公开(公告)号：US06218117B1

公开(公告)日：2001-04-17

申请号：US09097889

申请日：1998-06-15

申请人： Corinna Herrnstadt ,  Soumitra S. Ghosh ,  Robert E. Davis

发明人： Corinna Herrnstadt ,  Soumitra S. Ghosh ,  Robert E. Davis

IPC分类号： C12Q168

CPC分类号： C12Q1/6827 ,  C12Q1/6883 ,  C12Q2600/136 ,  C12Q2600/156 ,  C12Q2600/172

摘要： Compositions and methods based on quantification of extramitochondrial DNA (exmtDNA) sequences are provided that are useful for detecting the presence of or risk for having a disease associated with altered mitochondrial function, and for identifying agents suitable for treating such diseases. The exmtDNA sequences have strong homology to authentic mitochondrial DNA (mtDNA) sequences.

摘要翻译： 提供了基于定量线粒体DNA（exmtDNA）序列的组合物和方法，其可用于检测与改变的线粒体功能相关的疾病的存在或风险，以及用于鉴定适合于治疗这些疾病的药剂。 exmtDNA序列与真实的线粒体DNA（mtDNA）序列具有很强的同源性。

公开(公告)号：US5888498A

公开(公告)日：1999-03-30

申请号：US397808

申请日：1995-03-03

申请人： Robert E. Davis ,  Scott W. Miller

发明人： Robert E. Davis ,  Scott W. Miller

IPC分类号： A61K38/00 ,  A61K49/00 ,  C07D219/08 ,  C07K14/47 ,  C12N5/16 ,  C12N9/02 ,  C12P21/04 ,  C12Q1/68 ,  A61K48/00 ,  A01N63/00 ,  C12N15/00

CPC分类号： C12N5/16 ,  A61K49/0008 ,  C07K14/4711 ,  C07K14/4713 ,  C12N9/0053 ,  A01K2217/075 ,  A61K38/00 ,  C12N2503/00 ,  C12N2510/04

摘要： Cybrid cell lines which have utility as model systems for the study of disorders that are associated with mitochondrial defects are described. The cybrids are constructed by treating immortal cell lines with an agent that irreversibly disables mitochondrial electron transport, and then transfecting the cells with mitochondria isolated from diseased tissue samples. Preferably, the immortal cell lines used are of an undifferentiated type that can be induced to differentiate, which results in the cybrids also being able to be induced to differentiate. One such cybrid was constructed using neuroblastoma cells and mitochondria from a patient suffering from Alzheimer's Disease. Methods for using such cybrids for screening drugs and therapies for utility in treating such disorders are also provided. In addition, cybrid animals, methods of producing them, and methods of using them in drug and therapy screening are also provided.

摘要翻译： 描述了作为模拟系统用于研究与线粒体缺陷相关的病症的细胞系。 通过用不可逆地禁用线粒体电子传递的试剂处理永生细胞系，然后用从病变组织样品中分离的线粒体转染细胞来构建细胞。 优选地，使用的永生细胞系是可以诱导分化的未分化型，其导致细胞因子也能够诱导分化。 使用神经母细胞瘤细胞和来自患有阿尔茨海默病的患者的线粒体构建一个这样的细胞周期。 还提供了使用这种细胞用于筛选药物的方法和用于治疗这些疾病的疗法。 此外，还提供了细胞杂种动物，其制备方法以及将其用于药物和治疗筛选中的方法。

公开(公告)号：USD377131S

公开(公告)日：1997-01-07

申请号：US34433

申请日：1995-02-06

申请人： Robert E. Davis

设计人： Robert E. Davis

公开(公告)号：US5462607A

公开(公告)日：1995-10-31

申请号：US228575

申请日：1994-04-15

申请人： Pat A. Mestetsky ,  Robert E. Davis

发明人： Pat A. Mestetsky ,  Robert E. Davis

IPC分类号： A62D3/00 ,  C10G29/20 ,  C11D1/75 ,  C11D3/386 ,  C23G1/24 ,  B08B3/10 ,  B08B9/00 ,  B08B9/02 ,  B08B9/08

CPC分类号： C23G1/24 ,  C10G29/20 ,  C11D1/75 ,  C11D3/38618 ,  C11D3/38636 ,  C11D3/38645

摘要： A method of cleaning industrial equipment by utilizing an ebullated aqueous solution containing a surfactant and enzymes. The aqueous solution is preferably heated in a vessel, such as a batch coker fractionator in an oil refinery, to a temperature sufficient to ebullate or foam the solution and generate a substantial quantity of foam. The surfactant and enzymes are carried by the foam bubbles and transported from the vessel to a contaminated surface outside of the cascading and circulating system of the vessel where the surfactant and enzymes act to remove the contamination.

摘要翻译： 通过使用含有表面活性剂和酶的沸腾水溶液来清洁工业设备的方法。 水溶液优选在诸如炼油厂中的批次焦化器分馏器的容器中加热到足以使溶液沸腾或发泡的温度并产生大量的泡沫。 表面活性剂和酶由泡沫泡沫携带，并从容器运送到容器的级联和循环系统之外的污染表面，其中表面活性剂和酶用于除去污染物。

公开(公告)号：US5315921A

公开(公告)日：1994-05-31

申请号：US814009

申请日：1991-12-26

申请人： Robert E. Davis

发明人： Robert E. Davis

IPC分类号： F26B1/00 ,  F26B5/00 ,  A47J37/12

CPC分类号： F26B5/005 ,  F26B1/005

摘要： A method and apparatus for dehydrating waste food material. The food material is initially ground to a relatively small particle size and transferred to a porous container or basket in a cooking vessel. The vessel contains a quantity of oil, preferably waste cooking oil, and the oil is maintained at a level beneath the basket. The oil is heated and the heated oil is circulated from the lower end of the vessel and returned to the upper end of the vessel where it flows downwardly through the food material to vaporize the moisture and kill the bacteria in the food material. The circulation of the hot oil is continued for a period sufficient to fully dehydrate the food material and produce a dried product that can be used as an animal feed adjunct.

摘要翻译： 一种用于脱水废食品材料的方法和装置。 食物材料最初被研磨成相对较小的粒度并转移到烹饪容器中的多孔容器或篮子中。 该容器含有一定数量的油，优选废食物油，油保持在篮下方。 油被加热并且加热的油从容器的下端循环并返回到容器的上端，在那里其向下流过食物材料以蒸发水分并杀死食物中的细菌。 热油的循环持续时间足以使食物完全脱水，并产生可用作动物饲料添加剂的干燥产品。

公开(公告)号：US4629488A

公开(公告)日：1986-12-16

申请号：US839166

申请日：1986-03-03

申请人： Wilbur O. Doud ,  Robert E. Davis ,  Fred R. Sawyer

发明人： Wilbur O. Doud ,  Robert E. Davis ,  Fred R. Sawyer

IPC分类号： C03B9/193 ,  C03B9/34 ,  C03B9/38 ,  C03B11/12

CPC分类号： C03B9/3866 ,  C03B9/193 ,  C03B9/344 ,  C03B9/3825 ,  C03B9/3833 ,  C03B9/3875 ,  Y02P40/57

摘要： A parison mold portion (20) of an individual glassware molding machine, of the type having a parison mold (22), a split neck ring (28), a neck ring holder (30), an upper receiver cap (40), and a parison plunger (116) , is provided with means for cooling the neck ring (28) and the parison mold (22). The means for cooling the neck ring (28) and the parison mold (22) includes a plurality of first cooling holes (214) in the upper receiver cap (40), a plurality of second cooling holes (216) in the neck ring (28) that communicate with the plurality of first cooling holes (214), and a plurality of third cooling holes (230) in the parison mold (22) that communicate with the plurality of second cooling holes (216).

摘要翻译： 具有型坯模具（22），分割颈圈（28），颈圈保持器（30），上接收器盖（40）和类似物模型的型坯模具部分（20） 型坯柱塞（116）设置有用于冷却颈环（28）和型坯模具（22）的装置。 用于冷却颈环（28）和型坯（22）的装置包括在上接纳帽（40）中的多个第一冷却孔（214），颈环中的多个第二冷却孔（216） 与所述多个第一冷却孔（214）连通的多个第二冷却孔（216）以及与所述多个第二冷却孔（216）连通的所述型坯（22）中的多个第三冷却孔（230）。

公开(公告)号：US4614297A

公开(公告)日：1986-09-30

申请号：US613043

申请日：1984-05-22

申请人： Robert E. Davis ,  Patrick S. Maio ,  Lawrence J. Growney

发明人： Robert E. Davis ,  Patrick S. Maio ,  Lawrence J. Growney

IPC分类号： B65D5/02 ,  B65D5/42 ,  B65D5/43 ,  B65D5/54 ,  B65D5/66 ,  B65D8/02 ,  B65D5/08

CPC分类号： B65D5/0227 ,  B65D5/42 ,  B65D5/546 ,  B65D5/6661 ,  Y10S206/807

摘要： This relates to tamper resistant cartons wherein the outermost closure flap is provided with a sealing flap of which at least a portion functions as a tuck flap and which tuck flap passes between a front panel and a terminal inner panel with a tuck flap portion being bonded on its inner surface to the outer surface of the inner terminal panel in an inaccessible position whereby the carton cannot be opened without rupturing the same to the extent that tampering would be apparent.

摘要翻译： 这涉及防篡改纸箱，其中最外面的封闭翼片设置有密封翼片，其中至少一部分用作褶裥翼片，并且该褶裥翼片在前面板和终端内部面板之间通过，其中褶裥翼片部分粘合在 其内表面到内端子板的外表面处于不可接近的位置，由此不能打开纸箱而不破坏纸箱，直到篡改显而易见。

公开(公告)号：US4488865A

公开(公告)日：1984-12-18

申请号：US403769

申请日：1982-05-26

申请人： Robert E. Davis

发明人： Robert E. Davis

IPC分类号： B08B3/02 ,  F22B1/22 ,  F23C15/00 ,  F24H1/28 ,  G11C11/418 ,  H03K19/0185 ,  F23C11/04

CPC分类号： F23C15/00 ,  B08B3/02 ,  F22B1/22 ,  F24H1/28 ,  G11C11/418 ,  H03K19/01855 ,  B08B2230/01 ,  Y10T137/7842 ,  Y10T137/791

摘要： A pulsing combustion device (10) is disclosed including a combustion chamber (15) with a poppet valve (20) mounted for reciprocation in the combustion chamber (15). A pressurized combustible mixture is supplied to the poppet valve (20) with the combustion gases ignited in the combustion chamber (15). The poppet valve (20) is reciprocated in the combustion chamber (15) by the pressure of the pressurized combustible mixture and the pressure of the combustion gases. The poppet valve (20) regulates the flow of the combustible mixture into the combustible chamber. The pulsing combustion device (10) may be utilized in a steam cleaning device wherein the pulsing combustion device is surrounded by a flow of liquid.The pulsing combustion device may also be utilized for home heating with a fluid heated by the combustion device.

摘要翻译： PCT No.PCT / US81 / 01727 Sec。 371日期1982年5月26日 102（e）日期1982年5月26日PCT提交1981年12月22日PCT公布。 公开号WO82 / 02278 日本1987年7月8日公开了一种脉冲燃烧装置（10），其包括具有安装用于在燃烧室（15）中往复运动的提升阀（20）的燃烧室（15）。 在燃烧室（15）中点燃的燃烧气体将加压的可燃混合物供应到提升阀（20）。 提升阀（20）通过加压的可燃混合物的压力和燃烧气体的压力在燃烧室（15）中往复运动。 提升阀（20）调节可燃混合物进入可燃室的流量。 脉冲燃烧装置（10）可以用于蒸汽清洁装置中，其中脉冲燃烧装置被液体流包围。 脉冲燃烧装置也可用于利用燃烧装置加热的流体进行家庭加热。

公开(公告)号：US4479484A

公开(公告)日：1984-10-30

申请号：US218849

申请日：1980-12-22

申请人： Robert E. Davis

发明人： Robert E. Davis

IPC分类号： A47L7/00 ,  B08B3/02 ,  F22B1/22 ,  F22B31/00 ,  F23C15/00 ,  F24H1/28 ,  F24H1/00

CPC分类号： F23C15/00 ,  B08B3/026 ,  F22B1/22 ,  F24H1/28 ,  B08B2230/01

摘要： A pulsing combustion device is disclosed including a combustion chamber with a poppet valve mounted for reciprocation in the combustion chamber. A pressurized combustible mixture is supplied to the poppet valve with the combustion gases ignited in the combustion chamber. The poppet valve is reciprocated in the combustion chamber by the pressure of the pressurized combustible mixture and the pressure of the combustion gases. The poppet valve regulates the flow of the combustible mixture into the combustible chamber. The pulsing combustion device may be utilized in a steam cleaning device wherein the pulsing combustion device is surrounded by a flow of liquid.The pulsing combustion device may also be utilized for home heating with a fluid heated by the combustion device.

公开(公告)号：US4407300A

公开(公告)日：1983-10-04

申请号：US168018

申请日：1980-07-14

申请人： Robert E. Davis

发明人： Robert E. Davis

IPC分类号： A61B5/05

CPC分类号： A61B5/415 ,  A61B5/05 ,  A61B5/418

摘要： Methods for scanning and diagnosing the presence or absence of malignant cancerous tissue in areas such as mammary tissue and lymph nodes of human and animal bodies by measuring the electromotive force generated by a platinum electrode or probe in contact with skin or subcutaneous portions of a body area to be diagnosed for presence or absence of said malignant tissue, and recording as suspect areas of malignant growth at least those body areas which were in contact with the probe or electrode when a significant negative electromotive force in the order of minus two millivolts or less was measured, the electromotive force being measured across two electrodes or probes, one in contact with normal skin or tissue, and the other in contact with skin or subcutaneous portions of the body area to be diagnosed.

摘要翻译： 通过测量与身体区域的皮肤或皮下部分接触的铂电极或探针产生的电动势来扫描和诊断在人和动物体的乳腺组织和淋巴结等区域中存在或不存在恶性癌组织的方法 被诊断为存在或不存在所述恶性组织，并且当负2毫伏或更小数量级的显着负电动势为至少那些与探针或电极接触的身体区域时，记录为恶性生长的可疑区域 测量时，在两个电极或探针之间测量电动势，一个与正常皮肤或组织接触，另一个与要诊断的身体区域的皮肤或皮下部分接触。