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公开(公告)号：US06326398B1
公开(公告)日：2001-12-04
申请号：US09514862
申请日：2000-02-28
IPC分类号： C07C23356
CPC分类号： C07D295/192 , C07C235/74 , C07C311/29 , C07C317/22 , C07C2601/02 , C07C2601/04 , C07C2601/08 , C07C2601/14 , C07C2602/08 , C07C2602/10 , C07C2602/42 , C07D209/08 , C07D211/14 , C07D211/16 , C07D215/08 , C07D215/20 , C07D217/04 , C07D217/06 , C07D217/08 , C07D295/096 , C07D295/26 , C07D317/58 , C07D333/20
摘要： The present invention provides novel compounds of the Formula and prodrugs thereof, geometric and optical isomers thereof, and pharmaceutically acceptable salts of such compounds, prodrugs and isomers, wherein R1-R8 and W are as described herein. Pharmaceutical compositions containing such compounds, prodrugs, isomers or pharmaceutically acceptable salts thereof, and methods, pharmaceutical compositions and kits for treating obesity, hyperlipidemia, glaucoma, cardiac arrhythmia, skin disorders, thyroid disease, hypothyroidism and related disorders and diseases such as diabetes mellitus, atherosclerosis, hypertension, coronary heart disease, hypercholesteremia, depression and osteoporosis are also provided.
摘要翻译： 本发明提供了其新的式及其前药化合物，其几何和旋光异构体，以及这些化合物，前药和异构体的药学上可接受的盐，其中R 1 -R 8和W如本文所述。 含有这些化合物，前体药物，异构体或其药学上可接受的盐的药物组合物，以及用于治疗肥胖，高脂血症，青光眼，心律失常，皮肤病，甲状腺疾病，甲状腺功能减退和相关疾病以及疾病如糖尿病的方法，药物组合物和试剂盒， 还提供了动脉粥样硬化，高血压，冠心病，高胆固醇血症，抑郁症和骨质疏松症。
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公开(公告)号：US06291489B1
公开(公告)日：2001-09-18
申请号：US09297694
申请日：1999-05-05
IPC分类号： C07D21375
CPC分类号： C07D213/73 , C07D213/75
摘要： This invention relates to processes for preparing compounds of the formula (I) and to processes for preparing certain intermediates of the formula wherein R1 is nitro, amino or protected amino; R2 is H, fluoro, chloro CF3, nitro, (C1-C4)alkyl, (C1-C4)alkoxy, amino or protected amino; and X1 is OH or a suitable leaving group, used in that process. The invention also relates novel to compounds of the formulae (II).
摘要翻译： 本发明涉及制备式（I）化合物的方法及其制备方法，其中R1是硝基，氨基或被保护的氨基; R2是H，氟，氯，CF3，硝基，（C1-C4）烷基，（C1-C4）烷氧基，氨基或被保护的氨基; 并且X1是OH或合适的离去基团，用于该方法。 本发明还涉及新颖的式（II）化合物。
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公开(公告)号：US5139283A
公开(公告)日：1992-08-18
申请号：US633374
申请日：1990-12-21
申请人： Robert L. Dow , Philip S. Kornblum , Jay S. Lief
发明人： Robert L. Dow , Philip S. Kornblum , Jay S. Lief
IPC分类号： A63C11/22
CPC分类号： A63C11/221 , A63C11/227 , A63C11/24 , A63C2203/10 , Y10T403/32959
摘要： This invention discloses an adjustable and foldable ski pole which comprises two pole sections hinged together to be foldable into a uniquely convenient compact structure that can be carried safely and easily and can be easily stored in a car, boot bag or its own nylon bag while being adjustable for users of different heights. The ski pole has an especially robust construction to be durable and suitable for professional use. Further benefits are provided for retailers and ski rental agencies.
摘要翻译： 本发明公开了一种可调节和可折叠的滑雪杖，其包括铰接在一起的两个极部分，以可折叠成独特便利的紧凑结构，其可以安全且容易地携带并且可以容易地存储在汽车，靴子包或其自己的尼龙袋中，同时 可调节为不同高度的用户。 滑雪杆具有坚固的结构，耐用，适合专业使用。 为零售商和滑雪租赁公司提供进一步的收益。
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公开(公告)号：US08859773B2
公开(公告)日：2014-10-14
申请号：US13282964
申请日：2011-10-27
申请人： David A. Griffith , Robert L. Dow , Scott W. Bagley , Aaron Smith
发明人： David A. Griffith , Robert L. Dow , Scott W. Bagley , Aaron Smith
IPC分类号： C07D471/20 , C07D519/00 , A61K31/4725
CPC分类号： C07D471/20 , C07D519/00
摘要： The invention provides a compound of Formula (I) or a pharmaceutically acceptable salt thereof; wherein G is R1, R2 and R3 are as described herein; pharmaceutical compositions thereof; and the use thereof in treating diseases, conditions or disorders modulated by the inhibition of an acetyl-CoA carboxylase enzyme(s) in an animal.
摘要翻译： 本发明提供式（I）化合物或其药学上可接受的盐; 其中G为R 1，R 2和R 3如本文所述; 其药物组合物; 以及其用于治疗通过抑制动物体内的乙酰辅酶A羧化酶调节的疾病，病症或病症的用途。
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![4-AMINO-5-OXO-7,8-DIHYDROPYRIMIDO[5,4-F][1,4]OXAZEPIN-6(5H)-YL PHENYL DERIVATIVES](/abs-image/US/2010/08/12/US20100204119A1/abs.jpg.150x150.jpg)
45.发明申请4-AMINO-5-OXO-7,8-DIHYDROPYRIMIDO[5,4-F][1,4]OXAZEPIN-6(5H)-YL PHENYL DERIVATIVES 审中-公开4-氨基-5-氧代-7,8-二氢吡啶并[5,4-F] [1,4]氧杂环己烯-6（5H） - 苯基衍生物公开(公告)号：US20100204119A1
公开(公告)日：2010-08-12
申请号：US12697658
申请日：2010-02-01
IPC分类号： A61K38/16 , C07D498/04 , A61K31/553 , A61P3/10 , A61P3/04 , A61K31/56
CPC分类号： C07D498/04 , A61K31/553 , A61K45/06 , A61K2300/00
摘要： The invention provides compounds of Formula (I), wherein R1, R2a, R2b, R3, m and A are as defined herein, as well as compositions thereof and methods for treating a disease, condition or disorder that is modulated by the inhibition of the diacylglycerol O-acyltransferase 1 (DGAT-1) enzyme by administering the compounds of the present invention and/or compositions thereof.
摘要翻译： 本发明提供式（I）化合物，其中R 1，R 2a，R 2b，R 3，m和A如本文所定义，以及其组合物和治疗疾病，病症或病症的方法，其通过抑制 二酰基甘油O-酰基转移酶1（DGAT-1）酶，通过施用本发明的化合物和/或其组合物。
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公开(公告)号：US07241788B2
公开(公告)日：2007-07-10
申请号：US11433848
申请日：2006-05-12
申请人： Philip A. Carpino , Robert L. Dow
发明人： Philip A. Carpino , Robert L. Dow
IPC分类号： A61K31/415
CPC分类号： C07D471/04 , C07D487/04
摘要： Compounds of Formula (I) and (II) that act as cannabinoid receptor ligands and their uses in the treatment of diseases linked to the mediation of the cannabinoid receptors in animals are described herein
摘要翻译： 本文描述了作为大麻素受体配体的式（I）和（II）化合物及其在治疗与动物中的大麻素受体的介导相关的疾病中的用途
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公开(公告)号：US07145012B2
公开(公告)日：2006-12-05
申请号：US10823107
申请日：2004-04-12
申请人： Philip A. Carpino , Robert L. Dow
发明人： Philip A. Carpino , Robert L. Dow
IPC分类号： C07D471/02
CPC分类号： C07D471/04 , C07D487/04
摘要： Compounds of Formula (I) and (II) that act as cannabinoid receptor ligands and their uses in the treatment of diseases linked to the mediation of the cannabinoid receptors in animals are described herein
摘要翻译： 本文描述了作为大麻素受体配体的式（I）和（II）化合物及其在治疗与动物中的大麻素受体的介导相关的疾病中的用途
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公开(公告)号：US06930107B2
公开(公告)日：2005-08-16
申请号：US10763451
申请日：2004-01-23
IPC分类号： A61P11/06 , C07D253/075 , C07D401/12 , C07D403/12 , C07D405/12 , C07D409/12 , C07D409/14 , C07D413/12 , C07D413/14 , C07D417/12 , C07D451/06 , C07D453/02 , C07D471/04 , C07D471/08 , C07D471/10 , C07D491/10 , C07D491/20 , C07D493/04 , A61K31/53
CPC分类号： C07D253/075 , C07D401/12 , C07D403/12 , C07D405/12 , C07D409/12 , C07D409/14 , C07D413/12 , C07D413/14 , C07D417/12 , C07D451/06 , C07D453/02 , C07D471/04 , C07D471/08 , C07D471/10 , C07D491/10 , C07D493/04
摘要： The present invention provides novel compounds of the Formula I and prodrugs thereof, geometric and optical isomers thereof, and pharmaceutically acceptable salts of such compounds, prodrugs and isomers, wherein R1 to R8 and W are as described herein. Pharmaceutical compositions containing such compounds, prodrugs, isomers or pharmaceutically acceptable salts thereof, and methods, pharmaceutical compositions and kits for treating obesity, overweight condition, hyperlipidemia, thyroid disease, hypothyroidism, thyroid cancer and related disorders and diseases such as diabetes mellitus, atherosclerosis, hypertension, coronary heart disease, hypercholesteremia, depression, osteoporosis, cardiac arrhythmias, glaucoma and congestive heart failure are also provided.
摘要翻译： 本发明提供新的式I化合物及其前药，其几何和旋光异构体，以及这些化合物，前药和异构体的药学上可接受的盐，其中R 1至R 8， SUP>和W如本文所述。 含有这些化合物，前体药物，异构体或其药学上可接受的盐的药物组合物，以及用于治疗肥胖，超重状况，高脂血症，甲状腺功能减退，甲状腺癌和相关疾病以及疾病如糖尿病，动脉粥样硬化， 还提供高血压，冠心病，高胆固醇血症，抑郁症，骨质疏松症，心律失常，青光眼和充血性心力衰竭。
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公开(公告)号：US06545018B2
公开(公告)日：2003-04-08
申请号：US09966467
申请日：2001-09-27
IPC分类号： C07D21302
CPC分类号： C07D295/192 , C07C235/74 , C07C311/29 , C07C317/22 , C07C2601/02 , C07C2601/04 , C07C2601/08 , C07C2601/14 , C07C2602/08 , C07C2602/10 , C07C2602/42 , C07D209/08 , C07D211/14 , C07D211/16 , C07D215/08 , C07D215/20 , C07D217/04 , C07D217/06 , C07D217/08 , C07D295/096 , C07D295/26 , C07D317/58 , C07D333/20
摘要： The present invention provides novel compounds of the Formula and prodrugs thereof, geometric and optical isomers thereof, and pharmaceutically acceptable salts of such compounds, prodrugs and isomers, wherein R1-R8 and W are as described herein. Pharmaceutical compositions containing such compounds, prodrugs, isomers or pharmaceutically acceptable salts thereof, and methods, pharmaceutical compositions and kits for treating obesity, hyperlipidemia, glaucoma, cardiac arrhythmia, skin disorders, thyroid disease, hypothyroidism and related disorders and diseases such as diabetes mellitus, atherosclerosis, hypertension, coronary heart disease, hypercholesteremia, depression and osteoporosis are also provided.
摘要翻译： 本发明提供了其新的式及其前药化合物，其几何和旋光异构体，以及这些化合物，前药和异构体的药学上可接受的盐，其中R 1 -R 8和W如本文所述。 含有这些化合物，前体药物，异构体或其药学上可接受的盐的药物组合物，以及用于治疗肥胖，高脂血症，青光眼，心律失常，皮肤病，甲状腺疾病，甲状腺功能减退和相关疾病以及疾病如糖尿病的方法，药物组合物和试剂盒， 还提供了动脉粥样硬化，高血压，冠心病，高胆固醇血症，抑郁症和骨质疏松症。
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公开(公告)号：US06380223B1
公开(公告)日：2002-04-30
申请号：US09559384
申请日：2000-04-27
IPC分类号： C07D21302
CPC分类号： C07D455/06 , C07C49/747 , C07C49/755 , C07C69/76 , C07C215/74 , C07C235/66 , C07C251/44 , C07C251/52 , C07C251/60 , C07C255/53 , C07C255/54 , C07C271/44 , C07C271/52 , C07C281/04 , C07C307/02 , C07C309/65 , C07C309/66 , C07C309/73 , C07C311/04 , C07C311/08 , C07C311/51 , C07C317/18 , C07C333/04 , C07C2603/00 , C07C2603/26 , C07D207/09 , C07D211/46 , C07D213/22 , C07D213/30 , C07D213/40 , C07D213/75 , C07D231/40 , C07D231/56 , C07D239/34 , C07D241/18 , C07D241/20 , C07D249/08 , C07D249/14 , C07D257/04 , C07D271/06 , C07D271/07 , C07D277/24 , C07D277/28 , C07D277/56 , C07D295/088 , C07D295/13 , C07D295/185 , C07D295/205 , C07D303/14 , C07D317/36 , C07D333/16 , C07D413/04
摘要： The present invention provides non-steroidal compounds of formula I which are selective modulators (i.e., agonists and antagonists) of a steroid receptor, specifically, the glucocorticoid receptor. The present invention also provides pharmaceutical compositions containing these compounds and methods for using these compounds to treat animals requiring glucocorticoid receptor agonist or antagonist therapy. Glucocorticoid receptor modulators are useful to treat diseases, such as obesity, diabetes, inflammation and others as described below. The present invention also provides intermediates and processes for preparing these compounds.
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