C07C233/51 , C07C233/56 , C07C233/63 , C07C235/12 , C07C235/78 , C07C237/16 , C07C237/22 , C07C255/60 , C07C271/22 , C07C275/24 , C07C311/08 , C07C311/51 , C07C2601/08 , C07C2601/14 , C07C2602/08 , C07D213/82 , C07D239/28 , C07D239/34 , C07D239/36 , C07D257/04 , C07D261/18 , C07D263/32 , C07D265/30 , C07D271/06 , C07D295/15 , C07D309/32
摘要: The present invention provides a compound of formula I′; or a pharmaceutically acceptable salt thereof, wherein R1, R2, R3, R5, B1, X and n are defined herein. The invention also relates a method for manufacturing the compounds of the invention, and its therapeutic uses. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition.
摘要翻译: 本发明提供式I'化合物; 或其药学上可接受的盐,其中R 1,R 2,R 3,R 5,B 1,X和n如本文所定义。 本发明还涉及制备本发明化合物及其治疗用途的方法。 本发明还提供药理活性剂和药物组合物的组合。
-
6.
公开(公告)号:US20120252830A1
公开(公告)日:2012-10-04
申请号:US13490562
申请日:2012-06-07
申请人: Gary Mark Coppola , Yuki Iwaki , Rajeshri Ganesh Karki , Toshio Kawanami , Gary Michael Ksander , Muneto Mogi , Robert Sun
发明人: Gary Mark Coppola , Yuki Iwaki , Rajeshri Ganesh Karki , Toshio Kawanami , Gary Michael Ksander , Muneto Mogi , Robert Sun
IPC分类号: A61K31/197 , C07C235/74 , C07C235/12 , C07C235/82 , C07D303/46 , A61K31/336 , C07D307/68 , A61K31/341 , C07D333/38 , A61K31/381 , C07D213/81 , A61K31/44 , C07D239/28 , A61K31/505 , C07D231/14 , A61K31/415 , C07D207/34 , A61K31/40 , C07D233/90 , A61K31/4164 , C07D211/60 , A61K31/445 , C07D239/42 , C07D239/36 , A61P7/10 , A61P3/10 , A61P3/04 , A61P9/12 , A61P9/00 , A61P13/12 , A61P17/00 , A61P9/10 , A61P9/06 , A61P27/06 , A61P15/00 , A61P15/06 , A61P11/06 , A61P29/00 , A61P35/02 , A61P25/08 , A61P25/24 , A61P25/18 , A61P25/28 , A61P1/00 , A61P17/02 , A61P3/00 , C07C235/84
CPC分类号: A61K31/194 , A61K45/06 , C07C233/47 , C07C233/63 , C07C233/87 , C07C235/52 , C07C235/74 , C07C235/82 , C07C251/12 , C07C257/06 , C07C271/12 , C07C275/16 , C07C311/19 , C07C317/44 , C07C2601/02 , C07C2601/04 , C07C2601/14 , C07D207/34 , C07D209/18 , C07D213/56 , C07D213/81 , C07D213/82 , C07D231/14 , C07D239/28 , C07D261/18 , C07D271/10 , C07D277/64 , C07D285/12 , C07D303/48 , C07D307/68 , C07D309/40 , C07D333/24 , C07D333/40
摘要: The present invention provides a compound of formula I′; or a pharmaceutically acceptable salt thereof, wherein R1, R2, R3, X and n are defined herein. The invention also relates to a method for manufacturing the compounds of the invention, and its therapeutic uses. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition.
摘要翻译: 本发明提供式I'化合物; 或其药学上可接受的盐,其中R1,R2,R3,X和n如本文所定义。 本发明还涉及制备本发明化合物的方法及其治疗用途。 本发明还提供药理活性剂和药物组合物的组合。
-
7.
公开(公告)号:US08877815B2
公开(公告)日:2014-11-04
申请号:US13293560
申请日:2011-11-10
申请人: Rajeshri Ganesh Karki , Toshio Kawanami , Gary Michael Ksander , Qian Liu , Muneto Mogi , Nikolaus Schiering , Robert Sun
发明人: Rajeshri Ganesh Karki , Toshio Kawanami , Gary Michael Ksander , Qian Liu , Muneto Mogi , Nikolaus Schiering , Robert Sun
IPC分类号: A61K31/165 , C07D295/185 , C07C237/22 , C07D257/04 , C07D307/52 , C07C233/63 , C07D213/55 , C07C233/52 , C07D471/04 , C07D207/16
CPC分类号: C07C233/52 , C07C233/63 , C07C237/22 , C07C2601/08 , C07D207/16 , C07D213/55 , C07D257/04 , C07D295/185 , C07D307/52 , C07D471/04
摘要: The present invention provides a compound of formula I; or a pharmaceutically acceptable salt thereof, wherein R1, R2, R3, R4, R5, B, X, m and n are defined herein. The invention also relates to a method for manufacturing the compounds of the invention, and its therapeutic uses. The present invention further provides pharmaceutical composition of compounds of the invention, and a combination of pharmacologically active agents and a compound of the invention.
摘要翻译: 本发明提供式I化合物; 或其药学上可接受的盐,其中R 1,R 2,R 3,R 4,R 5,B,X,m和n如本文所定义。 本发明还涉及制备本发明化合物的方法及其治疗用途。 本发明还提供了本发明化合物的药物组合物,以及药理活性剂和本发明化合物的组合。
-
公开(公告)号:US08613194B2
公开(公告)日:2013-12-24
申请号:US13482389
申请日:2012-05-29
申请人: Robert Sun
发明人: Robert Sun
IPC分类号: F03G7/00
摘要: A tri-energy power generating device uses the light energy, the thermal energy and wind energy from the nature and transfers these energies into electric power so as to obtain environmentally friendly power. The tri-energy power generating device includes a thermal energy transfer unit, a light-thermo energy collecting unit disposed above the thermal energy transfer unit and a wind turbine unit. When the wind is sufficient, the cold air enters the thermal energy transfer unit from a lower end thereof to drive the wind turbine unit. When there is sufficient sunshine, the light-thermo energy collecting unit transfers the light into electric power to initiate the wind turbine unit and transfer the light into the thermal energy. The thermal energy is conducted to the thermal energy transfer unit and the air is heated to drive the wind turbine unit to generate electric power.
摘要翻译: 三能发电装置使用来自大自然的光能,热能和风能,并将这些能量转移到电力中,以获得环境友好的电力。 三能发电装置包括热能传递单元,设置在热能传递单元上方的光热能收集单元和风力涡轮机单元。 当风足够时,冷空气从其下端进入热能传递单元以驱动风力涡轮机单元。 当有充足的阳光时,光热能收集单元将光转移到电力中以启动风力涡轮机单元并将光转移到热能中。 热能被传导到热能传递单元,并且空气被加热以驱动风力涡轮机单元以产生电力。
-
公开(公告)号:US08575160B2
公开(公告)日:2013-11-05
申请号:US13511581
申请日:2010-11-29
申请人: Robert Sun , Lauren G. Monovich , Sylvie Chamoin , John Westbrook
发明人: Robert Sun , Lauren G. Monovich , Sylvie Chamoin , John Westbrook
IPC分类号: C07D487/04 , A61K31/4188 , A61K31/428
CPC分类号: C07D487/04 , C07D471/04
摘要: The present invention provides a compound of formula (I) or pharmaceutically acceptable salt thereof, wherein the variables R1, R2, R3, R4, R5, R7 and p are defined herein. The invention also relates to a method for manufacturing the compounds of the invention, and its therapeutic uses. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition.
摘要翻译: 本发明提供式(I)化合物或其药学上可接受的盐,其中变量R1,R2,R3,R4,R5,R7和p在本文中定义。 本发明还涉及制备本发明化合物的方法及其治疗用途。 本发明还提供药理活性剂和药物组合物的组合。
-
公开(公告)号:US20130065893A1
公开(公告)日:2013-03-14
申请号:US13511581
申请日:2010-11-29
申请人: Robert Sun , Lauren G. Monovich , Sylvie Chamoin , John Westbrook
发明人: Robert Sun , Lauren G. Monovich , Sylvie Chamoin , John Westbrook
IPC分类号: C07D487/04 , A61K31/4188 , A61K31/428 , A61K31/437 , A61K31/5377 , A61K31/4439 , A61K31/4725 , A61K31/4709 , A61P9/12 , A61P9/10 , A61P3/04 , A61P9/00 , A61P9/06 , A61P9/04 , A61P1/16 , C07D471/04
CPC分类号: C07D487/04 , C07D471/04
摘要: The present invention provides a compound of formula (I) or pharmaceutically acceptable salt thereof, wherein the variables R1, R2, R3, R4, R5, R7 and p are defined herein. The invention also relates to a method for manufacturing the compounds of the invention, and its therapeutic uses. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition.
摘要翻译: 本发明提供式(I)化合物或其药学上可接受的盐,其中变量R1,R2,R3,R4,R5,R7和p在本文中定义。 本发明还涉及制备本发明化合物的方法及其治疗用途。 本发明还提供药理活性剂和药物组合物的组合。
-
-
-
-
-
-
-
-
-