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41.发明申请Expandable fluoropolymer device for delivery of therapeutic agents and method of making 有权用于递送治疗剂的可扩展含氟聚合物装置和制备方法公开(公告)号：US20050154416A1
公开(公告)日：2005-07-14
申请号：US11068680
申请日：2005-02-28
申请人： Steve Herweck , Peter Gingras , Paul Martakos , Theodore Karwoski
发明人： Steve Herweck , Peter Gingras , Paul Martakos , Theodore Karwoski
CPC分类号： A61M25/1029 , A61L29/041 , A61M25/10 , A61M2025/0057 , A61M2025/105 , A61M2025/1075 , B29C47/00 , B29C47/0023 , B29C55/24 , B29C2049/465 , B29K2027/18 , B29L2022/022 , B29L2031/753 , B32B2305/026 , C08L27/18
摘要： A method of making a radially expandable fluid delivery device includes providing a tube of biocompatible fluoropolymer material with a predetermined porosity based on an extrusion and expansion forming process, applying a radial expansion force to the tube expanding the tube to a predetermined diameter dimension, and removing the radial expansion force. The tube is radially inelastic while sufficiently pliable to be collapsible and inflatable from a collapsed configuration to an expanded configuration upon introduction of an inflation force, such that the expanded configuration occurs upon inflation to the predetermined diameter dimension. The fluid delivery device is constructed of a microporous, biocompatible fluoropolymer material having a microstructure that can provide a controlled, uniform, low-velocity fluid distribution through the walls of the fluid delivery device to effectively deliver fluid to the treatment site without damaging tissue proximate the walls of the device.
摘要翻译： 一种制造可径向膨胀的流体递送装置的方法包括：基于挤出和膨胀成形方法提供具有预定孔隙率的生物相容性氟聚合物材料管，向扩管管的管施加径向膨胀力至预定直径尺寸， 径向膨胀力。 该管是径向无弹性的，同时在引入膨胀力时足够柔软地可从折叠构型膨胀到膨胀构型，使得膨胀构型在膨胀到预定直径尺寸时发生。 流体输送装置由具有微结构的微孔生物相容性含氟聚合物材料构成，微结构可以通过流体输送装置的壁提供受控的，均匀的低速流体分配，以有效地将流体输送到治疗部位，而不会损伤邻近的 设备的墙壁。
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42.发明申请Application of a therapeutic substance to a tissue location using a porous medical device 审中-公开使用多孔医疗装置将治疗物质施用于组织位置公开(公告)号：US20050113687A1
公开(公告)日：2005-05-26
申请号：US10943075
申请日：2004-09-15
申请人： Steve Herweck , Paul Martakos , Geoffrey Moodie , Roger Labrecque , Theodore Karwoski , Trevor Carlton
发明人： Steve Herweck , Paul Martakos , Geoffrey Moodie , Roger Labrecque , Theodore Karwoski , Trevor Carlton
IPC分类号： A61B5/05 , A61F2/82 , A61M20060101
CPC分类号： A61M25/10 , A61F2/82 , A61F2/958 , A61F2250/0067 , A61M25/1027 , A61M25/104 , A61M2025/105 , A61M2025/1088
摘要： A non-polymeric or biological coating applied to porous radially expandable interventional medical devices provides uniform drug distribution and permeation of the coating and any therapeutic agents mixed therewith into a targeted treatment area within the body. The coating is sterile, and is capable of being carried by a sterile medical device to a targeted tissue location within the body following radial expansion. The therapeutic coating transfers off the medical device due in part to a biological attraction with the tissue and in part to a physical transference from the medical device to the targeted tissue location in contact with the medical device. Thus, atraumatic local tissue transference delivery is achieved for uniform therapeutic agent distribution and controlled bio-absorption into the tissue after placement within a patient's body with a non-inflammatory coating.
摘要翻译： 应用于多孔径向可扩张介入医疗装置的非聚合物或生物涂层提供了涂层和与其混合的任何治疗剂的均匀药物分布和渗透到体内的目标治疗区域。 涂层是无菌的，并且能够在径向膨胀后由无菌医疗装置携带到身体内的目标组织位置。 治疗涂层部分地由于与组织的生物吸引而部分地转移离开医疗装置，并且部分地从医疗装置到与医疗装置接触的目标组织位置的物理转移。 因此，在用非炎性涂层放置在患者体内之后，实现了不均匀的局部组织转移递送，用于均匀的治疗剂分布和对组织的受控生物吸收。
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43.发明授权公开(公告)号：US06774155B2
公开(公告)日：2004-08-10
申请号：US10196692
申请日：2002-07-16
IPC分类号： C08F248
CPC分类号： C08J7/123 , A61F2/06 , A61F2250/0023
摘要： The invention is directed to methods for fabricating devices from polymer precursors, along with devices so fabricated. The methods of the invention include the steps of plasma treating a polymer based resin, paste, preform billet, or extrudate, and employing the treated polymer in the fabricated device. According to one embodiment, the fabricated device can include implantable prosthetics such as heart valves, sutures, vascular access devices, vascular grafts, shunts, catheters, single layered membranes, double layered membranes, and the like. Devices fabricated according to one embodiment of the invention include regions having selected porosity, permeability and/or chemistry characteristics.
摘要翻译： 本发明涉及从聚合物前体制造器件的方法以及如此制造的器件。 本发明的方法包括以下步骤：等离子体处理聚合物基树脂，糊料，预成型坯坯或挤出物，并在制造的装置中使用经处理的聚合物。 根据一个实施例，制造的装置可以包括可植入假肢，例如心脏瓣膜，缝线，血管通路装置，血管移植物，分流器，导管，单层膜，双层膜等。 根据本发明的一个实施方案制造的装置包括具有选择的孔隙率，渗透性和/或化学特性的区域。
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公开(公告)号：US06573311B1
公开(公告)日：2003-06-03
申请号：US09400813
申请日：1999-09-22
IPC分类号： C08F248
CPC分类号： C08J7/123 , A61F2/06 , A61F2250/0023
摘要： The invention is directed to methods for fabricating devices from polymer precursors, along with devices so fabricated. The methods of the invention include the steps of plasma treating a polymer based resin, paste, preform billet, or extrudate, and employing the treated polymer in the fabricated device. According to one embodiment, the fabricated device can include implantable prosthetics such as heart valves, sutures, vascular access devices, vascular grafts, shunts, catheters, single layered membranes, double layered membranes, and the like. Devices fabricated according to one embodiment of the invention include regions having selected porosity, permeability and/or chemistry characteristics.
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公开(公告)号：US06423089B1
公开(公告)日：2002-07-23
申请号：US09296349
申请日：1999-04-22
IPC分类号： A61F206
摘要： A vascular endoprosthesis is formed of a tubular liner preform with a continuous surface and having a diameter smaller than that of an intended vessel. The liner is inserted to a treatment site, and its sheet material undergoes a radially-directed expansion to a final size that fits the vessel. Insertion and in situ expansion are achieved using a catheter assembly in which either an internal stent, such as a stiff-filament helically woven tube, or an inflatable balloon urge the liner preform outwardly against the inner wall of the vessel. The stent, or one or more simple internal snap-rings anchor the expanded liner in place. The expanded liner is porous, or becomes more porous during expansion, and one or more aspects of its porosity are tailored to the intended treatment goal of immobilizing treatment material, isolating cells, or permitting controlled permeation of selected materials.
摘要翻译： 血管内假体由具有连续表面并且直径小于预期血管的直径的管状衬垫预制件形成。 将衬垫插入到处理部位，并且其片材经历径向膨胀至适合容器的最终尺寸。 使用导管组件实现插入和原位扩张，其中内部支架例如刚性丝状螺旋编织管或可膨胀气囊将衬垫预制件向外压靠在容器的内壁上。 支架或一个或多个简单的内部卡环将扩张的衬垫固定就位。 膨胀的衬垫是多孔的，或在膨胀期间变得更多孔，并且其孔隙率的一个或多个方面是针对固定化处理材料，分离细胞或允许所选材料的受控渗透的预期治疗目标。
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公开(公告)号：US06287337B1
公开(公告)日：2001-09-11
申请号：US09246312
申请日：1999-02-08
IPC分类号： A61F206
CPC分类号： A61F2/07 , A61F2/06 , A61F2/105 , A61F2/2412 , A61F2/88 , A61F2002/072 , A61F2240/001 , A61L27/16 , A61L27/34 , A61L27/507 , C08L27/18
摘要： A porous tube suitable for use as a vascular graft prosthesis and a method of making it is disclosed. It has a structure of porous polytetrafluoroethylene having a fibrous structure of nodes and fibers connecting the nodes together and an integrated intrawall circumferential support adjacent to areas of variable porosity. This invention provides a polytetrafluoroethylene polymer in a porous form useful as artificial internal organs for, for example vascular bypass, vascular access, and endovascular prosthesis. PTFE walls are found with radial zones of differing porosity are described.
摘要翻译： 公开了适合用作血管移植假体的多孔管及其制造方法。 它具有多孔聚四氟乙烯的结构，其具有连接节点的节点和纤维的纤维结构，以及与可变孔隙度区域相邻的整体的内部周向支撑。 本发明提供一种多孔形式的聚四氟乙烯聚合物，其用作例如血管旁路，血管通路和血管内假体的人造内脏。 发现PTFE壁具有不同孔隙率的径向区域。
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47.发明授权
公开(公告)号：US5474824A
公开(公告)日：1995-12-12
申请号：US268240
申请日：1994-06-29
IPC分类号： A61F2/06 , A61L27/16 , A61L27/56 , B29C47/00 , B29C55/00 , B29C69/00 , B29D23/00 , B29K27/12 , B29K105/04 , D02J1/06
CPC分类号： B29D23/001 , A61F2/06 , A61L27/16 , A61L27/56 , B01D67/0027 , B01D69/02 , B01D69/12 , B01D71/36 , B29C47/0004 , B29C47/0021 , B29C55/005 , B01D2325/02 , B29C47/0023 , B29C47/0026 , B29C47/0042 , B29C47/0057 , B29C47/062 , B29C47/065 , B29K2027/18 , B29K2105/04 , B29L2023/005 , B29L2023/007 , Y10T428/139 , Y10T428/1397 , Y10T428/24273 , Y10T428/249986 , Y10T428/24999 , Y10T428/249992 , Y10T428/31544
摘要： A process for producing a shaped porous article includes the steps of providing an extrudate of a fluoropolymer material which is capable of being stretched and bilaterally stretching the extrudate along a longitudinal axis. The stretching step is carried out under conditions sufficient to yield an article which is substantially uniformly stretched over a major portion of its length. After stretching, the material has a unique through-pore microstructure characterized by elongate nodes connected by fibrils. The stretched material is sintered while being maintained in its stretched state to produce the shaped porous article. A significant feature of the inventive process is that stretching is carried out by displacing both ends of the extruded material as opposed to known method wherein only one end of an extruded material is stretched, resulting in a microporous fluoropolymer article which are different than conventional fluoropolymer stretching/expansion processes.
摘要翻译： 一种生产成形多孔制品的方法包括以下步骤：提供含氟聚合物材料的挤出物，该挤出物能够沿着纵向轴线被拉伸和双向拉伸挤出物。 拉伸步骤在足以产生在其长度的主要部分上基本上均匀拉伸的制品的条件下进行。 拉伸后，该材料具有独特的通孔微结构，其特征在于由原纤维连接的细长节点。 拉伸的材料在保持拉伸状态下被烧结以产生成形的多孔制品。 本发明方法的一个重要特征是通过使挤出材料的两端位移来进行拉伸，与已知方法相反，其中仅挤出材料的一端被拉伸，得到与常规含氟聚合物拉伸不同的微孔含氟聚合物制品 /扩展过程。
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公开(公告)号：US20110144667A1
公开(公告)日：2011-06-16
申请号：US12877919
申请日：2010-09-08
申请人： Anthony Richard Horton , Paul Martakos , Steve A. Herweck , Theodore Karwoski , Joseph F. Ferraro
发明人： Anthony Richard Horton , Paul Martakos , Steve A. Herweck , Theodore Karwoski , Joseph F. Ferraro
IPC分类号： A61B17/08
CPC分类号： A61F2/0063 , A61F2210/0004 , A61F2210/0076 , A61F2220/0008 , A61F2220/0075 , A61F2230/0004 , A61F2250/0018 , A61F2310/00389 , A61K31/20 , A61L31/10 , A61L31/14 , A61L31/148
摘要： A hernia patch supporting tissue in-growth conforms to a tissue wall upon surgical installation and fixation within a patient. The hernia patch can include a base and positioning straps. The base is formed of two layers that are affixed to each other around the perimeter of the patch, for example by stitching. A stabilizing washer is provided between the two layers, and the stitch is provided peripherally around the stabilizing washer, keeping the washer free-floating between the layers. The base, positioning straps, and stabilizing washer are formed of a structure that does not separate the layers of the implant or form a space in the form of a pocket, and promotes more uniform and confluent tissue incorporation or in-growth after implantation. The hernia patch may further include a hydrolysable bioabsorbable cross-linked coating of a fatty acid based material, such as an omega-3 fatty acid based material.
摘要翻译： 支撑组织生长的疝补片在外科手术安装和固定在患者体内时符合组织壁。 疝补片可以包括基部和定位带。 底座由两层相互贴合，例如通过拼接而在贴片的周边彼此固定。 在两层之间设有一个稳定的垫圈，并且在周向围绕稳定垫圈设置线圈，保持垫片在层之间自由浮动。 基部，定位带和稳定垫圈由不分离植入物层或形成袋状空间的结构形成，并且在植入后促进更均匀和汇合的组织结合或生长。 疝补片可以进一步包括基于脂肪酸的材料如ω-3脂肪酸基材料的可水解生物可吸收的交联涂层。
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49.发明申请DRUG DELIVERY COATING FOR USE WITH A MEDICAL DEVICE AND METHODS OF TREATING VASCULAR INJURY 审中-公开用于医疗设备的药物输送涂料和治疗血管损伤的方法公开(公告)号：US20100004738A1
公开(公告)日：2010-01-07
申请号：US11919315
申请日：2006-04-28
IPC分类号： A61F2/82 , A61F2/00 , A61K31/439 , A61M25/00 , A61B17/03
CPC分类号： A61K31/436 , A61L27/54 , A61L29/16 , A61L31/16 , A61L2300/434 , A61L2300/45
摘要： The present inventions provide various embodiments of methods for one or more of treating vascular injury, neointima proliferation and/or local inflammation in a mammal by locally administering therapeutic compound comprising a mTOR targeting compound and a calcineurin inhibitor. In various aspects, the therapeutic compound comprises a bio-absorbable carrier component carrier component at least partially formed of a cellular uptake inhibitor and a cellular uptake enhancer, a mTOR targeting compound and a calcineurin inhibitor. In various aspects, the present invention provides for controlled delivery, which is at least partially characterized by total and relative amounts of a cellular uptake inhibitor and cellular uptake enhancer in a bio-absorbable carrier component.
摘要翻译： 本发明提供了通过局部施用包含mTOR靶向化合物和钙调磷酸酶抑制剂的治疗化合物来治疗哺乳动物血管损伤，新内膜增生和/或局部炎症中的一种或多种的方法的各种实施方案。 在各个方面，治疗化合物包括至少部分由细胞摄取抑制剂和细胞吸收增强剂，mTOR靶向化合物和钙调磷酸酶抑制剂形成的生物可吸收载体组分载体组分。 在各个方面，本发明提供受控递送，其至少部分地表征为生物可吸收载体组分中的细胞摄取抑制剂和细胞摄取增强剂的总量和相对量。
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公开(公告)号：US20080207756A1
公开(公告)日：2008-08-28
申请号：US11711389
申请日：2007-02-27
CPC分类号： A61K31/20
摘要： Exemplary embodiments of the invention provide a dispersing liquid for coating internal body tissues with a bio-absorbable oil, a method of making the dispersing liquid, methods of using the dispersing liquid and a kit for coating internal body tissues using the dispersing liquid. The dispersing liquid includes a suspension of a bio-absorbable oil suspended in a liquid carrier. The invention results in a uniform thin coating of bio-absorbable oil on internal body tissues.
摘要翻译： 本发明的示例性实施方案提供了用生物可吸收油涂覆内部身体组织的分散液，制备分散液的方法，使用分散液的方法和使用分散液涂覆内部身体组织的试剂盒。 分散液包括悬浮在液体载体中的生物可吸收油的悬浮液。 本发明导致生物吸收油在内部身体组织上的均匀薄涂层。
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