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    Mitochondria protecting agents for treating mitochondria associated diseases
    4.
    发明授权
    Mitochondria protecting agents for treating mitochondria associated diseases 失效
    线粒体保护剂用于治疗线粒体相关疾病

    公开(公告)号：US06498191B2

    公开(公告)日：2002-12-24

    申请号：US09733271

    申请日：2000-12-07

    申请人： Soumitra S. Ghosh ,  Scott W. Miller ,  Robert E. Davis ,  Walter H. Moos

    发明人： Soumitra S. Ghosh ,  Scott W. Miller ,  Robert E. Davis ,  Walter H. Moos

    IPC分类号： A61K31225

    CPC分类号： A61K31/155 ,  A61K31/00 ,  A61K31/05 ,  A61K31/06 ,  A61K31/136 ,  C07C39/08 ,  C07C39/11 ,  C07C39/19 ,  C07C69/017 ,  C07C215/78 ,  C07C215/80 ,  C07C217/84 ,  C07C279/18 ,  C07D215/20 ,  C07D311/72

    摘要： The present invention relates generally to mitochondria protecting agents for treating diseases in which mitochondrial dysfunction leads to tissue degeneration and, more specifically, to compounds, compositions and methods related to the same. The methods of this invention involve administration of a pharmaceutically effective amount of a mitochondria protecting agent to a warm-blooded animal in need thereof, and composition of this invention contain a mitochondria protecting agent in combination with a pharmaceutically acceptable carrier or diluent. Mitochondrial associated diseases which may be treated by the present invention include (but are not limited to) Alzheimer's Disease, diabetes mellitus, Parkinson's Disease, neuronal and cardiac ischemia, Huntington's disease and stroke.

    摘要翻译： 本发明一般涉及用于治疗线粒体功能障碍导致组织变性的线粒体保护剂，更具体地涉及与其相关的化合物，组合物和方法。 本发明的方法涉及向有需要的温血动物施用药学有效量的线粒体保护剂，本发明的组合物含有与药学上可接受的载体或稀释剂组合的线粒体保护剂。 可以通过本发明治疗的线粒体相关疾病包括（但不限于）阿尔茨海默氏病，糖尿病，帕金森病，神经元和心脏缺血，亨廷顿病和中风。

    Cellular and animal models for diseases associated with mitochondrial defects
    5.
    发明授权
    Cellular and animal models for diseases associated with mitochondrial defects 失效
    与线粒体缺陷相关疾病的细胞和动物模型

    公开(公告)号：US5888498A

    公开(公告)日：1999-03-30

    申请号：US397808

    申请日：1995-03-03

    申请人： Robert E. Davis ,  Scott W. Miller

    发明人： Robert E. Davis ,  Scott W. Miller

    IPC分类号： A61K38/00 ,  A61K49/00 ,  C07D219/08 ,  C07K14/47 ,  C12N5/16 ,  C12N9/02 ,  C12P21/04 ,  C12Q1/68 ,  A61K48/00 ,  A01N63/00 ,  C12N15/00

    CPC分类号： C12N5/16 ,  A61K49/0008 ,  C07K14/4711 ,  C07K14/4713 ,  C12N9/0053 ,  A01K2217/075 ,  A61K38/00 ,  C12N2503/00 ,  C12N2510/04

    摘要： Cybrid cell lines which have utility as model systems for the study of disorders that are associated with mitochondrial defects are described. The cybrids are constructed by treating immortal cell lines with an agent that irreversibly disables mitochondrial electron transport, and then transfecting the cells with mitochondria isolated from diseased tissue samples. Preferably, the immortal cell lines used are of an undifferentiated type that can be induced to differentiate, which results in the cybrids also being able to be induced to differentiate. One such cybrid was constructed using neuroblastoma cells and mitochondria from a patient suffering from Alzheimer's Disease. Methods for using such cybrids for screening drugs and therapies for utility in treating such disorders are also provided. In addition, cybrid animals, methods of producing them, and methods of using them in drug and therapy screening are also provided.

    摘要翻译： 描述了作为模拟系统用于研究与线粒体缺陷相关的病症的细胞系。 通过用不可逆地禁用线粒体电子传递的试剂处理永生细胞系，然后用从病变组织样品中分离的线粒体转染细胞来构建细胞。 优选地，使用的永生细胞系是可以诱导分化的未分化型，其导致细胞因子也能够诱导分化。 使用神经母细胞瘤细胞和来自患有阿尔茨海默病的患者的线粒体构建一个这样的细胞周期。 还提供了使用这种细胞用于筛选药物的方法和用于治疗这些疾病的疗法。 此外，还提供了细胞杂种动物，其制备方法以及将其用于药物和治疗筛选中的方法。

    Method and apparatus to use remote and local control modes to acquire and visually present data
    7.
    发明授权
    Method and apparatus to use remote and local control modes to acquire and visually present data 有权
    使用远程和本地控制模式来获取和可视化呈现数据的方法和装置

    公开(公告)号：US09117321B2

    公开(公告)日：2015-08-25

    申请号：US12913249

    申请日：2010-10-27

    申请人： Robert E. Davis ,  Michel B. Alberry ,  Timothy G. Ruther ,  Anthony J. Cichy

    发明人： Robert E. Davis ,  Michel B. Alberry ,  Timothy G. Ruther ,  Anthony J. Cichy

    IPC分类号： G06F3/00 ,  G01M17/00 ,  A61B5/00 ,  G07C5/08 ,  G07C5/00

    CPC分类号： G07C5/0825 ,  G07C5/008 ,  G07C2205/02

    摘要： A system comprising multiple devices that are operable when servicing a device-under service is described. A data acquisition (DAQ) device and a vehicle scanner device of the system are operable to acquire data from the device-under-service and to transmit the acquired data to a display device of the system. The DAQ device can operate in a local-control mode in which selection of DAQ mode for the DAQ device is carried out at the DAQ device. The DAQ device can operate in a remote-control mode in which selection of a DAQ mode for the DAQ device is carried out at the display device. The multiple devices may communicate with each other via one or more wireless network via one or more air interface protocols. Each device of the system may operate as a stand-alone device or in combination with multiple devices of the system.

    摘要翻译： 描述了包括在服务于正在服务的设备时可操作的多个设备的系统。 系统的数据采集（DAQ）设备和车辆扫描仪设备可操作以从服务中的设备获取数据并将所获取的数据发送到系统的显示设备。 DAQ设备可以在DAQ设备中执行DAQ设备的DAQ模式选择的本地控制模式下工作。 DAQ设备可以在远程控制模式下操作，其中在显示设备上执行DAQ设备的DAQ模式的选择。 多个设备可以经由一个或多个空中接口协议经由一个或多个无线网络彼此通信。 系统的每个设备可以作为独立设备操作，或者与系统的多个设备组合。

    Data File Correlation System And Method
    9.
    发明申请
    Data File Correlation System And Method 审中-公开
    数据文件相关系统与方法

    公开(公告)号：US20100023511A1

    公开(公告)日：2010-01-28

    申请号：US12572757

    申请日：2009-10-02

    申请人： Wincenty J. Borodziewicz ,  Robert E. Davis

    发明人： Wincenty J. Borodziewicz ,  Robert E. Davis

    IPC分类号： G06F17/30

    CPC分类号： G06F16/334

    摘要： A method for correlating data from a data source representing a single data file to a data target containing a plurality of data files is provided. The method includes normalizing the data from the data source, such as by removing white space and replacing data strings. One or more data strings are selected for use as preliminary selection criteria. The preliminary selection criteria are then used to search for one or more matches in the normalized data from the data source. If no match is found, one or more data strings are selected for use as secondary selection criteria. A correlation score is calculated if at least one match is found using the preliminary selection criteria.

    摘要翻译： 提供了一种用于将表示单个数据文件的数据源的数据与包含多个数据文件的数据目标相关联的方法。 该方法包括从数据源标准化数据，例如通过删除空格和替换数据字符串。 选择一个或多个数据串用作初步选择标准。 然后使用初步选择标准来搜索来自数据源的归一化数据中的一个或多个匹配。 如果没有找到匹配，则选择一个或多个数据字符串作为二级选择标准。 如果使用初步选择标准找到至少一个匹配，则计算相关得分。