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52 条记录 (耗时 0.035 秒)

    Processes for the synthesis of tertiary amines
    41.
    发明授权
    Processes for the synthesis of tertiary amines 有权
    合成叔胺的方法

    公开(公告)号：US08080661B2

    公开(公告)日：2011-12-20

    申请号：US12586843

    申请日：2009-09-29

    申请人： Peter X. Wang ,  Tao Jiang ,  David W. Berberich

    发明人： Peter X. Wang ,  Tao Jiang ,  David W. Berberich

    IPC分类号： C07D221/28

    CPC分类号： C07D489/12

    摘要： The invention provides processes for the preparation of morphinans having a tertiary amine. In particular, the present invention provides processes for the formation of tertiary amine alkaloids by direct N-alkylation of secondary amine alkaloids, the processes co-mediated by an alkylating agent and a protic solvent or a mixture of a protic solvent and an aprotic solvent.

    摘要翻译： 本发明提供了制备具有叔胺的吗啡喃的方法。 特别地，本发明提供了通过仲胺生物碱的直接N-烷基化形成叔胺生物碱的方法，该方法由烷基化剂和质子溶剂或质子溶剂和非质子溶剂的混合物共同介导。

    Preparation of Saturated Ketone Morphinan Compounds by Catalytic Isomerization
    42.
    发明申请
    Preparation of Saturated Ketone Morphinan Compounds by Catalytic Isomerization 有权
    通过催化异构化制备饱和酮吗啡喃化合物

    公开(公告)号：US20100261904A1

    公开(公告)日：2010-10-14

    申请号：US12757064

    申请日：2010-04-09

    申请人： Peter X. Wang ,  Tao Jiang ,  David W. Berberich

    发明人： Peter X. Wang ,  Tao Jiang ,  David W. Berberich

    IPC分类号： C07D489/00

    CPC分类号： C07D489/02 ,  C07D489/04

    摘要： The present invention provides processes for the preparation of saturated ketone morphinan compounds by catalytic isomerization. In particular, the invention provides processes for the conversion of a morphinan comprising an allyl alcohol ring moiety into a morphinan comprising a saturated ketone ring moiety by an isomerization reaction catalyzed by an allyl-transition metal catalyst.

    摘要翻译： 本发明提供了通过催化异构化制备饱和酮吗啡喃化合物的方法。 特别地，本发明提供了通过由烯丙基 - 过渡金属催化剂催化的异构化反应将包含烯丙醇环部分的吗啡喃转化成包含饱和酮环部分的吗啡喃的方法。

    Medical Devices for Localized Drug Delivery
    44.
    发明申请
    Medical Devices for Localized Drug Delivery 审中-公开
    医疗器械用于局部给药

    公开(公告)号：US20100068242A1

    公开(公告)日：2010-03-18

    申请号：US12516236

    申请日：2007-11-15

    申请人： Gary L. Cantrell ,  David W. Berberich

    发明人： Gary L. Cantrell ,  David W. Berberich

    IPC分类号： A61F2/00 ,  A61K31/4355 ,  A61P7/02

    CPC分类号： A61F2/88 ,  A61F2/90 ,  A61F2250/0068 ,  A61L31/16

    摘要： In certain embodiments, the invention relates to an implantable medical device that includes a body having an internal cavity. Receptor sites in the internal cavity may be adapted to repeatedly bind to, temporarily hold, and release an active agent. An opening may extend through the body and into the internal cavity to allow the active agent into and out of the internal cavity. This opening may be sized and shaped to prevent blood cells from entering the internal cavity through the opening while allowing the active agent to enter and/or exit the cavity via the opening. A polymeric structure may be located in the internal cavity. This polymeric structure may include artificial receptor site mimics for the active agent.

    摘要翻译： 在某些实施例中，本发明涉及一种可植入医疗装置，其包括具有内腔的主体。 内腔中的受体位点可以适于重复结合，暂时保持和释放活性剂。 开口可以延伸穿过主体并进入内部空腔，以允许活性剂进入和离开内部空腔。 该开口的尺寸和形状可以防止血细胞通过开口进入内腔，同时允许活性剂经由开口进入和/或离开腔。 聚合物结构可以位于内部空腔中。 该聚合物结构可以包括活性剂的人造受体位点模拟物。

    Medical Devices for Localized Drug Delivery
    46.
    发明申请
    Medical Devices for Localized Drug Delivery 审中-公开

    公开(公告)号：US20100305688A1

    公开(公告)日：2010-12-02

    申请号：US12472785

    申请日：2009-05-27

    申请人： Gary L. Cantrell ,  David W. Berberich

    发明人： Gary L. Cantrell ,  David W. Berberich

    IPC分类号： A61F2/82

    CPC分类号： A61F2/86 ,  A61F2230/0091 ,  A61F2250/0068 ,  A61K31/4741 ,  A61L31/10 ,  A61L31/16

    摘要： In certain embodiments, the invention relates to an implantable medical device that includes a body having an internal cavity. Receptor sites in the internal cavity may be adapted to repeatedly bind to, temporarily hold, and release an active agent. An opening may extend through the body and into the internal cavity to allow the active agent into and out of the internal cavity. This opening may be sized and shaped to prevent blood cells from entering the internal cavity through the opening while allowing the active agent to enter and/or exit the cavity via the opening. A polymeric structure may be located in the internal cavity. This polymeric structure may include artificial receptor site mimics for the active agent.

    Medical Devices for Localized Drug Delivery
    47.
    发明申请
    Medical Devices for Localized Drug Delivery 审中-公开

    公开(公告)号：US20100303882A1

    公开(公告)日：2010-12-02

    申请号：US12472398

    申请日：2009-05-27

    申请人： Gary L. Cantrell ,  David W. Berberich

    发明人： Gary L. Cantrell ,  David W. Berberich

    IPC分类号： A61F2/00 ,  A61K31/4741

    CPC分类号： A61F2/86 ,  A61F2230/0091 ,  A61F2250/0068 ,  A61K31/4741 ,  A61L31/10 ,  A61L31/16

    摘要： In certain embodiments, the invention relates to an implantable medical device that includes a body having an internal cavity. Receptor sites in the internal cavity may be adapted to repeatedly bind to, temporarily hold, and release an active agent. An opening may extend through the body and into the internal cavity to allow the active agent into and out of the internal cavity. This opening may be sized and shaped to prevent blood cells from entering the internal cavity through the opening while allowing the active agent to enter and/or exit the cavity via the opening. A polymeric structure may be located in the internal cavity. This polymeric structure may include artificial receptor site mimics for the active agent.