公开(公告)号：US06867248B1

公开(公告)日：2005-03-15

申请号：US10403244

申请日：2003-03-28

申请人： David P. Martin ,  Frank Skraly ,  Simon F. Williams

发明人： David P. Martin ,  Frank Skraly ,  Simon F. Williams

IPC分类号： A61K9/16 ,  A61K47/48 ,  A61L15/26 ,  A61L17/10 ,  A61L17/12 ,  A61L24/00 ,  A61L26/00 ,  A61L27/18 ,  A61L27/34 ,  A61L27/58 ,  A61L29/06 ,  A61L31/06 ,  A61L31/14 ,  C08G63/06 ,  C08G63/64 ,  C08G63/685 ,  C08G63/688 ,  C08G63/91 ,  C08K5/00 ,  C12N5/00 ,  C12P7/62 ,  C08L67/04

CPC分类号： C12P7/625 ,  A61K9/1647 ,  A61K47/593 ,  A61K47/6957 ,  A61L15/26 ,  A61L17/10 ,  A61L17/12 ,  A61L24/0042 ,  A61L26/0019 ,  A61L26/009 ,  A61L27/18 ,  A61L27/34 ,  A61L27/58 ,  A61L29/06 ,  A61L31/06 ,  A61L31/148 ,  C08G63/06 ,  C08G63/64 ,  C08G63/6852 ,  C08G63/6882 ,  C08G63/912 ,  C08K5/0033 ,  C12N5/0068 ,  C12N2533/30 ,  C08L67/04

摘要： Biocompatible polyhydroxyalkanoate compositions with controlled degradation rates have been developed. In one embodiment, the polyhydroxyalkanoates contain additives to alter the degradation rates. In another embodiment, the polyhydroxyalkanoates are formed of mixtures of monomers or include pendant groups or modifications in their backbones to alter their degradation rates. In still another embodiment, the polyhydroxyalkanoates are chemically modified. Methods for manufacturing the devices which increase porosity or exposed surface area can be used to alter degradability. For example, as demonstrated by the examples, porous polyhydroxyalkanoates can be made using methods that creates pores, voids, or interstitial spacing, such as an emulsion or spray drying technique, or which incorporate leachable or lyophilizable particles within the polymer. Examples describe poly(4HB) compositions including foams, coatings, meshes, and microparticles. As demonstrated by the examples, these polyhydroxyalkanoate compositions have extremely favorable mechanical properties, as well as are biocompatible and degrade within desirable time frames under physiological conditions. These polyhydroxyalkanoate materials provide a wider range of polyhydroxyalkanoate degradation rates than are currently available. Methods for processing these materials, particularly for therapeutic, prophylactic or diagnostic applications, or into devices which can be implanted or injected, are also described.

摘要翻译： 已经开发了具有受控降解速率的生物相容性聚羟基链烷酸酯组合物。 在一个实施方案中，聚羟基链烷酸酯含有改变降解速率的添加剂。 在另一个实施方案中，聚羟基链烷酸酯由单体的混合物形成或包括侧链基团或其主链中的修饰以改变其降解速率。 在另一个实施方案中，聚羟基链烷酸酯被化学改性。 用于制造增加孔隙率或暴露表面积的装置的方法可用于改变降解性。 例如，如通过实施例所证明的，多孔聚羟基链烷酸酯可以使用产生孔，空隙或间隙的方法，例如乳液或喷雾干燥技术，或者在聚合物内含有可浸出或可冷冻干燥的颗粒。 实例描述了包括泡沫，涂层，网格和微粒的聚（4HB）组合物。 如实施例所示，这些聚羟基链烷酸酯组合物在生理条件下在期望的时间范围内具有非常有利的机械性能以及生物相容性和降解性。 这些聚羟基链烷酸酯材料提供比目前可获得的更广泛的聚羟基链烷酸酯降解速率。 还描述了用于处理这些材料的方法，特别是用于治疗，预防或诊断应用，或可植入或注射的装置。

公开(公告)号：US06867247B2

公开(公告)日：2005-03-15

申请号：US10136499

申请日：2002-05-01

申请人： Simon F. Williams ,  David P. Martin ,  Frank A. Skraly

发明人： Simon F. Williams ,  David P. Martin ,  Frank A. Skraly

IPC分类号： A61B17/58 ,  A61F2/84 ,  A61K45/00 ,  A61L15/64 ,  A61L17/00 ,  A61L17/12 ,  A61L27/00 ,  A61L27/18 ,  A61L27/58 ,  A61L31/06 ,  A61L31/14 ,  C08G63/06 ,  C08K5/00 ,  C12P7/62 ,  C08L67/04

CPC分类号： A61L27/58 ,  A61F2/07 ,  A61F2210/0004 ,  A61K31/715 ,  A61L17/12 ,  A61L27/18 ,  A61L31/06 ,  A61L31/148 ,  A61L31/16 ,  A61L2300/00 ,  C08G63/06 ,  C08J9/26 ,  C08J2201/0444 ,  C08J2201/0482 ,  C08J2367/04 ,  C08K5/0033 ,  C08L67/04 ,  C12P7/625 ,  Y10S606/911

摘要： Devices formed of or including biocompatible polyhydroxyalkanoates are provided with controlled degradation rates, preferably less than one year under physiological conditions. Preferred devices include sutures, suture fasteners, meniscus repair devices, rivets, tacks, staples, screws (including interference screws), bone plates and bone plating systems, surgical mesh, repair patches, slings, cardiovascular patches, orthopedic pins (including bone filling augmentation material), adhesion barriers, stents, guided tissue repair/regeneration devices, articular cartilage repair devices, nerve guides, tendon repair devices, atrial septal defect repair devices, pericardial patches, bulking and filling agents, vein valves, bone marrow scaffolds, meniscus regeneration devices, ligament and tendon grafts, ocular cell implants, spinal fusion cages, skin substitutes, dural substitutes, bone graft substitutes, bone dowels, wound dressings, and hemostats. The polyhydroxyalkanoates can contain additives, be formed of mixtures of monomers or include pendant groups or modifications in their backbones, or can be chemically modified, all to alter the degradation rates. The polyhydroxyalkanoate compositions also provide favorable mechanical properties, biocompatibility, and degradation times within desirable time frames under physiological conditions.

公开(公告)号：US06610764B1

公开(公告)日：2003-08-26

申请号：US09218575

申请日：1998-12-22

申请人： David P. Martin ,  Frank Skraly ,  Simon F. Williams

发明人： David P. Martin ,  Frank Skraly ,  Simon F. Williams

IPC分类号： C08L6704

CPC分类号： C08G63/912 ,  A61K9/1647 ,  A61K47/593 ,  A61K47/6957 ,  A61L15/26 ,  A61L17/10 ,  A61L17/12 ,  A61L24/0042 ,  A61L26/0019 ,  A61L26/009 ,  A61L27/18 ,  A61L27/34 ,  A61L27/58 ,  A61L29/06 ,  A61L31/06 ,  A61L31/148 ,  C08G63/06 ,  C08G63/64 ,  C08G63/6852 ,  C08G63/6882 ,  C08J9/26 ,  C08J2201/0444 ,  C08J2201/0482 ,  C08J2367/04 ,  C08K5/0033 ,  C12N5/0068 ,  C12N2533/30 ,  C12P7/625 ,  C08L67/04

摘要： Biocompatible polyhydroxyalkanoate compositions with controlled degradation rates have been developed. In one embodiment, the polyhydroxyalkanoates contain additives to alter the degradation rates. In another embodiment, the polyhydroxyalkanoates are formed of mixtures of monomers or include pendant groups or modifications in their backbones to alter their degradation rates. In still another embodiment, the polyhydroxyalkanoates are chemically modified. Methods for manufacturing the devices which increase porosity or exposed surface area can be used to alter degradability. For example, as demonstrated by the examples, porous polyhydroxyalkanoates can be made using methods that creates pores, voids, or interstitial spacing, such as an emulsion or spray drying technique, or which incorporate leachable or lyophilizable particles within the polymer. Examples describe poly(4HB) compositions including foams, coatings, meshes, and microparticles. As demonstrated by the examples, these polyhydroxyalkanoate compositions have extremely favorable mechanical properties, as well as are biocompatible and degrade within desirable time frames under physiological conditions. These polyhydroxyalkanoate materials provide a wider range of polyhydroxyalkanoate degradation rates than are currently available. Methods for processing these materials, particularly for therapeutic, prophylactic or diagnostic applications, or into devices which can be implanted or injected, are also described.

摘要翻译： 已经开发了具有受控降解速率的生物相容性聚羟基链烷酸酯组合物。 在一个实施方案中，聚羟基链烷酸酯含有改变降解速率的添加剂。 在另一个实施方案中，聚羟基链烷酸酯由单体的混合物形成或包括侧链基团或其主链中的修饰以改变其降解速率。 在另一个实施方案中，聚羟基链烷酸酯被化学改性。 用于制造增加孔隙率或暴露表面积的装置的方法可用于改变降解性。 例如，如通过实施例所证明的，多孔聚羟基链烷酸酯可以使用产生孔，空隙或间隙的方法，例如乳液或喷雾干燥技术，或者在聚合物内含有可浸出或可冷冻干燥的颗粒。 实例描述了包括泡沫，涂层，网格和微粒的聚（4HB）组合物。 如实施例所示，这些聚羟基链烷酸酯组合物在生理条件下在期望的时间范围内具有非常有利的机械性能以及生物相容性和降解性。 这些聚羟基链烷酸酯材料提供比目前可获得的更广泛的聚羟基链烷酸酯降解速率。 还描述了用于处理这些材料的方法，特别是用于治疗，预防或诊断应用，或可植入或注射的装置。

公开(公告)号：US06555123B2

公开(公告)日：2003-04-29

申请号：US10123951

申请日：2002-04-16

申请人： Simon F. Williams ,  David P. Martin

发明人： Simon F. Williams ,  David P. Martin

IPC分类号： A61F200

CPC分类号： C12P7/625 ,  A61L27/18 ,  C08L67/04

摘要： Polyhydroxyalkanoate materials are provided which are suitable for repair of soft tissue, augmentation, and as viscosupplements in animals, particularly humans. The materials comprise liquid polyhydroxyalkanoate polymer compositions or polyhydroxyalkanoate microdispersions. Devices also are provided for storage and delivery of the polyhydroxyalkanoate compositions in vivo. Methods are provided for repairing or augmenting soft tissue in animals using the materials. In a preferred embodiment, the method include the steps of (a) selecting the animal soft tissue to be repaired or augmented; and (b) placing an injectable, liquid polyhydroxyalkanoate polymer or a polyhydroxyalkanoate microdispersion into the animal soft tissue, preferably using a minimally-invasive method such as injection. In another embodiment, the liquid polyhydroxyalkanoate polymer compositions or polyhydroxyalkanoate microdispersions are used as viscosupplements.

公开(公告)号：US06592892B1

公开(公告)日：2003-07-15

申请号：US09649978

申请日：2000-08-29

申请人： Simon F. Williams

发明人： Simon F. Williams

IPC分类号： A61K970

CPC分类号： A61L15/62 ,  A61K9/0034 ,  A61K9/0051 ,  A61K9/006 ,  A61K9/7023 ,  A61L15/26 ,  B09B2220/14 ,  C08L67/04

摘要： Materials suitable for preparing components of flushable drug delivery systems are described. These components include drug impermeable and drug permeable materials, including materials that can be used to control the rate of release of drugs from the device, and pressure sensitive adhesive compositions which are drug compatible. Methods for fabricating these devices, including transdermal drug delivery patches, are described.

摘要翻译： 描述适用于制备可冲洗药物递送系统的组分的材料。 这些组分包括药物不可渗透和药物可渗透的材料，包括可用于控制药物从装置释放的速率的材料和与药物相容的压敏粘合剂组合物。 描述了制造这些装置的方法，包括透皮药物递送贴片。

公开(公告)号：US20190247180A1

公开(公告)日：2019-08-15

申请号：US16262018

申请日：2019-01-30

申请人： Skander Limem ,  Said Rizk ,  Simon F. Williams

发明人： Skander Limem ,  Said Rizk ,  Simon F. Williams

IPC分类号： A61F2/12 ,  A61F2/00

CPC分类号： A61F2/12 ,  A61F2/0063 ,  A61F2210/0004 ,  A61F2230/008 ,  A61F2250/0067

摘要： Full contour absorbable implants for breast surgery redistribute breast volume between the breast's upper and lower poles in exact and desirable ratios. The implants preferably redistribute breast volume so that the upper pole breast volume is 20-40% of the total volume, and the lower pole breast volume is 60-80% of the total volume. The implants are also designed to provide specific curvatures to the poles of the breast, and to angulate the nipple areolar complex slightly skyward so that the patient's nipple is positioned at an angle above the nipple meridian reference line. The implants are designed to be transitory, with sufficient strength retention to allow transition from support of the breast by the implant to support by regenerated host tissue growing in and around the implants, without any significant loss of support during or subsequent to remodeling. The implants may optionally be used with permanent breast implants.

公开(公告)号：US5625030A

公开(公告)日：1997-04-29

申请号：US561139

申请日：1995-11-20

申请人： Simon F. Williams ,  Oliver P. Peoples

发明人： Simon F. Williams ,  Oliver P. Peoples

IPC分类号： C07B41/12 ,  C07B43/06 ,  C07K1/04 ,  C07K11/02 ,  C08G63/06 ,  C08G63/685 ,  C08G63/91 ,  C08L77/00

CPC分类号： C07K1/04 ,  C07B41/12 ,  C07B43/06 ,  C07K1/047 ,  C07K11/02

摘要： Methods for synthesizing oligomers containing hydroxy acids, and optionally containing other types of monomers or oligomers such as amino acids, carbohydrates, nucleotides and peptides, are provided which are rapid, simple, and readily automated. The oligomers have a C-terminal and an O, S or N-terminal end. The starting hydroxy acid can be covalently bound at either the C-terminal or O, S or N-terminal end to a solid support. The bond to the solid support can be an amide, thioester, ester, phosphate, silyl ether, carbamate, benzyl ether, or other linkage that can be cleaved either chemically or enzymatically.

摘要翻译： 提供了用于合成含有羟基酸的低聚物和任选地含有其它类型的单体或低聚物如氨基酸，碳水化合物，核苷酸和肽的方法，其是快速，简单且容易自动化的。 低聚物具有C末端和O，S或N-末端。 起始羟基酸可以在C末端或O，S或N-末端共价结合成固体支持物。 与固体支持物的键可以是酰胺，硫酯，酯，磷酸酯，甲硅烷基醚，氨基甲酸酯，苄基醚或可以化学或酶切割的其它连接。

公开(公告)号：US06746685B2

公开(公告)日：2004-06-08

申请号：US10289479

申请日：2002-11-06

申请人： Simon F. Williams

发明人： Simon F. Williams

IPC分类号： A61F202

CPC分类号： A61L27/18 ,  A61L31/06 ,  Y10T442/2525 ,  C08L67/04

摘要： Bioabsorbable biocompatible polymers which provide a good match between their properties and those of certain tissue structures are provided. The bioabsorbable biocompatible polymers can be prepared with tensile strengths, elongation to breaks, and/or tensile modulus (Young's modulus) values of the tissues of the cardiovascular, gastrointestinal, kidney and genitourinary, musculoskeletal, and nervous systems, as well as those of the oral, dental, periodontal, and skin tissues. Methods for processing the bioabsorbable biocompatible polymers into tissue engineering devices are also provided.

摘要翻译： 提供了提供它们的性质与某些组织结构之间良好匹配的生物可吸收的生物相容性聚合物。 生物可吸收的生物相容性聚合物可以用心血管，胃肠，肾脏和泌尿生殖器，肌肉骨骼和神经系统的组织的拉伸强度，断裂伸长率和/或拉伸模量（杨氏模量）值以及 口腔，牙科，牙周和皮肤组织。 还提供了将生物可吸收生物相容性聚合物加工成组织工程装置的方法。

公开(公告)号：US06514515B1

公开(公告)日：2003-02-04

申请号：US09518123

申请日：2000-03-03

申请人： Simon F. Williams

发明人： Simon F. Williams

IPC分类号： A61F202

CPC分类号： A61L27/18 ,  A61L31/06 ,  Y10T442/2525 ,  C08L67/04

摘要： Bioabsorbable biocompatible polymers which provide a good match between their properties and those of certain tissue structures are provided. The bioabsorbable biocompatible polymers can be prepared with tensile strengths, elongation to breaks, and/or tensile modulus (Young's modulus) values of the tissues of the cardiovascular, gastrointestinal, kidney and genitourinary, musculoskeletal, and nervous systems, as well as those of the oral, dental, periodontal, and skin tissues. Methods for processing the bioabsorbable biocompatible polymers into tissue engineering devices are also provided.