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    METHOD FOR PRODUCING REDUCED COENZYME Q10, METHOD FOR STABILIZING SAME, AND COMPOSITION COMPRISING SAME
    42.
    发明申请
    METHOD FOR PRODUCING REDUCED COENZYME Q10, METHOD FOR STABILIZING SAME, AND COMPOSITION COMPRISING SAME 审中-公开
    用于生产降低的聚苯乙烯的方法Q10，其稳定化方法和包含其的组合物

    公开(公告)号：US20120201802A1

    公开(公告)日：2012-08-09

    申请号：US13502181

    申请日：2010-10-14

    申请人： Takao Yamaguchi ,  Takaaki Jikihara ,  Shiro Kitamura ,  Yasuyoshi Ueda

    发明人： Takao Yamaguchi ,  Takaaki Jikihara ,  Shiro Kitamura ,  Yasuyoshi Ueda

    IPC分类号： A61K38/43 ,  A61K31/122 ,  A23L1/30 ,  C07C50/28

    CPC分类号： A61K36/53 ,  A23L33/10 ,  A23L33/105 ,  A23L33/15 ,  A23P10/30 ,  A23V2002/00 ,  A61K9/4875 ,  A61K31/09 ,  A61K31/122 ,  A61K36/15 ,  A61K36/736 ,  A61K36/82 ,  C07C41/26 ,  C07C41/46 ,  C07C43/23 ,  A23V2250/21 ,  A23V2250/314

    摘要： The present invention aims to provide a component having not only an ability to reduce oxidized coenzyme Q10 and an ability to stabilize reduced coenzyme Q10, but also nutrient, flavor, broad utility and the like, and a utilization method thereof. The present invention relates to a safe and convenient method of producing reduced coenzyme Q10, including reducing oxidized coenzyme Q10 by using, as a component derived from a naturally-occurring substance, which is safe for the body, any one or more components selected from the group consisting of an acerola extract, a tea extract, a rosemary extract, a pine bark extract and a Vaccinium vitis-idaea extract. In addition, the present invention also relates to a method of stabilizing reduced coenzyme Q10 in the co-presence of a component derived from a naturally-occurring substance, and a stabilized composition. Since the above-mentioned components derived from a naturally-occurring substance can also be expected to function as nutrients, the composition of the present invention is particularly useful as a pharmaceutical product, a supplement, a food with nutrient function claims, a food for specified health use, a nutritional supplement, a nutritional product, an animal drug, a cosmetic, a therapeutic drug and the like, which are required to show various effects.

    摘要翻译： 本发明的目的在于提供一种不仅具有减少氧化型辅酶Q10的能力和稳定还原型辅酶Q10的能力，而且还具有养分，风味，广泛用途等的成分及其利用方法。 本发明涉及一种生产还原型辅酶Q10的安全且方便的方法，其包括使用作为对身体安全的天然存在物质的成分的还原氧化型辅酶Q10，任何一种或多种选自 一组由槭树提取物，茶提取物，迷迭香提取物，松树皮提取物和痘苗提取物组成。 此外，本发明还涉及在衍生自天然存在物质的成分的共存下稳定还原型辅酶Q10的稳定化组合物的方法。 由于上述衍生自天然物质的组分也可以预期作为营养物质使用，所以本发明的组合物特别可用作药物产品，补充剂，具有营养功能要求的食品，特定食品 健康用品，营养补充剂，营养产品，动物药物，化妆品，治疗药物等，需要显示各种效果。

    Processes for producing coenzyme Q10
    43.
    发明授权
    Processes for producing coenzyme Q10 有权
    生产辅酶Q10的方法

    公开(公告)号：US07910340B2

    公开(公告)日：2011-03-22

    申请号：US11981181

    申请日：2007-10-31

    申请人： Kazuyoshi Yajima ,  Takahisa Kato ,  Akihisa Kanda ,  Shiro Kitamura ,  Yasuyoshi Ueda

    发明人： Kazuyoshi Yajima ,  Takahisa Kato ,  Akihisa Kanda ,  Shiro Kitamura ,  Yasuyoshi Ueda

    IPC分类号： C12P1/00 ,  C12P7/66

    CPC分类号： C12P7/66 ,  C12P7/22

    摘要： The present invention relates to a process for producing reduced coenzyme Q10 which comprises obtaining microbial cells containing reduced coenzyme Q10 at a ratio of not less than 70 mole % among the entire coenzymes Q10, optionally disrupting the cells and recovering thus-produced reduced coenzyme Q10. The present invention also relates to a process for producing oxidized coenzyme Q10 which comprises either recovering oxidized coenzyme Q10 after oxidizing the above-mentioned microbial cells or disrupted product thereof, or recovering reduced coenzyme Q10 from the above-mentioned microbial cells or disrupted product thereof to oxidize thus-obtained reduced coenzyme Q10 thereafter. According to the processes of the present invention, reduced coenzyme Q10 and oxidized coenzyme Q10 can be produced simply on the industrial scale.

    摘要翻译： 本发明涉及还原型辅酶Q10的制备方法，其包括在整个辅酶Q10中获得含有不少于70摩尔％的还原型辅酶Q10的微生物细胞，任选地破坏细胞并回收如此生产的还原型辅酶Q10。 本发明还涉及氧化型辅酶Q10的制造方法，该方法包括在氧化上述微生物细胞或其破坏的产物后回收氧化型辅酶Q10，或将还原型辅酶Q10从上述微生物细胞或其破坏性产物回收至 此后氧化由此得到的还原型辅酶Q10。 根据本发明的方法，可以简单地在工业规模上制备还原型辅酶Q10和氧化型辅酶Q10。

    Processes for producing coenzyme q10
    45.
    发明申请
    Processes for producing coenzyme q10 审中-公开
    生产辅酶q10的方法

    公开(公告)号：US20050069996A1

    公开(公告)日：2005-03-31

    申请号：US10500249

    申请日：2002-12-27

    申请人： Kazuyoshi Yajima ,  Takahisa Kato ,  Akihisa Kanda ,  Shiro Kitamura ,  Yasuyoshi Ueda

    发明人： Kazuyoshi Yajima ,  Takahisa Kato ,  Akihisa Kanda ,  Shiro Kitamura ,  Yasuyoshi Ueda

    IPC分类号： C12N1/14 ,  C12N1/20 ,  C12P7/22 ,  C12P7/66

    CPC分类号： C12P7/66 ,  C12P7/22

    摘要： The present invention relates to a process for producing reduced coenzyme Q10 which comprises obtaining microbial cells containing reduced coenzyme Q10 at a ratio of not less than 70 mole % among the entire coenzymes Q10, optionally disrupting the cells and recovering thus-produced reduced coenzyme Q10. The present invention also relates to a process for producing oxidized coenzyme Q10 which comprises either recovering oxidized coenzyme Q10 after oxidizing the above-mentioned microbial cells or disrupted product thereof, or recovering reduced coenzyme Q10 from the above-mentioned microbial cells or disrupted product thereof to oxidize thus-obtained reduced coenzyme Q10 thereafter. According to the processes of the present invention, reduced coenzyme Q10 and oxidized coenzyme Q10 can be produced simply on the industrial scale.

    摘要翻译： 本发明涉及还原型辅酶Q10的制备方法，其包括在整个辅酶Q10中获得含有不少于70摩尔％的还原型辅酶Q10的微生物细胞，任选地破坏细胞并回收如此生产的还原型辅酶Q10。 本发明还涉及氧化型辅酶Q10的制造方法，该方法包括在氧化上述微生物细胞或其破坏的产物后回收氧化型辅酶Q10，或将还原型辅酶Q10从上述微生物细胞或其破坏性产物回收至 此后氧化由此得到的还原型辅酶Q10。 根据本发明的方法，可以简单地在工业规模上制备还原型辅酶Q10和氧化型辅酶Q10。

    Method for producing coenzyme Q10 particle
    47.
    发明授权
    Method for producing coenzyme Q10 particle 有权
    辅酶Q10颗粒的生产方法

    公开(公告)号：US08568779B2

    公开(公告)日：2013-10-29

    申请号：US12522792

    申请日：2008-01-10

    申请人： Kento Kanaya ,  Shiro Kitamura ,  Takahiro Ueda

    发明人： Kento Kanaya ,  Shiro Kitamura ,  Takahiro Ueda

    IPC分类号： A61K9/16 ,  A61K31/122 ,  C07C46/10 ,  A61K9/107 ,  C07C50/28 ,  C09K15/08

    CPC分类号： A61K31/122 ,  A23V2250/314 ,  A61K9/1075 ,  A61K9/141 ,  A61K9/16 ,  A61K9/1617 ,  A61K9/1652 ,  A61K9/1688 ,  C07C46/10 ,  C07C50/28 ,  C09K15/08

    摘要： The present invention aims to provide a production method capable of industrially and producing coenzyme Q10 particles having a high content and superior powder flowability characteristics by simple facility and convenient operations. The present invention provides a method of producing coenzyme Q10 particles, including mixing coenzyme Q10 and a poor solvent by stirring at a temperature not less than the melting point of coenzyme Q10, dispersing coenzyme Q10 into the form of oil droplets, and cooling them to a solidification temperature of coenzyme Q10 or below while stirring the dispersion to give solid particles, wherein the poor solvent is an aqueous solution comprising an organic solvent and/or a surfactant having an HLB of 6 or above. According to the production method of the present invention, coenzyme Q10 particles markedly superior in powder characteristics, and having, for example, a powder flowability index of not less than 80 can be obtained.

    摘要翻译： 本发明的目的是提供一种能够通过简单的设备和方便的操作在工业上生产具有高含量和优异的粉末流动性特性的辅酶Q10颗粒的生产方法。 本发明提供一种生产辅酶Q10颗粒的方法，包括在不少于辅酶Q10的熔点的温度下搅拌辅助辅酶Q10和不良溶剂，将辅酶Q10分散成油滴形式，并将其冷却至 在搅拌分散体以得到固体颗粒的同时，辅酶Q10或更低的固化温度，其中不良溶剂是包含HLB为6或更高的有机溶剂和/或表面活性剂的水溶液。 根据本发明的制造方法，可以得到粉末特性显着优异的，具有例如不小于80的粉末流动指数的辅酶Q10颗粒。

    METHOD FOR PRODUCTION OF REDUCED COENZYME Q10 USING WATER-CONTAINING ORGANIC SOLVENT
    48.
    发明申请
    METHOD FOR PRODUCTION OF REDUCED COENZYME Q10 USING WATER-CONTAINING ORGANIC SOLVENT 有权
    使用含水有机溶剂生产降低COENZYME Q10的方法

    公开(公告)号：US20100234643A1

    公开(公告)日：2010-09-16

    申请号：US12740086

    申请日：2008-10-29

    申请人： Takahiro Ueda ,  Shiro Kitamura

    发明人： Takahiro Ueda ,  Shiro Kitamura

    IPC分类号： C07C45/41

    CPC分类号： C07C41/26 ,  C07C41/40 ,  C07C43/23

    摘要： The present invention aims to provide reduced coenzyme Q10, which is useful as food, food with nutrient function claims, food for specified health use, nutritional supplement, nutritional product, animal drug, drink, feed, cosmetic, pharmaceutical product, therapeutic drug, prophylactic drug and the like, and a production method of reduced coenzyme Q10. The present invention provides a production method of reduced coenzyme Q10, which includes reducing oxidized coenzyme Q10 with ascorbic acid or its analogue(s) as a reducing agent in a water-containing organic solvent at not more than pH 5. Using the method, the reaction time can be drastically shortened even without adding a basic substance and the like, and unpreferable side reactions can be minimized. Therefore, reduced coenzyme Q10 with high quality can be produced.

    摘要翻译： 本发明旨在提供可用作食物，具有营养功能要求的食物，用于特定健康用途的食物，营养补充剂，营养产品，动物药物，饮料，饲料，化妆品，药​​物，治疗药物，预防性药物的还原型辅酶Q10 药物等，以及还原型辅酶Q10的制造方法。 本发明提供还原型辅酶Q10的制造方法，该方法包括在不高于pH 5的含水有机溶剂中，用抗坏血酸或其类似物还原氧化型辅酶Q10作为还原剂。使用该方法， 即使没有添加碱性物质等，反应时间也可以大大缩短，并且不利的副反应可以最小化。 因此，可以生产具有高质量的还原型辅酶Q10。

    Method for production of reduced coenzyme Q10 using water-containing organic solvent
    49.
    发明授权
    Method for production of reduced coenzyme Q10 using water-containing organic solvent 有权
    使用含水有机溶剂生产还原型辅酶Q10的方法

    公开(公告)号：US08063254B2

    公开(公告)日：2011-11-22

    申请号：US12740086

    申请日：2008-10-29

    申请人： Takahiro Ueda ,  Shiro Kitamura

    发明人： Takahiro Ueda ,  Shiro Kitamura

    IPC分类号： C07C35/18 ,  C07C35/12

    CPC分类号： C07C41/26 ,  C07C41/40 ,  C07C43/23

    摘要： The present invention aims to provide reduced coenzyme Q10, which is useful as food, food with nutrient function claims, food for specified health use, nutritional supplement, nutritional product, animal drug, drink, feed, cosmetic, pharmaceutical product, therapeutic drug, prophylactic drug and the like, and a production method of reduced coenzyme Q10. The present invention provides a production method of reduced coenzyme Q10, which includes reducing oxidized coenzyme Q10 with ascorbic acid or its analogue(s) as a reducing agent in a water-containing organic solvent at not more than pH 5. Using the method, the reaction time can be drastically shortened even without adding a basic substance and the like, and unpreferable side reactions can be minimized. Therefore, reduced coenzyme Q10 with high quality can be produced.

    摘要翻译： 本发明旨在提供可用作食物，具有营养功能要求的食物，用于特定健康用途的食物，营养补充剂，营养产品，动物药物，饮料，饲料，化妆品，药​​物，治疗药物，预防性药物的还原型辅酶Q10 药物等，以及还原型辅酶Q10的制造方法。 本发明提供还原型辅酶Q10的制造方法，该方法包括在不高于pH 5的含水有机溶剂中，用抗坏血酸或其类似物还原氧化型辅酶Q10作为还原剂。使用该方法， 即使没有添加碱性物质等，反应时间也可以大大缩短，并且不利的副反应可以最小化。 因此，可以生产具有高质量的还原型辅酶Q10。

    REDUCED COENZYME Q10-CONTAINING COMPOSITION WHICH IS STABLE AGAINST OXIDATION, AND METHOD FOR STABILIZATION OF REDUCED COENZYME Q10
    50.
    发明申请
    REDUCED COENZYME Q10-CONTAINING COMPOSITION WHICH IS STABLE AGAINST OXIDATION, AND METHOD FOR STABILIZATION OF REDUCED COENZYME Q10 有权
    减少含氧化合物Q10的组合物对氧化物有稳定作用，以及降低COENZYME Q10稳定化的方法

    公开(公告)号：US20090181002A1

    公开(公告)日：2009-07-16

    申请号：US12092925

    申请日：2006-11-07

    申请人： Takahiro Ueda ,  Shiro Kitamura

    发明人： Takahiro Ueda ,  Shiro Kitamura

    IPC分类号： A61K38/43 ,  A61P43/00

    CPC分类号： A61K9/4858 ,  A61K9/4875 ,  A61K31/05

    摘要： The present invention provides a method for stabilization of reduced coenzyme Q10 characterized by concurrently containing a propylene glycol fatty acid ester in a composition containing reduced coenzyme Q10, and a composition containing reduced coenzyme Q10 and a propylene glycol fatty acid ester as essential constituting ingredients. According to the present invention, reduced coenzyme Q10, which is useful as a food, food with nutrient function claims, food for specified health use, nutritional supplement, nutritional product, animal drug, drink, feed, cosmetic, pharmaceutical product, therapeutic drug, prophylactic drug and the like can be stabilized especially without being made into a complicated composition.

    摘要翻译： 本发明提供还原型辅酶Q10的稳定化方法，其特征在于含有还原型辅酶Q10的组合物中含有丙二醇脂肪酸酯，还含有还原型辅酶Q10和丙二醇脂肪酸酯作为必要构成成分的组合物。 根据本发明，可用作食品的具有营养功能的食品的还原型辅酶Q10，用于特定健康用途的食物，营养补充剂，营养产品，动物药物，饮料，饲料，化妆品，药​​物产品，治疗药物， 预防药物等可以稳定化，而不会形成复杂的组合物。