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    High loading of immobilized enzymes on activated carbon supports
    42.
    发明授权
    High loading of immobilized enzymes on activated carbon supports 失效
    固定化酶在活性炭载体上的高负载量

    公开(公告)号：US4289853A

    公开(公告)日：1981-09-15

    申请号：US147353

    申请日：1980-05-07

    申请人： James E. Bailey ,  Yong K. Cho

    发明人： James E. Bailey ,  Yong K. Cho

    IPC分类号： C12N11/06 ,  C12N11/14 ,  C12N11/02

    CPC分类号： C12N11/06 ,  C12N11/14

    摘要： Enzymes are immobilized on activated carbon supports at high load levels and with high stability by reacting an activated carbon support with a carbodiimide or an isoxazolium salt to form active organic radicals on the surface of the activated carbon support and thereafter treating the carbon support with an enzyme solution to immobilize the enzyme on the carbon support. The immobilization of enzymes on activated carbon provides immobilized enzymes which are easily handled and which are stabilized against denaturation by hydrogen peroxide.

    摘要翻译： 酶通过活性炭载体与碳二亚胺或异恶唑盐反应而在高负载水平下固定在活性炭载体上并具有高稳定性，以在活性炭载体的表面上形成活性有机基团，然后用酶处理碳载体 溶液将酶固定在碳载体上。 酶在活性炭上的固定提供了易于处理的固定化酶，并且其被稳定以防止过氧化氢变性。

    Method and apparatus for monitoring tissue fluid content for use in an implantable cardiac device
    45.
    发明授权
    Method and apparatus for monitoring tissue fluid content for use in an implantable cardiac device 有权
    用于监测可植入心脏装置中使用的组织液含量的方法和装置

    公开(公告)号：US08428717B2

    公开(公告)日：2013-04-23

    申请号：US10684759

    申请日：2003-10-14

    申请人： Li Wang ,  Yong K. Cho ,  Kevin Kuehn ,  Glenn C. Zillmer ,  Nirav V. Sheth

    发明人： Li Wang ,  Yong K. Cho ,  Kevin Kuehn ,  Glenn C. Zillmer ,  Nirav V. Sheth

    IPC分类号： A61N1/365

    CPC分类号： A61B5/4869 ,  A61B5/0537 ,  A61B5/0538 ,  A61B5/7203 ,  A61B5/7285 ,  A61N1/3627 ,  A61N1/36521 ,  A61N1/3962

    摘要： A fluid status monitoring system for use in implantable cardiac stimulation or monitoring devices is provided for monitoring changes in thoracic fluid content. A fluid status monitor includes excitation pulse generating and control circuitry, and voltage and current measurement and control circuitry for performing a series of cardiac-gated, intra-thoracic impedance measurements. The cardiac-gated measurements are filtered or time-averaged to provide a fluid status impedance value, with respiratory noise removed. Based on comparative analysis of the fluid status impedance value, a clinically relevant trend in fluid status may be tentatively diagnosed and a fluid status response provided. Cross-check intra-thoracic impedance measurements performed using the same or a different excitation pathway and a different measurement pathway than the primary intra-thoracic impedance measurement configuration may be used to verify a tentative diagnosis.

    摘要翻译： 提供用于植入式心脏刺激或监测装置的流体状态监测系统，用于监测胸腔液含量的变化。 流体状态监测器包括激励脉冲发生和控制电路以及用于执行一系列心脏门控胸腔内阻抗测量的电压和电流测量和控制电路。 心脏门控测量被过滤或时间平均以提供流体状态阻抗值，消除呼吸噪声。 基于流体状态阻抗值的比较分析，可以暂时诊断流体状态的临床相关趋势，并提供流体状态响应。 使用与主要的胸内阻抗测量配置相同或不同的激发途径和不同的测量路径进行的交叉检查胸内阻抗测量可用于验证临时诊断。

    Algorithm for the automatic determination of optimal AV an VV intervals
    50.
    发明授权
    Algorithm for the automatic determination of optimal AV an VV intervals 有权
    用于自动确定最佳AV的VV间隔的算法

    公开(公告)号：US07228174B2

    公开(公告)日：2007-06-05

    申请号：US10135912

    申请日：2002-04-29

    申请人： John E. Burnes ,  Yong K. Cho ,  David Igel ,  Luc R. Mongeon ,  John C. Rueter ,  Harry Stone ,  Jodi Zilinski

    发明人： John E. Burnes ,  Yong K. Cho ,  David Igel ,  Luc R. Mongeon ,  John C. Rueter ,  Harry Stone ,  Jodi Zilinski

    IPC分类号： A61N1/362

    CPC分类号： A61N1/3627 ,  A61N1/36521 ,  A61N1/3682 ,  A61N1/3684

    摘要： Methods and devices for determining optimal Atrial to Ventricular (AV) pacing intervals and Ventricular to Ventricular (VV) delay intervals in order to optimize cardiac output. Impedance, preferably sub-threshold impedance, is measured across the heart at selected cardiac cycle times as a measure of chamber expansion or contraction. One embodiment measures impedance over a long AV interval to obtain the minimum impedance, indicative of maximum ventricular expansion, in order to set the AV interval. Another embodiment measures impedance change over a cycle and varies the AV pace interval in a binary search to converge on the AV interval causing maximum impedance change indicative of maximum ventricular output. Another method varies the right ventricle to left ventricle (VV) interval to converge on an impedance maximum indicative of minimum cardiac volume at end systole. Another embodiment varies the VV interval to maximize impedance change.

    摘要翻译： 用于确定最佳心房与心室（AV）起搏间隔和心室间室（VV）延迟间隔的方法和装置，以优化心输出量。 在选择的心脏周期时间内，跨心脏测量阻抗，优选亚阈值阻抗，作为腔室扩张或收缩的量度。 为了设定AV间隔，一个实施例测量长AV间隔上的阻抗以获得指示最大心室扩张的最小阻抗。 另一个实施例测量一个周期的阻抗变化，并且改变二进制搜索中的AV步速间隔以收敛于AV间隔，从而引起指示最大心室输出的最大阻抗变化。 另一种方法将右心室改变为左心室（VV）间隔，以收敛于指示最终心脏收缩最小心脏容积的阻抗最大值。 另一实施例改变VV间隔以最大化阻抗变化。