Abstract:
Compositions and methods are provided for preparing an hsiRNA mixture and for silencing of gene expression in vivo. The composition relates to a mutant RnaseIII. The methods are directed to reacting a preparation of dsRNA with an effective amount of a mutant RNAse III to produce the hsiRNA mixture.
Abstract:
Circuitry for reducing propagation delays in calculation of a value for use in a floating point multiply-accumulate operation. In the circuitry, a carry-save adder receives values of three input operands from three latches. A carry-lookahead adder receives the outputs from the carry-save adder and implements an XOR operation on a most-significant bit along with its own logic operation to produce the value for the floating point multiply-accumulate operation. Modification of the carry-lookahead adder to perform the XOR operation results in elimination of an entire stage of logic.
Abstract:
Accordingly, the present invention provides an improved process for the production of Portland slag cement using granulated blast furnace slag, which comprises: (viii) forming of cement clinker by known process, (ix) ball-milling of cement clinker for a period ranging between 30-60 minutes in dry condition, (x) reducing size of granulated blast furnace slag by any process to obtain the size in the range between 210 to 100 μm for using as feed for attrition mill, (xi) wet milling of granulated blast furnace slag for a period ranging between 5-15 minutes in an attrition mill using granulated blast furnace slag to water ratio in the range of 1:1 to 1:2 and granulated blast furnace slag to grinding bail ratio in the range of 1:5 to 1:15, (xii) removing water from the slurry obtained after attrition milling by known process, (xiii) drying of the obtained slurry by known process, (xiv) mixing intimately of: attrition milled slag obtain in step (vi) in the range of: 50 to 95% by weight ball-milled clinker obtain in step (ii) in the range of: 05 to 45% by weight gypsum in the range of: 01 to 05% by weight for a period in the range of 15 to 30 minutes.
Abstract:
An isolated DNA sequence set forth in SEQ ID NO: 32, which is differentially expressed in apical buds of plant Caragana jubata (Pall.) under freezing conditions, is disclosed.
Abstract translation:公开了在冷冻条件下在植物Caragana jubata(Pall。)的顶芽中差异表达的SEQ ID NO:32所示的分离的DNA序列。
Abstract:
Present embodiments of the invention describe computational methods for performing a systematic, genome-wide search for novel drug targets in pathogenic organisms for example, the human filarial parasites. Cofactor independent phosphoglycerate mutase (iPGM) was identified by this search as a candidate target for identifying therapeutic agents for use in treating animal or plant subjects infected with parasitic nematodes, microbial pathogens including microsporidia, fungi etc. A consensus amino acid or nucleotide sequence that characterizes iPGM is further provided.
Abstract:
A method, system, and computer program product for systematically collecting metrics implementation data for use by an enterprise is provided. In one embodiment, a metrics capability self assessment (MCSA) system determines a set of information sections important in determining implementation of metrics in an organization within the enterprise. The MCSA system also determines a set of questions for each information section which measure the degree of implementation of metrics within a given one of set of information sections. These are typically determined by a group within the enterprise and entered into the MCSA system. The MCSA system then provides a user with the set of questions and receives responses to the set of questions. These questions are presented to each organization and project site within the organization on a periodic basis to ensure a systematic collection of information. Based on the answers, a scale is assigned to each group site or project site within the organization, wherein the scale provides a simple means of determining the level of metrics implementation of a group. Responses from the various project sites and organization sites may then be grouped into statistical information for presentation to a user. The information can be used either statistically or in raw form by a user to make plans and changes in metric systems to enable the enterprise to become more efficient and make better use of metrics.
Abstract:
p38beta2 polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing p38beta2 polypeptides and polynucleotides in the design of protocols for the treatment of central nervous system disorder such as senile dementia of the Alzheimer's type (SDAT), mutiple sclerosis, cerebral malaria, stroke, head trauma and spinal cord injury; cardiovascular diseases such as restenosis and atherosclerosis; inflammatory diseases such as Adult Respiratory Disease Syndrome (ARDS), Rheumatoid arthritis, Osteoarthritis, Inflammatory Bowel Disease (IBD), psoriasis, derratitis, asthma; and other such diseases or conditions associated with dysregulated or excess cytokines such as osteoporosis, sepsis due to surgical or traumatic incident, chronic renal failure, AIDs, cachexia and autoimmune conditions such as lupus erthyromatosis, host graft rejection and graft verus host disease, among others, and diagnostic assays for such conditions.
Abstract:
Systems and methods are provided for supporting multiple access point names for trusted wireless local area network (LAN.) In one method, the method includes receiving a packet at a mobile access gateway from a UE operating in a trusted wireless LAN, determining at the mobile access gateway an access point name (APN) associated with the received packet, and analyzing a binding update list (BUL) table to identify an IP address of the UE used by the determined APN. The method further includes modifying a source IP address of the received packet to the IP address of the UE used by the determined APN, and transmitting the packet to a home network associated with the APN.