公开(公告)号：US20230256091A1

公开(公告)日：2023-08-17

申请号：US18012218

申请日：2021-01-31

申请人： SOOCHOW UNIVERSITY

发明人： Fenghua MENG ,  Zhiyuan ZHONG

IPC分类号： A61K39/39 ,  C08G63/688 ,  A61P35/00

CPC分类号： A61K39/39 ,  C08G63/6882 ,  A61P35/00 ,  A61K2039/55561

摘要： An anti-tumor nano adjuvant is obtained by loading a drug on the vesicle formed by a reversibly cross-linked biodegradable polymer with an asymmetric membrane structure; the drug is an oligonucleotide activating an immune response; the vesicle formed by the degradable polymer is obtained by the self-assembly of a polymer followed by cross-linking; the molecular chain of the polymer includes a hydrophilic chain segment, a hydrophobic chain segment and positively charged molecules, successively connected; the hydrophobic chain segment is a polycarbonate chain segment and/or a polyester chain segment, which is compounded and loaded with a drug by electrostatic interaction; and the membrane is a polycarbonate chain segment and/or a polyester chain segment, which is reversibly cross-linked, biodegradable and has good biocompatibility, the dithiolane in the side chain thereof is similar to thioctic acid, a natural antioxidant in human body, and the shell thereof is based on PEG and targets cancer cells.

公开(公告)号：US20180312630A1

公开(公告)日：2018-11-01

申请号：US15503350

申请日：2015-08-13

申请人： THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

发明人： Heather D. Maynard

IPC分类号： C08G63/91 ,  A61K47/34 ,  A61K38/19 ,  C08G63/08 ,  C08G63/688

CPC分类号： C08G63/91 ,  A61K38/00 ,  A61K38/193 ,  A61K47/30 ,  A61K47/34 ,  C07H3/04 ,  C08B37/0006 ,  C08F2220/285 ,  C08F2438/03 ,  C08G63/6852 ,  C08G63/6882 ,  C08G63/78 ,  C08G63/912 ,  C12P19/12

摘要： Structures and methods of making biodegradable trehalose co-polymers are disclosed. Specifically, biodegradable trehalose co-polymers consist of the general structure R5[R1R2C—CR3R4]n-[DG]m-R6, wherein R1-R4 are independently selected from hydrogen or a side chain comprising at least one carbon atom, and wherein at least one of R1-R4 is a side chain comprising -L-trehalose, wherein L is a linker molecule that links trehalose to the monomer through at least one of the trehalose hydroxyl groups (—OH), wherein DG is a biodegradable group, and wherein R5 and R6 are end groups.

公开(公告)号：US20160326349A1

公开(公告)日：2016-11-10

申请号：US15148378

申请日：2016-05-06

申请人： Novus International Inc.

发明人： Graciela B. Arhancet ,  Xiaojun Wang ,  Scott Long ,  Matthew William Mahoney

IPC分类号： C08K5/372 ,  C07C319/20 ,  C07C323/52

CPC分类号： C08K5/372 ,  C07C319/20 ,  C07C323/52 ,  C08G63/6882 ,  C08G63/912 ,  C08K5/41 ,  C08L67/04 ,  C08L27/06

摘要： Hydrocarbyl terminated polyester compounds comprising sulfur-containing repeat units that are useful as plastic modifiers, polymer blend compositions comprising the hydrocarbyl terminated polyester compounds, methods for modifying the performance properties of polymers, and methods for preparing the hydrocarbyl terminated polyester compounds.

摘要翻译： 包含可用作塑料改性剂的含硫重复单元的烃基封端的聚酯化合物，包含烃基封端的聚酯化合物的聚合物共混物组合物，改性聚合物性能的方法，以及制备烃基封端的聚酯化合物的方法。

公开(公告)号：US09011832B2

公开(公告)日：2015-04-21

申请号：US13763101

申请日：2013-02-08

申请人： Novus International Inc.

发明人： Graciela B. Arhancet ,  Matthew Mahoney ,  Xiaojun Wang

IPC分类号： C07D319/12 ,  C08G75/02 ,  C08G67/00

CPC分类号： C07D319/12 ,  A23K20/10 ,  A23K50/10 ,  A23K50/75 ,  C07D265/33 ,  C08G63/6882 ,  C08G63/85 ,  C08G67/00 ,  C08G75/02 ,  C08L67/00 ,  C08L67/04

摘要： The present invention provides cyclic dimers of alpha acids and polymers derived therefrom. Also provided are processes for preparing and methods of using the cyclic dimers and the polymers derived from the cyclic dimers.

摘要翻译： 本发明提供α-酸的环状二聚体和由其衍生的聚合物。 还提供了制备方法和使用环状二聚体和衍生自环状二聚体的聚合物的方法。

公开(公告)号：US20140087149A1

公开(公告)日：2014-03-27

申请号：US14027280

申请日：2013-09-16

申请人： Ticona LLC

发明人： Kamlesh P. Nair ,  Young Shin Kim ,  James P. Shepherd ,  Prabuddha Bansal

IPC分类号： C08G63/688 ,  H05K1/03 ,  C09D167/04

CPC分类号： C08G63/6882 ,  B32B27/286 ,  B32B27/36 ,  B32B2457/08 ,  C08G63/688 ,  C08J5/18 ,  C08J2367/02 ,  C09D167/04 ,  C09K19/28 ,  C09K19/3809 ,  H05K1/0333 ,  H05K1/0346 ,  Y10T428/24802 ,  Y10T428/269 ,  Y10T428/2982

摘要： An aromatic copoly(ester-sulfone) that contains one or more aromatic ester repeating units and one or more aromatic sulfonyl repeating units is provided. While a wide variety of aromatic ester repeating units may be employed, the polymer is nevertheless “low naphthenic” to the extent that it contains a minimal content of repeating units derived from naphthenic hydroxycarboxylic acids and naphthenic dicarboxylic acids. Despite the absence of a high level of conventional naphthenic acid repeating units, the present inventors have discovered that selective control over the type and relative concentration of the aromatic sulfonyl repeating units can lead to “low naphthenic” polymers that are not only soluble in certain solvents, but also capable of exhibiting good mechanical properties. Thus, the ability of the resulting polymer to be dissolved or dispersed in various solvents can be enhanced without sacrificing performance.

摘要翻译： 提供含有一个或多个芳族酯重复单元和一个或多个芳族磺酰基重复单元的芳香族共聚（酯 - 砜）。 虽然可以使用各种各样的芳族酯重复单元，但是聚合物仍然是“低环烷烃”，其含有源自环烷基羟基羧酸和环烷二羧酸的重复单元的最小含量。 尽管不存在高水平的常规环烷酸重复单元，但是本发明人已经发现，对芳族磺酰基重复单元的类型和相对浓度的选择性控制可导致不仅溶于某些溶剂的“低环烷烃”聚合物 ，而且能够表现出良好的机械性能。 因此，可以在不牺牲性能的情况下提高所得聚合物溶解或分散在各种溶剂中的能力。

公开(公告)号：US20130287725A1

公开(公告)日：2013-10-31

申请号：US13861898

申请日：2013-04-12

申请人： Denis BARRITAULT ,  Jean-Pierre CARUELLE

发明人： Denis BARRITAULT ,  Jean-Pierre CARUELLE

IPC分类号： A61K31/795 ,  A61K31/721 ,  A61K31/765

CPC分类号： A61K31/795 ,  A61K31/721 ,  A61K31/765 ,  C08B37/0021 ,  C08G63/6882

摘要： A process for treating fibroses including administering a therapeutically effective amount of a pharmaceutical composition which includes at least one biocompatible polymer of the following general formula (I): AaXxYy wherein: A represents a monomer selected from the group consisting of a sugar or —(O—CH2—CH2—CO)—, X represents a carboxyl group bonded to monomer A, Y represents a sulfate or sulfonate group bonded to monomer A a represents the number of monomers A such that the mass of the polymers of formula (I) is greater than approximately 5,000 da, x represents a substitution rate of the monomers A by the groups X, which is between approximately 20 and 150%, and y represents a substitution rate of the monomers A by the groups Y, which is between approximately 30 and 150%.

摘要翻译： 一种治疗纤维组织的方法，包括给予治疗有效量的药物组合物，其包含至少一种以下通式（I）的生物相容性聚合物：AaXxYy其中：A表示选自糖或 - （O -CH 2 -CH 2 -CO） - ，X表示与单体A键合的羧基，Y表示与单体A键合的硫酸酯或磺酸酯基，a表示单体A的数量，使式（I）的聚合物的质量为 大于约5,000Da，x表示基团X的单体A的取代率，其为约20至150％，y表示单体A的取代速率，基团Y为约30和 150％。

公开(公告)号：US08476220B2

公开(公告)日：2013-07-02

申请号：US13160099

申请日：2011-06-14

申请人： Denis Barritault ,  Jean-Pierre Caruelle

发明人： Denis Barritault ,  Jean-Pierre Caruelle

IPC分类号： A61K31/00

CPC分类号： A61K31/795 ,  A61K31/721 ,  A61K31/765 ,  C08B37/0021 ,  C08G63/6882

摘要： A process for treating fibroses including administering a therapeutically effective amount of a pharmaceutical composition which includes at least one biocompatible polymer of the following general formula (I): AaXxYy wherein: A represents a monomer selected from the group consisting of a sugar or —(O—CH2—CH2—CO)—, X represents a carboxyl group bonded to monomer A and is contained within a group according to the following formula: —R—COO—R′, in which R is a bond or an aliphatic hydrocarbon chain, optionally branched and/or unsaturated, and which can contain one or more aromatic rings except for benzylamine and benzylamine sulfonate, and R′ represents a hydrogen atom or a cation, Y represents a sulfate or sulfonate group bonded to monomer A and is contained within a group according to one of the following formulas: —R—O—SO3—R′, —R—N—SO3—R′, —R—SO3—R′, in which R is a bond or an aliphatic hydrocarbon chain, optionally branched and/or unsaturated, and which can contain one or more aromatic rings except for benzylamine and benzylamine sulfonate, and R′ represents a hydrogen atom or a cation, a represents the number of monomers A such that the mass of the polymers of formula (I) is greater than approximately 5,000 da, x represents a substitution rate of the monomers A by the groups X, which is between approximately 20 and 150%, and y represents a substitution rate of the monomers A by the groups Y, which is between approximately 30 and 150%.

摘要翻译： 一种治疗纤维组织的方法，包括给予治疗有效量的药物组合物，其包含至少一种以下通式（I）的生物相容性聚合物：AaXxYy其中：A表示选自糖或 - （O -CH 2 -CH 2 -CO） - ，X表示与单体A键合的羧基，并且包含在根据下式的基团中：-R-COO-R'，其中R是键或脂族烃链， 任选的支链和/或不饱和的，并且可以含有一个或多个除苄基胺和苄胺磺酸盐以外的芳环，R'表示氢原子或阳离子，Y表示与单体A键合的硫酸盐或磺酸盐基团， 基团，其中R是一个键或一个脂族烃链，任选支链和/或其中一个选自下列通式之一：-RO-SO3-R'，-RN-SO3-R'，-R-SO3-R' 不饱和的，可以含有一种或多种芳香剂 c环，除了苄胺和苄胺磺酸盐，R'表示氢原子或阳离子，a表示式（I）的聚合物的质量大于约5,000Da的单体A的数量，x表示取代 基团X的单体A的速率在约20至150％之间，y表示单体A由基团Y在约30至150％之间的取代率。

公开(公告)号：US20110243881A1

公开(公告)日：2011-10-06

申请号：US13160099

申请日：2011-06-14

申请人： Denis Barritault ,  Jean-Pierre Caruelle

发明人： Denis Barritault ,  Jean-Pierre Caruelle

IPC分类号： A61K31/795 ,  A61K31/721 ,  A61P9/10 ,  A61P39/06 ,  A61P9/00 ,  A61P25/00 ,  A61P17/00

CPC分类号： A61K31/795 ,  A61K31/721 ,  A61K31/765 ,  C08B37/0021 ,  C08G63/6882

摘要： A process for treating fibroses including administering a therapeutically effective amount of a pharmaceutical composition which includes at least one biocompatible polymer of the following general formula (I): AaXxYy wherein: A represents a monomer selected from the group consisting of a sugar or —(O—CH2—CH2—CO)—, X represents a carboxyl group bonded to monomer A and is contained within a group according to the following formula: —R—COO—R′, in which R is a bond or an aliphatic hydrocarbon chain, optionally branched and/or unsaturated, and which can contain one or more aromatic rings except for benzylamine and benzylamine sulfonate, and R′ represents a hydrogen atom or a cation, Y represents a sulfate or sulfonate group bonded to monomer A and is contained within a group according to one of the following formulas: —R—O—SO3—R′, —R—N—SO3—R′, —R—SO3—R′, in which R is a bond or an aliphatic hydrocarbon chain, optionally branched and/or unsaturated, and which can contain one or more aromatic rings except for benzylamine and benzylamine sulfonate, and R′ represents a hydrogen atom or a cation, a represents the number of monomers A such that the mass of the polymers of formula (I) is greater than approximately 5,000 da, x represents a substitution rate of the monomers A by the groups X, which is between approximately 20 and 150%, and y represents a substitution rate of the monomers A by the groups Y, which is between approximately 30 and 150%.

摘要翻译： 一种治疗纤维组织的方法，包括给予治疗有效量的药物组合物，其包含至少一种以下通式（I）的生物相容性聚合物：AaXxYy其中：A表示选自糖或 - （O -CH 2 -CH 2 -CO） - ，X表示与单体A键合的羧基，并且包含在根据下式的基团中：-R-COO-R'，其中R是键或脂族烃链， 任选的支链和/或不饱和的，并且可以含有一个或多个除苄基胺和苄胺磺酸盐以外的芳环，R'表示氢原子或阳离子，Y表示与单体A键合的硫酸盐或磺酸盐基团， 基团：-R-O-SO 3 -R'，-R-N-SO 3 -R'，-R-SO 3 -R'，其中R是一个键或脂族烃链，任选地 分支和/或不饱和 并且可以含有除苄基胺和苄胺磺酸盐以外的一个或多个芳环，R'表示氢原子或阳离子，a表示式（I）的聚合物的质量更大的单体A的数量 大于约5,000Da，x表示基团X的单体A的取代速率，基团X在约20至150％之间，y表示单体A的取代速率，基团Y为约30至150 ％。

公开(公告)号：US07998922B2

公开(公告)日：2011-08-16

申请号：US10695574

申请日：2003-10-28

申请人： Denis Barritault ,  Jean-Pierre Caruelle

发明人： Denis Barritault ,  Jean-Pierre Caruelle

IPC分类号： A61K31/00

CPC分类号： A61K31/795 ,  A61K31/721 ,  A61K31/765 ,  C08B37/0021 ,  C08G63/6882

摘要： A biocompatible polymer constituted by a sequence of identical or different components of the general formula (I): AaXxYy, in which A represents a monomer, X represents a carboxyl group fixed on a monomer A, Y represents a sulfate or sulfonate group fixed on a monomer A; a represents the number of monomers A, x represents the substitution rate of the set of monomers A by the groups X, y represents the substitution rate of the set of monomers A by the groups Y. The invention also pertains to the pharmaceutical or diagnostic compositions containing at least one polymer of general formula (I).

摘要翻译： 由通式（I）的相同或不同组分的序列构成的生物相容性聚合物：AaXxYy，其中A表示单体，X表示固定在单体A上的羧基，Y表示固定在单体A上的硫酸盐或磺酸盐基团 单体A; a表示单体A的数量，x表示基团X的单体A组的取代率，y表示基团Y的单体A组的取代率。本发明还涉及药物或诊断组合物 含有至少一种通式（I）的聚合物。

公开(公告)号：US20090202927A1

公开(公告)日：2009-08-13

申请号：US10585642

申请日：2005-06-09

申请人： Tetsuya Yano ,  Takashi Kenmoku ,  Tatsuki Fukui ,  Ako Kusakari ,  Chieko Mihara

发明人： Tetsuya Yano ,  Takashi Kenmoku ,  Tatsuki Fukui ,  Ako Kusakari ,  Chieko Mihara

IPC分类号： G03G13/04 ,  G03G9/097 ,  C08G63/06 ,  G03G15/22 ,  G03G15/02

CPC分类号： C08G63/6882 ,  C08G63/06 ,  C08G63/6852

摘要： To provide: a charge control agent having negative chargeability, which contributes to environmental conservation and the like to an increased degree, has high performance (high charge amount, quick rise-up of charge, excellent stability with time, and high environmental stability), and has improved dispersibility; a toner for developing an electrostatic charge image containing the charge control agent; and an image forming method and an image forming apparatus each using the toner for developing an electrostatic charge image. A charge control agent for controlling a charged state of powder, characterized by including one or more units each represented by the following chemical formula (1) in a molecule.

摘要翻译： 为了提供：具有负电荷性的电荷控制剂，其有助于提高环境保护等，具有高性能（高充电量，充电快速上升，优异的稳定性和高环境稳定性）， 并具有改善的分散性; 用于显影含有电荷控制剂的静电荷图像的调色剂; 以及各自使用用于显影静电荷图像的调色剂的图像形成方法和图像形成装置。 一种用于控制粉末的带电状态的电荷控制剂，其特征在于在分子中包含一个或多个由以下化学式（1）表示的单元。